Herbal Arctostaphylos uva-ursi, the Free Radicals Scavenger Functional Herb

Herbal Arctostaphylos uva-ursi may have a potential effect in reducing the risk and treatment of oxidative stress-related diseases, some studies suggested.

Oxidative stress is a production of the imbalance of ratio of free radicals and antioxidant in the bost body.

The imbalance of the ratio of free radicals and antioxidant in the bost body can be caused either by the overproduction of free radicals or antioxidant enzymes are suppressed by the outside sources.

However, most outside sources that suppress the levels of antioxidant enzymes also play an important role in stimulating the overexpression of free radicals, such as chemical toxins

Free radicals are unstable atoms with the unpaired electron in the outer ring. Therefore, in order for them to become stable, free radical either donates or steals an electron from stable molecules, leading to a chain of reaction that facilitates the onset of oxidative stress.

The chain once starts, it can not stop until the electron on the outer ring is paired or inhibited by antioxidant.

Free radical has been known to cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA.

Antioxidants are stable molecules found abundantly in fruits, vegetable, and herbal medicine.

If oxidative stress-related diseases are associated with the overproduction of free radicals, then long-term intake of a healthy diet high in fruits, vegetable and less in red meat and saturated and trans fat and processed foods can reduce the risk of the diseases in the healthy individuals.

Dr. Halliwell B, in the study to reaffirm the effect of healthy dietary patterns against the onset of oxidative stress said, " diet-derived antioxidants may be particularly important in protecting against these diseases" and

"The physiological relevance of these effects is uncertain, as is the optimal intake of most diet-derived antioxidants. In principle, these questions could be addressed by examining the effects of dietary composition and/or antioxidant supplementation upon parameters of oxidative damage in vivo".

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

In the examining the Dr. Bol'shakova IV, the lead author at the Emanuel Institute of Biochemical Physics claim, that Arctostaphylos uva.processes a significant antioxidant property in the inhibition of free radicals generation, researchers launched an investigation to evaluate the concentration of compound that inhibited cell growth by 50% (IC(50)) of a range of phytochemicals and plant extracts.

All selected extracts were differentiated according to the antioxidant and genoprotective effects under conditions of oxidative stress in U937 cells.

Two phytochemicals-resveratrol and citroflavan-3-ol isolated from the herbal Arctostaphylos uva-ursi demonstrated the highest IC50 value of 13.7 microg/mL, compared to the lowest at 9,400 microg/mL. of Echinacea.

Extract of herbal Arctostaphylos uva-ursi displayed a significant attenuation of the oxidative stress induced by the etoposide injection by inhibiting the expression of H2O2- and tBOOH-induced DNA damage.

These result reconfirmed the findings of Dr. Bol'shakova IV team that herbal Arctostaphylos uva-ursi as a non-nutrient dietary constituent may act as significant bioactive compounds in enhancing the antioxidants activity and stimulating the production of antioxidant enzymes if the herb is administrated in an animal model.

Moreover, Dr.Matsuda H the antioxidant team leader at the Kinki University, Osaka in the finding the natural compounds or whole food with potential antioxidant effects evaluated the inhibitory effect of 50% ethanol extracts obtained from the leaves of six Arctostaphylos plants (A. patula, A. viscida, A. canescens, A. Columbiana, A. nevadensis and A. uva-ursi) (Ericaceae).

Injection of the extracts of A. patula showed potent inhibition against tyrosinase, the enzyme that cause oxidation of the skin pigment.

Also, Arctostaphylos uva-ursi not only inhibited the production of melanin from dopachrome by autoxidation and but reduced the over exhibited SOD (superoxide dismutase, free radical)-like activity.

Additionally, Arctostaphylos uva-ursi processed a moderate absorbance in the UV-B area.

The results not only reaffirm the claim of Dr. Bol'shakova IV suggestion but also introduce a new herbal whitening medicine for the skin.

