Monday, October 15, 2018

Detoxification: How To Detox And Nourish Your Liver For Optimal Health, Citation Provided By PubMed


The western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, addictive substances, and less in fruits and vegetables.

These types of harmful substances are toxic and induced a shift in microbiota composition in enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation(10).

Some researchers suggested that the escalating consumption of fat and sugar in Western countries are associated parallelly in an increased incidence of cardiovascular disease during the latter 20th century(10).
Also, according to the report in The American Journal of Pathology and studied mice module, Western diet altered the bile acid profile and elevated liver inflammation(12) as well as promoted other Western-pattern diet-related diseases, including nonalcoholic fatty liver disease, metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis(11).

Our body's detoxified functions try to get rid of them every day. When they fail, the toxins can cause a disruption of hormone production, damage to our body's detoxification organs and the immune system, leading to hormone imbalance and the development of chronic ailments.

The Natural Remedies Detox And Nourish Your Liver include
1. Milk thistle

Milk thistle, a flowering plant of the daisy family have been traditionally claimed in treating chronic liver disease.

The herbal medicine contains silymarin with impressive functions in protected liver function and expelled liver toxins.

In a study to compared Cirsium japonicum DC's flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effects similar to those of Cirsium japonicum DC's flavonoids against toxins caused by injection of carbon tetrachloride (CCl4)(1)

Dr. Ma Q, the lead scientist said, "The results indicated that the pretreatment with C. japonicum flavonoids could significantly reverse CCl4-induced L02 cell viability decrease similarly to silymarin".

Silymarin is a mixture of flavonoids from Silybum marianum(milk thistle), a traditional European food plant with clear hepatoprotective effects.

2. Licorice
Licorice is a legume plant and native southern Europe and parts of Asia.

The herbal medicine contains a bioactive compound glycyrrhizin, which demonstrated a significant liver protective effect against liver toxins through suppression of hepatic stellate cell inactivation of liver fibrosis in some studies(3).

According to the seven-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) against acetaminophen-induced liver damage observed by activity of alanine transaminase and aspartate aminotransferase, application of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines in induction of liver damage and toxicity(2).

Further differentiation of this metabolomic assay, suggested that glycyrrhizin exert a significant protective effect against acetaminophen-induced liver damage induced by toxic acetaminophen through reversing fatty acid metabolism(2).

3. Tabebuia heptaphylla
Tabebuia heptaphylla is the botanical name of Pau d'Arco
The herbal plant contains alkaloids, flavonoids, sulfur, and essential oils which have a strong effect in enhanced helping to support the immune activity(4).

The herb displayed a strong hepaprotective effect against liver damage and toxicity, probably due to major bioactive compound flavonoids(4).

4. Stilingia root

Stilinga root not only strengthens the immune cells but also prevent and treating food allergies and eczema by stimulating the removal of toxins accumulation in the liver caused by long-term eating of preservatives, canned foods, fast foods, and excessive alcohol drinking.

According to the Scovill's compound syrup of sarsaparilla and stillingia, or, Blood and liver syrup for the cure of scrofula and all diseases of the blood and liver by A.L. Scovill & Co, stillingia root processes a strong hepaprotective effect against liver disease and liver toxins.

5. Prickly ash

Prickly ash is also known as toothache tree. It has been used traditionally as a digestive aid and to strengthen the nervous system. Prickly ash is considered as a tonic and stimulant herb for the liver and gallbladder.

As a holistic cleanser, Prickly ash eliminates toxins, including liver toxicity(5).


6. St. John Wort

St. John wort is also known as Tipton weed or Klamath weed.

The herb has been used popularly for its effect in ameliorated depression.

Major bioactive flavonoids and 3-O-coumaroylquinic acid process anti-inflammation and antioxidant effects in stimulating the immune system in fighting allergies and in protected liver against toxins(6).
.
Dr. Aydin A and colleagues in the study of the effects of St. John wort on hepatic ischemia suggested that application of H. perforatum on rat model exerts a strong liver protection against hepatic ischemia locally and systemically(6),

Its chromone glycosides also showed moderate hepatoprotective activity with EC(50) values of 160.2 microM and 217.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells(7).




7. Fennel
Fennel contains anethole, polymers and essential oil with function in improved liver and pancreas in the metabolism of fats and sugars.

