Cardiotoxicity is a condition caused by toxin accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and the intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine, and Vitamin B deficiency have also been found to induce cardiotoxicity.
Cardiomyopathy is a severe case of cardiotoxicity.
Cardiomyopathy in most occurs in patients under chemotherapy. However, a group of diseases or disorders can also lead to damaged heart muscle. Injury to the heart muscle may induce cardiomyopathy, including viruses - such as human immunodeficiency virus (HIV), infection, long-standing high blood pressure, chronic or long-term alcohol use, and diabetes.
Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include
* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.
*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.
* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of cardiovascular diseases, researchers examined the protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.
According to the results of the experiment, doxorubicin (10 mg/kg) -induced cardiac toxicity in male Wistar rats showed an increase of necrosis and apoptosis in heart tissues.
Furthermore, the elevation of malondialdehyde and protein carbonyl levels and catalase activity associated with the expression of oxidative stress also wee found in the doxorubicin (10 mg/kg) rats.
The doxorubicin (10 mg/kg) rats also exhibited depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues, accompanied by the increases of myeloperoxidase activity, total calcium content, and the expression of Bcl-2 protein in heart tissues.
Most importantly, all parameters induced by the injection of doxorubicin alterations were effectively attenuated by the administration of the purified standardized extract (1.5% withanolides; manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg).
Based on the evidence, researchers said, "Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug".
Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of Cardiotoxicity induced by medications, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats by Hamza A1, Amin A, Daoud S. (PubMed)
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