Thursday, December 31, 2015

The smoothie tangerine peels, grape and cucumber for reduced risk and treatment of Acne

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

 The smoothie for people with high risk and treatment of  Acne 

Yield: 2 serving (about 8 ounce each)

1 medium tangerine peels
1 cup grapes
1/2 cup of cucumbers
1 cup rice milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Combination of tangerine peel(5), grape(1) and cucumber(7)may consist a potential of pharmaceutical values as the ingredients are found effectively in reduced risk and Acne in recent studies.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins. It is the internal causes of acne.
Acne is most common type of skin, affecting billions of people all over world. The dream of finding natural sources for reducing risk and treatment of acne may induce billions and billions dollars of commercial profits of discovered pharmaceutical companies,
Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape, as an antimicrobial and anti-inflammatory substances may speed acne recovery from invaded and progression of acne(1), according to the University of Catania,
The phytochemical also has been found effectively in treating acne vulgaris due to its suppression of sebaceous growth by suppressing survival and growth in response to extracellular signals(2).

Dr. Taylor EJ and the research at the David Geffen School of Medicine, said," The ...antibacterial activity and reduced cytotoxicity.....demonstrated by resveratrol.... highlight its potential as a novel therapeutic option or adjuvant therapy in the treatment of acne vulgaris"(3).

Furthermore, resveratrol in the extracts from some herbal medicines also exhibited antibiofilm activity by inhibited the antimicrobial susceptibility of biofilm-associated cells induced the pathogenesis of acne vulgaris(4).

Tangerines, an orange-colored citrus fruit, a type of, mandarin orange originated to Tangier, Morocco, are now cultivated all over the world in suitable climate for commercial profits due to their health effects.
Nobiletin, a phytochemical compound from the group of flavonoid found abundantly in the citrus peels of tangerine exhibited the similar function of acne drugs 13-cis retinoic acid and all-trans retinoic acid(5), may be an effective candidate for acne therapy through reduction of sebocyte proliferation, sebum production and progression of cell apoptosis by suppressing survival and growth in response to extracellular signals(5).

Cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. Due to its silica in skin promotion health benefits, the fruits have been added to some cosmetic gel for treatment of skin diseases(6).According to the Harvard Medical School, topical silica–gold nanoshells at 800 nm exhibited mild anti inflammatory effects and decrease the pathophysiology of acne vulgaris in regulation of sebaceous gland of that induced an effective treatment of moderate-to-severe facial acne, depending to the assessments of disease severity(7).
In support to the above, the University of California study using 150nm silica-gold nanoshell, reduced the acne expression through inducing photothermal disruption of sebaceous glands without damaging collateral skin(8).
Acne Support Group. said,",,, used Silicol Skin for 6 weeks, ...statistically significant 86% overall improvement was reported, with most participants citing the chin as showing the greatest change"(9).

Taking altogether, smoothie with combine of Tangerine peel, grape and cucumber may be effective in reduced risk of the development and progression and treatment of patient with acne.
People with higher risk of acne due to family history, .... should drink 1 serving daily and people with acne should drink as much as they can depending to digestive toleration.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html