The herbal medicine also has a strong effect in dissolved fat deposits of the body and restored damaged liver cells that cause jaundice, hepatitis and other liver disorders(8)(9).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)
(2) Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism by Yu J, Jiang YS, Jiang Y, Peng YF, Sun Z, Dai XN, Cao QT, Sun YM, Han JC, Gao YJ(PubMed)
(3) Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis by Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza,Carlos Rodríguez-Montalvo, and Delia Elva Cruz-Vega(PMC)
(4) Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids by Chin-Lin Hsu*†, Gow-Chin Yen‡§1, in The Enzymes, 2014(Science Direct)
(5) Facts and benefits of Prickly Ash(Health Benefits Times)
(6) The effects of Hypericum perforatum on hepatic ischemia-reperfusion injury in rats by Aydin A, Sakrak O, Yilmaz TU, Kerem M(PubMed)
(7) Chromone glycosides and hepatoprotective constituents of Hypericum erectum by An RB1, Jeong GS, Beom JS, Sohn DH, Kim YC(PubMed)
(8) Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice by Warnet JM1, Christen MO, Thevenin M, Biard D, Jacqueson A, Claude JR(PubMed)
(9) Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice by Cho HI1, Kim KM, Kwak JH, Lee SK, Lee SM(PubMed)
(10)Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation by Agus A1, Denizot J1, Thévenot J1,2, Martinez-Medina M1, Massier S1, Sauvanet P1,3, Bernalier-Donadille A4, Denis S2, Hofman P5, Bonnet R1,6, Billard E1,7, Barnich N(PubMed)
(11) Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis by Schierwagen R1, Maybüchen L1, Zimmer S2, Hittatiya K3, Bäck C4, Klein S1, Uschner FE1, Reul W1, Boor P5, Nickenig G2, Strassburg CP1, Trautwein C4, Plat J6, Lütjohann D7, Sauerbruch T1, Tacke F4, Trebicka J(PubMed)
(12) Western Diet Consumption May Increase Risk of Chronic Liver Inflammation in Men by All India | NDTV Food Desk | Updated: July 12, 2017, 16:05 IST(NDTV)

Sunday, October 14, 2018

Infectious Diseases: The Herbs That Suppress Over Growth of Candida, Scientists Say

Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.


Herbalism or phytotherapy is a traditional medicine used botany and plants for treatment of a variety of ailments. Today, it has become increasingly important for many scientists who intend to find the natural agents with the same effectiveness as conventional medicine without inducing serious side effects.

However, the finding of this whole food medication has been facing many obstacles including limited financial support, because, the discovery of such plants will provide no commercial benefit and patent right to producers.

According to Dr. Marjorie Murphy Cowan in the study of "Plant Products as Antimicrobial Agents" said, "While 25 to 50% of current pharmaceuticals are derived from plants, none are used as antimicrobials. Traditional healers have long used plants to prevent or cure infectious conditions" and " Plants are rich in a wide variety of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids, which have been found in vitro to have antimicrobial properties"(a).

Western medicine is trying to duplicate herbal successes with the synthetic version for the patent right without using the whole herb ingredients which have caused overexpression of serious adverse effects.

ROS species have duo functions that are well documented for playing an important role in our body as both beneficial and deleterious molecules in the expression of cytotoxicity against abnormal cells alternation and initiation of chronic ailments such as overgrowth of candida by causing an imbalance of the ratio among antioxidants and free radicals, respectively.

In free radical overexpression initiated overgrowth candida, certain herb-derived compounds exerted a strong antioxidant effect that targets Candida and restores health and balance.

According to the Jamia Millia Islamia, diallyl disulfide (DADS), an important organosulphur compound found in garlic inhibited the overgrowth of candida through decreasing activity of all antioxidant enzymes except catalase in Candida species antioxidant system.

These result suggested that application of diallyl disulfide (DADS) caused an increase of oxidative stress and damage to the fungal cells(b).


The Anti Over Growth of Candida Herbal Medicine
1. Berberis

Berberis is a genus of about 450-500 species of deciduous and evergreen shrubs from 1-5 m tall with thorny shoots, belongings to the family Berberidaceae, native to the temperate and subtropical regions of Europe, Asia, Africa, North America, and South America. Europe has a few species, and North America only two. The stem, root bark, and fruit of barberry containing alkaloids and berberine have been used in traditional medicine or dietary supplement, to treat fungal infections(270), Candida albicans(270), yeast(271), parasites, and bacterial/viral infections(270).

Berberine may also enhance the immune system through its antioxidant activity(272) by preventing candida yeasts from producing lipase(273)(274), an enzyme used to help them in colonization(274) and induced infection(274).

