Medical Advisor Journals

Wednesday, September 28, 2016

Phytochemicals in Foods- The Effects of Naringenin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Naringenin

Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxiant with many health benefits.

Health benefits
1. Antioxidant, radical scavenging and biomolecule activity
In the affirmation of the capacity of flavonoid naringenin and its glycoside naringin in the comparison of theirs antioxidant capacities, radical scavenging and biomolecule activities found that naringenin exhibited higher antioxidant capacity and hydroxyl and superoxide radical scavenger efficiency than naringin and both flavanones were equally effective in reducing DNA damage. However, they show no protective effect on oxidation of GSH, according to the study of "Antioxidantproperties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study" byCavia-Saiz M, Busto MD, Pilar-Izquierdo MC, Ortega N, Perez-Mateos M, Muñiz P.(1)

2. Colon cancer
In the comparison of flavonoids and limonoids and theirs effects on colon cancer found that The ability of dietary apigenin and naringenin to reduce HMACF, lower proliferation (naringenin only) and increase apoptosis may contribute toward colon cancer prevention, according to "Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats" by Leonardi T, Vanamala J, Taddeo SS, Davidson LA, Murphy ME, Patil BS, Wang N, Carroll RJ, Chapkin RS,Lupton JR, Turner ND.(2)

3. Lung metastasis
In the investigation of Naringenin and its defect in lung metastasis in a breast cancer found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells, according to the study of "Naringenin reduces lung metastasis in a breast cancer resection model" by Qin L, Jin L, Lu L, Lu X, Zhang C, Zhang F, Liang W.(3)

4. Anti cancers and tumors
In the study of Naringenin and its anti cancer and tumor effects found that NGEN promotes apoptosis in rat C6 glioma model by promoting the apoptotic effect, modulation of Bcl-2/Bax ratio leads to release of Cyt C from mitochondria, thereby activation of caspase-3 and caspase-9 is mediated by enhanced expression of Cx43, according to "Naringenin promote apoptosis in cerebrally implanted C6 glioma cells" by Sabarinathan D, Mahalakshmi P, Vanisree AJ.(4)

5. Pulmonary fibrosis
In the analyzing Naringenin and its effect in idiopathic pulmonary fibrosis which can lead to lung cancer found that Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving the immunosuppressive environment through down-regulating transforming growth factor-beta1 and reducing regulatory T cells. Naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis, according to "Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis" by Du G, Jin L, Han X, Song Z, Zhang H, Liang W.(5)

6. Multidrug-resistant cancer cells
In the observation of 12 phenolic compounds, including three stilbenes, two flavonoids, two coumarins, one neolignan, and four lignans, isolated from Euphorbia and Pycnanthus species or obtained by derivatization and theirs effects against multidrug-resistant human cancer cells found that the most active compound was the flavonoid naringenin, found to be 15-fold more effective against the atypical MDR subline of gastric carcinoma than in parental drug-sensitive cells, according to "Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells' by Duarte N, Lage H, Abrantes M, Ferreira MJ.(6)

7. Hepatic lipid metabolism
In the examination of naringenin and its effect of disruption of lipid andcarbohydrate homeostasis which may contribute to an important factor in the development of prevalent metabolic diseases such as diabetes, obesity, and atherosclerosis found that naringenin regulates the activity of nuclear receptors PPARalpha, PPARgamma, and LXRalpha as it activates the ligand-binding domain of both PPARalpha and PPARgamma, while inhibiting LXRalpha in GAL4-fusion reporters, according to "Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha" by Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y.(7)

8. Hepatitis C virus (HCV)
In the evaluation of naringenin and its effect Hepatitis C virus (HCV) infection found that naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production. The combination ofnaringenin with STAT-C agents could potentially bring a rapid reduction in HCV levels during the early treatment phase, an outcome associated with sustained virological response, according to "Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism" by Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y.(8)

9. Cholesterol-lowering activity
In the affirmation of naringenin and its Cholesterol-lowering effect found thatnaringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet, according to "Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats" by Lee SH, Park YB, Bae KH, Bok SH, Kwon YK, Lee ES, Choi MS.(9)

10. Anti-inflammatory effects
In the evaluation of the mechanisms of action of the effective compounds. Flavone, the isoflavones daidzein and genistein, the flavonols isorhamnetin, kaempferol and quercetin, the flavanone naringenin, and the anthocyanin pelargonidin amd theirs anti-inflammatory effects found that they inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner, according to "Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages" by Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E.(10)

