Sunday, August 26, 2018
Detoxification: How to Detoxify Your Liver, Holistically and Scientifically
Detoxification is a natural process in removal of toxic substances of human body, mainly carried out by the liver and kidney.
1. Milk thistle(Backed by studies)
Milk thistle, a flower plant of the daisy family have been traditionally claimed in treating chronic liver disease.
Silymarin, a major bioactive compound isolated from milk thistle exerted a significant liver protective effects through liver regeneration, healing liver damage rapidly and prevented accumulation of lipid in the liver via activation of detoxification system
2. Licorice(Backed by studies)
Licorice is a legume plant and and native to southern Europe and parts of Asia.
According to the study by the joint study lead by the Capital Medical University, licorice demnostrated liver protective effect by reducing the liver toxicity and accelerated healing of liver injury.
Glycyrrhizin, a major chemical constituents found in licorice procresses a strong activity against liver damage and injure through stimulation of fatty acid metabolism and influence detoxification of xenobiotics in liver, the Duksung Women's University suggested.
3. Tabebuia heptaphylla(Backed by studies)
Tabebuia heptaphylla is also known as pink trumpet tree used in traditional medicine for neutralized poisons in the liver and treatment of liver diseases.
Alkaloids, major chemical compound isolated from Tabebuia heptaphylla protected liver against injure and damage caused by abnormal lipid and carbohydrate metabolism and recovery processes of liver xenobiotic-metabolizing function through its member berberine.
4. St. John wort(Backed by studies)
St. John wort is also known as tipton weed or klamath weed.
According to the study by Uniwersytet Medyczny we Wrocławiu, St. John wort with abundant chemical compound hyperforin, procresses hetapoprotect effect through increased increase the activity of cytochrome P450 in the liver in accelerated elimination of toxin from the body.
The herb also activated nuclear pregnane X receptor with function in detoxified xenobiotic substances from the liver.
5. Fennel(Backed by studies)
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
Essential oils from fennel showed a marked hepatoprotective effect against hepatotoxicity induced by toxic substance through its antioxidants
Estragole (4-allyl-1-methoxybenzene) is a naturally occurring food flavoring agent found in basil, fennel exerted liver cleansing activity through glucuronidation of 1'-HE is a major detoxification pathway.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Healthy Diet: Eat Dried Peas, to Normalize Syndromes of 3 Triple H (Hypertension, Hyperlipidemia and Hyperglycemia)
Hypertension, hyperglycemia and hyperlipidemia are most prevalent modifiable risk factors for development of diabetes, cardiovascular diseases and stroke.
Intake of dried pea and bean fibers daily and regularly may reduce risk and treatment of hypertension, Hyperlipidemia and Hyperglycemia, some scientists suggested.
Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.
The Nutrients and Chemical constituents
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A ( Beta carotene, lutein and zeaxanthin)
6. B vitamins
7. Vitamin C
8. Calcium
9. Iron
10. Magnesium
11. Phosphorus
12. Potassium
13. Zinc
14. Chemical constituents include saponin pisatin, L-pipecolic acid, glycoside-Pisatoside, tocopherols, cerebroside, etc.
1. The Effects of Dried Peas and Hypertension
Hypertension is a chronic condition characterized by abnormal high blood pressure.
According to the Veterans' Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases.but also reduced risk of hypertension.
Dr. Anderson JW, the led author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".
Additionally, in the examined iineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.
Dr. Marques FZ, the led researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function".
These result demonstrated a significant effect of fibers intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factor related to cardiovascular health and function, including blood pressure.
Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated to several nutritional factors intake may be one of the best solution in reduced hypertensive incidence.
2. The Effects of Dried Peas on HyperlipidemiaHyperlipidemia is a condition characterized by high levels of cholesterol in the blood stream.
