Cardiotoxicity is a condition caused by toxin accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and the intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine, and Vitamin B deficiency have also been found to induce cardiotoxicity.
Cardiomyopathy is a severe case of cardiotoxicity.
Cardiomyopathy in most occurs in patients under chemotherapy. However, a group of diseases or disorders can also lead to damaged heart muscle. Injury to the heart muscle may induce cardiomyopathy, including viruses - such as human immunodeficiency virus (HIV), infection, long-standing high blood pressure, chronic or long-term alcohol use, and diabetes.
Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include
* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.
*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.
* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of cardiovascular diseases, researchers examined the protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.
According to the results of the experiment, doxorubicin (10 mg/kg) -induced cardiac toxicity in male Wistar rats showed an increase of necrosis and apoptosis in heart tissues.
Furthermore, the elevation of malondialdehyde and protein carbonyl levels and catalase activity associated with the expression of oxidative stress also wee found in the doxorubicin (10 mg/kg) rats.
The doxorubicin (10 mg/kg) rats also exhibited depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues, accompanied by the increases of myeloperoxidase activity, total calcium content, and the expression of Bcl-2 protein in heart tissues.
Most importantly, all parameters induced by the injection of doxorubicin alterations were effectively attenuated by the administration of the purified standardized extract (1.5% withanolides; manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg).
Based on the evidence, researchers said, "Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug".
Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of Cardiotoxicity induced by medications, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats by Hamza A1, Amin A, Daoud S. (PubMed)
Thursday, September 3, 2020
Wednesday, September 2, 2020
Herbal Ashwagandha Protects the Heart Against Damage in Post Myocardial Injury
The circulatory system consists of the heart, blood vessels, and blood with the function to transport of nutrients, oxygen, and hormones to cells throughout the body and removal of metabolic wastes (carbon dioxide, nitrogenous wastes).
Cardiovascular disease is a class of chronic conditions associated with the heart and blood vessels.
According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.
Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.
In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression, and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.
The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the promotion of cardio-functioning, researchers examined the efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion compared to that of Vit E,
The study included Wistar rats (150-200 g) that were divided into six groups and received orally saline (sham, control group), Ws-50/kg (Ws control and treated group) and Vit E-100 mg/kg (Vit E control and treated group) respectively for 1 month.
According to the results of the experiment of Vit E and Ws treated groups that were anesthetized subjected to 45 min occlusion of the LAD coronary artery followed by 60 min reperfusion on the 31st day,
* Postischemic reperfusion rats showed significant cardiac necrosis, depression of left ventricular functions (MAP, LVEDP, (+) and (-)LVdP/dt) and a significant fall in GSH (p < 0.01), SOD, CAT (p < 0.05).
* Postischemic reperfusion rats also demonstrated a fail in LDH and increased cardio stress markers and levels of MDA, compared to the sham group.
* In comparison tested, Ws and Vit E favorably modulated most of the hemodynamic, biochemical and histopathological parameters though no significant restoration in GSH, mean arterial pressure VAP.
* More importantly, chronic administration of Ws on markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) compared to Vit E that does not stimulate the synthesis of endogenous antioxidants compared to sham.
Based on the evidence, researchers said, "Ws significantly reduced myocardial injury and emphasize the beneficial action of Ws as a cardioprotective agent".
Taken altogether, Ashwagandha may be considered supplements for the treatment of myocardial injury, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment by Gupta SK1, Mohanty I, Talwar KK, Dinda A, Joshi S, Bansal P, Saxena A, Arya DS. (PubMed)
Cardiovascular disease is a class of chronic conditions associated with the heart and blood vessels.
According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.
Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.
In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression, and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.
The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in lifestyle and diet.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the promotion of cardio-functioning, researchers examined the efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion compared to that of Vit E,
The study included Wistar rats (150-200 g) that were divided into six groups and received orally saline (sham, control group), Ws-50/kg (Ws control and treated group) and Vit E-100 mg/kg (Vit E control and treated group) respectively for 1 month.
According to the results of the experiment of Vit E and Ws treated groups that were anesthetized subjected to 45 min occlusion of the LAD coronary artery followed by 60 min reperfusion on the 31st day,
* Postischemic reperfusion rats showed significant cardiac necrosis, depression of left ventricular functions (MAP, LVEDP, (+) and (-)LVdP/dt) and a significant fall in GSH (p < 0.01), SOD, CAT (p < 0.05).