11. Immunity
In the unvestigation of Naringenin, a flavonoid in grapefruits and citrus fruits and its effec in immune system found that naringenin potently suppressed picryl chloride (PCl)-induced contact hypersensitivity by inhibiting the proliferation and activation of T lymphocytes. In vitro, both of the activated hapten-specific T cells and the T cells stimulated with anti-CD3/anti-CD28 showed growth arrest afternaringenin treatment, according to "A novel regulatory mechanism ofnaringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression" by Fang F, Tang Y, Gao Z, Xu Q.(11)

12. Etc.

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and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Phytochemicals in Foods- The Effects of Hesperidin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Hesperidin

Hesperidin is a Flavanones, belonging to the flavonoid in Flavonoids (polyphenols)(C28H34O15), found abundantly in citrus fruits.

Health Benefits
1. Cholesterol lowering
In the investigation of Hesperidin, the most important flavanone of Citrus sp., and its effect of lowering cholesterol found that hesperidin significantly increases HDL and lowers cholesterol, LDL, total lipid and triglyceride plasma levels in normolipidemic rats and in rats with diet- and triton-induced hyperlipidemia, according to "Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat" byMonforte MT, Trovato A, Kirjavainen S, Forestieri AM, Galati EM, Lo Curto RB.(1)

2. Hypertension
In the evaluation of Long-term administration of hesperidin (HES) or glucosyl hesperidin (GHES), a water-soluble analogue of HES and theirs effects on antihypertensive effect on spontaneously hypertensive rats found that HES as well as GHES improves serum cholesterol composition and that GHES inhibits hypertrophy in vasculature as well, according to "Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature" by Ohtsuki K, Abe A, Mitsuzumi H, Kondo M, Uemura K, Iwasaki Y, Kondo Y.(2)

3. Anti-infection
in the administration of a citrus flavonoid hesperidin (HES) and its effect on infection found that HES markedly suppressed plasma levels of TNF-alpha and high mobility group box chromosomal protein 1 (HMGB-1), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection, according to "A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice" by Kawaguchi K, Kikuchi S, Hasunuma R, Maruyama H, Yoshikawa T, Kumazawa Y.(3)

4. Anti-inflammatory activity
In the investigation of hesperidin (50 and 100 mg kg-1, s.c.) and its anti-inflammatory activity found that hesperidin obtained from citrus cultures may present a potential therapeutical use as a mild anti-inflammatory agent, being also useful as a precursor of new flavonoids endowed with such activity, according to"Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice" by Emim JA, Oliveira AB, Lapa AJ.(4)

5. Sedative and antinociceptive effects
In the observation of hesperidin (hesperetin-7-rhamnoglucoside) and its sedative activity found that a possible beneficial use of the association of hesperidin with benzodiazepines, not only to improve human sedative therapy, but also in the management of pain, according to "Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines" by Loscalzo LM, Wasowski C, Paladini AC, Marder M.(5)

6. Nutrigenomic effect
In the analyzing citrus polymethoxylated flavones (PMFs), mainly tangeretin, or citrus flavanone glucosides, hesperidin and naringin and theirs effect found that that regular consumption of orange juice for 4 weeks alters leukocyte gene expression to an anti-inflammatory and anti-atherogenic profile, and hesperidindisplays a relevant role in the genomic effect of this beverage, according to "Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study" by Milenkovic D, Deval C, Dubray C, Mazur A, Morand C.(6)

7. Endothelial cells
In the observation of investigate the different effects of three representative flavonoids-hesperidin, naringin, and resveratrol and their effect on intracellular adhesion molecule-1 (ICAM-1) induction in human umbilical vein endothelial cells (HUVECs) found that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells, according to "Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells" by Kim SW, Kim CE, Kim MH.(7)

8. Plasma concentration
in the examination of hesperidin (Hp) and naringin (Nar), two major citrus flavanones and theirs effect in regulating of bone metabolism found that the higher efficacy of Hp at a lower plasma concentration than naringin, as well as the identification of the major circulating metabolite of hesperidin (hesperetin-7-O-glucuronide) underlines the importance of flavanone bioavailability and metabolism in their biological efficacy and suggests a structure-function relationship in the mechanism of action of the active metabolites, according to "Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism" by Habauzit V, Sacco SM, Gil-Izquierdo A, Trzeciakiewicz A, Morand C, Barron D, Pinaud S, Offord E, Horcajada MN.(8)

