Adding a portion of dried beans into your diet may have a potential effect in reduced risk of cancers onset, according to the Division of Cancer Prevention, National Cancer Institute.
Dried beans are the nutritionally mighty member of the legume family, belonging to the family Fabaceae.
The healthy sources of dried legume, including protein, fibers, vitamins and minerals such as dietary fiber, fat, protein, vitamin A ( beta-carotene, lutein and zeaxanthin), B vitamins, vitamin C, calcium, iron, magnesium, phosphorus, potassium, ... and zinc can be included in any one diet,
Certain genetic mutations may have significant influences in the risk of cancers, such as BRCA1 and BRCA2 genes which can elevate the risk of breast and ovarian cancers.
According to statistic, women who carry mutated gene BRCA1 and 2 have a 50 to 85 percent increased risk of developing the disease by age of 70.
Other causes of cancer are unknown, however, researchers suggested that smoking and use of tobacco, unhealthy diet, family history, inactive physical activity, long-term exposure to sun and other types of radiation, infected viruses, and infectious diseases are some of the potential risk factors that may have a strong impact on the development of cancers.
Cancer is a class of diseases characterized by cell growth uncontrollably and disorderly, affecting all the organs and tissue.
Depending on its invasive nature, some cancers can travel a distance away from the original site to infect other parts of the body.
In the study to investigate 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders and during 2,193,751 person-years of follow-up from 1995/1996-2000, researchers found that
*. Intake of vegetables shows a significant effect in reduced risk of certain types of cancer.
* The relative hazard ratio risk of cancers was reduced to .95 in compared to control
*. Risk of cancers is reduced substantially as shown in the highest tertile of Leguminosae group (dried beans, string beans, and peas, 0.80, 0.67-0.96) compared to other groups.
Dried bean and string bean with abundant fiber scored the lower and lowerest relative risk ratio in compared to peas and other kinds of vegetables.
Further analysis of diets of African-American men and women, undergoing colonoscopies in order to examine the relationship between selected dietary factors and the risk for colon polyps, according to the multiple logistic regression model used to adjust for potential confounding variables and to determine which factors influence colorectal adenoma risk, researchers said, " consumption of legumes such as dried beans, split peas, or lentils was negatively associated with risk (of cancers)" and "Legumes are a good source of dietary fiber and of phytochemical compounds that may play a role in reducing adenoma formation or growth".
Once again, dried beans exerted the highest effect in reduced risk of colorectal adenoma in compared to other types of legume.
Interestingly, in broader scope of further exploration of the association between legume intake and cancer risk in a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls, researchers suggested, intake of legume including dried peas demonstrate a substantially decreased risk of stomach and prostate cancer and other forms of cancer, including
*. Cavity and pharynx cancer had a relative odd risk ratio of OR=0.48
*. Esophagus cancer with OR = 0.54
*. Larynx cancer with OR = 0.55
*. Upper aerodigestive tract cancer with OR = 0.50
*. Stomach cancer with OR = 0.69
*. Colorectum cancer with OR = 0.43
*. Kidney cancer relative had an odd risk ratio of.OR = 0.41
* With relative odd risk ratio of .68 on all sites combined
After adjusting to other risk factors researchers concluded, "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder".
These results suggested that the protective effect of dried beans in inhibited most types of cancer occurrence may be a result of improvement of host cells integrity against alternation of cells DNA transcription in the induction of cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Legume intake and the risk of cancer: a multisite case-control study in Uruguay by Aune D1, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M.(PubMed)
(2) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL. (PubMed)
(3) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study by Freedman ND1, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC.(PubMed)
Friday, October 12, 2018
Thursday, October 11, 2018
8 Foods That Kill Prostate Cancer Cells, Scientists Say
The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with the tendency to affect even younger age population.
Evidence in the Far East recent diet suggested, over consuming bad fats in any time in history accompanied with unhealthy diet and lifestyle may be the possible causes of the disease, linking to the economic prosperity over last 3 decades.
Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue.
At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.
Most prostate cancers are slow growing. And Enlarged prostate and prostate cancer in most cases are detected during physical (rectum) exams.
Some researchers suggested that certain abnormal expression of hormones may have a strong effect in increased risk of prostate cancer, including high levels of hormone androgen and insulin-like growth factor-1 (IGF-1).
In other words, patients with prostate cancer are linearly associated with high levels of hormonal testosterone and insulin-like growth factor-1 (IGF-1).
Although genetic mutation may have a direct effect in induced prostate cancer incidence, such as BRCA1, BRCA2, MSH2 and MLH1, the direct causes of prostate cancer are still debatable.
However, there are some risk factors that have significant impacts to induce early onset of the disease.