References
(1) Cosmetics for acne: indications and recommendations for an evidence-based approach by Dall'oglio F1, Tedeschi A, Fabbrocini G, Veraldi S, Picardo M, Micali G.(PubMed)
(2) Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway by Kim SY1, Hyun MY2, Go KC1, Zouboulis CC3, Kim BJ1.(PubMed)
(3) Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro by Taylor EJ1, Yu Y, Champer J, Kim J.(PubMed)
(4) Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin,resveratrol and salidroside as active compounds by Coenye T1, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(PubMed)
(5) A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters by Sato T1, Takahashi A, Kojima M, Akimoto N, Yano M, Ito A.(PubMed)
(6) Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice by Hirai T1, Yoshioka Y2,3,4, Takahashi H5,6, Ichihashi K7, Udaka A8, Mori T9, Nishijima N10, Yoshida T11, Nagano K12, Kamada H13,14, Tsunoda S15,16, Takagi T17,18, Ishii KJ19,20, Nabeshi H21, Yoshikawa T22, Higashisaka K23,24, Tsutsumi Y(PubMed)
(7) Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles by Paithankar DY1, Sakamoto FH2, Farinelli WA2, Kositratna G2, Blomgren RD1, Meyer TJ1, Faupel LJ1, Kauvar AN3, Lloyd JR4, Cheung WL5, Owczarek WD6,Suwalska AM6, Kochanska KB6, Nawrocka AK6, Paluchowska EB6, Podolec KM7, Pirowska MM7, Wojas-Pelc AB7, Anderson RR2.(PubMed)
(8) Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic by Paithankar D1, Hwang BH2, Munavalli G3, Kauvar A4, Lloyd J5, Blomgren R6, Faupel L6, Meyer T6, Mitragotri S7.(PubMed)
(9) The effects of Silicol Skin on moderate to severe acne: UK field survey by Acne Support Group(PubMed)
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Most Common Diseases of elder: Respiratory Disease: Asthma - The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
                                       Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                                      The Diagnosis

If you are experience some of the above symptoms and if your doctor suspects that you have asthma, after recording your family history and completing the physical exam, the test which your doctor orders include
1. Chest X-Ray
In the study of the medical records of 58 patients aged 18-40 with the diagnosis of mild to moderate asthmato assess the value of the chest X-ray in helping to make the diagnosis of asthma at the primary care level, researchers at theHarvard University Health Services, showed that the number of asthmatic patients with CXR+ and SPI – (n = 23) was significantly larger than the number with CXR- and SPI+ (n = 10), which indicates that for mild asthma the chest X-ray may be more sensitive than spirometry even though not as specific(28). Other suggested that the X-ray request was an action not based on sound clinical judgement. Cost savings and a reduction in radiation exposure can be made by eliminating unnecessary chest X-ray requests(29).
2. Spirometry
Spirometry is a lung (or pulmonary) function test to measure the lung function in studying the air volume and flow rate within the lungs. According to the study by Department of Community Medicine, University of Tromsø the ability of GPs to differentiate between asthma and COPD seems to have considerably improved during the last decade, probably due to the dissemination of spirometry and guidelines for COPD diagnosis(30).
3. Peak Flow Testing –
Peak Flow Testing is a self-assessment to evaluate lung function The peak expiratory flow (PEF), also known as peak expiratory flow rate (PEFR) is to measure the airway
obstruction.
4. Impulse oscillometry (IOS)
Impulse oscillometry is a noninvasive and rapid technique requiring only passive cooperation by the patient. Pressure oscillations are applied at the mouth to measure pulmonary resistance and reactance. It is employed by health care professionals to help diagnose pediatric pulmonary diseases such asthma and cystic fibrosis; assess therapeutic responses; and measure airway resistance during provocation testing(31).In the study to to evaluate whether impulse oscillometry, an easy-to-perform technique, can detect asthmatic airway obstruction stage, researchers at the Shanghai Pudong New Area People’s Hospital, found that IOS provides an accurate, reliable, and patient-friendly technique for classifying asthmatic airway obstruction(32).

5. Allergy Tests for Asthma
if you doctor suspects that your asthma may be triggered as a result of an allergic reaction. Allergy tests may be ordered to determine the exact cause of your allergy and asthma. In the study to determine the predictive value of allergy and pulmonary function tests for the diagnosis of asthma in athletes, showed that positive prick tests were recorded in 44.4% of athletes (in 60.5% of asthmatics, in 95.2% of rhinitics and in 21.0% of nonasthmatic – nonrhinitic subjects). Skin-tests positivity was not related to the abnormal spirometric data found in individual cases. Provocation tests with bronchodilators or exercise did not appear sensitive enough to diagnose mild forms of asthma in subjects with normal basal spirometric values(33).
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Wednesday, December 30, 2015