* Postischemic reperfusion rats also demonstrated a fail in LDH and increased cardio stress markers and levels of MDA, compared to the sham group.
* In comparison tested, Ws and Vit E favorably modulated most of the hemodynamic, biochemical and histopathological parameters though no significant restoration in GSH, mean arterial pressure VAP.
* More importantly, chronic administration of Ws on markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) compared to Vit E that does not stimulate the synthesis of endogenous antioxidants compared to sham.
Based on the evidence, researchers said, "Ws significantly reduced myocardial injury and emphasize the beneficial action of Ws as a cardioprotective agent".
Taken altogether, Ashwagandha may be considered supplements for the treatment of myocardial injury, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment by Gupta SK1, Mohanty I, Talwar KK, Dinda A, Joshi S, Bansal P, Saxena A, Arya DS. (PubMed)
Tuesday, September 1, 2020
Bromelain Inhibits the Onset of Acute Diarrhea in Vivo
Diarrhea is an acute condition of loose, watery stools (bowel movements). In other words, if you have loose stools three or more times in one day, you are considered to have diarrhea.
Most cases of diarrhea are acute that last for a few days. However, chronic diarrhea that lasts for a long period of time is an indication of other medical conditions, including irritable bowel disorder, or inflammatory bowel disease.
Accompanied by loose and watery stool, patients with chronic diarrhea also experience abdominal cramps and pain, fever, blood, and mucus in the stool, bloating, nausea, and the urge of a bowel movement.
Most common causes of diarrhea are an infection caused by bacterias and virus. Some medications such as antibiotics also have been found to induce acute diarrhea.
The condition in some cases can also be induced by lactose intolerance, fructose, artificial sweeteners, and other digestive disorder such as Crohn's disease, ulcerative colitis, celiac disease.
Acute diarrhea can be treated successfully if the cause is found. Untreated diarrhea has been found to cause complications of dehydration, particularly in children and a weakened the immune system in older adults
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a natural compound for the treatment of diarrhea, researchers examined the effects of bromelain on K88 positive enterotoxigenic Escherichia coli (K88+ ETEC), an important cause of diarrhea in young piglets.
The study included bromelain (0, 12.5, or 125 mg) orally administered to just weaned piglets for 10 days following by the commencement of bromelain treatment, piglets were challenged with K88+ ETEC (5 x 10(10) K88ac:0149) for seven days.
Injection of 12.5 or 125 mg showed a significant effect in reducing the incidence of K88+ ETEC diarrhea and protected piglets from a life-threatening disease.
Both doses of bromelain treated pigs also had significantly increased weight gain compared to untreated pigs.
However, bromelain only temporarily inhibited K88+ ETEC receptor activity observed by the receptor activity being regenerated 30 hours following treatment, consistent with the regeneration of new enterocytes.
In other words, both doses of bromelain can only temporarily inactivate ETEC receptors in vivo and protect against ETEC induced diarrhea.
These results strongly suggested that bromelain treatment prevented the attachment of K88+ ETEC to piglet small intestines that inhibits the risk of K88+ ETEC pathogenesis.
Based on the finding, Dr. Chandler DS, the lead scientist wrote, "Bromelain may, therefore, be an effective prophylaxis against ETEC infection".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of diarrhea, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli by Chandler DS1, Mynott TL. (PubMed)
Most cases of diarrhea are acute that last for a few days. However, chronic diarrhea that lasts for a long period of time is an indication of other medical conditions, including irritable bowel disorder, or inflammatory bowel disease.
Accompanied by loose and watery stool, patients with chronic diarrhea also experience abdominal cramps and pain, fever, blood, and mucus in the stool, bloating, nausea, and the urge of a bowel movement.
Most common causes of diarrhea are an infection caused by bacterias and virus. Some medications such as antibiotics also have been found to induce acute diarrhea.
The condition in some cases can also be induced by lactose intolerance, fructose, artificial sweeteners, and other digestive disorder such as Crohn's disease, ulcerative colitis, celiac disease.
Acute diarrhea can be treated successfully if the cause is found. Untreated diarrhea has been found to cause complications of dehydration, particularly in children and a weakened the immune system in older adults
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a natural compound for the treatment of diarrhea, researchers examined the effects of bromelain on K88 positive enterotoxigenic Escherichia coli (K88+ ETEC), an important cause of diarrhea in young piglets.