The list includes age, family history, race, low levels of vitamin D in the blood, excessive alcohol drinking, obesity,..... and enlarged prostate.
Foods That Kill Prostate Cancer Cells include
1. Flaxseed
Flaxseed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed.
Flax is an erect annual plant that can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.
Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76). And, a diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).
2. Vegetable oil
Vegetable oil is a triglyceride extracted from vegetables.
Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79).
Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model. And, 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).
3. Honey
The rich golden liquid is the miraculous product made by bees using nectar from flowers. The liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manners(81).
4. Chickpea
Garbanzo beans also known as chickpea is an edible legume of genus Cicer, belongings to the family Fabaceae, with high sources of protein and mineral, native to the Middle East.
7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).
5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumors xenografted in athymic mice(83).
And polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ-specific cancers, through disruption of the overall process of carcinogenesis by inhibition of DNA synthesis and ROS production, regulation of cell cycle arrest and modulation of survival/proliferation pathways(84).
Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways, depending on their concentration, the cell system, the type or stage of the pathological process(85).
6. Black pepper
Black pepper is a flowering vine in the family Piperaceae, used as a spice and seasoning.
Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose-dependent manner.
And, In caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).
7. Green tea
Green tea containing more amount of antioxidants than any drinks or foods with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of preprostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).
In green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti-PCa (89) effect by modulation of signaling pathways.
Also, a combination of quercetin and green tea showed a significant increase in inhibition of proliferation, androgen receptor, and phosphatidylinositol 3-kinase/Akt signaling(tumorgenesis in early stage), and stimulation of apoptosis(90).
In short, Green tea, a potent anti-prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in various types of cancer.
8. Organic fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.
In Japan, the incidence of prostate cancer in aging men are low in compared to the West.
This result may be due to tradition Japanese diet in the exertion of prostate cancer protective effects
In fact, Traditional Japanese diet rich in soybean products and fish is associated with reduced prostate cancer risk(92).
In China, lower risk of prostate cancer is associated with consumption of soy foods and isoflavones found abundantly in fermented soybean products(93).
Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.
Conclusion
The prevalence and widespread of prostate cancer may be diet, demographic and lifestyle-related disease(94)(95)(96).
Eating healthy, with plenty of vegetables and fruits has always been considered a preventive approach. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. (PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. (PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH. (PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrate inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen-Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. (PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. (PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW. (PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL. (PubMed)
(95) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)
Evidence in the Far East recent diet suggested, over consuming bad fats in any time in history accompanied with unhealthy diet and lifestyle may be the possible causes of the disease, linking to the economic prosperity over last 3 decades.
Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue.
At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.
Most prostate cancers are slow growing. And Enlarged prostate and prostate cancer in most cases are detected during physical (rectum) exams.
Some researchers suggested that certain abnormal expression of hormones may have a strong effect in increased risk of prostate cancer, including high levels of hormone androgen and insulin-like growth factor-1 (IGF-1).
In other words, patients with prostate cancer are linearly associated with high levels of hormonal testosterone and insulin-like growth factor-1 (IGF-1).
Although genetic mutation may have a direct effect in induced prostate cancer incidence, such as BRCA1, BRCA2, MSH2 and MLH1, the direct causes of prostate cancer are still debatable.
However, there are some risk factors that have significant impacts to induce early onset of the disease.
The list includes age, family history, race, low levels of vitamin D in the blood, excessive alcohol drinking, obesity,..... and enlarged prostate.
Foods That Kill Prostate Cancer Cells include
1. Flaxseed
Flaxseed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed.
Flax is an erect annual plant that can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.
Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76). And, a diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).
2. Vegetable oil
Vegetable oil is a triglyceride extracted from vegetables.
Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79).
Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model. And, 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).
3. Honey
The rich golden liquid is the miraculous product made by bees using nectar from flowers. The liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manners(81).
4. Chickpea
Garbanzo beans also known as chickpea is an edible legume of genus Cicer, belongings to the family Fabaceae, with high sources of protein and mineral, native to the Middle East.
7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).
5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumors xenografted in athymic mice(83).
And polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ-specific cancers, through disruption of the overall process of carcinogenesis by inhibition of DNA synthesis and ROS production, regulation of cell cycle arrest and modulation of survival/proliferation pathways(84).
Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways, depending on their concentration, the cell system, the type or stage of the pathological process(85).
6. Black pepper
Black pepper is a flowering vine in the family Piperaceae, used as a spice and seasoning.
Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose-dependent manner.
And, In caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).
7. Green tea
Green tea containing more amount of antioxidants than any drinks or foods with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of preprostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).