In a study of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomizedly assigned to a high-fibre bean-rich diet that achieved mean (SD) fibre intakes of 35.5 (18.6) g day for women and 42.5 (30.3) g day for men, or a low-carbohydrate diet, researchers found that
1. High bean fiber intake showed a better weight loss and weight control in compared to low carbohydrate diet group.
2. Intake of bean fiber group expressed a significant decreased of Low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to other group.
Dr. Tonstad S, the led author said, "A high-fibre bean-rich diet was as effective as a low-carbohydrate diet for weight loss, although only the bean-rich diet lowered atherogenic lipids".
Additionally, in dyslipidemia rats study to evaluate the effects of grain-bean package, dietary fiber (DF) extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase (FAS) activity in high-fat, high-cholesterol feeding by randomly assigned into normal control group, hyperlipidemia model group, grain-bean package group, grain-bean package DF group and grain corn group, researchers after adjusting to other risk factors filed the following results
1. Rats in hyperlipidemic model group showed a increased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) in compared to groups
2. In compared to hyperlipidemic model group, grain-bean package group, grain-bean package DF group, expressed significantly decreased total cholesterol (TC), triglyceridaemia (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose and significantly increased HDL-C levels.
The results of these findings demonstrated that dietary fiber can improve blood lipids levels indyslipidemic subject, decrease FAS activity and regulating SREBP-1c mRNA in glucose metabolic expression.
3. The Effects of Dried Peas on HyperglycemiaHyperglycemia is a medical condition characterized by abnormal high levels of glucose circulated in the blood stream.
Dried peas, a good sources of protein and fiber, is one of many rich-protein recommended for vegetarian.
Together with a low glycemic index, the peas may be considered as a high-fiber foods for daily carbohydrate intake in prediabetes.
Evidences of studies showed that a low-glycemic load meal containing psyllium soluble fiber is significantly improves the breakfast postprandial glycemic, insulinemic in adults with Type 2 DM.
In the study to compare the glycemic and insulinemic responses to 3 different meals based on dried peas, potatoes, or both in patients with type 2 diabetes, intake of the pea meal expressed a significant in tine delay of the increased postprandial plasma glucose and insulin concentrations, in compared to other meal.
Since carbohydrates counting in dried peas have been disregarded, the nutrient dried peas should be included in the consumption of low-glycemic, high-fiber foods at the expense of high-glycemic, low-fiber foods for prediabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)
(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)(4) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(5) [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats].[Article in Chinese] by Liu Y, Zhai C, Sun G, Zhang H, Jiang M, Zhang H, Guo J, Lan X.(PubMed)
(6) Evaluation of a high-fiber diet in hyperlipidemia: a review by Ullrich IH.(PubMed)(7) Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus by Clark CA, Gardiner J, McBurney MI, Anderson S, Weatherspoon LJ, Henry DN, Hord NG.(PubMed)
(8) Comparison of the effects of dried peas with those of potatoes in mixed meals on postprandial glucose and insulin concentrations in patients with type 2 diabetes by Schäfer G, Schenk U, Ritzel U, Ramadori G, Leonhardt U.(PubMed)
Anti-aging: The Hidden Secretes and Truth of Skin Aging, You Probably Don't Know
Aging in a natural process is getting old.
Biologically, the process may also characterized by ceased dividing (cellular senescence) of single cells within an organism.
Skin aging is one of most visible process which occurs constantly in our skin organ
Theories of aging
What cause aging? The question that has been asked throughout the human history, but it doesn't seem to get any answer but raises many more unanswered question. While many theories try to answer the question by related aging to tear and wear of the body, others deal with how the organs and systems in the body develop and deteriorate overtime, etc.