The study included bromelain (0, 12.5, or 125 mg) orally administered to just weaned piglets for 10 days following by the commencement of bromelain treatment, piglets were challenged with K88+ ETEC (5 x 10(10) K88ac:0149) for seven days.
Injection of 12.5 or 125 mg showed a significant effect in reducing the incidence of K88+ ETEC diarrhea and protected piglets from a life-threatening disease.
Both doses of bromelain treated pigs also had significantly increased weight gain compared to untreated pigs.
However, bromelain only temporarily inhibited K88+ ETEC receptor activity observed by the receptor activity being regenerated 30 hours following treatment, consistent with the regeneration of new enterocytes.
In other words, both doses of bromelain can only temporarily inactivate ETEC receptors in vivo and protect against ETEC induced diarrhea.
These results strongly suggested that bromelain treatment prevented the attachment of K88+ ETEC to piglet small intestines that inhibits the risk of K88+ ETEC pathogenesis.
Based on the finding, Dr. Chandler DS, the lead scientist wrote, "Bromelain may, therefore, be an effective prophylaxis against ETEC infection".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of diarrhea, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli by Chandler DS1, Mynott TL. (PubMed)
Monday, August 31, 2020
Ashwagandha Showed a Strong Anti-Fungal Activity Against Candida Albicans
Fungal infection is a common disease caused by an overgrowth of fungus.
In other words, it is the condition in which the immune system that protects the body against microorganisms has been overwhelming by the overgrowth of fungus.
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeasts, fungi, and molds that live among the gut flora in the human mouth and gastrointestinal tract.
In fact, under normal circumstances, Candida albicans that does not cause harmful effects, but overgrowth results in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population.
According to the joint study, in many cases, biofilm (microorganisms with cells stick to each other on a surface) formation gene mutations are often associated with increased Candida resistance toward antifungal agents.
Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the infectious diseases, researchers examined the effects of withanamides in W. somnifera anti-fungal activity on Candida albicans (C. albicans).
The study included 9 vaginal samples collected using the sterile swap and Falcon tube by the gynecological specialists.
Based on the results of the tested analysis, withanamides incubated with C. Albicans showed a minimum inhibitory concentration (MIC) against C. Albicans, equivalent to 50 ppm to 250 ppm.
In other words, withanamides extract isolated from W. somnifera exhibited strong activity against infectious disease caused by C. Albicans.
After taking into account of con and cofounders, researchers wrote, "The results of this study showed that the antifungal activity of wind cheese against C. Albicans is good, so it can be used as a drug to treat infections caused by C. Albicans".
Taken altogether, Ashwagandha processes abundantly withanamides may be considered a functional herb for the treatment of infectious diseases associated with C. Albicans, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antifungal effects of the extract of the Withania somnifera on Candida albicans by ereshteh Javadian 1 Zahra Sepehri 2 Saeideh Saeidi 3 Mehdi Hassanshahian. (Advanced Herbal Medicine)
(2) The Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth - The Effectiveness of Antifungal products by Kyle J. Norton
In other words, it is the condition in which the immune system that protects the body against microorganisms has been overwhelming by the overgrowth of fungus.
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeasts, fungi, and molds that live among the gut flora in the human mouth and gastrointestinal tract.
In fact, under normal circumstances, Candida albicans that does not cause harmful effects, but overgrowth results in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population.
According to the joint study, in many cases, biofilm (microorganisms with cells stick to each other on a surface) formation gene mutations are often associated with increased Candida resistance toward antifungal agents.
Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.
Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.
In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.
According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.
More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the infectious diseases, researchers examined the effects of withanamides in W. somnifera anti-fungal activity on Candida albicans (C. albicans).
The study included 9 vaginal samples collected using the sterile swap and Falcon tube by the gynecological specialists.
Based on the results of the tested analysis, withanamides incubated with C. Albicans showed a minimum inhibitory concentration (MIC) against C. Albicans, equivalent to 50 ppm to 250 ppm.
In other words, withanamides extract isolated from W. somnifera exhibited strong activity against infectious disease caused by C. Albicans.
After taking into account of con and cofounders, researchers wrote, "The results of this study showed that the antifungal activity of wind cheese against C. Albicans is good, so it can be used as a drug to treat infections caused by C. Albicans".