2. Clover(Trifolium)
Clover used as a spice in cuisines all over the world, is the aromatic dried flower buds of a tree in the Syzygium, belongings to the family Myrtaceae, native to Indonesia. Tellimagrandin II, in clover oil, exhibited significantly anti-herpesvirus(275) and anti-oxidant(275)(276) properties and antiseptic property through phytochemical eugenol(277) used in dentistry to relieve pain(277), prevent a bacterial infection(278) and boost the immune system(279).

3. Goldenseal((Hydrastis Canadensis)
Goldenseal is a perennial herb in the species of Hydrastis Canadensis, belongings to the family Ranunculaceae, native to southeastern Canada and the northeastern United States, used widely in traditional medicine to treat functional disorders of gastrointestinal(280), including atonic dyspepsia, chronic constipation, liver toxicity(281), etc.

Berberine, a compound found in goldenseal has demonstrated significant anti-fungal activity(282)(283)(284) by preventing candida yeasts from producing lipase, an enzyme involved in colonization.

4. Oregano(Origanum vulgare) Oil
Oregano is a common species of Origanum, belongings to the family Lamiaceae, native to warm-temperate western and southwestern Eurasia and the Mediterranean region.

Carvacrol, a monoterpenoid phenol phytochemical found in oregano oil inhibited the growth of several bacteria strains(285), including candida albicans due to its antimicrobial properties that disrupt the bacteria membrane(286).

5. Cinnamon
Cinnamon is a spice obtained from the inner bark of trees from the genus Cinnamomum, belongings to the family Lauraceae, used in traditional medicine to treat digestive system disorder(287)(289), insulin sensitive(288)(290) and enhance the immune system in regulated cells growth due to its antioxidant activity(290).

The cinnamon essential oil has antimicrobial properties(291)(292), which can prevent, limit or destroy the fungal overgrowth(293).

6. Allspice
Allspice also called Jamaica pepper is a spice of dried unripe fruit of Pimenta dioica, belongings to the family Myrtaceae, native to southern Mexico and Central America. The herb has been used in folk medicine in relieving indigestion and gas(294) and as a deodorant.

Phenylpropene found in allspice volatile oils has shown to exhibit an antimicrobial property(295), including Candida albicans(296)

7. Lavender(Lavandula angustifolia)
The lavender is a genus Lavandula of flowering plants in the mint family Lamiaceae, originated in Asia, used in herbal medicine to treat the microbial infection(297) for the skin and reduce inflammation(298)(299).

Its essential oil components linalool and linalyl acetate showed both fungistatic and fungicidal activity(300)(301) against C. albicans strains in reducing fungal progression and the spread of infection in host tissue(301).