The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Bone cancer

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of Bone Cancer and Bone Cancer

Yield: 2 serving (about 8 ounce each)
1 1/2 cups blackberry
1/3 tsp cucumin
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of ovarian cancer has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Blackberry(1), green tea and turmeric may be the next generation of pharmaceutical ingredients for reduced risk and treatment of bone cancer, recent study suggested

Bone cancer is an abnormal growth of cells within the bone that have became cancerous. Bone cancer may be classified as primary canceroriginated in the bone, and secondary cancer originated from elsewhere.

Black berry, a edible fruit produced species in the Rubus genus in the Rosaceae family has found to consist a various health effects including suppressing tumor growth through its antioxidants flavonols and ellagitannins(1). According to the joint study lead by the Universidade Estadual Paulista-UNESP, DNA damage in bone marrow and peripheral blood cells and chromosomal aberrations, was significant reduced in a 2000 mg/kg dose due to the presence of its phytochemical compounds tormentic acid, stigmasterol, quercitinglucoronide (miquelianin) and niga-ichigoside F1 (2).
Dr. Dai J and colleagues at the niversity of Kentucky, in support of the berry;s antiproliferative and anti-inflammatory properties disclosed," in a concentration-dependent manner, total anthocyanin concentrations in the range of 0-40 microg/mL suppressed both high-dose (10 microg/mL) and low-dose (0.1 microg/mL) lipid A-induced interleukin-12 release from mouse bone marrow-derived dendritic cells"(3).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

Curcumin, the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma, by inhibiting the over-expression of gene (Notch1) associated with tumor progression, according to Dr. Li Y, and scientists at the Qilu Hospital, Shandong University(4).
In chondrosarcoma, a soft tissue sarcoma, curcumin, an active compound induced tumor apoptosis and inhibited tumor proliferation, invasion, angiogenesis, and metastasis of cancer cells, through  protein in regulated cell cycle and tumor suppression gene p53(5).
The joint study in support of the effect of curcumin in reduced risk and treatment of bone cancer, said," IL-1 signaling(in the regulation of immune and inflammatory responses) and VEGF-A expression(involved progression and prognosis of cancer) are blocked by Curcumin in chondrosarcoma cells" and "Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression" of that "may be an additional treatment option in chondrosarcoma"(6).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-gallate, the major ingredient found in green tea may be a potential anti-TNFα(inflammatory cytokine) as a therapeutic option for osteolytic painas it attenuated symptom of pain in bone cancer through inhibiting the pro inflammatory cytokines(7).
Dr. Jeong JY and the research team at the joint study by the National Institute of Animal Science discovered that Epigallocatechin-3-gallate (EGCG) inhibited the expression levels of various genes and proteins involved in adipogenesis of which involved the reduction of cell viability and arrested the cell cycle at the gap 2/mitosis phase in bone-marrow mesenchymal stem cells(8).
Furthermore, in support of the green tea effects on bone cancer cells, the University of Madras showed that Green tea, polyphenol exhibited antioxidant effect through a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity(9).