In green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti-PCa (89) effect by modulation of signaling pathways.
Also, a combination of quercetin and green tea showed a significant increase in inhibition of proliferation, androgen receptor, and phosphatidylinositol 3-kinase/Akt signaling(tumorgenesis in early stage), and stimulation of apoptosis(90).
In short, Green tea, a potent anti-prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in various types of cancer.
8. Organic fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.
In Japan, the incidence of prostate cancer in aging men are low in compared to the West.
This result may be due to tradition Japanese diet in the exertion of prostate cancer protective effects
In fact, Traditional Japanese diet rich in soybean products and fish is associated with reduced prostate cancer risk(92).
In China, lower risk of prostate cancer is associated with consumption of soy foods and isoflavones found abundantly in fermented soybean products(93).
Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.
Conclusion
The prevalence and widespread of prostate cancer may be diet, demographic and lifestyle-related disease(94)(95)(96).
Eating healthy, with plenty of vegetables and fruits has always been considered a preventive approach. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. (PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. (PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH. (PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrate inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen-Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. (PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. (PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW. (PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL. (PubMed)
(95) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)
Wednesday, October 10, 2018
How to Determine the Severity of Allergic Reactions
Allergy is the overreaction of the immune system to harmless substances after entering our body affecting 1 in every 3 people.
Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
overproduction of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against a harmless substance with an aim to mediate the release of histamine and other mediators from mast cells and basophils, that lead to an allergic reaction, including mucus secretion, sneezing, itching, etc.
Food allergy is a result of overproduction of antibody Immunoglobulin E (IgE) of the immune system in responding to harmless ingredients in the foods such as peanut, shrimp, crayfish, lobster, walnuts, peanuts, soy, legume, etc., after eating.
Food allergy is severe food intolerance, in some cases, it may be fatal or hospitalized.
A. Food allergy can be classified into 2 types, depending on the length of the reaction of the immune system
1. Fixed food allergy
Fixed food allergy is defined as symptoms of allergy appeared immediately as soon as the allergic food is eaten.
2. Marked (Cyclic) allergies
This types of allergic symptoms may take longer to take effects, usually, hour or days after the allergic food is eaten. Coiled foods allergy affects 90% of the patient of all cases.
B. How to determine the severity of the allergic effects
Depending on the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
1. The severity scale from +1 to +4
+1. The first level of stimulation
If there are no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient has become irritable, hyperactive, tense, thirsty, etc. after suspected allergic food is eaten
+3. The third level of stimulation
The patient has become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient has become a mania, agitation, overexcitement, etc.
Other severity scales may also be used for all allergies, such as 1-6. 6 being the most severe. I think 0 is nonallergic.
2. Degeneration scale from -1 to -4
-1. If a patient is experiencing symptoms of the reaction of a runny nose, hive, diarrhea, etc.
-2. If a patient is experiencing symptoms of the reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experiencing symptoms of the reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experiencing symptoms of the reaction of severe depression, paranoia, etc.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
overproduction of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against a harmless substance with an aim to mediate the release of histamine and other mediators from mast cells and basophils, that lead to an allergic reaction, including mucus secretion, sneezing, itching, etc.
Food allergy is a result of overproduction of antibody Immunoglobulin E (IgE) of the immune system in responding to harmless ingredients in the foods such as peanut, shrimp, crayfish, lobster, walnuts, peanuts, soy, legume, etc., after eating.
Food allergy is severe food intolerance, in some cases, it may be fatal or hospitalized.
A. Food allergy can be classified into 2 types, depending on the length of the reaction of the immune system
1. Fixed food allergy
Fixed food allergy is defined as symptoms of allergy appeared immediately as soon as the allergic food is eaten.
2. Marked (Cyclic) allergies
This types of allergic symptoms may take longer to take effects, usually, hour or days after the allergic food is eaten. Coiled foods allergy affects 90% of the patient of all cases.
B. How to determine the severity of the allergic effects
Depending on the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
1. The severity scale from +1 to +4
+1. The first level of stimulation
If there are no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient has become irritable, hyperactive, tense, thirsty, etc. after suspected allergic food is eaten
+3. The third level of stimulation
The patient has become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient has become a mania, agitation, overexcitement, etc.
Other severity scales may also be used for all allergies, such as 1-6. 6 being the most severe. I think 0 is nonallergic.
2. Degeneration scale from -1 to -4
-1. If a patient is experiencing symptoms of the reaction of a runny nose, hive, diarrhea, etc.