1. Somatic mutation theory
In this theory, aging is due to our inherited genes that come directly from our parents. Since the conception occurred, our body cells continue to divide and replication themselves. Since the division and replication are a life long precess at some point, for what ever reason, if cells division and replication can process incorrectly, leading to mutation of incorrect copy of DNA. Although the cause of this incorrect process are unknown, but researchers found that exposures to toxins, radiation or ultraviolet light, artificial ingredients, unhealthy life style, etc. can increase the risk of cells mutation and the cells copied incorrectly can mutate themselves, leading to accumulation of incorrect gene cells that trigger a chain reaction of an auto-catalytic nature in producing more and more fincorrect gene cell, until it finally is brought under controlled, this processes can lead to aging. As an organism, the immune system tries to destroy or scavenger these mutated genes but at some points, it is over whelming, leading chronic age related diseases.
2. Error catastrophe theory
The error catastrophe of aging, originally proposed by Leslie Orgel in 1963. Our body immune system helps to maintain the structural integrity of DNA not only for cell survival but also for the transfer of correct genetic information to the daughter cells. Error catastrophe indicated that alterations DNA and the incorrect placement of amino acids in protein synthesis could result in a progressive degradation aging as a result of these abnormal protein are no longer functioning as chemical passengers or signalers.
3. Protein glycosylation
Protein glycosylation is a result of chemical reaction of glucose with vary proteins, including enzyme, elastin and collagen in the blood. The cross linked protein glycosylation leads to cell to cell adhesion causing stiffness and rigidity of individual cells, reducing the cells function in taking nutrients and expelling waste.
If the cross link protein glycosylation occurs in the elastin and collagen, it will cause brittle skin, causing aging, but it happens in the organs it will be more serious and sometimes life threatening.
4. The neuroendocrine theory
First proposed by Professor Vladimir Dilman and Ward Dean MD, this theory postulates on wear and tear of the neuroendocrine system. In neuroendocrine system, the master pituitary gland secrets hormones to direct other glands in secreting their hormones and works conjunction with the hypothalamus glands form a command post in the nervous system in closely direct the function of most of the body functions.
but as we age, the hypothalamus loses its ability as a hormone regulator as its receptors of which uptake other gland hormones become less sensitive to them, including sex hormones, DHEA, serotonin, melatonin, etc.
As for cortisol, a hormone secreted by the adrenal glands due to stress, is produced with abundance as we age.
5. Immune system decline theory
As we age, our immune system is weakening that cause us become vulnerable to the dangerous pathogens, including microbial and viral invasion. Within the immune system, the thymus glands which play an important role in helping formation of the immune system scavenger that reduces the function of immune system further that allow irregular cell growth cause of aging spot, tumors, cancer, infection, inflammation and onset of chronic illness.
6. Genetic programming theory
Genetic programming theory propose that aging is programmed as the cells cycle in our body are also genetic program since their inception. the explanation is that all the cells are undergoing certain time in division over the a said amount of time before dying, leading to conclusion that people with the long live genetic program live longer than others who do not.
The theory also emphasizes the genetic diseases as a result of genetic programing diminished life span, regardless external and internal influence.
Further refinement of the programmed senescence theory was developed by Bernard Strehler, who proposed that as cells are program to perform specific functions within the organism that cause them to lose some of the ability to duplicate their genetic information, leading to aging.
7. Hayflick limit
The Hayflick limit (or Hayflick Phenomena) theory discovered by Leonard Hayflick and a biologist in 1966. In vitro study, the number of times a fibroblast diploid cells will divide before it stops. The discover is conferring a major hypothesis if the cell division can prolong in a infinite matter without conditions which cause damage of the cells, then organism can liver forever.
Exceptions:
Stem cells
Since stem cells can continue to regenerate new cells for the entire lifespan of the organism, without limit, thus constituting a notable exception to the Hayflick limit theory.
Cancer cells
Cancer cell in biological aspect, have found a way around the limit by becoming a group of immortalized cells produced from cell division that have no limit as to how many times this immortalized cell division might take place.
8. The telomerase theory
The tolomerrase theory is a continuation of support to the Hayflick limit (or Hayflick Phenomena) theory involved in telomeres and telomerase. Telomeres are the structure at the end of the chromosome. As each time the cell divides, its telomeres is shortened, at certain length, the cell stops division and goes into senescence.