8. Chamomile
Chamomile is a common name for several daisy-like plants, genus Matricaria belongings to the family Asteraceae, native to Europe and western Asia used in traditional medicine to aid sleep(302), treat diarrhea(303) and reduce oxidative stress(304). Chamomile containing the high amount of flavonoids is best known for its antioxidant(303), such as antiseptic and antibiotic properties against virus bacteria invasion(305)(306(307)) including candida ablicans(308).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(a) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)
(b) Effect of diallyldisulphide on an antioxidant enzyme system in Candida species by Yousuf S1, Ahmad A, Khan A, Manzoor N, Khan LA(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)
(270) Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla by Freile ML1, Giannini F, Pucci G, Sturniolo A, Rodero L, Pucci O, Balzareti V, Enriz RD.(PubMed)
(271) Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. Musumeci R1, Speciale A, Costanzo R, Annino A, Ragusa S, Rapisarda A, Pappalardo MS, Iauk L.(PubMed)
(272) In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects. Abd El-Wahab AE, Ghareeb DA1, Sarhan EE, Abu-Serie MM, El Demellawy MA.(PubMed)
(273) Inhibition of biofilm formation and lipase in Candida albicans by culture filtrate of Staphylococcus epidermidis in vitro. Bhattacharyya S1, Gupta P2, Banerjee G2, Jain A2, Singh M2.(PubMed)
(274) Differential Candida albicans lipase gene expression during alimentary tract colonization and infection. Schofield DA1, Westwater C, Warner T, Balish E.(PubMed)
(275) Medicinal Plants in Australia Volume 4: An Antipodean Apothecary
(276) Ellagitannin(Wikipedia)
(2377) Oil of clover(Wikipedia)
(278) Anti-virulence potential of eugenyl acetate against pathogenic bacteria of medical importance by Musthafa KS1, Voravuthikunchai SP.(PubMed)
(279) Immunomodulatory activity of geranial, geranial acetate, gingerol, and eugenol essential oils: evidence for humoral and cell-mediated responses. Farhath S1, Vijaya P1, Vimal M2.(PubMed)
(280) Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni by Cwikla C1, Schmidt K, Matthias A, Bone KM, Lehmann R, Tiralongo E.(PubMed)
(281) Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in ratsby Yamaura K1, Shimada M, Nakayama N, Ueno K.(PubMed)
(282) In vitro antifungal activity of the berberine and its synergism with fluconazole by Iwazaki RS1, Endo EH, Ueda-Nakamura T, Nakamura CV, Garcia LB, Filho BP.(PubMed)
(283) Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents by Park KD1, Lee JH, Kim SH, Kang TH, Moon JS, Kim SU.(PubMed)
(284) Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans by Dhamgaye S1, Devaux F2, Vandeputte P3, Khandelwal NK4, Sanglard D3, Mukhopadhyay G5, Prasad R4.(PubMed)
(285) Effect of two monoterpene phenols on antioxidant defense system in Candida albicans by Khan A1, Ahmad A2, Ahmad Khan L3, Padoa CJ4, van Vuuren S5, Manzoor N6.(PubMed)
(286) Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candidaby Ahmad A1, Khan A, Akhtar F, Yousuf S, Xess I, Khan LA, Manzoor N.(PubMed)
(287) Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage by Ozbayer C1, Kurt H, Ozdemir Z, Tuncel T, Moheb Saadat S, Burukoglu D, Senturk H, Degirmenci I, Gunes HV.(PubMed)
(288) Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients by Askari F1, Rashidkhani B2, Hekmatdoost A3.(PubMed)
(289) Regular ingestion of cinnamon cortex pulveratus offers gastroprotective activity in mice by Tankam JM1, Sawada Y, Ito M.(PubMed)
(290) An overview on chemical composition, bioactivity, and processing of leaves of Cinnamomum tamala by Sharma V1, Rao LJ.(PubMed)
(291) Antimicrobial activities of commercial essential oils and their components against food-borne pathogens and food spoilage bacteria by Mith H1, Duré R2, Delcenserie V2, Zhiri A3, Daube G2, Clinquart A2.(PubMed)
(292) The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants by Miller AB1, Cates RG, Lawrence M, Soria JA, Espinoza LV, Martinez JV, Arbizú DA.(PubMed)
(293) Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis by Pires RH1, Montanari LB, Martins CH, Zaia JE, Almeida AM, Matsumoto MT, Mendes-Giannini MJ.(PubMed)
(294) Properties and Uses for Herbs and Spices
(295) Fumigant activity of (E)-anethole identified in Illicium verum fruit against Blattella germanica by Chang KS1, Ahn YJ.(PubMed)
(296) Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens by Botelho MA1, Nogueira NA, Bastos GM, Fonseca SG, Lemos TL, Matos FJ, Montenegro D, Heukelbach J, Rao VS, Brito GA.(PubMed)
(297) Hydrolates from lavender (Lavandula angustifolia) - their chemical composition as well as aromatic, antimicrobial and antioxidant properties by Prusinowska R1, Śmigielski K, Stobiecka A, Kunicka-Styczyńska A.(PubMed)
(298) Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania by Spiridon I1, Colceru S, Anghel N, Teaca CA, Bodirlau R, Armatu A.(PubMed)
(299) Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma by Ueno-Iio T1, Shibakura M2, Yokota K1, Aoe M1, Hyoda T1, Shinohata R1, Kanehiro A3, Tanimoto M3, Kataoka M1.(PubMed)
(300) Lavandula luisieri essential oil as a source of antifungal drugs by Zuzarte M1, Gonçalves MJ, Cruz MT, Cavaleiro C, Canhoto J, Vaz S, Pinto E, Salgueiro L.(PubMed)(301) Antifungal activity of phenolic-rich Lavandula multifida L. essential oil by Zuzarte M1, Vale-Silva L, Gonçalves MJ, Cavaleiro C, Vaz S, Canhoto J, Pinto E, Salgueiro L.(PubMed)
(302) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
(303) Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats by Sebai H1, Jabri MA2, Souli A3, Rtibi K3, Selmi S3, Tebourbi O4, El-Benna J5, Sakly M4.
(PubMed)
(304) Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress by Bhaskaran N1, Shukla S, Kanwal R, Srivastava JK, Gupta S.(PubMed)
(305) Study of antimicrobial activity of chamomile oil by Aggag ME, Yousef RT.(PubMed)
(306) Phenolic acids profile, antioxidant and antibacterial activity of chamomile, common yarrow and immortelle (Asteraceae)by Mekinić IG, Skroza D, Ljubenkov I, Krstulović L, Možina SS, Katalinić V.(PubMed)
(307) A novel colorimetric broth microdilution method to determine the minimum inhibitory concentration (MIC) of antibiotics and essential oils against Helicobacter pylori by Weseler A1, Geiss HK, Saller R, Reichling J.(PubMed)
(308) All-natural composite wound dressing films of essential oilsencapsulated in sodium alginate with antimicrobial properties by Liakos I1, Rizzello L2, Scurr DJ3, Pompa PP2, Bayer IS4, Athanassiou A5.(PubMed)