Taken altogether, Ashwagandha processes abundantly withanamides may be considered a functional herb for the treatment of infectious diseases associated with C. Albicans, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antifungal effects of the extract of the Withania somnifera on Candida albicans by ereshteh Javadian 1 Zahra Sepehri 2 Saeideh Saeidi 3 Mehdi Hassanshahian. (Advanced Herbal Medicine)
(2) The Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth - The Effectiveness of Antifungal products by Kyle J. Norton
Sunday, August 30, 2020
Herbal Coltsfoot(Tussilago farfara), the Liver-protective Remedy
The liver is the largest internal and only organ in the human body that can regenerate itself.
The liver is the first line of detoxing defense by filtering the blood that comes from the digestive tract, before passing them to other organs and tissues in the body.
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound which processes a liver protective effect, researchers examined the highly active photocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum) and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers and PC-1 extract exhibited the strongest anti-lipid peroxidation (LPO)O and antihemolytic effects.
According to the tested results, PC-1 extract activated the Nrf2/antioxidant response is more effective comapred to the extracts of other photocomposition.
Furthermore, oral administration of PC-1 extract (100-200 mg/kg) markedly protected the rat liver injury acutely or chronically against intoxicated by carbon tetrachloride.
The liver protective activity of PC-1 was attributed to the activation of the levels of antioxidant enzymes in the host and the improvement of liver histology, blood chemistry parameters.
Moreover, the osmotic fragility test (OFT) also addressed that PC-1 extract inhibited the destruction of red blood cells in carbon tetrachloride intoxicated rats.
Based on the findings, researchers said, " these data support the strategy of in-vitro plant selection for developing efficacious tissue-protective photocomposition".
Taken altogether, coltsfoot may be considered a liver protective remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity by Aralbaeva AN1, Mamataeva AT1, Zhaparkulova NI2, Utegalieva RS1, Khanin M3, Danilenko M4, Murzakhmetova MK. (PubMed)
The liver is the first line of detoxing defense by filtering the blood that comes from the digestive tract, before passing them to other organs and tissues in the body.
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound which processes a liver protective effect, researchers examined the highly active photocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum) and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers and PC-1 extract exhibited the strongest anti-lipid peroxidation (LPO)O and antihemolytic effects.
According to the tested results, PC-1 extract activated the Nrf2/antioxidant response is more effective comapred to the extracts of other photocomposition.
Furthermore, oral administration of PC-1 extract (100-200 mg/kg) markedly protected the rat liver injury acutely or chronically against intoxicated by carbon tetrachloride.
The liver protective activity of PC-1 was attributed to the activation of the levels of antioxidant enzymes in the host and the improvement of liver histology, blood chemistry parameters.
Moreover, the osmotic fragility test (OFT) also addressed that PC-1 extract inhibited the destruction of red blood cells in carbon tetrachloride intoxicated rats.
Based on the findings, researchers said, " these data support the strategy of in-vitro plant selection for developing efficacious tissue-protective photocomposition".
Taken altogether, coltsfoot may be considered a liver protective remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity by Aralbaeva AN1, Mamataeva AT1, Zhaparkulova NI2, Utegalieva RS1, Khanin M3, Danilenko M4, Murzakhmetova MK. (PubMed)
Saturday, August 29, 2020
Herbal Bilberry, A Natural Treatment for Peyronie's disease
Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.
Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.
Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.
Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.
Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment with significantly increase the likelihood of therapeutic success.
By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.
According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.
Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.
In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.
The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.
Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."
Taken altogether, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)
Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.
Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.
Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.
Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment with significantly increase the likelihood of therapeutic success.
By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.
According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.
Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.
In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.
The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.
Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."
Taken altogether, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)
Friday, August 28, 2020
Bromelain Modulates the Immune Function Against Allergic Airway Disease (AAD)
Chronic allergic airways disease (AAD) is a group of the disease characterized by airway inflammation and airway hyperresponsiveness (AHR).
Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by persistent production of proinflammatory cytokines by the immune system in the airway.
On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.
The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airways conditions.
Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improved quality of life through avoidance of irritants.
If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.
Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".
And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".
In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain in reducing the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.
On day 4, phosphate buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS were administrated to the bromelain (intervention) group (n = 10).
According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.
Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.
The efficacy bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.
In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory property.
Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic airway disease ADD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D
Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by persistent production of proinflammatory cytokines by the immune system in the airway.
On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.
The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airways conditions.
Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improved quality of life through avoidance of irritants.
If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.
Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".
And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".
In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain in reducing the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.
On day 4, phosphate buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS were administrated to the bromelain (intervention) group (n = 10).
According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.
Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.
The efficacy bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.
In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory property.
Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic airway disease ADD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D
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