The experiment shows, the cell senescence can be reversed by controlling the genes of telomerase autocatalytic nature, which in turn, promotes the forever cell division capacity
9. The free radical theory
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.
10. Other theories
a. Rate of living and lifespan
Rate of living is defined that a bigger organism, the longer it lives with human is one of the exception due to its slower rate of metabolism and lower rate of free radical activity, leading to low levels of age lipid pigment, resulting in longer life span. Experiment show that there 100,000 free radicals hit everyday in rat, comparing 10, 000 in human.
b. Caloric restriction
Caloric restriction hypothesis suggested in a study of young rat showed that if a rat is put into restricted diet with given of necessary nutrients, it lives longer than those were allowed to eat freely. With the result also the same in the old rat, the theory also suggest eating less may cause less toxins in the body that affects the immune system and reduces the risk of hormone change, leading to free radicals cause of aging.
c. Age spots
Age spots are mainly composed of lipofuscin and lipopigment caused by reaction of free radical and peroxidation, leading to the formation of age spot, as a result of oxygen species interact with autophagocytic degradation occurring inside the lysosomes.
d. Protein oxidation
Protein oxidation cay affect protein function in normal and pathological processes as a result of postranslation protein being alter by reduce oxygen species (ROS) cause of damage to enzyme, leading to dysfunction of its role resulting in aging.
e. Fast track of aging
The theory suggest that there are many of diseases and syndromes of which can contribute to faster track to aging
* Hutchison-Gilford syndrome
It is an extremely rare genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. Those born with progeria typically live to thirteen years, although many have been known to live into their late teens and early twenties and rare individuals may even reach their forties due to genes mutation.
*Werner syndrome
It is Adult progeria, an disorder causes the appearance of premature aging. The syndrome does not develop until they reach puberty is caused by autosomal recessive disorder due to alter gene on chromosome 8.
f. Altered genes
Alter genes are the work of Friedman and Johnson 1988 " .... the effect of elevated expression of SIR2 in yeast appears to be conserved in C. elegans (Tissenbaum & Guarente 2001) and Drosophila (Rogina & Helfand 2004), and mutations in genes encoding components of the target of rapamycin (TOR) pathway also extend the lifespan in all four organisms... "
"... It was originally suspected that extension of lifespan by reduced IIS might turn out to be a worm peculiarity. This was because mutations in genes in the IIS pathway can also cause the worms to enter a type of developmental arrest (dauer), normally seen only in response to low food or crowding (Riddle & Albert 1997). Dauer larvae are long lived, and the long life of IIS mutant adult worms could therefore have been a result of re-expression in the adult of the genes that make the dauer larva long lived...."
g. Free radical connection
Free radical is any atom or molecule that has a single unpaired electron in an outer shell and accumulation of free radical damage over time can cause aging. Theory is first proposed by Denham Harman in the 1950sand in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species into the 1970s. Study showed that nutant strains of the roundworm that are more susceptible to free radicals have shortened lifespans, and those with less susceptibility have longer lifespans
If free radical causes damage to the DNA repaired enzymes, it can increase the risk of unrepaired DNA damage, leading protein synthesis incorrectly. In fact, free radicals can inflict damage to all celsl in body such as endocrine glands, leading to decreasing of hormone secretion, resulting in aging and Kupffer cell in liver, causing endotoxins accumulated in the blood, leading to more free radicals attacks the immune system, etc.
10. Hormone depletion
The researchers found that if an decrease or absence of the pituitary gland hormones mice is given enough amount of pituitary hormones, it lives longer than a control group of normal mice as it stimulates the production of growth and other hormones such as prolactin, adrenocorticotropic hormone, thyroid-stimulating hormone, etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Detoxification: Body Cleansing With A Holistically and Scientifically Prudent Diet
Detoxification is a natural process in removal of toxic substances of human body, mainly carried out by the liver and kidney.
