Medical Advisor Journals

Sunday, December 27, 2015

Most common diseases of 50 plus: Musculo-Skeletal disorders: Chronic Low back pain Treatment in conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

Treatment in conventional medicine perspective

A.1. Non surgical treatment
1. Exercise therapy
Exercise therapy is the most widely used type of conservative treatment for low back pain. Systematic reviews have shown that exercise therapy is effective for chronic but not for acute low back pain. In a study of Exercise therapy for chronic nonspecific low-back pain, suggested that compared to usual care, exercise therapy improved post-treatment pain intensity and disability, and long-term function. It is effective at reducing pain and function in the treatment of chronic low back pain. There is no evidence that one particular type of exercise therapy is clearly more effective than others. However, effects are small and it remains unclear which subgroups of patients benefit most from a specific type of treatment(37).
Other showed that Exercise therapy that consists of individually designed programs, including stretching or strengthening, and is delivered with supervision may improve pain and function in chronic nonspecific low back pain(38).
1.1. Hip mobilizations and exercise
In the study to to investigate the short-term outcomes in patients with CLBP managed with impairment-based manual therapy and exercise directed at the hip joints, found that an impairment-based approach directed at the hip joints may lead to improvements in pain, function, and disability in patients with CLBP(39).
2. Cognitive behavioral therapy
Cognitive behavioral therapy (CBT) is a beneficial treatment for chronic nonspecific back pain, leading to improvements in a wide range of relevant cognitive, behavioral and physical variables. This is especially evident when CBT is compared to treatment as usual or wait-list controls, but mixed and inconclusive when compared with various other treatments, according to the study by Uni Health, Uni Research, Bergen, Norway(40).
Other researchers suggested that the self-rated treatment effectiveness and satisfaction appeared to be higher in the three active treatments. Several physical performance tasks improved in Active Physical Treatment (APT) and Combined Treatment of APT and CBT (CT) but not in Cognitive-Behavioral Treatment (CBT). No clinically relevant differences were found between the CT and APT, or between CT and CBT(41).
3. Medication
The range of regularly prescribed pharmacological agents to treat Chronic Low back pain extends from nonopioids (paracetamol, NSAIDs, and COX-2 inhibitors) to opioids, antidepressants and anticonvulsants(42).