Taken all together, Herbal Arctostaphylos uva-ursi may be considered a functional food for the prevention and an adjunct therapy combine with primary medicine for the treatment of oxidative-related diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References

(1) [Antioxidant properties of plant extracts].[Article in Russian] by Bol'shakova IV, Lozovskaia EL, Sapezhinskiĭ II. (PubMed)

(2) Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells by O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. (PubMed)

(3) Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. by Matsuda H, Higashino M, Nakai Y, Iinuma M, Kubo M, Lang FA. (PubMed)

Herbal Cascara Sagrada's Emodin Which Inhibits Pancreatic Cancer Cells Against Spreading

Scientists may have found a functional herb bioactive compound which processes anti-pancreatic cancer activity with no side effects, some scientists suggested.

Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.

In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.

The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.

Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender, and family history are some prevalent risk factors of pancreatic cancer.

According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.

The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.

Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.

In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival

Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors, and reduced eNOS phosphorylation in cell proliferation.

However, Emodin had no effect on VEGFR expression in vivo.

Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".

Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).

The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.

Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.

In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV), and tumor weight compared to monotherapy.

Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".

Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)

Ashwagandha Protects the Liver Against Injury

The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.

The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.


Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases, surgery to stop the bleeding and remove the part of injury may be necessary.

Most cases of liver injury can lead to abdominal pain and tenderness caused by bleeding blood in the abdomen that irritates the abdominal tissue.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

The most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swollen and tenderness.


Depending on the degree of injury, patients are either treated with nonoperative management and observation for a full self-recovery or surgery.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention and treatment of liver diseases, researchers examined the effects of withanolides (WA) from Withania somnifera root extract on hepatic toxicity in an animal model


According to the tested analysis, the application of WA profoundly protects wild-type mice but not Nrf2-disrupted mice against APAP hepatotoxicity.

Where Nrf2 is a protein that regulates the expression of antioxidant proteins against oxidative damage.

In vivo and in vitro, WA is a potent inducer of Nrf2-dependent cytoprotective enzyme expression.

In other words, WA protects the liver damage against oxidative stress by enhancing the function by the activation of antioxidant enzyme protein independently to a redox-regulated substrate adaptor protein Keap1 and dependently on pathway associated with limit proliferation in cells.

Taken altogether, Ashwagandha processed a high amount of bioactive compound WA may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms by Palliyaguru DL1, Chartoumpekis DV2, Wakabayashi N2, Skoko JJ2, Yagishita Y2, Singh SV2, Kensler TW. (PubMed)

Herbal Ashwagandha Inhibits the Parameters Associated with Epilepsy in Vivo

Epilepsy is a neurological disorder associated with sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, caused by abnormal electrical activity in the brain.

Approximately, 1.2 percent of U.S. people have active epilepsy. More than 65 million people have epilepsy globally.

Additionally, about 1 in 26 people will develop epilepsy at some point during their lifetime.

The most common causes of epilepsy are low oxygen during birth, head injuries that occur during birth or from accidents during youth or adulthood, brain tumors, genetic mutation, infections such as meningitis or encephalitis.

The most common symptoms of epilepsy are temporary confusion, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, and psychic symptoms such as fear, anxiety, or deja vu.

Experimentally, melatonin, a hormone that regulates the sleep-wake cycle. has been found to attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy.

Melatonin also processed additional benefits include improved physical, emotional, cognitive, and social functions.

On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children.


The hormone showed very low toxicity in clinical practice, according to the study by the Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the management of the neurological disorder, researchers investigated the effect of Withania somnifera (WS) root extract and withanolide A (WA) in the management of temporal lobe epilepsy.


According to the tested analysis, in the epileptic test group of rats, levels of antioxidants are found to substantially decrease compared to the increase of the levels of peroxide.

Oxidative stress caused by an imbalance of the ratio of antioxidants and free radicals in the tested rats, induced significant decrease levels of proteins associated with systemic inflammation, compared to the increase of pro-apoptotic proteins.

Moreover, the epileptic condition of the tested rats also showed to increase the muscarinic receptor binding, which leads to reduced function of transduction of cholinergic signals and increases mRNA expression involved of the inhibition of the cell growth in the cerebral cortex.