However, prolonged period exposed to toxins may lead to organs failure, causing a disruption of hormone production, damage to other organs and weakening immune system.
1. Spinach
Besides being rich in vitamin A, E, C , minerals such as iron, potassium, magnesium, zinc and calcium that are vital for a healthy heart. it also contains antioxidants, lutein and beta carotene with function in strengthen immune defense against the forming of free radicals.
People with kidney disease should not eat spinach, due to highly oxalate, without drinking a lot of water or juice intake of spinach may increase the risk of forming kidney stones.
According to the study by the University of Tuscia, spinach exerted detoxifying effect in Chlorosis develops in Spinacia oleracea L. plants against exposed to Cd in the basal leaves through phytochelatin production and the nitrogen and sulfur metabolic pathways as dead leaves detach from the plant, they carry away the sequestered Cd(1). .
Furthermore, in model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo, researchers found that application of chlorophyll isolated from spinach enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway in regulated aging progression through detoxification and antioxidant activities(2).
2. Broccoli
Broccoli is high in vitamin C, an antioxidant with property in reduced inflammation and inhbited forming of free radicals caused by toxins in our body.
Study shows that some of the chemicals such as indole 3, selenium and diindolymethane exerted anti cancer properties through preventing and repairing DNA damaging cells.
According to study by the Research and Development Division, Kagome Co., Ltd., broccoli sprout extract (BSEx) expressed a significantly liver protective effect casued by various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.on liver gene expression and acute liver injury in the rat(3).
Additionally, 3-methylsuphinylpropyl and 4-methylsulphinylbutyl glucosinolates. ioslated from broccoli demonstrated strong activity in enhanced ability to induce phase 2 detoxification enzymes in mammalian cells(4).
3. Garlic
Garlic is a super natural food with proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure as well as increasing the transportation of oxygen and simulate the production of insulin if needed.
Allicin, an antibody isolated from garlic reduced inflammation and fought off degeneration caused by virus, bacteria by strengthening our immune system.
The sulfur element processed a rejuvenate property by increasing the function of liver in removing toxins.
According to the Kagoshima University, sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells(5).
Moreover, in the rat model NDEA-induced hepatocarcinogenesis, researchers found that application of garlic oil (GO) inhibited the infectious cells through activated changes of hepatic phase Ⅰ detoxified enzymes (including cytochrome P450 enzyme (CYP) 2E1, CYP1A2 and CYP1A1) and phase Ⅱ detoxified enzymes (including glutathione S transferases (GSTs) and UDP- Glucuronosyltransferases (UGTs))(6).
4. Green tea
Green tea processes highest antioxidants in compared to other foods with the same volume.
In the study of 70 rats randomly assigned into 4 groups of 10 and satudied over 2 months. Group 1: Normal diet and tap water; Group 2: 10 mg/kg intraperitoneal lead acetate weekly over 8 weeks; Group 3: Lead acetate + 100 mg/kg green tea, Group 4: Extract green tea, researchers found that green tea treated group inhibited lead exposure observed by weight change and lowest sperm abnormalities in compared to lead group with no treatment(7).
In redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) aspects, application of green tea EGCG, exhibited chemoprevention and cytoprotection in modulated Nrf2-mediated cellular events through its abilbity in regulated the expression of antioxidant proteins to protect against oxidative damage triggered by injury and inflammation(8).
5. Tomato
alpha and beta carotene found abundantly in tomatoes strengthen immune system in fighting off inflammation from bacteria and virus in initiated chronic diseases.
Lycopene, a powerful pigment phytochemical inhibited free radicals to facilitated cytotoxicity in induction of cell damage and apoptosis.
According to the joint study lead by the Washington State University, lycopene isolated from tomato exerted its host protective effects in modulation of Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms(9),
Similar to garlic, lycopene also activated changes of hepatic phase Ⅰ detoxified enzymes and phase Ⅱ detoxified enzymes against PAH-induced toxicity.