3.1. Non-steroidal anti-inflammatory drugs (NSAIDs)
Transdermal fentanyl significantly improved visual analog scale scores and Oswestry Disability Index scores in 73% of patients, especially those with specific low back pain awaiting surgery; however, it did not decrease pain in 27% of patients, including patients with non-specific low back pain or multiple back operations(43).
Side effects include nausea, vomiting, diarrhea, constipation, decreased appetite, rash, dizziness, headache, drowsiness, etc.
3.2. Opioids
tapentadol’s μ-opioid agonism makes a greater contribution to analgesia in acute pain, while noradrenaline reuptake inhibition makes a greater contribution in chronic neuropathic pain models. Tapentadol also produces fewer adverse events than oxycodone at equianalgesic doses, and thus may have a ‘μ-sparing effect’, according to the study by Johns Hopkins University School of Medicine(44)
Side effects include Nausea, dizziness, constipation, CNS sedation, etc.
3.3. Antidepressants
Selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of medication used as antidepressants in the treatment of depression, anxiety disorders, and some other disorders. In a study of a total of 575 patients enrolled, 45 of 89 (50.6%) taking SSRIs/SNRIs and 303 of 486 (62.3%) not taking SSRIs/SNRIs successfully titrated to oxymorphone ER, showed that during the double-blind treatment phase, there was no significant difference in the frequency of serious AEs in patients treated with oxymorphone ER taking (1/29; 3.4%) versus those not taking (3/146; 2.0%) SSRIs/SNRIs. Visual analog scale scores were similar in patients taking versus those not taking SSRIs/SNRIs throughout the study(45).
Side effects include nausea/vomiting, drowsiness, headache, bruxism, tinnitus, extremely vivid or strange dreams, dizziness, fatigue, etc.
3.4. Anticonvulsants
Anticonvulsants benzodiazepines, the medication used in the treatment of epileptic seizures and has been used as adjunctive medications for acute low back pain, but have a high incidence of sedation(46).
Side effects are not limited to dependency, rebound anxiety, memory impairment, discontinuation syndrome, muscle weakness, dizziness, mental confusion, depression, etc.
3.5. Antispasmodic drug
Eperisone had an analgesic and muscle relaxant effect in patients with LBP. It should be noted that while it is common practice in rheumatology to combine a pain killer with a muscle relaxant in order to achieve a satisfactory result on both symptoms, the present results with eperisone were achieved with a single drug. With an improved tolerability profile compared with nonsteroidal anti-inflammatory drugs, and a lack of significant adverse effects on the CNS, eperisone hydrochloride represents a valuable alternative to traditional analgesics and muscle relaxants for the treatment of LBP, according to the study by Service of Rehabilitation and Functional Reeducation, S. Orsola-Malpighi Hospital, Bologna(47).
Side effects are not limited to redness, itching, urticaria, edema, rash, pruritus, sleepiness, insomnia, headache, nausea and vomiting, anorexia, abdominal pain, etc.
4. Injection
In the comparison of the clinical effectiveness of FJ injections (FJI) and FJ radiofrequency (FJRF) denervation in patients with chronic low back pain, found that the first choice should be the FJI and if pain reoccurs after a period of time or injection is not effective, RF procedure should be used for the treatment of chronic lumbar pain(47a).
5. Others
In the study to evaluate the use and direct medical costs of pharmacologic and alternative treatments for patients with osteoarthritis (OA) and chronic low back pain (CLBP), researchers at the Avalon Health Solutions, Inc., Philadelphia, Pennsylvania, indicated that Opioids were the most frequently prescribed medication (>70%) in both groups, followed by nonselective nonsteroidal anti-inflammatory drugs (>50%). Over 30% received antidepressants, >20% received benzodiazepines, and 15% in each group received sedative hypnotics. Use of alternative treatments was as follows: chiropractor, OA 11%, CLBP 34%; physical therapy, 20% in both groups; transcutaneous electrical nerve stimulations (TENS), OA 14%, CLBP 22%; acupuncture, hydrotherapy, massage therapy, and biofeedback, <3% in both groups. Mean (SD) total healthcare costs among these patients were, OA: $15,638 ($22,595); CLBP: $11,829 ($20,035). Pharmacologic therapies accounted for approximately 20% of these costs, whereas alternative treatments accounted for only 3% to 4% of the total costs(48).
According to the study of group-based multidisciplinary rehabilitation program and oral drug treatment versus oral drug treatment alone, the group-based multidisciplinary program could improve most domains of quality of life in chronic low back pain patients in the 6-month period. However, there were no significant differences between two groups in sub scales such as general health, social function and role emotional(49).
Also in a clinical trial comparing group-based multidisciplinary biopsychosocial rehabilitation and intensive individual therapist-assisted back muscle strengthening exercises, showed that both groups showed long-term improvements in pain and disability scores, with only minor statistically significant differences between the 2 groups. The minor outcome difference in favor of the group-based multidisciplinary rehabilitation program is hardly of clinical interest for individual patients(50).
A.2. Surgical treatments
Most patients with back pain will not benefit from surgery and is performed when conservative treatment is not effective in reducing pain or if anatomic abnormalities consistent with the distribution of pain are identified. The most common types of low back surgery include
1. Microdiscectomy
In retrospective cohort study of patients who underwent LMD in 2004-2005 were invited to participate and were re-evaluated clinically and radiologically after a three to five year follow-up, found that although many patients may be symptomatic following LMD, significant disability and dissatisfaction are uncommon. Female sex, young age, lack of exercise, and chronic preoperative LBP may predict a worse outcome. Disc collapse is a universal finding, particularly at L4-L5. Neither DSC nor Modic changes seem to affect patient outcome(51).
2. Discectomy(SD)
Recurrent or persistent low back pain (LBP) after surgical discectomy (SD) for intervertebral disc herniation has been well documented(52)
3. Laminectomy
In the study of Twenty age-matched Sprague-Dawley male rats divided into operative and non-operative (control) groups, operative animals underwent a bilateral L5-L6 laminectomy with right-side L5-6 disc injury, a post-laminectomy pain model previously published by this lab, showed that the post-laminectomy condition creates quantifiable fibrosis of the spinal nerve to surrounding structures and supports the conclusion that this fibrosis may play a role in the post-laminectomy pain syndrome(53).
4. Spinal fusion
In the study to determine the prognostic accuracy of tests for patient selection that are currently used in clinical practice to identify those patients with chronic LBP who will benefit from spinal fusion, showed that no subset of patients with chronic LBP could be identified for whom spinal fusion is a predictable and effective treatment. Best evidence does not support the use of current tests for patient selection in clinical practice(54).
5. Etc.
In a meta-analysis of randomised controlled trials to investigate the effectiveness of surgical fusion for the treatment of chronic low back pain compared to non-surgical intervention, by searching the Several electronic databases (MEDLINE, EMBASE, CINAHL and Science Citation Index) from 1966 to 2005, found that the pooled mean difference in ODI between the surgical and non-surgical groups was in favour of surgery (mean difference of ODI: 4.13, 95%CI: −0.82 to 9.08, p