-2. If a patient is experiencing symptoms of the reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experiencing symptoms of the reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experiencing symptoms of the reaction of severe depression, paranoia, etc.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) How Far Can We Control the Severity of Food Allergic Reaction by Controlling Exposure to Allergenic Foods? ILSI Europe Workshop, 16 September 2016, Brussels
(2) Allergy DiagnosisReference Guide
(1) How Far Can We Control the Severity of Food Allergic Reaction by Controlling Exposure to Allergenic Foods? ILSI Europe Workshop, 16 September 2016, Brussels
(2) Allergy DiagnosisReference Guide
Tuesday, October 9, 2018
Scientists Discover A Potent And Natural Alternative to Anti Depressants Without Inducing Any Side Effects
Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.
Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.
The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, in loss of interest in usually pleasurable activities.
And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, appetite,.... particularly, in a change of sleep pattern or difficult to sleep.
In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate to a lot of different factors that affect our mental health.
According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with no consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).
If you are experiencing some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.
If you are taking conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....
Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested
Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world.
In vivo, application of green tea(GT) and GABA green tea (GGT) expressed a protective activity of against post-stroke depression (PSD), a common consequence of stroke, according to the joint study lead by the Pavia University.
And, in a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......
Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to amount of intake.
Compared amount intake, participants consumed ≥4 cups green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those consumed less than 1 cup/d.
The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.
These results suggested that green tea consumption have a linear effect correlated to numbers of cup intake per day without mentioning the effects of maximum cups that patients can take.
Dr. Pham NM, the lead author in the study said, "higher consumption of green tea, coffee and caffeine may confer protection against depression".
Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.
Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.
However, oral administration of large amount daily should be taken with care, particularly, in people with yin constituent.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T 1.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M 1.(PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF. (PubMed)
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.
Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.
The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, in loss of interest in usually pleasurable activities.
And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, appetite,.... particularly, in a change of sleep pattern or difficult to sleep.
In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate to a lot of different factors that affect our mental health.
According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with no consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).
If you are experiencing some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.
If you are taking conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....
Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested
Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world.
In vivo, application of green tea(GT) and GABA green tea (GGT) expressed a protective activity of against post-stroke depression (PSD), a common consequence of stroke, according to the joint study lead by the Pavia University.
And, in a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......
Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to amount of intake.
Compared amount intake, participants consumed ≥4 cups green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those consumed less than 1 cup/d.
The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.
These results suggested that green tea consumption have a linear effect correlated to numbers of cup intake per day without mentioning the effects of maximum cups that patients can take.
Dr. Pham NM, the lead author in the study said, "higher consumption of green tea, coffee and caffeine may confer protection against depression".
Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.
Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.
However, oral administration of large amount daily should be taken with care, particularly, in people with yin constituent.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T 1.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M 1.(PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF. (PubMed)
Sunday, October 7, 2018
9 Fruits That Kill Breast Cancer Cells, Revealed By MEDLINE Studies
The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but to discover an effective prevention and treatment with little or no side effects has proven difficult.
According to statistic, the risk of getting invasive breast cancer during the lifetime of women is 1/8.
A healthy diet with plenty vegetables and fruits(1)(2)(3) with a change of lifestyle(4)(5)(6) may be the only choice for women in reducing the risk of the diseases.
1. Blueberry
Blueberry is a flowering plant, belongings to the family Eriaceae, native to Northern America.
Triple-negative breast cancer TNBC, cancer does not express the genes for estrogen receptor (ER), progesterone receptor(PR), and HER2(gene) affecting approximately 15% of all cancer cases.
Female MDA-MB-231 tumor-bearing mice fed with a high-fat diet with 5% whole blueberry powder (BB), inhibited TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways through the immune response in reduced tumor growth and metastasis(40).
In 17β-estradiol-mediated mammary tumorigenesis, 5% blueberry diet, decreased tumor volume and multiplicity significantly, by down-regulation of CYP 1A1(enzymes, able to activate compounds with carcinogenic properties) and ER-α (a receptor activated by the sex hormone estrogen)genes expression and also favorable modulation of microRNA (mir-18a and mir-34c) levels in gene regulation(41).
Other chemical constituents such as anthocyanin and anthocyanin-pyruvic acid adduct extract of blueberry restricted cancer cell proliferation by acting as cell anti invasive factors and chemoinhibitors(42).
2. Avocado
Avocados, the green-skinned, pear-shaped fruit that ripens after harvesting are a commercially valuable fruit cultivated in tropical climates throughout the world, native to the Caribbean, Mexico, South America, and Central America, belongings to the flowering plant family Lauraceous.
Avocado-produced toxin persin may contain a positive anti-breast cancer effect(43).
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Application of persin in animal model, selectively induced G2-M cell cycle arrest and cell death through the caspase-dependent pathway(44).
3. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Methanolic extract of strawberry (MESB) fruits induced cytotoxicity in cancer cells, irrespective of origin, in a concentration- and time-dependent manner, in the testing against leukaemia (CEM) and breast cancer (T47D) cell lines through induction of intrinsic pathway of apoptosis by activating p73 (a tumor suppressor) in breast cancer cells, when tumor suppressor gene p53 was mutated(46).
Polyphenols, a major chemical component found in strawberry, exhibited cytotoxic with doses of approximately 50 microg/ml, inducing 50% reduction in cell survival in both the normal and the tumor lines, including (MCF-7) breast cancer cell lines(47).
In another study, freeze-dried fruits of two strawberry cultivars ethanol extract strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell lines(48).
4. Pomegranate
Pomegranate is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
Pomegranate extracts and genistein exerted anti-cancer effect in inhibition of cell proliferation and induction of apoptosis in human breast cancer cells(MCF-7) in doses and time depending manner(49) by downregulated HR genes (a ubiquitous cellular pathway that mediates transfer of genetic information) and increased expression of microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (regulation of gene expression)(50).
Pomegranate fruit extracts (PFEs), on dose-dependent, inhibited NF-kB-dependent reporter gene responses associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression as these genes are associated with tumor cell invasion and metastasis(51).
6. Grapes
Resveratrol, a polyphenolic compound known as a good chemopreventive agent for inhibiting carcinogenesis processes that target the regulators of cell function and DNA replication, found abundantly in grapes, berries and peanuts are associated to reduced risk of breast cancer.
HS-1793, a synthetic version of the compound of resveratrol-induced G2/M(DNA damage checkpoint) arrest in the cell cycle progression through induction of p53(tumor suppressor gene)-dependent apoptosis in MCF-7 cells(52).
Catechin (RQC), a polyphenol, was effective in ameliorated mammary tumor growth and metastasis, by reduced Akt (multiple cellular process activity, induced the activation of AMPK(cellular energy)), and inhibited mTOR(mediate cellular responses) signaling in breast cancer cells(53).
In Her-2 breast cancer, fox grape seed extract increased the expression of Bax(an apoptosis promoter) and AIF(Apoptosis-inducing factor), and decreased total PARP(cellular processes) expression, leading to significant downregulation of Her-2 in MCF-7 cells(54).
7. Pineapple
Pineapple is a species of Ananas Comos, belongings to the family Bromeliaceae and native to southern Brazil and Paraguay, cultivated for commercial uses.
Pineapple rich of vitamins and mineral and digesting enzyme bromelin seems to help digestion after a high protein meal.
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Bromelain, a major chemical constituent exerted anti-metastasis against breast cancer by upregulating the function of c-Jun N-terminal kinase in cell proliferation, differentiation, survival and migration, and p38 kinase to cause programmed cell death(56).
In GI-101A breast cancer cells, bromelain induced cell death via activation of the apoptosis mechanism, in increased dose-dependent by promoting apoptosis and cytokine processing of caspase-9 and caspase-3 coinciding with the elevation of serum CK18 levels(56).
In the brMDA-MB-231 mammary carcinoma, oral administration of bromelain increased the reduced bMAK- and MAK-cell activity in cell cycle regulation from 7.8% to 54% (bMAK-cell activity) and from 16% to 47% (MAK-cell activity by stimulating the deficient monocytic cellular cytotoxicity of the mammary tumor(57).
8. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, originated in Central Asia.
In estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cell lines, apple phytochemical extracts significantly inhibited cell proliferation in a dose-dependent manner and cell cycle modulation(58).
In breast carcinoma, Mcf-7 and Mcf-7, Her18 cells, peels of apple were effective in antiproliferation accompanied by a G0-G1 phase arrest in cell cycle through activated tumor suppressor protein that suppressed the regulation of cell invasion, metastasis, and angiogenesis(59).
Study of apple extracts and quercetin 3-beta-d-glucoside combination also showed to possess the synergistic effect in MCF-7 cell proliferation(60).
9. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to Southeast Asia.
Polymethoxyflavones (PMFs), a chemical compound found in sweet orange (Citrus sinensis L.) peel, induced Ca(2+)-mediated apoptosis in human breast cancer cells through proapoptotic activity(61).
D-limonene, another compound in orange peel oil, in rodent studies, also exhibited chemotherapeutic activity against mammary cells, through the induction of tumor cell apoptosis, tumor redifferentiation, and/or suppression of key proteins of cell growth-regulating (62).
Taken Together, vegetables(7)(8) and fruits(9)(10) or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the breast cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(44) A novel plant toxin, persin, within vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL.(PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.(PubMed)
(46) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double-strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD.(PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC.(PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND.(PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF.(PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- of Vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.(PubMed)
(58) Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL.(PubMed)
Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but to discover an effective prevention and treatment with little or no side effects has proven difficult.