9. Bone mineral density
In administration of hesperidin, one of the main flavonoid present in oranges and its effect in bone found that Hp consumption resulted in a significant increase inbone mineral density (BMD). Indeed, 6-mo-old HpSH rats had a similar BMD to 9-mo-old nontreated SH adult rats, suggesting an accelerated bone mass gain in the young rats. In contrast, in intact adult rats, Hp did not further increase BMD but did improve their bone strength, according to the study of "Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bonemass and strength in young and adult intact rats" by Horcajada MN, Habauzit V, Trzeciakiewicz A, Morand C, Gil-Izquierdo A, Mardon J, Lebecque P, Davicco MJ, Chee WS, Coxam V, Offord E.(9)

10. Memory dysfunction
In the research of Hesperidin (50 and 100 mg/kg, po) and its effect ischemic reperfusion cerebral injury-induced memory dysfunction found that hesperidintreatment significantly attenuated histopathological alterations compared to control (I/R) animals. L-arginine (100 mg/kg) pretreatment attenuated the protective effect of the lower dose of hesperidin on memory behavior, according to "Hesperidinpre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction" by Gaur V, Kumar A.(10)

11. Bleeding bladder varices
In the study of hesperidin 150 mg bid or tid for 30 days in 4 cases and its effect on bleeding bladder varicose veins found that 2 cases that bled the haematuria disappeared and in the 4 cases in the control cystoscopy the varicose veins had disappeared, according to "[Use of flavonoids (hesperidin) in the treatment of bleeding bladder varices]. [Article in Spanish]" by Granados Loarca EA.(11)

12. Diabetes
In the confirmation of hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) and theirs hypoglycemic and hypolipidemic effects found thathesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats, according to "Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes" by Akiyama S, Katsumata S, Suzuki K, Nakaya Y, Ishimi Y, Uehara M.(12)

13. Etc.

**Overdose of glucoside hesperidin decreased bone density loss, according to the study of "Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice" by Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y.(a)

Pregnancy Miracle
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Phytochemicals in Foods- The Effects of Isorhamnetin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Isorhamnetin

Isorhamnetin is an O-methylated flavonol, a type of Flavonols, belonging to Flavonoids (polyphenols) found in Tagetes lucida.

Health benefits
1. Antioxidant activity
in the investigation the phenolic composition and antioxidant activities of aqueous infusions from wild-grown caper ( Capparis spinosa L.) and sea fennel ( Crithmum maritimum L.) from the Dalmatia region (Croatia) after their submission to an in vitro digestion process. HPLC/UV-vis-DAD/ESI-MS analysis of the caper infusion identified rutin, kaempferol 3-O-rutinoside, and isorhamnetin 3-O-rutinoside as dominant flavonoids found that Both infusions exhibited good and dose-dependent antioxidant activity before in vitro digestion by the DPPH method, the β-carotene bleaching method, and copper-induced oxidation of human LDL, according to the study of "Phenolic Composition and Antioxidant Activity of Aqueous Infusions from Capparis spinosa L. and Crithmum maritimum L. before and after Submission to a Two-Step in Vitro Digestion Model" by Siracusa L, Kulisic-Bilusic T, Politeo O, Krause I, Dejanovic B, Ruberto G.(1)

2. Stabilization of beta-catenin
In the evaluation of isorhamnetin and its effect of anti-adipogenic effects in stabilization of beta-catenin found that Isorhamnetin inhibited the adipocyte differentiation of hAMSCs. Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3, according to "Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of beta-catenin protein" by Lee J, Lee J, Jung E, Hwang W, Kim YS, Park D.(2)

3. Anti-inflammatory properties
In the observation of quercetin and its major metabolites quercetin-3-glucuronide (Q3G) and isorhamnetin and theirs effects on on inflammatory gene expression found that Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation, according to "Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155" by Boesch-Saadatmandi C, Loboda A, Wagner AE, Stachurska A, Jozkowicz A, Dulak J, Döring F, Wolffram S, Rimbach G.(3)