0.10, I2

44.4%). Surgical treatment was associated with a 16% pooled rate of early complication (95%CI: 12–20, I2

0%). Surgical fusion for chronic low back pain favoured a marginal improvement in the ODI compared to non-surgical intervention. This difference in ODI was not statistically significant and is of minimal clinical importance. Surgery was found to be associated with a significant risk of complications. Therefore, the cumulative evidence at the present time does not support routine surgical fusion for the treatment of chronic low back pain(55). Others suggested that Fusion surgery is more effective than standard rehabilitation for improving pain in people with chronic non-radicular low back pain, but it is no better than intensive rehabilitation with a cognitive behavioural component(56).
Surgery can be considered in persons who have experienced significant functional disabilities and in those with unremitting pain, especially pain lasting longer than 12 months despite multiple nonsurgical treatments. Good evidence supports the use of spinal fusion for treating back pain caused by fractures, infections, progressive deformity, or instability with spondylolisthesis(57).

Thursday, December 24, 2015

The Magnificent Smoothie for Protection and Treatment against Memory and Learning Deficit

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk Stress and Stress
Yield: 2 serving (about 8 ounce each)
1 1/2 cups blue berry
1/2 cup green tea drink (Make from 2 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1/2 cup Ginseng drink, (Make from 1 gram of dried root, soaped into a cup of hot water for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of memory and learning ability is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.
Memory and Learning ability has been one cognitive degenerative worriness of patient with dementia, due to its progression and increased proportion with aging.
Green tea(1), Ginseng(5) and blueberry(9) may be next generation pharmaceutical agent used for enhancing the Memory and Learning ability, probably due to their phytochemicals in attenuated the cognitive dysfunction induced memory and learning loss.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Epidemiologically, green tea antioxidant such as polyphenols, is considered as protective agents in neurodegenerative diseases such as Alzheimer's disease (AD)(1).

In Learning and Memory Deficits in Ischemic Rats, the phytochemical also improved learning and memory deficits in a cerebral ischemia animal model, through inhibition of free radicals in reactive oxygen species(2).
In fact, chronic administration of green tea epigallocatechin gallate (EGCG), ameliorated learning and memory deficits in STZ-diabetic rats through attenuation of oxidative stress in dose-dependent-manner and in modulation of NO(3).

Dr. Li Q and the research team at the Peking University said," long-term green tea catechin administration prevents spatial learning and memory impairment" in animal model " by decreasing Abeta(1-42) oligomers and proteins in hippocampus "(4).

Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root).

Ginsenoside, the main constituent of ginseng, consisting the neuro protective effect, epidemiologically, showed to prevent memory loss in animal model after 8 months of administration(5), through effective of its antioxidant property.
Dr. Petkov V and , Mosharrof AH said," Standardized ginseng extract, in dose depend manner, improved learning and memory.....( as well as) greatly increased the locomotor activity of mice"(6).