According to statistic, the risk of getting invasive breast cancer during the lifetime of women is 1/8.
A healthy diet with plenty vegetables and fruits(1)(2)(3) with a change of lifestyle(4)(5)(6) may be the only choice for women in reducing the risk of the diseases.
1. Blueberry
Blueberry is a flowering plant, belongings to the family Eriaceae, native to Northern America.
Triple-negative breast cancer TNBC, cancer does not express the genes for estrogen receptor (ER), progesterone receptor(PR), and HER2(gene) affecting approximately 15% of all cancer cases.
Female MDA-MB-231 tumor-bearing mice fed with a high-fat diet with 5% whole blueberry powder (BB), inhibited TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways through the immune response in reduced tumor growth and metastasis(40).
In 17β-estradiol-mediated mammary tumorigenesis, 5% blueberry diet, decreased tumor volume and multiplicity significantly, by down-regulation of CYP 1A1(enzymes, able to activate compounds with carcinogenic properties) and ER-α (a receptor activated by the sex hormone estrogen)genes expression and also favorable modulation of microRNA (mir-18a and mir-34c) levels in gene regulation(41).
Other chemical constituents such as anthocyanin and anthocyanin-pyruvic acid adduct extract of blueberry restricted cancer cell proliferation by acting as cell anti invasive factors and chemoinhibitors(42).
2. Avocado
Avocados, the green-skinned, pear-shaped fruit that ripens after harvesting are a commercially valuable fruit cultivated in tropical climates throughout the world, native to the Caribbean, Mexico, South America, and Central America, belongings to the flowering plant family Lauraceous.
Avocado-produced toxin persin may contain a positive anti-breast cancer effect(43).
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Application of persin in animal model, selectively induced G2-M cell cycle arrest and cell death through the caspase-dependent pathway(44).
3. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Methanolic extract of strawberry (MESB) fruits induced cytotoxicity in cancer cells, irrespective of origin, in a concentration- and time-dependent manner, in the testing against leukaemia (CEM) and breast cancer (T47D) cell lines through induction of intrinsic pathway of apoptosis by activating p73 (a tumor suppressor) in breast cancer cells, when tumor suppressor gene p53 was mutated(46).
Polyphenols, a major chemical component found in strawberry, exhibited cytotoxic with doses of approximately 50 microg/ml, inducing 50% reduction in cell survival in both the normal and the tumor lines, including (MCF-7) breast cancer cell lines(47).
In another study, freeze-dried fruits of two strawberry cultivars ethanol extract strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell lines(48).
4. Pomegranate
Pomegranate is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
Pomegranate extracts and genistein exerted anti-cancer effect in inhibition of cell proliferation and induction of apoptosis in human breast cancer cells(MCF-7) in doses and time depending manner(49) by downregulated HR genes (a ubiquitous cellular pathway that mediates transfer of genetic information) and increased expression of microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (regulation of gene expression)(50).
Pomegranate fruit extracts (PFEs), on dose-dependent, inhibited NF-kB-dependent reporter gene responses associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression as these genes are associated with tumor cell invasion and metastasis(51).
6. Grapes
Resveratrol, a polyphenolic compound known as a good chemopreventive agent for inhibiting carcinogenesis processes that target the regulators of cell function and DNA replication, found abundantly in grapes, berries and peanuts are associated to reduced risk of breast cancer.
HS-1793, a synthetic version of the compound of resveratrol-induced G2/M(DNA damage checkpoint) arrest in the cell cycle progression through induction of p53(tumor suppressor gene)-dependent apoptosis in MCF-7 cells(52).
Catechin (RQC), a polyphenol, was effective in ameliorated mammary tumor growth and metastasis, by reduced Akt (multiple cellular process activity, induced the activation of AMPK(cellular energy)), and inhibited mTOR(mediate cellular responses) signaling in breast cancer cells(53).
In Her-2 breast cancer, fox grape seed extract increased the expression of Bax(an apoptosis promoter) and AIF(Apoptosis-inducing factor), and decreased total PARP(cellular processes) expression, leading to significant downregulation of Her-2 in MCF-7 cells(54).
7. Pineapple
Pineapple is a species of Ananas Comos, belongings to the family Bromeliaceae and native to southern Brazil and Paraguay, cultivated for commercial uses.
Pineapple rich of vitamins and mineral and digesting enzyme bromelin seems to help digestion after a high protein meal.