However, the administration of the WS reversed the altered muscarinic receptor expression, oxidative stress, and resultant derailment in cell signaling in experimental rats.

Based on the findings, researchers said, "Withania somnifera and withanolide A play important roles in central muscarinic receptor functional balance and activation of the antioxidant system in the cerebral cortex in temporal lobe epilepsy".

Taken altogether, Ashwagandha may be considered supplements for the management of epilepsy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: restorative role of Withania somnifera by Anju TR1, Smijin S2, Jobin M3, Paulose CS. (PubMed)
(2) Melatonin in experimental seizures and epilepsy by Banach M1, Gurdziel E, Jędrych M, Borowicz KK. (PubMed)

Herbal Arctostaphylos uva-ursi, Releases the Body Toxins through Kidney Urinary Secretion

Scientists may have found a functional herbal medicine that process a significant effect in promoting the secretion of toxin through increasing the urinary flow, some studies suggested.

The diuretic effect is the activity of substances that promote urinary secretion.

Many diuretics medicine can interfere with the functioning kidney in the regulation the levels of water in the body, leading to worsening kidney function and abnormal electrolyte levels.

Certain medications that treat conditions of high blood pressure, glaucoma and edema can damage the kidney function by overworking the kidney in water release.


Dr. Yusra Habib Khan, the lead author in the study "Chronic Kidney Disease, Fluid Overload and Diuretics: A Complicated Triangle" said, "The use of diuretics was associated with adverse renal outcomes indicated by a decline in eGFR (Glomerular filtration rate (GFR) is a measure of the function of the kidneys) and increased risk of (renal replacement therapy) RRT initiation in our cohort of NDD-CKD patients".



Therefore, the intake of medicine that has a negative effect in kidney function and diuretics medicine should be taken with extreme care. If you are currently taking some of the above medicine, please make that you know the adverse effects.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.

Besides the major constituents of phenolic glycoside arbutin, tannins, and flavonoids, herbal medicine also contains free hydroquinocoumaric acidaric acid, caffeic acid, salicylic acid, flavonoid quercetin, and triterpenes ursolic acid.

Because of increased awareness of conventional medication's side effects, there is increasing interest in the health and wellness benefits of herbs and botanicals. According to the Laboratoire de Pharmacognosie, in an animal study, Arctostaphylos uva-ursi and hydroalcoholic extracts increased urine flow. Urinary sodium excretion in rats.
Use of herbal diuresis should be taken with care and under professional prescription as the application may have a strong effect on the increase of urine flow rates to induce renal clearance of the toxicant.

In the article written by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013, the author wrote, intoxications that are most likely to respond to force diuresis are those with a high level of renal excretion of the primary toxicant (e.g., bromide, lithium, amphetamine, phenobarbital, and salicylate).

Protein-bound toxins are not cleared efficiently by diuresis.

However, the patient must not be anuric or significantly oliguric

The primary problems associated with force diuresis include potential fluid overload and electrolyte abnormalities.

Michael E. Peterson DVM, MS, continued, "The practitioner should monitor for hyponatremia, hypokalemia, water intoxication, pulmonary edema, and cerebral edema. Additionally, some toxins such as tricyclic antidepressants and many sedative-hypnotics increase the patient’s susceptibility to interstitial pulmonary edema. Forced diuresis is contraindicated in these intoxications"

These results suggested that although herbal Arctostaphylos uva-ursi may be potent to detox the body toxin through increasing the urinary secretion. However, caution should be taken to prevent damage to kidney and kidney function.

Please make sure you only take the Arctostaphylos uva-ursi extract with the permission of the specialists in the related field.

However, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Arctostaphylos uva-ursi diuretic possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosellaL., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats BY Beaux D, Fleurentin J, Mortier F.(PubMed)
(2) Toxicologic Decontamination by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013. (Science Direct)

Herbal Ashwagandha Improves Nonrestorative Sleep in Human Study

Why sleep is so important? you might already know that a normal night of sleep is about eight hours as recommended by most doctors.