According to the joint study lead by Zhejiang University, ginseng reduced the loss and injury of neurons, prevented the early onset of various neurodegenerative diseases, and attenuated impairment of hippocampus-dependent learning and memory,... through antioxidant effect of its Ginseng Rb fraction(8).

Furthermore, in basic and clinical trials, ginseng not only ameliorated on learning and memory deficits due to hippocampal lesions and aging but also enhanced the central nervous system function and hippocampal formation(7).

Blueberry is a flower plant, belong to the family Eriaceae and native to Northern America. Its flavonoid, has exhibited the significant reversal of age-related deficits on spatial memory and learning, through its interaction of signalling pathways, transcription factors and gene and/or protein expression(9).

Polyphenol-rich wild blueberry extract, in adult, male, 3-4-month-old Balb-c mice, improved learning and memory function through expression of brain antioxidant properties and inhibition of AChE activity(10).

Dr. Spencer JP at the University of Reading said," ..., a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning" and " possess the greatest potential to act on the cognitive processes"(11), probably due to its effect in activating signalling pathways, reducing neuroinflammation and inducing vascular effects potentially capable of causing new nerve cell growth in the hippocampus(12).

The finding of the effectiveness of Green Tea, Ginseng and blueberry and theirs phytochemicals may serve as cornerstones of pharmaceutical target for further studies to establish a potential medication for treatment of Memory and Learning deficits in patient with Neuro deficit disease.

People who are at high risk of Memory and Learning deficit due to aging, genetic mutation genes such as amyloid precursor protein (APP),.....should drink at least one serving daily and people with Memory and Learning ability should drink the juices no more than 4 servings a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

References
(1) Green tea polyphenols protect against okadaic acid-induced acute learning and memory impairments in rats by Li H1, Wu X1, Wu Q1, Gong D1, Shi M1, Guan L1, Zhang J1, Liu J1, Yuan B1, Han G2, Zou Y3.(PubMed)

(2) Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Wu KJ1, Hsieh MT, Wu CR, Wood WG, Chen YF.(PubMed)

(3) Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress by Baluchnejadmojarad T1, Roghani M.(PubMed)

(4) Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus by Li Q1, Zhao HF, Zhang ZF, Liu ZG, Pei XR, Wang JB, Li Y.(PubMed)

(5) Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus by Zhao H1, Li Q, Zhang Z, Pei X, Wang J, Li Y.(PubMed)

(6) Effects of standardized ginseng extract on learning, memory and physical capabilities by Petkov VD1, Mosharrof AH.(PubMed)

(7) Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning andmemory deficits in an animal model of amnesia by Nishijo H1, Uwano T, Zhong YM, Ono T.(PubMed)

(8) Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration by Xu K1, Zhang Y2, Wang Y1, Ling P2, Xie X1, Jiang C1, Zhang Z3, Lian XY1.(PubMed)

(9) Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects by Rendeiro C1, Guerreiro JD, Williams CM, Spencer JP.(PubMed)

(10) Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity by Papandreou MA1, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN.(PubMed)

(11) The impact of fruit flavonoids on memory and cognition by Spencer JP1.(PubMed)

(12) Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology by Vauzour D1.(PubMed)

Most common diseases of 50 plus: Musculo-Skeletal disorders: Chronic Low back pain Prevention - the Easy Ways

2. Tai Chi
In the study to review the history, the philosophy, and the evidence for the role of Tai Chi in a few selected chronic pain conditions found that the ancient health art of Tai Chi contributes to chronic pain management in 3 major areas: adaptive exercise, mind-body interaction, and meditation. Tai Chi seems to be an effective intervention in osteoarthritis, low back pain, and fibromyalgia(34).

3. Moderate alcohol consumption and quit smoking

As alcohol dependency and smoking are the risk factor of chronic low back pain.

4. Moderate exercise
Moderate exercise are associated to reduced risk of chronic low back pain as it increases oxygenation and blood circulation in the body(35).

