The smoothie tangerine peels, grape and cucumber for reduced risk and treatment of Acne

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk and treatment of  Acne 

Yield: 2 serving (about 8 ounce each)

1 medium tangerine peels

1 cup grapes
1/2 cup of cucumbers
1 cup rice milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Combination of tangerine peel(5), grape(1) and cucumber(7)may consist a potential of pharmaceutical values as the ingredients are found effectively in reduced risk and Acne in recent studies.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins. It is the internal causes of acne.

Acne is most common type of skin, affecting billions of people all over world. The dream of finding natural sources for reducing risk and treatment of acne may induce billions and billions dollars of commercial profits of discovered pharmaceutical companies,

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape, as an antimicrobial and anti-inflammatory substances may speed acne recovery from invaded and progression of acne(1), according to the University of Catania,

The phytochemical also has been found effectively in treating acne vulgaris due to its suppression of sebaceous growth by suppressing survival and growth in response to extracellular signals(2).

Dr. Taylor EJ and the research at the David Geffen School of Medicine, said," The ...antibacterial activity and reduced cytotoxicity.....demonstrated by resveratrol.... highlight its potential as a novel therapeutic option or adjuvant therapy in the treatment of acne vulgaris"(3).

Furthermore, resveratrol in the extracts from some herbal medicines also exhibited antibiofilm activity by inhibited the antimicrobial susceptibility of biofilm-associated cells induced the pathogenesis of acne vulgaris(4).

Tangerines, an orange-colored citrus fruit, a type of, mandarin orange originated to Tangier, Morocco, are now cultivated all over the world in suitable climate for commercial profits due to their health effects.
Nobiletin, a phytochemical compound from the group of flavonoid found abundantly in the citrus peels of tangerine exhibited the similar function of acne drugs 13-cis retinoic acid and all-trans retinoic acid(5), may be an effective candidate for acne therapy through reduction of sebocyte proliferation, sebum production and progression of cell apoptosis by suppressing survival and growth in response to extracellular signals(5).

Cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. Due to its silica in skin promotion health benefits, the fruits have been added to some cosmetic gel for treatment of skin diseases(6).According to the Harvard Medical School, topical silica–gold nanoshells at 800 nm exhibited mild anti inflammatory effects and decrease the pathophysiology of acne vulgaris in regulation of sebaceous gland of that induced an effective treatment of moderate-to-severe facial acne, depending to the assessments of disease severity(7).

In support to the above, the University of California study using 150nm silica-gold nanoshell, reduced the acne expression through inducing photothermal disruption of sebaceous glands without damaging collateral skin(8).

Acne Support Group. said,",,, used Silicol Skin for 6 weeks, ...statistically significant 86% overall improvement was reported, with most participants citing the chin as showing the greatest change"(9).

Taking altogether, smoothie with combine of Tangerine peel, grape and cucumber may be effective in reduced risk of the development and progression and treatment of patient with acne.

People with higher risk of acne due to family history, .... should drink 1 serving daily and people with acne should drink as much as they can depending to digestive toleration.

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References

(1) Cosmetics for acne: indications and recommendations for an evidence-based approach by Dall'oglio F1, Tedeschi A, Fabbrocini G, Veraldi S, Picardo M, Micali G.(PubMed)

(2) Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway by Kim SY1, Hyun MY2, Go KC1, Zouboulis CC3, Kim BJ1.(PubMed)

(3) Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro by Taylor EJ1, Yu Y, Champer J, Kim J.(PubMed)

(4) Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin,resveratrol and salidroside as active compounds by Coenye T1, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(PubMed)

(5) A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters by Sato T1, Takahashi A, Kojima M, Akimoto N, Yano M, Ito A.(PubMed)
(6) Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice by Hirai T1, Yoshioka Y2,3,4, Takahashi H5,6, Ichihashi K7, Udaka A8, Mori T9, Nishijima N10, Yoshida T11, Nagano K12, Kamada H13,14, Tsunoda S15,16, Takagi T17,18, Ishii KJ19,20, Nabeshi H21, Yoshikawa T22, Higashisaka K23,24, Tsutsumi Y(PubMed)
(7) Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles by Paithankar DY1, Sakamoto FH2, Farinelli WA2, Kositratna G2, Blomgren RD1, Meyer TJ1, Faupel LJ1, Kauvar AN3, Lloyd JR4, Cheung WL5, Owczarek WD6,Suwalska AM6, Kochanska KB6, Nawrocka AK6, Paluchowska EB6, Podolec KM7, Pirowska MM7, Wojas-Pelc AB7, Anderson RR2.(PubMed)
(8) Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic by Paithankar D1, Hwang BH2, Munavalli G3, Kauvar A4, Lloyd J5, Blomgren R6, Faupel L6, Meyer T6, Mitragotri S7.(PubMed)
(9) The effects of Silicol Skin on moderate to severe acne: UK field survey by Acne Support Group(PubMed)