4. Skin inflammation
In the analyzing the aerial parts of Artemisia capillaris Thunberg (Compositae)(AR), containing Nine major compounds, scopoletin, scopolin, scoparone, esculetin, quercetin, capillarisin, isorhamnetin, 3-O-robinobioside, isorhamnetin 3-O-galactoside and chlorogenic acid and theirs effect on Skin inflammation found that AR and some of their major constituents are 5-LOX inhibitors, and these in vitro and in vivo activities may contribute to the therapeutic potential of AR in skin inflammatory disorders in traditional medicine, according to "Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents" by Kwon OS, Choi JS, Islam MN, Kim YS, Kim HP.(4)

5. Myelogenous erythroleukaemia cells
In the confirmation of isorhamnetin3-O-rutinoside (I3-O-R) of ethyl acetate extract (EA) obtained from Nitraria retusa leaves and its effect on human chronic myelogenous erythroleukaemia cells (K562) found that Apoptosis, revealed by DNA fragmentation and PARP cleavage, was observed after 48-h incubation of these human myelogenous erythroleukaemia cells (K562), with the tested products. Likewise, caspase 3 and caspase 8 activities were induced in the presence of the EA extract and I3-O-R after 48 h of incubation, according to "Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells" by Boubaker J, Bhouri W, Ben Sghaier M, Ghedira K, Dijoux Franca MG, Chekir-Ghedira L.(5)

6. Cytotoxicity
In the examination of heterogenoside E and F, isolated from Lysimachia heterogenea Klatt, together with the eight known compounds, includingisorhamnetin-3-O-galactopyranoside found that The cytotoxic activities of anagallisin C, heterogenoside E and F were weak, according to "Two new triterpenoids from Lysimachia heterogenea Klatt and evaluation of their cytotoxicity" by Huang XA, Shen XL, Hu YJ, Liu YM, Liu KL, Zhang FX, Zhou XX.(6)

7. Hepatoprotective activities
In the investigation of antioxidant and hepatoprotective activities of phenolic rich fraction (PRF) of Seabuckthorn leaves on CCl(4) including 319.33 mg gallic acid equivalent (GAE)/g PRF and some of its phenolic constituents, such as gallic acid, myricetin, quercetin, kaempferol and isorhamnetin and theirs effect onhepatoprotective activities found that PRF has potent antioxidant activity, prevent oxidative damage to major biomolecules and afford significant protection against CCl(4) induced oxidative damage in the liver found that Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves" by Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN.(7)

8. Osteoporosis
In the analyzing crude ethanolic extract of TSZ. the seeds of Cuscuta chinensis (Tu-Si-Zi, TSZ), including quercetin, kaempferol, isorhamnetin, hyperoside and astragalin and theirs effects found that the clinical use of TSZ in the treatment of osteoporosis, and demonstrated that kaempferol and hyperoside are the active compounds in TSZ for the osteogenic effect, according to "Antiosteoporotic compounds from seeds of Cuscuta chinensis" by Yang L, Chen Q, Wang F, Zhang G.(8)

9. Skin cancer
In the analyzing 3'-Methoxy-3,4',5,7-tetrahydroxyflavone (isorhamnetin) in fruits and medicinal herbs and its effect on skin cancer found that sorhamnetin inhibited epidermal growth factor (EGF)-induced neoplastic cell transformation. It also suppressed anchorage-dependent and -independent growth of A431 human epithelial carcinoma cells. Isorhamnetin attenuated EGF-induced COX-2 expression in JB6 and A431 cells. In an in vivo mouse xenograft using A431 cells,isorhamnetin reduced tumor growth and COX-2 expression, according to "Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K" by Kim JE, Lee DE, Lee KW, Son JE, Seo SK, Li J, Jung SK, Heo YS, Mottamal M, Bode AM, Dong Z, Lee HJ.(9)

10. cytochrome P-450 1A1 (CYP1A1) activity
In the examination of a standard reference material of a Ginkgo biloba extract (GBE), containing kaempferol, quercetin, isorhamnetin, ginkgolides and bilobalid found that demonstrated a strong induction (p < 0.005) of CYP1A1 activity and a slight, but significant (p < 0.005), decrease of this activity in the presence of B[a]P by the GBE at the realistic exposure level of 100 μg/ml, according to "Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells" by Ribonnet L, Callebaut A, Nobels I, Scippo ML, Schneider YJ, De Saeger S, Pussemier L, Larondelle Y.(10)

11. Etc.

Pregnancy Miracle
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Using Holistic Ancient Chinese Medicine