5. Avoid recurrent Low back injure
Recurrent Low back injure and injure which has been not treated well may come back to haunt you when you get older, according to traditional Chinese medicine.

6. Yoga
In a seven day randomized control single blind active study in an residential Holistic Health Centre in Bangalore, India, assigned 80 patients (37 female, 43 male) with CLBP to yoga and physical exercise groups, showed that Seven days intensive residential Yoga program reduces pain, anxiety, and depression, and improves spinal mobility in patients with CLBP more effectively than physiotherapy exercises(36).

7. Healthy diet including calcium and vitamin D to prevent osteoporosis causes of chronic low back pain.
8. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
Red flags*
Recent significant trauma, Milder trauma if age is greater than 50 years, Unexplained weight loss, Unexplained fever, Immunosuppression, Previous or current cancer, Intravenous drug use, Osteoporosis, Chronic corticosteroid use, Age greater than 70 years, Focal neurological deficit, Duration greater than 6 week(a)
(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(33) http://www.ncbi.nlm.nih.gov/pubmed/22654693
(34) http://www.ncbi.nlm.nih.gov/pubmed/22609642
(35) http://www.ncbi.nlm.nih.gov/pubmed/23131528
(36) http://www.ncbi.nlm.nih.gov/pubmed/22500659

Wednesday, December 23, 2015

Research by Kyle J. Norton, The Incredible smoothie Blueberry, Grape and Green tea Prevention and Treatment of Anxiety

In adult rats study, consumed approximately 3.2 mg kg(-1)day (oral), of the anthocyanins found in fruits especially in blueberry, significantly reduced the memory deficits, anxiety and improved locomotion(3).

Dr. Valcheva-Kuzmanova S and, Zhelyazkova-Savova M. in the classification of aronia melanocarpa fruit juice rich with anthocyanin suggested that the juice exhibited neither an anxiolytic-like effect with no changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory(4)

Grape, containing high amount of resveratrol, is a woody vines of the genus Vitis, belonginjgs to the family Vitaceae, native to southern Turkey. Epidemiological studies, strong evidences through the accumulated data suggested that dietary supplements rich in important phytochemicals resveratrol significantly decreases anxiety/depressive behaviours(6).
Pterostilbene, a natural analog of resveratrol, exhibited anxiolytic-like activity without effecting locomotor activity, through regulating cellular processes(7).
Dr.Sönmez U and the research team at the Dokuz Eylul University Inciralti, in the study of traumatic brain injury in immature rats said," resveratrol decreased anxiety and increased cortex/hippocampus dependent memory of animals subjected to blunt head trauma"(8).

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Flavanols, a natural products found in green tea, inhibited anxiety like symptoms in adult male C57BL/6 mice, through mood-modulating effects(9).
Dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis has found to associate to depression and anxiety, chronic administration of catechin (CTN) significantly alleviated of the complex symptoms associated with depression and anxiety disorders, on chronic CORT-induced behavioral alterations using the forced swimming test (FST), according to the Acupuncture and Meridian Science Research Center(10).
Furthermore, "(-)-epigallocatethin-3-O-gallate (EGCG) (another catechins phytochemical found in green tea),... reverses caffeine-induced anxiogenic-like effects" and "exhibited anxiolytic effects in an animal model" Dr. Park KS and the research team at the Chungbuk National University said.

Taking altogether, people who are at increased risk of anxiety due to family history, gene mutation .....should drink at least one serving daily and people with chronic anxiety should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

References

(1) Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B by Dreiseitel A1, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG.(PubMed)

(2) Effect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests by Damián JP1, Acosta V, Da Cuña M, Ramírez I, Oddone N, Zambrana A, Bervejillo V, Benech JC.(PubMed)

(3) Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children by Richards G1, Smith A2.(PubMed)

(4) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT.(PubMed)