Taking altogether people who are at increased risk of  Bone cancer due to family history or gene mutation .....should drink at least one serving daily and people with  bone cancer should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) The blackberry fruit: a review on its composition and chemistry, metabolism and bioavailability, and health benefits by Kaume L1, Howard LR, Devareddy L. (PubMed)
(2) In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage by Tolentino F1, Araújo PA1, Marques Ede S1, Petreanu M2, Andrade SF2, Niero R2, Perazzo FF3, Rosa PC4, Maistro EL5(PubMed)(3) Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. by Dai J1, Patel JD, Mumper RJ.(PubMed)
(4) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling by Li Y1, Zhang J, Ma D, Zhang L, Si M, Yin H, Li J.(PubMed)
(5) Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway by Lee HP1, Li TM, Tsao JY, Fong YC, Tang CH.(PubMed)
(6) Curcumin blocks interleukin-1 signaling in chondrosarcoma cells by Kalinski T1, Sel S2, Hütten H3, Röpke M4, Roessner A1, Nass N1.(PubMed)
(7) Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model by Li Q1, Zhang X2.(PubMed)
(8) Epigallocatechin-3-gallate-induced free-radical production upon adipogenic differentiation in bovine bone-marrow mesenchymal stem cells by Jeong JY1,2, Park MN2, Cho ES3, Jang HJ4, Park S5, Lee HJ6.(PubMed)
(9) Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats by Pandurangan AK1, Periasamy S, Anandasadagopan SK, Ganapasam S, Srinivasalu SD.(PubMed)
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Most Common Diseases of elder: Respiratory Disease: Asthma - The Causes

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
                                                           Asthma 

 Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                            The Causes 

1. Smoking and second hand smoke
Smoking is considered as one of major cause of lung diseases, including asthma. According to the study by Texas Tech University Health Science Center, Airway mucosal permeability is increased in smokers, which could lead to increased clearance of inhaled corticosteroids from the airways. Smokers also have decreased histone deacetylase activity, which is necessary for corticosteroids to fully suppress cytokine production, and can lead to corticosteroid resistance. The study also indicated that In asthmatic patients who smoke, disease control is poorer than in asthmatic nonsmokers. Of all forms of SHS, maternal exposure seems to have the largest impact on asthma by increasing the frequency and severity of the disease and decreasing lung function. Asthmatic children exposed to multiple household smokers face an increased risk for respiratory illness-related absences from school, and these effects persist during adolescence but weaken during adulthood(6).
2. Allergies
People who are sufferred from alergies are most likely to develop asthma. The allergic march is a progression of atopic disease from eczema to asthma, and then to allergic rhinoconjunctivitis. It appears to be caused by a regional allergic response with breakdown of the local epithelial barrier that initiates systemic allergic inflammation. Genetic and environmental factors predispose to developing the allergic march, according to the study by Department of Surgery, Cape Cod Hospital, Hyannis(7). Other indicated that Allergen exposure contributes to the risk of asthma exacerbations, but other precipitating factors, such as viruses, can interact and increase the risk. According to the study by hôpitaux universitaires de Strasbourg, deteriorating asthma can be related to increased exposure to allergens, particularly allergens from house dust mite, cockroach, cat, rodent, mold or pollen. Several studies have demonstrated that sensitization to respiratory allergens and allergen exposure increases the risk of exacerbation of asthma. When asthma exacerbations are work-related, occupational allergens may be implicated(8).

3. Occupational and environmental exposures
Occupational and exposure history may increase the risk of respiratory problems. According to a report by Dr, Hoy RF., there is a case of a man, 23 years of age and previously well, presents with 2 months of cough, shortness of breath and weight loss. Occupational and exposure history identifies him as commencing work at a mushroom farm 12 months ago where he is exposed to dust from the mixing of mushroom compost. He is not required to use respiratory protection at work. His cough and chest tightness usually start in the afternoon at work and persist into the evening. Some of the effects of exposures may be immediate, whereas others such as asbestos-related lung disease may not present for many decades. Airborne contaminants may be the primary cause of respiratory disease or can exacerbate pre-existing respiratory conditions such as asthma and chronic obstructive pulmonary disease(9).