Taken together, intake of above food daily and regularly may have profound and positive effect in promote optimal health through cleansing the body toxin. However, in take of supplement of above foods should be taken with exceptional care as acute liver toxicity were reported in some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Does the different proteomic profile found in apical and basal leaves of spinachreveal a strategy of this plant toward cadmium pollution response? by Fagioni M1, Zolla L.(PubMed)
(2) Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan by Wang E1, Wink M1(PubMed)
(3) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.(PubMed)
(4) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells by Mithen R1, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J.(PubMed)
(5) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells by Chang HS1, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O.(PubMed)
(6) Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes by Zhang CL1, Zeng T, Zhao XL, Xie KQ.(PubMed)
(7) Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate by Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4(PubMed)
(8) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG by Na HK1, Surh YJ.(PubMed)
(9) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors byPall ML1, Levine S2.(PubMed)
However, prolonged period exposed to toxins may lead to organs failure, causing a disruption of hormone production, damage to other organs and weakening immune system.
1. Spinach
Besides being rich in vitamin A, E, C , minerals such as iron, potassium, magnesium, zinc and calcium that are vital for a healthy heart. it also contains antioxidants, lutein and beta carotene with function in strengthen immune defense against the forming of free radicals.
People with kidney disease should not eat spinach, due to highly oxalate, without drinking a lot of water or juice intake of spinach may increase the risk of forming kidney stones.
According to the study by the University of Tuscia, spinach exerted detoxifying effect in Chlorosis develops in Spinacia oleracea L. plants against exposed to Cd in the basal leaves through phytochelatin production and the nitrogen and sulfur metabolic pathways as dead leaves detach from the plant, they carry away the sequestered Cd(1). .
Furthermore, in model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo, researchers found that application of chlorophyll isolated from spinach enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway in regulated aging progression through detoxification and antioxidant activities(2).
2. Broccoli
Broccoli is high in vitamin C, an antioxidant with property in reduced inflammation and inhbited forming of free radicals caused by toxins in our body.
Study shows that some of the chemicals such as indole 3, selenium and diindolymethane exerted anti cancer properties through preventing and repairing DNA damaging cells.
According to study by the Research and Development Division, Kagome Co., Ltd., broccoli sprout extract (BSEx) expressed a significantly liver protective effect casued by various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.on liver gene expression and acute liver injury in the rat(3).
Additionally, 3-methylsuphinylpropyl and 4-methylsulphinylbutyl glucosinolates. ioslated from broccoli demonstrated strong activity in enhanced ability to induce phase 2 detoxification enzymes in mammalian cells(4).
3. Garlic
Garlic is a super natural food with proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure as well as increasing the transportation of oxygen and simulate the production of insulin if needed.
Allicin, an antibody isolated from garlic reduced inflammation and fought off degeneration caused by virus, bacteria by strengthening our immune system.
The sulfur element processed a rejuvenate property by increasing the function of liver in removing toxins.
According to the Kagoshima University, sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells(5).
Moreover, in the rat model NDEA-induced hepatocarcinogenesis, researchers found that application of garlic oil (GO) inhibited the infectious cells through activated changes of hepatic phase Ⅰ detoxified enzymes (including cytochrome P450 enzyme (CYP) 2E1, CYP1A2 and CYP1A1) and phase Ⅱ detoxified enzymes (including glutathione S transferases (GSTs) and UDP- Glucuronosyltransferases (UGTs))(6).
4. Green tea
Green tea processes highest antioxidants in compared to other foods with the same volume.
In the study of 70 rats randomly assigned into 4 groups of 10 and satudied over 2 months. Group 1: Normal diet and tap water; Group 2: 10 mg/kg intraperitoneal lead acetate weekly over 8 weeks; Group 3: Lead acetate + 100 mg/kg green tea, Group 4: Extract green tea, researchers found that green tea treated group inhibited lead exposure observed by weight change and lowest sperm abnormalities in compared to lead group with no treatment(7).
In redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) aspects, application of green tea EGCG, exhibited chemoprevention and cytoprotection in modulated Nrf2-mediated cellular events through its abilbity in regulated the expression of antioxidant proteins to protect against oxidative damage triggered by injury and inflammation(8).
5. Tomato
alpha and beta carotene found abundantly in tomatoes strengthen immune system in fighting off inflammation from bacteria and virus in initiated chronic diseases.
Lycopene, a powerful pigment phytochemical inhibited free radicals to facilitated cytotoxicity in induction of cell damage and apoptosis.
According to the joint study lead by the Washington State University, lycopene isolated from tomato exerted its host protective effects in modulation of Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms(9),
Similar to garlic, lycopene also activated changes of hepatic phase Ⅰ detoxified enzymes and phase Ⅱ detoxified enzymes against PAH-induced toxicity.
Taken together, intake of above food daily and regularly may have profound and positive effect in promote optimal health through cleansing the body toxin. However, in take of supplement of above foods should be taken with exceptional care as acute liver toxicity were reported in some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Does the different proteomic profile found in apical and basal leaves of spinachreveal a strategy of this plant toward cadmium pollution response? by Fagioni M1, Zolla L.(PubMed)
(2) Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan by Wang E1, Wink M1(PubMed)
(3) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.(PubMed)
(4) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells by Mithen R1, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J.(PubMed)
(5) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxificationenzymes in rat hepatoma H4IIE cells by Chang HS1, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O.(PubMed)
(6) Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes by Zhang CL1, Zeng T, Zhao XL, Xie KQ.(PubMed)
(7) Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate by Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4(PubMed)
(8) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG by Na HK1, Surh YJ.(PubMed)
(9) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors byPall ML1, Levine S2.(PubMed)
Friday, August 24, 2018
All About Green Tea: Habitual Green Tea in Ameliorated Risk of Stroke
Green tea is found to consist a therapeutic and substantial effect in reduced risk and treatment of stroke, some scientists suggested
Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Stroke is a medical condition of emergency caused by reduced or interrupted blood circulation to the brain, such as blocking artery induced ischemic stroke and leaking or bursting of a blood vessel precipitated hemorrhagic..
According to statistic, in US, every year, approximately 795,000 people suffer a stroke, a leading cause of serious and long-term disability.
Evaluation of green tea effect in risk of stroke was found to associated of certain mechanism involving numbers of aspects.
The review of medical literature published online suggested that green tea with strong inhibition of high blood pressure, a primary risk factor of stroke through its antioxidant and vasodilative activities induced by phytochemical flavonoids in improved blood circulation to the brain. Although increased acute blood pressure was found in some studies, this acute effect did not translate into significant alterations in ambulatory blood pressure during regular tea consumption.
The impact of tea or catechin consumption precipitated nitric oxide formation, as an essential gas signal molecule to protect the brain against in facilitated ischemic stroke and hemorrhagic stroke by relaxed vascular smooth muscle cells and induced vasodilatation through regulating network of blood vessel and peripheral nerve tissues.
Amazingly, catechin also reduced NO levels through endothelial function by increased platelets aggression in post stroke.
In fact, green tea theanine, a bioactive chemical constituents also found to process anti stroke development through stimulating NO production of the cells in the inner wall of arteries in reduced risk of vascularconstrction and promoted blood circulation, thus decreasing risk of an artery-blocking clot, a major cause of stroke,
Further analysis also discovered that glutamate molecule found in theanine may also play an important role in attenuated risk of stroke through neuroprotective effect by decreased middle cerebral artery occlusion and cerebral infarction caused by blocking or narrowing the arteries in supplying blood and oxygen to the brain.