(5) Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats by Valcheva-Kuzmanova S1, Zhelyazkova-Savova M.(PubMed)
(6) Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review by Nabavi SM, Daglia M, Braidy N, Nabavi SF.(PubMed)
(7) Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation by Al Rahim M1, Rimando AM, Silistreli K, El-Alfy AT.(PubMed)
(8) Neuroprotective effects of resveratrol against traumatic brain injury in immature rats by Sönmez U1, Sönmez A, Erbil G, Tekmen I, Baykara B.(PubMed)
(9) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice by Stringer TP1, Guerrieri D1, Vivar C1, van Praag H1.(PubMed)

Most common diseases of 50 plus: Musculo-Skeletal disorders: Chronic Low back pain - The Diagnosis and Complications

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

The Diagnosis

1. Health and family history and physical exam
If you are experience low back pain, a decrease in sensation, and weakness of the extremities, the diagnosis may include a complete family history including the prior and current illnesses and injuries and a physical exam include pressure on (palpate) the spine, which may cause tenderness over the affected area. The pain may radiate along the course of a rib to the anterior chest or abdomen. Gait and posture can be affected by disc herniation that causes spinal cord compression and are usually evaluated during the physical exam(24).
2. Other tests may include
a. X ray
b. CT scan
c. MRI
d. Radiography of the spine
e. Etc.
But other suggested that immediate, routine lumbar spine imaging in patients with LBP and without features indicating a serious underlying condition(Red flags*) did not improve outcomes compared with usual clinical care without immediate imaging. Clinical care without immediate imaging seems to result in no increased odds of failure in identifying serious underlying conditions in patients without risk factors for these conditions. In addition to lacking clinical benefit, routine lumbar imaging is associated with radiation exposure (radiography and CT) and increased direct expenses for patients and may lead to unnecessary procedures. This evidence confirms that clinicians should refrain from routine, immediate lumbar imaging in primary care patients with nonspecific, acute or subacute LBP and no indications of underlying serious conditions(25)(26). Lumbar imaging for low-back pain without indications of serious underlying conditions does not improve clinical outcomes. Therefore, clinicians should refrain from routine, immediate lumbar imaging in patients with acute or subacute low-back pain and without features suggesting a serious underlying condition(27).

Complications

1. Mental health
found that adults aged 65 years and above with chronic impairing LBP had higher mental health scores, reported significantly less depression, and used less antidepression medication relative to the younger age groups, according to the study of a crosssectional, telephone survey of 5,357 households was conducted to identify 732 adults with chronic, impairing LBP(28).
2. Sleep disturbance, and interleukin-6
In adults with CLBP, poorer sleep quality was associated with higher IL-6 levels, and both sleep and IL-6 related to pain reports. Inflammatory processes may play a significant role in the cycles of pain and sleep disturbance. Clinical interventions that improve sleep and reduce concomitant inflammatory dysregulation hold promise for chronic pain management, according to the study by Rochester Center for Mind-Body Research, University of Rochester Medical Center(29).
Others suggested that The sleep of the patients with CLBP was significantly altered compared with that of the healthy controls, in proportion to the impact of low back pain on daily life(30).
3. Maladaptive movement and motor control impairments
Eighty five percent of chronic low back pain (CLBP) disorders have no known diagnosis leading to a classification of ‘non-specific CLBP’ that leaves a diagnostic and management vacuum. Dr. O’Sullivan P. said ” These pain disorders are predominantly mechanically induced and patients typically present with mal-adaptive primary physical and secondary cognitive compensations for their disorders that become a mechanism for ongoing pain”(31).
4. Somatic dysfunction (by the presence of any of 4 TART criteria: tissue texture abnormality, asymmetry, restriction of motion, or tenderness)
In a Cross-sectional study nested within a randomized controlled trial, by The Osteopathic Research Center, Fort Worth, demonstrated that somatic dysfunction, particularly in the lumbar and sacrum/pelvis regions, is common in patients with chronic LBP. Forthcoming extensions of the OSTEOPATHIC Trial will assess the efficacy of OMT according to baseline levels of somatic dysfunction(32).
5. Etc.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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Sources
Red flags*
Recent significant trauma, Milder trauma if age is greater than 50 years, Unexplained weight loss, Unexplained fever, Immunosuppression, Previous or current cancer, Intravenous drug use, Osteoporosis, Chronic corticosteroid use, Age greater than 70 years, Focal neurological deficit, Duration greater than 6 week(a)
(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(24) http://www.mdguidelines.com/degeneration-thoracic-or-thoracolumbar-intervertebral-disc
(25) http://www.ncbi.nlm.nih.gov/pubmed/21214357.
(26) http://www.ncbi.nlm.nih.gov/pubmed/11701101
(27) http://www.ncbi.nlm.nih.gov/pubmed/19200918
(28) http://jah.sagepub.com/content/22/8/1213.full.pdf+html
(29) http://www.ncbi.nlm.nih.gov/pubmed/21188850.
(30) http://www.ncbi.nlm.nih.gov/pubmed/18389288
(31) http://www.ncbi.nlm.nih.gov/pubmed/16154380
(32) http://www.ncbi.nlm.nih.gov/pubmed/22802542