4. Obesity
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. In the study to to examine the relationship between central obesity and asthma outcomes in a group of Iranian asthma patients, researchers showed that there is a significant association of WHR-based central obesity with forced expiratory volume in 1 s (FEV(1)) (β = -9.04; p-value = .044) and forced vital capacity (FVC) (β = -10.52; p-value = .012). Logistic regression analysis showed a significant increased risk of asthma attacks in 3 months with Asian WC-based central obesity [odds ratio (OR) = 6.31, 95% confidence interval (CI): 1.16-34.41]; emergency room (ER) visits with NIH WC-based (OR = 5.15, 95% CI: 1.36-19.55) and Asian WC-based (OR = 18.72, 95% CI: 1.92-182.63) central obesity; and hospitalization in 1 year with NIH WC-based (OR = 5.28, 95% CI: 1.28-21.84) and Asian WC-based (OR = 12.39, 95% CI: 1.29-119.53) central obesity(10).
Some study suggested that asthma in the obese patient might be more responsive to leukotriene modifiers, orchestrated by leptin and/or adiponectin derived from adipose tissue, than to inhaled corticosteroids, possibly reflecting differences in the underlying airway inflammation in obese vs. non-obese asthmatics(11).

5. Exercise-Induced Asthma
Vigorous exercise can cause a narrowing of the airways in asthma patient.There is a report of a 44-year-old man with a history of seasonal allergic rhinitis but no asthma, who reported difficulty breathing when playing tennis and a 45-year-old woman who presented with persistent, generally well-controlled asthma, who was now experiencing bouts of coughing and wheezing during exercise. EIB is a frequently encountered problem among patients presenting to primary care specialists. Affected patients should be made aware of the importance of proactive treatment with a short-acting beta agonist before initiating any exercise(12).

6. Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. It is considered as one the causes of asthma. There is a report of an 11-year-old boy who was referred to a pediatric respiratory clinic for asthma that was not responsive to inhaled medications. The child presented with a one-year history of dyspnea on exertion, cough and wheeze. He also complained of chronic dyspepsia. The presence of GI symptoms, in addition to abnormalities on chest radiograph and spirometry, suggested the presence of achalasia(13).

7. Sinusitis
Sinusitis is defined as a condition of inflammation of the paranasal sinuses of which can develop headache as a result of exposure to a cold or flu virus, or an allergic reaction to pollen, mold, dust or smoke, etc..Sinusitisaffects 37 million people each year. Some researchers suggested that there is a close relationship between allergic rhinitis and asthma, food allergy, and atopic dermatitis. Rhinitis and sinusitis often coexist and are commonly referred to with the term rhinosinusitis. These conditions are also linked in the so-called atopic march, which is the sequential appearance of atopic manifestations starting with atopic dermatitis and later followed by food allergy, allergic rhinitis, and asthma(14).

8. Upper Respiratory Infections
upper respiratory viral infections are strongly associated in time with hospital admissions for asthma in children and adults. Rhinoviruses were the major pathogen implicated, and the majority of viral infections and asthma admissions occurred during school attendance, according to the study by the Department of Medical Statistics and Computing, University of Southampton(15).

9. Irregular Mentruation
Irregular menstruation are associated with asthma. In the study of a total of 8588 women (response rate 77%) participated in an 8 year follow up postal questionnaire study of participants of the ECRHS stage I in Denmark, Estonia, Iceland, Norway, and Sweden. Only non-pregnant women not taking exogenous sex hormones were included in the analyses (n = 6137), showed that Irregular menstruation was associated with asthma (OR 1.54 (95% CI 1.11 to 2.13)), asthma symptoms (OR 1.47 (95% CI 1.16 to 1.86)), hay fever (OR 1.29 (95% CI 1.05 to 1.57)), and asthma preceded by hay fever (OR 1.95 (95% CI 1.30 to 2.96)) among women aged 26-42 years(16).

10. Sulphite additives
Topical, oral or parenteral exposure to sulphites (mainly from the consumption of foods and drinks that contain these additives) has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions(16a).