According to the study of 82 369 Japanese (aged 45-74 years; without cardiovascular disease [CVD] or cancer in 1995 and 1998 for Cohort I and II, respectively) received 13 years of mean follow-up through the end of 2007. green tea consumption of green tea 2 to 3 and ≥ 4 cups/d showed a significant effect in reduced risk of stroke with the multivariable-adjusted hazard ratios of 0.86 (0.78-0.95) and 0.80 (0.73-0.89), respectively in compared to non drinkers. And Higher green tea consumption reduced the risks of stroke subtypes, especially in intracerebral hemorrhage.
Other researchers suggested that green tea efficacy in reduced risk of stroke may be also associated to antioxidant effect in protection of endothelial function in blood circulation by reduced high blood cholesterol induced plaque build-up in the arteries in blocking blood flow to the brain, particularly in reactive oxygen species (ROS) precipitation of lipid peroxidation.
The effect of green tea in reduced insulin resistance in healthy adults may also contribute to lower risk of stroke, according to the cohort of 1509 nondiabetic participants from the Northern Manhattan Study (mean [SD] age, 11 [10] years; 64.2% women; 58.9% Hispanics).
Dr. Arab L said, "Regardless of their country of origin, individuals consuming >or=3 cups of tea per day had a 21% lower risk of stroke than those consuming <1 cup per day (absolute risk reduction, 0.79; CI, 0.73 to 0.85). The proportion of heterogeneity not explained by chance alone was 23.8%".
The information findings suggested that habitual green tea consumption may have a therapeutic in reduced risk of stroke development in general population.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1)The impact of green tea and coffee consumption on the reduced risk of strokeincidence in Japanese population: the Japan public health center-based study cohort by Kokubo Y1, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.(PubMed)
(2)Coffee, tea, and cocoa and risk of stroke by Larsson SC1(PubMed)
(3) The Impact of Green Tea Consumption on the Prevention of Hemorrhagic Stroke by Lee SM1, Choi NK, Yoon BW, Park JM, Han MK, Park BJ.(PubMed)
(4) Green and Black Tea Consumption and Risk of Stroke A Meta-Analysis by Lenore Arab, PhD; Weiqing Liu, MS; David Elashoff, PhD(Stroke. 2009;40:1786-1792.)
(5) Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study by Rundek T1, Gardener H, Xu Q, Goldberg RB, Wright CB, Boden-Albala B, Disla N, Paik MC, Elkind MS, Sacco RL.(PubMed)
Thursday, August 9, 2018
All About Green Tea: Green Tea in Ameliorated Risk and Prevented Onset of Intestinal Ischemia
Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats ramdonly assigned to Group I (ischemia-reperfusion,I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similarly to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application..
The above illustration indicated that long term intake of green tea injection may exhibit a strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia- reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In other similar study with male specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory mytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented onset of intestinal ischemia. People with high risk in development of intestinal ischemia may consider to add 1 or 2 cups of green tea into their daily diet.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats ramdonly assigned to Group I (ischemia-reperfusion,I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) with sham I/R, researchers found that injection of green tea group showed an impressive restoration of intestinal mucosa in compared to ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), green tea group expressed a significant improvement of antioxidants similarly to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application..
The above illustration indicated that long term intake of green tea injection may exhibit a strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia- reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with function in secreted the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In other similar study with male specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory mytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered as a functional food in reduced risk and prevented onset of intestinal ischemia. People with high risk in development of intestinal ischemia may consider to add 1 or 2 cups of green tea into their daily diet.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Wednesday, August 1, 2018
All About Green Tea: Green tea In Modulated Fat Metabolism
Green tea may have a therapeutic and positive effect in reduced abnormal fat metabolism, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaulation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated to substantial impact on lysophospholipid metabolism, in contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of over weight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce onset and progression of over weight and obesity. However, intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaulation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated to substantial impact on lysophospholipid metabolism, in contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of over weight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce onset and progression of over weight and obesity. However, intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
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