Tuesday, December 22, 2015

The Unforgettable Smoothie of Blue berry Juice, dart chocolate and Green tea for prevention and treatment of Stress

Organic mulberry fruits, containing high amount of anthocyanins has been found to process anti cancer(2) and inflammatory diseases(3) through vary mechanisms.

According to the Meikai University School of Dentistry, mulberry juice may also consist of anti stress activity 4 hours after cessation of oral administration due to its antioxidant effects(4).

In animal study, the juice also exhibited anti stress property throughi its radical scavenging activity(5), DR. Sakagami H and the research team at the Meikai University School of Dentistry suggested

Dark chocolate or plain chocolate produced by seeds of cocoa directly has found to blocks feelings of pain and depression temporarily due to the effects of its phytochemical polyphenols(6).In the comparison of Dark chocolate (DC), Milk chocolate (MC), Whitechocolate (WC). in 60 subjects, Intake of dark chocolate daily during a period of 2 weeks effectively reduce stress in females(6).
In psychological stress in healthy men with aged 20-50 years, Dr. von Känel R and the research team at the University of Konstanz, said,"(Through) attenuated stress reactivity of the hypercoagulability marker D-dimer,... a single consumption of flavonoid-rich dark chocolate blunted the acute prothrombotic response to psychosocial stress"(7).

Furthermore, 3 weeks consumption of 50 g flavonoid-rich dark chocolate also showed to reduce oxidative stress through improving the lipoprotein profile in healthy humans, more so in women than in men, and inducing a protective effect on the cardiovascular system(8).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

according to the literatures found on PubMed, green phtochemicals showed effectively in reduce symptoms induced by psychological stress.

According to the University of Shizuoka, intake of green tea inhibited the increase of stress effect through improving the mood swing during and after mental stress load(9), attenuating learning and memory impairment(10).

Dr. Ross SM said,"Green tea also reduce psychological stress through its antioxidant L-theanine (suntheanin): an amino acid derived from green tea"(11).

People who are at increased risk of stress due to family history or gene mutation .....should drink at least one cup daily and people with chronic stress should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Role of cortisol and superoxide dismutase in psychological stress induced anovulation by Kala M1, Nivsarkar M2.(PubMed)
(2) Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer by Peiffer DS1, Wang LS2, Zimmerman NP3, Carmella SG4, Kuo CT5, Chen JH2, Oshima K6, Huang YW7, Hecht SS8, Stoner G9.(PubMed)
(3) The anti-inflammatory and antifibrosis effects of anthocyanin extracted from black soybean on a Peyroniedisease rat model by Sohn DW1, Bae WJ2, Kim HS1, Kim SW1, Kim SW3.(PubMed)
(4) Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions by Sakagami H1, Asano K, Satoh K, Takahashi K, Kobayashi M, Koga N, Takahashi H, Tachikawa R, Tashiro T, Hasegawa A, Kurihara K, Ikarashi T, Kanamoto T,Terakubo S, Nakashima H, Watanabe S, Nakamura W.(PubMed)
(5)
(6) Effects of chocolate intake on Perceived Stress; a Controlled Clinical Study by Al Sunni A1, Latif R1.(PubMed)
(7) Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men by von Känel R, Meister RE, Stutz M, Kummer P, Arpagaus A, Huber S, Ehlert U, Wirtz PH1.(PubMed)
(8) Effect of consumption of dark chocolate on oxidative stress in lipoproteins and platelets in women and in men by Nanetti L1, Raffaelli F, Tranquilli AL, Fiorini R, Mazzanti L, Vignini A.(PubMed)
(9) Intake of green tea inhibited increase of salivary chromogranin A after mental task stress loads by Yoto A1, Murao S, Nakamura Y, Yokogoshi H(PubMed)
(10) Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal autophagic flux by Gu HF1, Nie YX2, Tong QZ3, Tang YL4, Zeng Y2, Jing KQ2, Zheng XL5, Liao DF6.(PubMed)
(11) L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), onstress response parameters by Ross SM1.(PubMed)