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22017607
(2) http://www.ncbi.nlm.nih.gov/pubmed/20097210
(3) http://www.ncbi.nlm.nih.gov/pubmed/20579867
(4) http://www.ncbi.nlm.nih.gov/pubmed/21975819
(5) http://www.ncbi.nlm.nih.gov/pubmed/21951288
(6) http://www.ncbi.nlm.nih.gov/pubmed/21934645
(7) http://www.ncbi.nlm.nih.gov/pubmed/21723907
(8) http://www.ncbi.nlm.nih.gov/pubmed/21463675
(9) http://www.ncbi.nlm.nih.gov/pubmed/21330379
(10) http://www.ncbi.nlm.nih.gov/pubmed/21329749

Herbal Therapy: The Aloe Vera effects on Irritable bowel syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Aloe Vera

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.

Irritable bowel syndrome

Irritable bowel syndrome is defined as a condition, if a patient is diagnosed with abdominal pain or discomfort, bloating, and alteration of bowel habits at least three times a month for the last 3 months without preexistence of other disease.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

The benefits
Aloe vera (AV) has long been suggested by herbal medicine in treating irritable bowel syndrome (IBS) symptoms. In the comparison of the effectiveness of a mixture of Aloe vera (AV) and Matricaria recutita (German chamomile, GC) in treating Irritable bowel syndrome, GC inhibited only small bowel transit while the AV/GC mixture delayed gastric emptying at the doses of 150 and 300 mg/kg. The AV/GC mixture also reduced colonic transit and small bowel transit at the dose of 150 mg/kg. In other randomised double-blind placebo-controlled trial of to test the effects of aloe vera for irritable bowel syndrome, there was no evidence that AV benefits patients with IBS and superior to placebo in improving quality of life proven Irritable Bowel Syndrome patients, but in 49 completed the protocol to 1 month and 41 to 3 months. Eleven of thirty-one (35%) AV patients, and 6 of 27 (22%) placebo patients responded at 1 month (p = 0.763). Diarrhoea predominant patients showed a trend towards a response to treatment at 1 month (10/23 V 2/14, p = 0.07).

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S.
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin,http://www.herballegacy.com/Baldwin_Chemical.html
(3) Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects by Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-Esfahani HR, Abdollahi M.(PubMed)
(4) Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome.
Davis K, Philpott S, Kumar D, Mendall M.(PubMed)
(5) A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life by Hutchings HA, Wareham K, Baxter JN, Atherton P, Kingham JG, Duane P, Thomas L, Thomas M, Ch'ng CL, Williams JG.(PubMed)
(7) Oral aloe vera-induced hepatitis(PubMed)
(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-monthdouble blind placebo-controlled study(PubMed)

Herbal Therapy: The Aloe Vera effects on Skin diseases

Skin diseases

Skin diseases is defined as a condition of skin damage and classified according to each pathogenic causes of diseases.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

The benefits
In the a systematic review of Aloe vera's clinical effectiveness, topical application of aloe vera is not an effective preventative for radiation-induced skin injuries, but might be effective for genital herpes and psoriasis.In support to above, study by Feily A, Namazi MR. indicated that Topical application of aloe vera is not an effective in sunburn or suntan protection, but might be effective in treating genital herpes, psoriasis, human papilloma virus, seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus, frostbite, burn, wound healing and inflammation.

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.

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Herbal Therapy: The Aloe Vera effects on Psoriasis

Psoriasis

Psoriasis is defined as chronic condition of inflammatory skin disease, affecting the joins and mostly happens to people who are obese are predisposed to diabetes and heart disease.
The Ingredients
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

The benefits
Many herbal extracts have been used as topical management of plaque psoriasis, including Aloe vera based on multiple studies. Aloe vera gel is used in alternative medicine over the century for the treatment of skin diseases, including psoriasis, and recent study showed that ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness and an overall antipsoriatic activity of high effective rate. Other in the comparison of comparion to evaluate the efficacy of Topical aloe vera (AV) and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis, AV cream may be more effective than 0.1% TA cream found to be more effective in reducing the clinical symptoms of psoriasis. Unfortunately, in diverse dermatologic conditions, even though there are some promising results with the use of aloe vera, but clinical effectiveness of oral and topical aloe vera may require further studies, according to the study of Dr. Feily A, and Dr. Namazi MR.

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.