Saturday, October 13, 2018

The Best Detoxification Diet, Scientists Suggest

American diet contains high saturated, trans fat, and other harmful substances such as sugar, caffeine, pesticides, addictive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Some researchers suggested that diet and exposure to environmental toxins can damage the function of the mitochondria in cells in converting food to energy, affecting the organs function in protection of the body in all aspects.

The damage to mitochondria can increase overexpression of free-radicals in the induction of cytotoxicity to cells and tissue through a negative chain reaction

Foods that can detoxify our body against cytotoxicity include
1. Spinach
Spinach contains
* High levels of vitamin A, E, C, the free radical scavengers with function in reduced oxidative stress by improving production of antioxidant enzymes(1)(2).

* Numbers of trace minerals act as an antioxidant in inhibited ROS species such as iron, potassium, magnesium, zinc, and calcium(2). The presences of trace minerals in equate amount are vital for a healthy heart.

* Antioxidants, such as lutein and beta-carotene(3) strengthen our immune system and fight against the forming of free radicals.

People with kidney disease should not eat spinach, because it is rich with oxalates.

Without drinking a lot of water or juice, intake of the veggie will increase the risk of kidney stones formation.

2. Broccoli
Broccoli is high in vitamin C(1), an antioxidant that has a property in reduced the risk of inflammation and prevented forming of free radicals caused by toxins in our body.


The study shows that some of the chemicals such as indole 3, selenium and diindolymethane have anti-cancer properties and help to prevent and repair DNA damaging cells(4)(9).

3. Garlic
Garlic is a supernatural food. Besides having a proven record in preventing heart diseases, lower cholesterol level, elevated blood pressure(5), it also contains high amounts of allicin, an antibody that helps to reduce inflammation and fight off degeneration caused by virus, bacteria, strengthening our immune system(6) and forming of free radicals(7).

The sulfur element helps to rejuvenate our body by increasing the function of the liver in removing toxins(7).

4. Blackberry

Besides having a large amount of vitamin C and E(1) blackberry also contains anthocyanins and ellagic acid that work together in preventing inflammation, improving mental performance as well as strengthening the immune system(8). Its antioxidant function also removes the accumulation of heavy metal toxins in our body(9).

5. Mellon
Mellon contains high amounts of antioxidant enzyme(9), minerals(2) and the powerful antioxidant chlorophyll(9), which is rich in antioxidants, vital minerals such as magnesium, iron, potassium, calcium, and essential fatty acids(2) with functions in removed heavy metals accumulated in the brain and toxins in our kidney(10)

6. Green tea
Green tea balances the PH level(11) in the blood, it also contains polyphenolic catechins, a powerful antioxidant that strengthens the immune system(9), fights against free radicals building up and detoxes our body through urinary secretion(9)(12).

7. Cooked Tomato
Tomatoes contain high amounts of alpha and beta-carotene that help to strengthen the body's immune system fight off inflammation from bacteria and virus causing many types of chronic diseases(3).