11. Cold air
Endurance athletes show an increased prevalence of airway hyperresponsiveness. In the study of a total, 64 elite athletes (32 swimmers and 32 cold-air athletes), 32 mild asthmatic subjects and 32 healthy controls underwent allergy skin prick testing, methacholine challenge and induced sputum analysis found that there is a significant airway inflammation only in competitive athletes with airway hyperresponsiveness. However, the majority of elite athletes showed evidence of bronchial epithelial damage that could possibly contribute to the development of airway hyperresponsiveness(17a).
11. Etc.
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Tuesday, December 29, 2015

The Curable Smoothie of Papaya for Reduced Severity of Symptoms and Treatment of Anemia (β-thalassemia and sickle cell disease)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk of Anemia and Anemia
Yield: 2 serving (about 8 ounce each)
1 1/2 cups papaya
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of anemia is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Most people understand that anemia is caused by iron deficiency in the bloodstream, but in reality anemia is characterized by deficiency in the hemoglobin of the red blood cells diminishing the ability of the blood to transport oxygen to our cells and to remove carbon dioxide.

Antioxidant plays an important role in the influences of the pharmacologic induction of fetal hemoglobin (HbF) for treatment of β-thalassemia and sickle cell disease through expression in the fetal liver, spleen and bone marrow(1).

Recent studies suggested that chronic consumption of the combination of papaya(2) may be beneficiary to reduce symptoms and treatment  for patients with anemia such as β-thalassemia and sickle cell disease.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries. Vitamin C found abundantly in papaya out of all fruits, according to the Chinese Academy of Medical Science, improved the levels of hemoglobin-based oxygen carriers (HBOCs) through the indication of the oxygen binding curves and the molecular weights(2).
In patients with sickle cell hemoglobin from both parents and are associated with unusually large numbers of immature blood cells, C. papaya seed oil significantly increased HbSSM and HbSSF human sickle cell blood peroxidase activity and hemoglobin concentration significantly, through exhibited particular antisickling properties and reduced oxidative stress in sickle cell patient(3).

In patients with beta-thalassemia major and intermedia and E-beta-thalassemia due to defects and mutations in the beta-globin gene, fermented papaya preparation (FPP) improve the status of anemia through increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased free radicals generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS) in beta-thal, major and intermedia, (in Israel) and E-beta-thal patients(4).
Dr. Olalla-Saad ST said, "... reduction of oxidative status in red blood cells of patients with β- and E-β-thalassemia (β-thal) treated with fermented papaya preparation"(5) of that reducing the severity of the symptoms of anemia(6).

In fact, on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples, long term consumption of tropical fruit extract, Carica papaya produced significant less numbers of sickle cells, the Covenant University study suggested(7).

People who are at increased risk of anemia due to family history, genetic mutation .....should drink at least 2 serving daily and people with chronic anemia should drink the juices as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway by Macari ER1, Lowrey CH.(PubMed)
(2) Antioxidant effects of vitamin C on hemoglobin-based oxygen carriers derived from human cord blood by Chen G1, Duan Y1, Liu J1, Wang H1, Yang C1,2.(PubMed)
(3) Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT.(PubMed)
(4) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation.
Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA.(PubMed)
(5) Fermented papaya preparation for β-thalassemia? by Olalla-Saad ST1.(PubMed)
(6) Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E.(PubMed)
(7) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)
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The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Ovarian Cancer

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of Ovarian Cancer and Ovarian Cancer

Yield: 2 serving (about 8 ounce each)
1/2 Broccoli
1  cup Cranberry
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place whole food papaya, cinnamon and green tea drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of ovarian cancer has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Recent study suggested that broccoli(1), cranberry(5) and green tea(8) may process phytochemicals and ingredients  effectively in reduced risk and treatment of ovarian cancer.

Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe. According to the review of data base studies of Medline (Pubmed), Embase and Web of Science databases intake of cruciferous vegetables is associated to reduce risk of cancer.(4).
Sulforaphane, a major chemical constituent found in cruciferous vegetables, including broccoli, has exerted its anti ovarian cancer effects through induction of apoptosis and cell-cycle arrest in various mechanism which induced cancer cells growth(1). According to the Mount Sinai School of Medicine, the phytocemical inhibited cancer cell cycle phase progression through a decrease in the cell division in S and G2M phases with 18% of the cells underwent apoptosis after 2 days, 42% of the cells apoptosis after 3 days of incubation(2).
In ovarian cancer cell lines SKOV3, C3, and T3 cells, sulforaphane exhibited antiproliferative effects in all 3 ovarian cancer cell lines through tageting the signal transduction pathway Akt which promotes survival and growth of ovarian cells(3).

Cranberry is a species of Vaccinium oxycoccos, belong9ngs to the family Ericaceae, found in the cooler part of Northern America. The fruit has been found to process certain phytochemicals including flavonols and flavan-3-ols for SKOV-3 and OVCAR-8 in inhibiting reduction ovarian cancer cells, through cytotoxic and anti-proliferative properties(5).

According to the Women and Infants Hospital of Rhode Island study, proanthocyanidins isolated from cranberry, exerted significant potent anti ovarian cancer and anti-angiogenic properties, through blocking the vascular endothelial growth factor (VEGF) in blood circulation(6).

Furthermore, the fruit's polyphenolic extracts, also exhibited cell-line specific cytotoxicity, induced apoptosis of platinum-resistant ovarian cancer cells, SKOV-3 ovarian cancer cells(7).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.

Functional mutations in BRCA (breast cancer-gene) 1 or 2 is found to associated to 60 % risk of ovarian cancer. The Curtin University of Technology, drinking tea daily and drinking tea for >30 years exhibited a greatest risk declined in the development of ovarian cancer, in a study of a total of 652 controls comprised 340 hospital visitors, 261 non-neoplasm hospital outpatients conducted in China during 1999-2000(9).
According to the review of data based of Medline, EMBASE and SciVerse (last researched: July 2011), green tea inhibited the epithelial ovarian cancer cell lines, by downregulating the expression of inflammation, cell signalization, cell motility and angiogenesis proteins(8).
In a cohort study included 254 patients recruited during 1999-2000 with histopathologically confirmed epithelial ovarian cancer, after followed up for a minimum of 3 years, drinking green tea enhances survival of epithelial ovarian cancer in does dependent-manner(10).

Taking all together, women with high risk of ovarian cancer due to family history and gene mutation should drink at least a serving daily and those with ovarian cancer should drink as much as possible depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells by Bryant CS1, Kumar S, Chamala S, Shah J, Pal J, Haider M, Seward S, Qazi AM, Morris R, Semaan A, Shammas MA, Steffes C, Potti RB, Prasad M, Weaver DW,Batchu RB.(PubMed)
(2) Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells by Chuang LT1, Moqattash ST, Gretz HF, Nezhat F, Rahaman J, Chiao JW.(PubMed)
(3) Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells by Chaudhuri D1, Orsulic S, Ashok BT.(PubMed)
(4) Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis by Hu J1, Hu Y1, Hu Y1, Zheng S2.(PubMed)
(5) The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells by Wang Y1, Han A2, Chen E2, Singh RK2, Chichester CO3, Moore RG2, Singh AP1, Vorsa N1.(PubMed)
(6) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG.(PubMed)
(7) Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin by Singh AP1, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N.(PubMed)
(8) Green tea for ovarian cancer prevention and treatment: a systematic review of the in vitro, in vivo and epidemiological studies by Trudel D1, Labbé DP, Bairati I, Fradet V, Bazinet L, Têtu B.(PubMed)
(9) Tea consumption and ovarian cancer risk: a case-control study in China by Zhang M1, Binns CW, Lee AH.(PubMed)
(10) Green tea consumption enhances survival of epithelial ovarian cancer by Zhang M1, Lee AH, Binns CW, Xie X.(PubMed)
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Most Common Diseases of elder: Respiratory Disease: Asthma - The Risk factors

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
                                                           Asthma 