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References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin,http://www.herballegacy.com/Baldwin_Chemical.html
(3) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis.
Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(4)A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
(5) Aloe vera in dermatology: a brief review by Feily A, Namazi MR.(PubMed)
(7) Oral aloe vera-induced hepatitis(PubMed)(8) Oral type II collagen in thetreatment of rheumatoid arthritis. A six-month double blind placebo-controlledstudy(PubMed)

Tuesday, September 27, 2016

Phytochemicals in Foods- The Effects of Rutin

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Rutin

Rutin also known as rutoside, quercetin-3-O-rutinoside and sophorin is aFlavonols, belong to Flavonoids (polyphenols) of Phenolic compounds found orange, grapefruit, lemon, lime, berries mulberry, cranberries, buckwheat etc.

Health Benefits
1. Platelet aggregation
In the research of methanol extract of Sophora japonic, containing the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10) and its effect on anti-platelet activity, found that compounds, 1, 3, and 7 showed approximately 2.5-6.5 fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (IC50: 19.9 and 99.8 microM; 20.3 and 53.8 microM; 25.9 and 123.4 microM, respectively) than acetylsalicylic acid (ASA, IC50: 63.0 and 350.0 microM). Compound 2 was an approximately 22-40 fold stronger inhibitor than ASA on AA and U46619 induced aggregation (IC50: 1.6 and 15.6 microM, respectively), according to the study of "Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica" by Kim JM, Yun-Choi HS.(1)

2. Anti-inflammatory activity
In the investigation of Rutin, a natural flavone derivative and its anti inflammatory effect found that Oral administration of rutin reduced rat paw swelling starting 2 hours after lambda-carrageenan injection. Rutin reduced significantly (p < 0.05) and in a dose-dependant manner the polymorphonuclear neutrophils chemotaxis to fMet-Leu-Phe, according to the study of "Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation" by Selloum L, Bouriche H, Tigrine C, Boudoukha C.(2)

3. Diabetes-increased aging effect
In the observation of 1 g.kg-1.day-1 rutin, an aldose reductase inhibitor and irs effect on products from the advanced Maillard reaction which increase during aging and diabetes found that even though rutin prevent the accumulation of fluorescence are unknown, but these observations raise the question of whether they could be identical. If fluorescence is a marker for age-related pathologies and diabetic sequelae, aminoguanidine and rutin could have therapeutic effects in their prevention, according to "Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin" by Odetti PR, Borgoglio A, De Pascale A, Rolandi R, Adezati L.(3)

4. Diabetes, Hyperglycemia and dyslipidemia
In the analyzing Dietary antioxidant compounds such as flavonoids and its protection against early-stage diabetes mellitus, found that Rutin (50 mg kg(-1)) reduced (p<0.05) blood glucose and improved the lipid profile in STZ-induced diabetic rats and concluded that that rutin can improve hyperglycemia and dyslipidemia while inhibiting the progression of liver and heart dysfunction in STZ-induced diabetic rats, acccording to "Influence of rutin treatment on biochemical alterations in experimental diabetes" by Fernandes AA, Novelli EL, Okoshi K, Okoshi MP, Di Muzio BP, Guimarães JF, Fernandes Junior A.(4)

5. Fatty liver disease
In evaluation of rutin, a common dietary flavonoid and the hypolipidemic effect of iton fatty liver disease found that rutin could attenuate lipid accumulation by decreasing lipogenesis and oxidative stress in hepatocyte, according to "Rutininhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells" by Wu CH, Lin MC, Wang HC, Yang MY, Jou MJ, Wang CJ.(5)

6. Peptic ulcer
In examination of Oroxylum indicum, Zingiber officinale, Olea europaea L., Foeniculum vulgare, Alchornea glandulosa, Tephrosia purpurea, containing phenolic compounds, namely, baicalein, cinnamic acid, oleuropein, rutin, quercetin, and tephrosin, respectively, as active constituents amd theirs effect on Peptic ulcer, the most common gastrointestinal tract (GIT) found that Polyphenols display a number of pharmacological properties in the GIT area, acting as antisecretory, cytoprotective, and antioxidant agents. The antioxidant properties of phenolic compounds have been widely studied, but it has become clear that their mechanisms of action go beyond the modulation of oxidative stress. Various polyphenolic compounds have been reported for their anti-ulcerogenic activity with a good level of gastric protection. Besides their action as gastroprotective, according to "Role of phenolic compounds in peptic ulcer: An overview" by Sumbul S, Ahmad MA, Mohd A, Mohd A.(6)