The vegetable also contains lycopene(13), a powerful antioxidant that prevents the forming of free radicals caused by the accumulation of toxic substances in the body when working together with lutein(3). Be sure that the veggie is well cooked(14).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats by Michael J. Ryan,1 Holly J. Dudash,1 Megan Docherty,1 Kenneth B. Geronilla,1,2 Brent A. Baker,2G. Gregory Haff,1 Robert G. Cutlip,2 and Stephen E. Alway(PubMed)
(2) Vitamins and minerals functioning as antioxidants with supplementation considerations Lee R. McDowell1 , Nancy Wilkinson, Rachel Madison and Tara Felix Department of Animal Sciences University of Florida
(3) Potential Role of Carotenoids as Antioxidants in Human Health and Disease by Joanna Fiedor* and Květoslava Burda(PubMed)
(4) Nutritional Epigenetic Regulators in the Field of Cancer by Michael Schnekenburger1, Marc Diederich2, in Epigenetic Cancer Therapy, 2015
(5) Garlic and Cardiovascular Disease: A Critical Review Khalid Rahman Gordon M. Lowe, The Journal of Nutrition, Volume 136, Issue 3, 1 March 2006, Pages 736S–740S,https://doi.org/10.1093/jn/136.3.736S
(6) The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention by Georgia Schäfer1 and Catherine H. Kaschula(PubMed)
(7) The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins by Rabinkov A1, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L(PubMed)
(8) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days by Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X(PubMed)
(9) Free radicals, antioxidants, and functional foods: Impact on human health by. Lobo, A. Patil, A. Phatak, and N. Chandra(PubMed)
(10) Toxicity, mechanism and health effects of some heavy metals by Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, Blessy B. Mathew, and Krishnamurthy N. Beeregowda(PubMed)
(11) Evaluation of the pH and titratable acidity of teas commercially available in Brazilian market ORIGINAL | ORIGINAL Avaliação do pH e titrabilidade ácida de chás comercialmente disponíveis no mercado brasileiro
(12) 5 Kidney Cleansing Drinksby Dr. Group by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
(13) Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview by Jalil Pirayesh Islamian, Ph.D.* and Habib Mehrali, M.Sc(PubMed)
(14) Cooking Tomatoes Boosts Disease-Fighting Power, Date: April 23, 2002 (by Cornell University)

Friday, October 12, 2018

Dried Bean The Legume That Protects Cell Integrity And DNA Transcription Against Most Types Of Cancer Onset, Medline Studies Revealed

Adding a portion of dried beans into your diet may have a potential effect in reduced risk of cancers onset, according to the Division of Cancer Prevention, National Cancer Institute.

Dried beans are the nutritionally mighty member of the legume family, belonging to the family Fabaceae.

The healthy sources of dried legume, including protein, fibers, vitamins and minerals such as dietary fiber, fat, protein, vitamin A ( beta-carotene, lutein and zeaxanthin), B vitamins, vitamin C, calcium, iron, magnesium, phosphorus, potassium, ... and zinc can be included in any one diet,

Certain genetic mutations may have significant influences in the risk of cancers, such as BRCA1 and BRCA2 genes which can elevate the risk of breast and ovarian cancers.

According to statistic, women who carry mutated gene BRCA1 and 2 have a 50 to 85 percent increased risk of developing the disease by age of 70.

Other causes of cancer are unknown, however, researchers suggested that smoking and use of tobacco, unhealthy diet, family history, inactive physical activity, long-term exposure to sun and other types of radiation, infected viruses, and infectious diseases are some of the potential risk factors that may have a strong impact on the development of cancers.

Cancer is a class of diseases characterized by cell growth uncontrollably and disorderly, affecting all the organs and tissue.

Depending on its invasive nature, some cancers can travel a distance away from the original site to infect other parts of the body.

In the study to investigate 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders and during 2,193,751 person-years of follow-up from 1995/1996-2000, researchers found that
*. Intake of vegetables shows a significant effect in reduced risk of certain types of cancer.

* The relative hazard ratio risk of cancers was reduced to .95 in compared to control

*. Risk of cancers is reduced substantially as shown in the highest tertile of Leguminosae group (dried beans, string beans, and peas, 0.80, 0.67-0.96) compared to other groups.

Dried bean and string bean with abundant fiber scored the lower and lowerest relative risk ratio in compared to peas and other kinds of vegetables.

Further analysis of diets of African-American men and women, undergoing colonoscopies in order to examine the relationship between selected dietary factors and the risk for colon polyps, according to the multiple logistic regression model used to adjust for potential confounding variables and to determine which factors influence colorectal adenoma risk, researchers said, " consumption of legumes such as dried beans, split peas, or lentils was negatively associated with risk (of cancers)" and "Legumes are a good source of dietary fiber and of phytochemical compounds that may play a role in reducing adenoma formation or growth".

Once again, dried beans exerted the highest effect in reduced risk of colorectal adenoma in compared to other types of legume.

Interestingly, in broader scope of further exploration of the association between legume intake and cancer risk in a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls, researchers suggested, intake of legume including dried peas demonstrate a substantially decreased risk of stomach and prostate cancer and other forms of cancer, including
*. Cavity and pharynx cancer had a relative odd risk ratio of OR=0.48

*. Esophagus cancer with OR = 0.54

*. Larynx cancer with OR = 0.55

*. Upper aerodigestive tract cancer with OR = 0.50

*. Stomach cancer with OR = 0.69

*. Colorectum cancer with OR = 0.43

*. Kidney cancer relative had an odd risk ratio of.OR = 0.41

* With relative odd risk ratio of .68 on all sites combined


After adjusting to other risk factors researchers concluded, "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder".