Most common diseases of 50 plus: Types of Musculo-Skeletal disorders: Chronic Low back pain - The Risk Factors

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

The Risk factors

1. Aging
Elder is at higher risk of chronic back pain due to discs degeneration(17a)
2. Repetitive bending and lifting can usually lead to severe back pain and sciatica over a period of 30 years as a result of ‘Annulus-driven’ disc degeneration involves a radial fissure and/or a disc prolapse, has a low heritability, mostly affects discs in the lower lumbar spine(17)
3. An increased risk for incident chronic LBP if exposed twice to awkward postures(18)
4. Sex, race and Lumbar symptoms
Musculoskeletal impairment was the most prevalent impairment in people aged up to 65 years, and spine impairments the most frequently reported subcategory of musculoskeletal impairment (51·7%). The annual rates varied significantly by sex and age (table 2). Back and spine impairments were more common in women (70·3 per 1000 population) than in men (57·3 per 1000 population), and more common among white people(68·7 per 1000 people) than black people (38·7
per 1000 people). In 1988, back and spine impairments resulted in over 185 million days of restricted activity (21·0 per impairment), which included 83 million days confined to bed (5·4 per impairment; table 3). About 56% of days of restricted activity occurred among women. Lumbar symptoms were
2·86 times more likely than thoracic symptoms to become chronic(19).
5. Smoking
Daily smoking increases the risk of LBP among young adults, and this effect seems to be dose-dependent. Back pain treatment programs may benefit from integrating smoking habit modification. The prevalence of chronic LBP was 23.3% in daily smokers and only 15.7% in non-smokers(20).
6. Psychiatric disorders are assciated to the inscreased risk of transition to chronicity in men with first onset low back pain(21)
7. Alcohol dependency
Alcohol consumption appears to be associated with complex and chronic LBP only and in people with alcohol consumption dependence(22).
8. Others
Occupational factors, presence of multiple functional symptoms, Disease-related factors, onorganic disease, pain in the legs, significant disability at onset, a protracted initial episode, multiple recurrences, a history of low back pain, spinal condition, etc. are all assocoated with higher risk to develop chronic back pain(23).
9. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
Red flags*
Recent significant trauma, Milder trauma if age is greater than 50 years, Unexplained weight loss, Unexplained fever, Immunosuppression, Previous or current cancer, Intravenous drug use, Osteoporosis, Chronic corticosteroid use, Age greater than 70 years, Focal neurological deficit, Duration greater than 6 week(a)
(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(17) http://www.ncbi.nlm.nih.gov/pubmed/22881295
(17a) http://www.ncbi.nlm.nih.gov/pubmed/22892966
(18) http://www.ncbi.nlm.nih.gov/pubmed/21897339
(19) http://www.societyns.org/runn/2008/andersson_pain.pdf
(20) http://www.ncbi.nlm.nih.gov/pubmed/19796577
(21) http://www.ncbi.nlm.nih.gov/pubmed/20735749
(22) http://www.ncbi.nlm.nih.gov/pubmed/23146385
(23) http://www.ncbi.nlm.nih.gov/pubmed/9090769