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                                The Risk factors

1. Wheezing rhinovirus illnesses
Virus-induced wheezing episodes in infancy often precede the development of asthma. Researchers at the the Department of Pediatrics, University of Wisconsin-Madison, showed that Nearly 90% (26 of 30) of children who wheezed with RV in Year 3 had asthma at 6 years of age.From birth to age 3 years, wheezing with respiratory syncytial virus (RSV) (odds ratio [OR], 2.6), rhinovirus (RV) (OR, 9.8), or both RV and RSV (OR , 10) was associated with increased asthma risk at age 6 years. In Year 1, both RV wheezing (OR, 2.8) and aeroallergen sensitization (OR, 3.6) independently increased asthma risk at age 6 years. By age 3 years, wheezing with RV (OR, 25.6) was more strongly associated with asthma at age 6 years than aeroallergen sensitization (OR, 3.4)(17).

2. Airflow obstruction
Asthma and family history of allergic rhinitis are important risk factors associated with airflow. according to the Department of Pediatrics, Lerdsin General Hospitalobstruction(18).

3. Gender
If you are women, you are at increased risk to develop asthma. According to the study by the Department of Woman and Child Health, Karolinska Institutet, in adolescence, the pattern changes and onset of wheeze is more prevalent in females than males. Asthma, after childhood, is more severe in females than in males, and is underdiagnosed and undertreated in female adolescents(19).

4. Stress
Researchers at the Departments of Family Medicine and Pediatrics, University of Pittsburgh, suggested that stress, whether at the individual(i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence) or community (i.e.neighborhood violence; neighborhood disadvantage) level, influences asthma and asthma morbidity(20).

5. Gene
a study by National Taiwan University, showed that GSTP1, INSIG2 and IL4Ra may influence the lifetime asthma susceptibility through gene-gene interactions in schoolchildren. Home dampness combined with each one of the genes STAT6, IL13 and ADRB2 could raise the asthma risk(21). Other suggested that rs17880588 showed a significant association with asthma in the Saudi population due to the association of between asthma and 5 single-nucleotide polymorphisms (SNPs) in the interleukin 17 (IL17) gene. Levels of IL17A and IL17F were significantly upregulated in the asthma patients(22).

6. Airway inflammation and hyperreactivity
People with Air way hyperreactivity are at increased risk to develop asthma as a result of the immune system over response to allergan. Some study suggested that epidermal growth factor receptor (EGFR) signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model(23).

5. Atopy and viral infection
Atopy – such as eczema, allergic rhinitis, allergic conjunctivitis and virual infection are associated with higher risk to asthma development. According to the study by The University of Western Australia, suggested that underlying this bipartite process (Viral infections occurring against a background of allergic sensitization to aeroallergens as a uniquely potent risk factor for the expression of acute severe asthma-like symptoms and for the ensuing development of asthma that can persist through childhood and into adulthood) are a series of interactions between antiviral and atopic inflammatory pathways that are mediated by local activation of myeloid cell populations in the airway mucosa and the parallel programming and recruitment of their replacements from bone marrow(24).

6. Family history
Family history of asthma in one or more first-degree relatives was consistently identified as a risk factor for asthma. But although a positive family history predicts an increased risk of asthma, it identifies a minority of children at risk. Positive family history may have utility in targeting some individual prevention efforts, but the low positive predictive value limits its value as a means to direct environmental remediation efforts, according to the study the Department of Medical History and Ethics, University of Washington(25).

7. Smoke during Pregnancy
Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies.
During pregnancy, asthma exacerbations are more common and more severe in current smokers than never smokers. The risk of effects of maternal asthma on the fetus may be greater among smokers(26).

8. Low birth weight
There is a strong independent association between low birth weight and asthma. For 1988 national birth cohort, an estimated 4000 excess asthma cases were attributable to birth weight less than 2500 g(27).

9. Etc.
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