Medical Advisor Journals

Friday, June 30, 2017

Thyroid hormone: Thyroid cancer and I-131 therapy

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thyroid hormone

Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.

Thyroid hormone: Thyroid cancer and I-131 therapy

In the study in overview of the benefits of I-131 therapy for ablation, adjuvant treatment, and treatment of locoregional and/or metastasis of well-differentiatedthyroid cancer and considers the risks of complications of I-131 therapy, showed that although there are never-ending controversies regarding I-131 therapy in well-differentiated thyroid cancer, the benefits and risks are becoming better understood. This in turn helps the treating physician and patient in making decisions regarding therapy(63).

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Sources
(63) http://www.ncbi.nlm.nih.gov/pubmed/20001720

Thursday, June 29, 2017

Thyroid hormone: Treatment of patients with anaplastic thyroid cancer

Thyroid hormone: Treatment of patients with anaplastic thyroid cancer

Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 months. In a retrospectively reviewed medical records of 13 anaplastic thyroid cancer patients who received multidisciplinary treatment between 2006 and 2010, showed thatthe median patient age at diagnosis was 69 years, and six patients had stage IVc diseases. Eight patients received primary surgery followed by radiotherapy or concurrent chemoradiotherapy (CCRT). Five patients received weekly doxorubicin-based definitive CCRT, but only one patient's condition remained stable, while the rest experienced rapid disease progression. The median progression-free survival was 2.8 months (95% CI, 1.2-4.4 months), and the median overall survival was 3.8 months (95% CI, 3.0-4.6 months)(62).

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Sources
(62) http://www.ncbi.nlm.nih.gov/pubmed/22318823

Wednesday, June 28, 2017

Thyroid hormone Analysis of patients with anaplastic thyroid cancer

Thyroid hormone Analysis of patients with anaplastic thyroid cancer

In the study to to analyze the clinicopathologic characteristics of patients diagnosed with ATC expected to undergo curative thyroidectomy, with the goal of finding differences between patients surviving ≥6 months and <6 months, found that ATC showed female predominance. Patients initially presented with neck mass, and median age was 55 years. In patients with ATC who are expected to undergo curative thyroidectomy, surgery should actively be considered as primary therapy for patient survival when the size is <5 cm(61).

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Sources
(61) http://www.ncbi.nlm.nih.gov/pubmed/22977757

Tuesday, June 27, 2017

Thyroid hormone: Thyroid Nodule Size and Cancer

Thyroid hormone: Thyroid Nodule Size and Cancer

In the study to evaluate the association of nodule size upon cancer risk in a retrospective cohort analysis at an academic hospital with 4955 consecutive patients evaluated between 1995 and 2009, found that Increasing thyroid nodule size impacts cancer risk in a nonlinear fashion. A threshold is detected at 2.0 cm, beyond which cancer risk is unchanged. However, the risk of follicular carcinomas and other rare thyroid malignancies increases as nodules enlarge(60).

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Sources
(60) http://www.ncbi.nlm.nih.gov/pubmed/23275525

Monday, June 26, 2017

Thyroid hormone: Hereditary medullary thyroid carcinoma (HMTC)

Thyroid hormone: Hereditary medullary thyroid carcinoma (HMTC)

In the study to investigate the role of germline inheritance of polymorphisms in CYP1A2*F, CYP1A1m1, GSTP1, NAT2 and TP53 genes in hereditary medullarythyroid carcinoma (HMTC) patients of 132 patients with HMTC, 88 first-degree relatives of HMTC patients and 575 control individuals, found that
the inheritance of specific genes determining the individual response to environmental toxins may contribute to the risk and phenotypic variability that exists in patients with HMTC(59).

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Sources
(59) http://www.ncbi.nlm.nih.gov/pubmed/23278115

Sunday, June 25, 2017

Thyroid hormone: Thyroid disease in pregnancy and childhood

Thyroid hormone: Thyroid disease in pregnancy and childhood

Thyroid function in pregnancy is characterised by a T4 surge at 12 weeks declining thereafter. Fetal brain development depends on T4 transport into the fetus which in turn depends on sufficient maternal iodine supply. In the study to measure free T4 using direct equilibrium dialysis, as well as total T4 and TSH in 287 pregnant women at 27 weeks' gestation, found that Increasing maternal TSH was related to better performance on tests of cognition and language at 12 months but not at later ages. At 60 months, there was inconsistent evidence that higher TSH was related to improved attention. We found no convincing evidence that maternal TH during the second half of pregnancy was related to impaired child neurodevelopment(58).

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Sources
(58) http://www.ncbi.nlm.nih.gov/pubmed/22132346

Saturday, June 24, 2017

Thyroid hormone: Subclinical hypothyroidism in pregnancy

Thyroid hormone: Subclinical hypothyroidism in pregnancy

In the study to evaluate the intellectual development of children of mothers who had M-SCH during the pregnancy for these children with 68 children were recruited, after excluding those age < 4 or age > 15, 44, found that IQ level and cognitive performance of children born to LT4-treated hypothyroid mothers is similar in those whose mothers have M-SCH during pregnancy compared with those whose mothers have normal serum TSH concentrations during pregnancy(57).

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Sources
(57) http://www.ncbi.nlm.nih.gov/pubmed/21943136