Why it is important, because during sleep our bodies repair the wear and tear of muscle tissue, consolidate memories, and release hormones to regulate our growth and appetites and enhance the immune system, etc. sleep disorders can reduce the functions of the immune system in fighting against disease and sickness.


Nonrestorative sleep (NRS) is a condition in which the sleep has not been sufficiently refreshing or restorative upon waking, despite sleeping an adequate number of hours, accompanied by daytime impairment, pain, fatigue, and electroencephalogram (EEG) arousals in non-REM sleep in some patients.

In other words, NRS is a peripheral symptom of insomnia or as a feature of medical conditions like fibromyalgia and chronic fatigue syndrome.
* Insomnia
Insomnia is a sign and symptom of sleep disorder in which a person has difficulty falling asleep and/or staying asleep or sleep of poor quality, including nonrestorative sleep, which can lead to substantial impairments in the quality of life and functional capacity of an individual.


Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime, and women suffer from insomnia more often than men.

* Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

* Chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a medical disorder that cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment for at least 6 months.

The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.


In the urgency to discover a natural ingredient for the treatment of sleep disorders, researchers examined the effects of Ashwagandha (Withania somnifera) on patients with nonrestorative sleep (NRS).
According to the Restorative Sleep Questionnaire-weekly version (RSQ-W) questionnaire and other test assays, in a double-blind, randomized, placebo-controlled interventional study in NRS population, a daily supplement of ashwagandha extract compared with placebo in subjects with NRS at 6 weeks from baseline,
* Exerted Anti-anxiety effects.

* Relieved insomnia and stress-induced depression.

* Reduced cortisol concentrations and the immunosuppressive effect of stress.

* Lowered CRP by inhibiting the expression of pro-inflammatory responses in the body.

Taken altogether, Ashwagandha may be considered a therapy for the treatment of nonrestorative sleep (NRS), pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withaniasomnifera) extract on nonrestorative sleep by Deshpande A, Irani N, Balakrishnan R. (PubMed)

Herbal Ashwagandha, an Adjunct Therapy for Cystic Fibrosis

Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in children and young adults, leading to difficulty breathing and coughing up mucus due to frequent lung infections.

However, the condition has also been found in the pancreas, liver, kidneys, and intestine.

According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.


Believe it or not, most cases of CF are diagnosed by age 2.

The most common symptoms are depending on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, clubbing of the fingers and toes.

In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.

Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.

In severe cases, a lung transplant may be the only option.

Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.


According to statistics provided by the Canadian Cystic Fibrosis Foundation, approximately 1 in every 3,600 children born in Canada has CF.

In age perspective,
* 60% of patients are diagnosed in the first year of life, and 90% by 10 years of age.

* More than 47% of all Canadians with CF are over the age of 18 years.

* As of 2002, the median age of survival of Canadians with CF is 37 years of age.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.


In the urgency to discover a natural ingredient for the treatment of diseases associated with genetic disorders, researchers examined the effects of Withaferin A (WFA), a steroidal lactone from the plant Withania Somnifera L. Dunal on cystic fibrosis.

According to the tested analysis, WFA blocks platelet-activating factor (PAF)-induced activation of NFκB in the induction of inflammation through the innate immune cells and inflammatory T cells.

More precisely, WFA inhibited the NFκB activation that leads to a reduction of the increased expression of IL-8 and NFκB subunit p65 translocation involved in inflammation.

In other words, WFA demonstrated anti-inflammatory activity in the cystic fibrosis model.

Based on the evidence, researchers said, "the airways of CF patients can be specifically targeted for delivery of therapeutics, we propose that WFA should be further studied as an anti-inflammatory agent in models of CF-related inflammation mediated by NFκB".

Taken altogether, Ashwagandha processed a high amount of bioactive compound WFA may be considered supplements for the treatment of cystic fibrosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation by Rangan Maitra, Melissa A Porter, Shan Huang & Brian P Gilmour (BMC)