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Bromelain, a major chemical constituent exerted anti-metastasis against breast cancer by upregulating the function of c-Jun N-terminal kinase in cell proliferation, differentiation, survival and migration, and p38 kinase to cause programmed cell death(56).
In GI-101A breast cancer cells, bromelain induced cell death via activation of the apoptosis mechanism, in increased dose-dependent by promoting apoptosis and cytokine processing of caspase-9 and caspase-3 coinciding with the elevation of serum CK18 levels(56).
In the brMDA-MB-231 mammary carcinoma, oral administration of bromelain increased the reduced bMAK- and MAK-cell activity in cell cycle regulation from 7.8% to 54% (bMAK-cell activity) and from 16% to 47% (MAK-cell activity by stimulating the deficient monocytic cellular cytotoxicity of the mammary tumor(57).
8. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, originated in Central Asia.
In estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cell lines, apple phytochemical extracts significantly inhibited cell proliferation in a dose-dependent manner and cell cycle modulation(58).
In breast carcinoma, Mcf-7 and Mcf-7, Her18 cells, peels of apple were effective in antiproliferation accompanied by a G0-G1 phase arrest in cell cycle through activated tumor suppressor protein that suppressed the regulation of cell invasion, metastasis, and angiogenesis(59).
Study of apple extracts and quercetin 3-beta-d-glucoside combination also showed to possess the synergistic effect in MCF-7 cell proliferation(60).
9. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to Southeast Asia.
Polymethoxyflavones (PMFs), a chemical compound found in sweet orange (Citrus sinensis L.) peel, induced Ca(2+)-mediated apoptosis in human breast cancer cells through proapoptotic activity(61).
D-limonene, another compound in orange peel oil, in rodent studies, also exhibited chemotherapeutic activity against mammary cells, through the induction of tumor cell apoptosis, tumor redifferentiation, and/or suppression of key proteins of cell growth-regulating (62).
Taken Together, vegetables(7)(8) and fruits(9)(10) or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the breast cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(44) A novel plant toxin, persin, within vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL.(PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.(PubMed)
(46) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double-strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD.(PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC.(PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND.(PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF.(PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- of Vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.(PubMed)
(58) Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL.(PubMed)
How to Prevent Over Expression of Melanin Inducing Age Spots Naturally
Green tea may have a therapeutic and positive effect in reducing age spots caused by overexpression of melanin, some scientists suggested.
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more of these subjects.
Age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by the hormones imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application of EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of a natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) are molecules with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, application of EGCG protected the expression of the decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in the formation of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1. (PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more of these subjects.
Age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by the hormones imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application of EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of a natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) are molecules with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, application of EGCG protected the expression of the decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in the formation of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1. (PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
Saturday, October 6, 2018
How to Protect Yourself From Allergies Naturally
Including a portion of fennel in your daily diet may improve the body anti-allergic activities, some scientists suggested.
The results of the differentiation were carried out by numbers of universities and published on online medical literature.
Allergic effect associated with nonharmful allergens caused by an overreaction of the immune system may induce symptoms of skin rash, sneezing,....
In some cases, an allergic reaction can be life-threatening (anaphylaxis), depending on the severity of immune responses.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to confirm the potential efficacy of fennel for antiallergic use, inhibitory actions of the fruiton 5-lipoxgenase (5-LOX) and β-hexosaminidase release, researchers found that application of fennel extract at ethanol 70% with IC50 of 3.2 μg/ml, exerts a potential effect in inhibited 5-LOX-catalyzed leukotriene production in mediation of allergy, and other immune responses.
β-hexosaminidase released from activated mast cells are responsible for the allergic inflammatory reactions associated with immune response.
5-Lipoxygenase (5-LOX), an enzyme plays important roles in infection and allergic responses.
Although many ingredients isolated from fennel fruit demonstrated an inhibitory effect in the reduced immune overreaction of the unharmful allergens, phenylpropanoid, trans-anethole, showed the considerable inhibitory action of 5-LOX in compared to others, particularly at IC50 of 51.6 μM of trans-anethole
However, the fennel bioactive compound trans-anethole displayed insignificant effect on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells in compared to other ingredients.
RBL-2H3 cell line is a commonly used histamine-releasing cell line in immunological research of. inflammatory and allergic activities.
These results suggested, depending on the stimulation of allergens, fennel demonstrated anti-allergic activity through expression of different constituents in both the plant (FR) and trans-anethole alone.
Dr. the lead author after taking into account of other co-founders, said, "FR and several major constituents are 5-LOX inhibitors and they may have the potential for treating 5-LOX-related disorders".
Additionally, according to the study of Yonsei University, oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract in tested animal model exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions, a delayed type hypersensitivity usually takes a few days to develop.