These results suggested that the protective effect of dried beans in inhibited most types of cancer occurrence may be a result of improvement of host cells integrity against alternation of cells DNA transcription in the induction of cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Legume intake and the risk of cancer: a multisite case-control study in Uruguay by Aune D1, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M.(PubMed)
(2) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL. (PubMed)
(3) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study by Freedman ND1, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC.(PubMed)

Thursday, October 11, 2018

8 Foods That Kill Prostate Cancer Cells, Scientists Say

The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with the tendency to affect even younger age population.

Evidence in the Far East recent diet suggested, over consuming bad fats in any time in history accompanied with unhealthy diet and lifestyle may be the possible causes of the disease, linking to the economic prosperity over last 3 decades.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue.

At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Most prostate cancers are slow growing. And Enlarged prostate and prostate cancer in most cases are detected during physical (rectum) exams.

Some researchers suggested that certain abnormal expression of hormones may have a strong effect in increased risk of prostate cancer, including high levels of hormone androgen and insulin-like growth factor-1 (IGF-1).

In other words, patients with prostate cancer are linearly associated with high levels of hormonal testosterone and insulin-like growth factor-1 (IGF-1).

Although genetic mutation may have a direct effect in induced prostate cancer incidence, such as BRCA1, BRCA2, MSH2 and MLH1, the direct causes of prostate cancer are still debatable.

However, there are some risk factors that have significant impacts to induce early onset of the disease.

The list includes age, family history, race, low levels of vitamin D in the blood, excessive alcohol drinking, obesity,..... and enlarged prostate.

Foods That Kill Prostate Cancer Cells include
1. Flaxseed

Flaxseed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed.

Flax is an erect annual plant that can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.

Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76). And, a diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).

2. Vegetable oil
Vegetable oil is a triglyceride extracted from vegetables.

Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79).

Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model. And, 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).

3. Honey

The rich golden liquid is the miraculous product made by bees using nectar from flowers. The liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manners(81).


4. Chickpea

Garbanzo beans also known as chickpea is an edible legume of genus Cicer, belongings to the family Fabaceae, with high sources of protein and mineral, native to the Middle East.

7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).

5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumors xenografted in athymic mice(83).

And polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ-specific cancers, through disruption of the overall process of carcinogenesis by inhibition of DNA synthesis and ROS production, regulation of cell cycle arrest and modulation of survival/proliferation pathways(84).

Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways, depending on their concentration, the cell system, the type or stage of the pathological process(85).

6. Black pepper
Black pepper is a flowering vine in the family Piperaceae, used as a spice and seasoning.

Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose-dependent manner.

And, In caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).

7. Green tea
Green tea containing more amount of antioxidants than any drinks or foods with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of preprostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).

In green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti-PCa (89) effect by modulation of signaling pathways.

Also, a combination of quercetin and green tea showed a significant increase in inhibition of proliferation, androgen receptor, and phosphatidylinositol 3-kinase/Akt signaling(tumorgenesis in early stage), and stimulation of apoptosis(90).

In short, Green tea, a potent anti-prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in various types of cancer.

8. Organic fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.

In Japan, the incidence of prostate cancer in aging men are low in compared to the West.

This result may be due to tradition Japanese diet in the exertion of prostate cancer protective effects

In fact, Traditional Japanese diet rich in soybean products and fish is associated with reduced prostate cancer risk(92).

In China, lower risk of prostate cancer is associated with consumption of soy foods and isoflavones found abundantly in fermented soybean products(93).

Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.

Conclusion
The prevalence and widespread of prostate cancer may be diet, demographic and lifestyle-related disease(94)(95)(96).

Eating healthy, with plenty of vegetables and fruits has always been considered a preventive approach. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. (PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. (PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH. (PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrate inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen-Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. (PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. (PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW. (PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL. (PubMed)
(95) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

Wednesday, October 10, 2018

How to Determine the Severity of Allergic Reactions

Allergy is the overreaction of the immune system to harmless substances after entering our body affecting 1 in every 3 people.

Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
overproduction of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against a harmless substance with an aim to mediate the release of histamine and other mediators from mast cells and basophils, that lead to an allergic reaction, including mucus secretion, sneezing, itching, etc.