7. Mitochondrial damage
In the confirmation of consumption of diets rich in flavonoids is associated with reduced risk of Mitochondrial damage found that pretreatment with rutin at the dose of 80 mg/kg daily for 42 days to isoproterenol-induced rats prevented all the biochemical alterations. Transmission electron microscopic study also confirmed the protective effects of rutin on the structure of heart mitochondria. Thus, rutinreduced the extent of mitochondrial damage induced by isoproterenol and prevented cardiac mitochondrial dysfunction, according to "Protective effects ofrutin on mitochondrial damage in isoproterenol-induced cardiotoxic rats: an in vivo and in vitro study" by Punithavathi VR, Shanmugapriya K, Prince PS.(7)

8. Cardiovascular health
In the testing the hypothesis of the consumption of a diet rich in flavonoids can be associated with a reduced risk for cardiovascular disease found that hamster fed with 2% cranberry concentrate powder (HFHC+CE); a HFHC with 0.1% rutin(HFHC+Rutin); and a HFHC with 30 mg/kg vitamin E (HFHC+Vit.E) diet for either 12 or 20 weeks, found that Ratios of plasma high-density lipoprotein cholesterol (HDL-C) to very-low-density lipoprotein cholesterol and of plasma HDL-C to low-density lipoprotein cholesterol were significantly higher in animals consuming HFHC+Vit.E, according to the strudy of "Effects of a flavonol-rich diet on selectcardiovascular parameters in a Golden Syrian hamster model" by Kalgaonkar S, Gross HB, Yokoyama W, Keen CL.(8)

9. Ischemia-reperfusion brain injury-related disorders
In the investigation of rutin's effect on cerebral ischemia-reperfusion (IR) injury caused by free radical induced neural damage found that the elevated level of thiobarbituric acid reactive species (TBARS), H(2)O(2) and protein carbonyl (PC) in MCAO group was attenuated significantly in rutin-pretreated group and concluded that rutin treatment may represent a novel approach in lowering the risk or improving the function of ischemia-reperfusion brain injury-related disorders, according to Rutin protects the neural damage induced by transient focal ischemia in rats" by Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, Islam F.(9)

10. Degenerative diseases
In the affirmation of rutin and its effect on against several degenerative diseasesand particularly brain diseases found that The anti-oxidant and anti-inflammatory properties of Citrus flavonoids can play a key role in their activity against several degenerative diseases and particularly brain diseases. Diosmin and rutin have a demonstrated activity as a venotonic agent and are present in several pharmaceutical products, according to "Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity" by Benavente-García O, Castillo J.(10)

11. Periodontal disease
In the study of isolation from the mouths of 2 healthy subjects, hydrolysed innocuous rutin, a flavonoid glycoside, to its genotoxic aglycon quercetin and its effect on local carcinogenic process found that a hypothesis for a novel role of the oral microflora in a disease process other than caries and periodontal disease, namely intra-oral cancer, is presented. The possibility of a bacterial liberation of the genotoxic quercetin in situ could be but one example of its involvement in the local carcinogenic process, according to "Activation of rutin by human oral bacterial isolates to the carcinogen-mutagen quercetin" by Parisis DM, Pritchard ET.(11)

12. Anti cancer
In the investigation of Tilia × viridis, a Tilia species distributed widely in Buenos Aires, Argentin and its anti oxidantive effect found that the extract was found to present a selective antiproliferative activity on a lymphoma cell line and this was related to free radical scavenging activity. In addition, one of its main compounds,rutin, showed antioxidant effects related to peroxidase activity. T. × viridis may therefore be a source of antioxidant compounds that contribute to a selective antiproliferative action on tumoral cells, acting by modulation of H(2)O(2) levels, according to "HPLC fingerprint of a flower extract of Tilia × viridis and correlation with antiproliferative and antioxidant activity" by Marrassini C, Anesini C, Ferraro G.(12)

13. Etc.

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Wednesday, September 28, 2016

Phytochemicals in Foods- The Effects of Naringenin

Phytochemicals in Foods- The Effects of Hesperidin

Phytochemicals in Foods- The Effects of Isorhamnetin

Herbal Therapy: The Aloe Vera effects on Irritable bowel syndrome

Herbal Therapy: The Aloe Vera effects on Skin diseases

Herbal Therapy: The Aloe Vera effects on Psoriasis

Tuesday, September 27, 2016

Phytochemicals in Foods- The Effects of Rutin