Further analysis suggested that application of fennel also reduced inflammatory factors activated by
the immune response in the induction of systemic inflammation against allergens in causing damage to the body through its antioxidants and stimulated productions of antioxidant enzymes from the host, such as superoxide dismutase (SOD) and catalase and the high-density lipoprotein-cholesterol level.in the prevention of lipid peroxidation in initiated by ROS.
Moreover, the application also reduced levels of malondialdehyde (MDA), which is an indication and maker of oxidative stress.
Interestingly, F. vulgare fruit methanolic extract expressed a strong effect in inhibition of nitric oxide (NO) produced by the innate immune system through activated macrophages in inhibited pathogens replication.
The above differentiation was supported by the literature of "Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology"
posted in the BioMed Research International.
According to the study, oral injection of the methanolic extract of F. vulgare fruit at200 mg/kg once a day for 7 days showed a significant inhibitory effect on DNFB- (2,4-dinitrofluorobenzene-) induced delayed type hypersensitivity through fennel immunosuppressive properties.
2,4-dinitrofluorobenzene (DNFB) may induce allergic contact dermatitis.
The information collected indicated that fennel, its bioactive compounds, and extracts may be considered as a functional food for reduced risk immune over the response to unharmful allergens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents by Lee JH1, Lee DU, Kim YS, Kim HP. (PubMed)
(2) Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare by Choi EM1, Hwang JK. (PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
The results of the differentiation were carried out by numbers of universities and published on online medical literature.
Allergic effect associated with nonharmful allergens caused by an overreaction of the immune system may induce symptoms of skin rash, sneezing,....
In some cases, an allergic reaction can be life-threatening (anaphylaxis), depending on the severity of immune responses.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to confirm the potential efficacy of fennel for antiallergic use, inhibitory actions of the fruiton 5-lipoxgenase (5-LOX) and β-hexosaminidase release, researchers found that application of fennel extract at ethanol 70% with IC50 of 3.2 μg/ml, exerts a potential effect in inhibited 5-LOX-catalyzed leukotriene production in mediation of allergy, and other immune responses.
β-hexosaminidase released from activated mast cells are responsible for the allergic inflammatory reactions associated with immune response.
5-Lipoxygenase (5-LOX), an enzyme plays important roles in infection and allergic responses.
Although many ingredients isolated from fennel fruit demonstrated an inhibitory effect in the reduced immune overreaction of the unharmful allergens, phenylpropanoid, trans-anethole, showed the considerable inhibitory action of 5-LOX in compared to others, particularly at IC50 of 51.6 μM of trans-anethole
However, the fennel bioactive compound trans-anethole displayed insignificant effect on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells in compared to other ingredients.
RBL-2H3 cell line is a commonly used histamine-releasing cell line in immunological research of. inflammatory and allergic activities.
These results suggested, depending on the stimulation of allergens, fennel demonstrated anti-allergic activity through expression of different constituents in both the plant (FR) and trans-anethole alone.
Dr. the lead author after taking into account of other co-founders, said, "FR and several major constituents are 5-LOX inhibitors and they may have the potential for treating 5-LOX-related disorders".
Additionally, according to the study of Yonsei University, oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract in tested animal model exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions, a delayed type hypersensitivity usually takes a few days to develop.
Further analysis suggested that application of fennel also reduced inflammatory factors activated by
the immune response in the induction of systemic inflammation against allergens in causing damage to the body through its antioxidants and stimulated productions of antioxidant enzymes from the host, such as superoxide dismutase (SOD) and catalase and the high-density lipoprotein-cholesterol level.in the prevention of lipid peroxidation in initiated by ROS.
Moreover, the application also reduced levels of malondialdehyde (MDA), which is an indication and maker of oxidative stress.
Interestingly, F. vulgare fruit methanolic extract expressed a strong effect in inhibition of nitric oxide (NO) produced by the innate immune system through activated macrophages in inhibited pathogens replication.
The above differentiation was supported by the literature of "Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology"
posted in the BioMed Research International.
According to the study, oral injection of the methanolic extract of F. vulgare fruit at200 mg/kg once a day for 7 days showed a significant inhibitory effect on DNFB- (2,4-dinitrofluorobenzene-) induced delayed type hypersensitivity through fennel immunosuppressive properties.
2,4-dinitrofluorobenzene (DNFB) may induce allergic contact dermatitis.
The information collected indicated that fennel, its bioactive compounds, and extracts may be considered as a functional food for reduced risk immune over the response to unharmful allergens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents by Lee JH1, Lee DU, Kim YS, Kim HP. (PubMed)
(2) Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare by Choi EM1, Hwang JK. (PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
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