Food allergy is a result of overproduction of antibody Immunoglobulin E (IgE) of the immune system in responding to harmless ingredients in the foods such as peanut, shrimp, crayfish, lobster, walnuts, peanuts, soy, legume, etc., after eating.

Food allergy is severe food intolerance, in some cases, it may be fatal or hospitalized.

A. Food allergy can be classified into 2 types, depending on the length of the reaction of the immune system
1. Fixed food allergy
Fixed food allergy is defined as symptoms of allergy appeared immediately as soon as the allergic food is eaten.

2.  Marked (Cyclic) allergies
This types of allergic symptoms may take longer to take effects, usually, hour or days after the allergic food is eaten. Coiled foods allergy affects 90% of the patient of all cases.

B. How to determine the severity of the allergic effects
Depending on the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
1. The severity scale from +1 to +4
+1. The first level of stimulation
If there are no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient has become irritable, hyperactive, tense, thirsty, etc. after suspected allergic food is eaten
+3. The third level of stimulation
The patient has become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient has become a mania, agitation, overexcitement, etc.

Other severity scales may also be used for all allergies, such as  1-6. 6 being the most severe. I think 0 is nonallergic.

2. Degeneration scale from -1 to -4
-1. If a patient is experiencing symptoms of the reaction of a runny nose, hive, diarrhea, etc.
-2. If a patient is experiencing symptoms of the reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experiencing symptoms of the reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experiencing symptoms of the reaction of severe depression, paranoia, etc.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) How Far Can We Control the Severity of Food Allergic Reaction by Controlling Exposure to Allergenic Foods? ILSI Europe Workshop, 16 September 2016, Brussels
(2) Allergy DiagnosisReference Guide

Tuesday, October 9, 2018

Scientists Discover A Potent And Natural Alternative to Anti Depressants Without Inducing Any Side Effects

Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.

According to general belief, people who suffer from depression may experience some mental and physical symptoms, observed by screen assay for depression in clinical settings.

The most common mental symptoms are feeling sad without reason and guilty, emotionally out of control, trouble concentrating or remembering, lack of motivation, having negative thoughts,...., particularly, in loss of interest in usually pleasurable activities.

And most common physical symptoms include lack of energy or fatigue, difficulty performing daily activities, changes in sexual desire, appetite,.... particularly, in a change of sleep pattern or difficult to sleep.

In concern to the causes of depression, researchers do not know why some people are more susceptible to the syndrome while some don't. However, depression may associate to a lot of different factors that affect our mental health.


According to the mapping risk factors for depression across the lifespan, the development of depression may involve a complex interplay of environmental and genetic risk factors including widowhood, physical abuse during childhood, obesity, having 4-5 metabolic risk factors, sexual dysfunction, job strain and with no consistent evidence for the causal effects of obesity, smoking, and alcohol consumption(4).


If you are experiencing some of the above symptoms, you may be at the early onset of depression. Please make that you see the related field specialist immediately.

If you are taking conventional antidepressants, such as sertraline (Zoloft), fluoxetine (Prozac, Sarafem) citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil, Pexeva, Brisdelle), fluvoxamine (Luvox), please make sure you know the adverse effects such as increased appetite, weight gain, loss of sexual desire, fatigue, drowsiness, insomnia. dry mouth, blurred vision, constipation,.....

Green tea may have a profound effect in reduced risk and treatment of depression, some scientists suggested


Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world.

In vivo, application of green tea(GT) and GABA green tea (GGT) expressed a protective activity of against post-stroke depression (PSD), a common consequence of stroke, according to the joint study lead by the Pavia University.

And, in a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......

Also, according to a cross-sectional study of consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, conducted by the joint venture lead by the Fukuoka Women's University, green tea consumption is associated to reduce symptoms of depression, depending to amount of intake.

Compared amount intake, participants consumed ≥4 cups green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those consumed less than 1 cup/d.

The multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was 0·57.

These results suggested that green tea consumption have a linear effect correlated to numbers of cup intake per day without mentioning the effects of maximum cups that patients can take.

Dr. Pham NM, the lead author in the study said, "higher consumption of green tea, coffee and caffeine may confer protection against depression".

Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.

Taking together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily.

However, oral administration of large amount daily should be taken with care, particularly, in people with yin constituent.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T 1.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M 1.(PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
(4) Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies by Köhler CA1, Evangelou E2, Stubbs B3, Solmi M4, Veronese N5, Belbasis L6, Bortolato B7, Melo MCA1, Coelho CA1, Fernandes BS8, Olfson M9, Ioannidis JPA10, Carvalho AF. (PubMed)