Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Herbalism or phytotherapy is a traditional medicine used botany and plants for treatment of a variety of ailments. Today, it has become increasingly important for many scientists who intend to find the natural agents with the same effectiveness as conventional medicine without inducing serious side effects.
However, the finding of this whole food medication has been facing many obstacles including limited financial support, because, the discovery of such plants will provide no commercial benefit and patent right to producers.
According to Dr. Marjorie Murphy Cowan in the study of "Plant Products as Antimicrobial Agents" said, "While 25 to 50% of current pharmaceuticals are derived from plants, none are used as antimicrobials. Traditional healers have long used plants to prevent or cure infectious conditions" and " Plants are rich in a wide variety of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids, which have been found in vitro to have antimicrobial properties"(a).
Western medicine is trying to duplicate herbal successes with the synthetic version for the patent right without using the whole herb ingredients which have caused overexpression of serious adverse effects.
ROS species have duo functions that are well documented for playing an important role in our body as both beneficial and deleterious molecules in the expression of cytotoxicity against abnormal cells alternation and initiation of chronic ailments such as overgrowth of candida by causing an imbalance of the ratio among antioxidants and free radicals, respectively.
In free radical overexpression initiated overgrowth candida, certain herb-derived compounds exerted a strong antioxidant effect that targets Candida and restores health and balance.
According to the Jamia Millia Islamia, diallyl disulfide (DADS), an important organosulphur compound found in garlic inhibited the overgrowth of candida through decreasing activity of all antioxidant enzymes except catalase in Candida species antioxidant system.
These result suggested that application of diallyl disulfide (DADS) caused an increase of oxidative stress and damage to the fungal cells(b).
The Anti Over Growth of Candida Herbal Medicine
1. Berberis
Berberis is a genus of about 450-500 species of deciduous and evergreen shrubs from 1-5 m tall with thorny shoots, belongings to the family Berberidaceae, native to the temperate and subtropical regions of Europe, Asia, Africa, North America, and South America. Europe has a few species, and North America only two. The stem, root bark, and fruit of barberry containing alkaloids and berberine have been used in traditional medicine or dietary supplement, to treat fungal infections(270), Candida albicans(270), yeast(271), parasites, and bacterial/viral infections(270).
Berberine may also enhance the immune system through its antioxidant activity(272) by preventing candida yeasts from producing lipase(273)(274), an enzyme used to help them in colonization(274) and induced infection(274).
2. Clover(Trifolium)
Clover used as a spice in cuisines all over the world, is the aromatic dried flower buds of a tree in the Syzygium, belongings to the family Myrtaceae, native to Indonesia. Tellimagrandin II, in clover oil, exhibited significantly anti-herpesvirus(275) and anti-oxidant(275)(276) properties and antiseptic property through phytochemical eugenol(277) used in dentistry to relieve pain(277), prevent a bacterial infection(278) and boost the immune system(279).
3. Goldenseal((Hydrastis Canadensis)
Goldenseal is a perennial herb in the species of Hydrastis Canadensis, belongings to the family Ranunculaceae, native to southeastern Canada and the northeastern United States, used widely in traditional medicine to treat functional disorders of gastrointestinal(280), including atonic dyspepsia, chronic constipation, liver toxicity(281), etc.
Berberine, a compound found in goldenseal has demonstrated significant anti-fungal activity(282)(283)(284) by preventing candida yeasts from producing lipase, an enzyme involved in colonization.
4. Oregano(Origanum vulgare) Oil
Oregano is a common species of Origanum, belongings to the family Lamiaceae, native to warm-temperate western and southwestern Eurasia and the Mediterranean region.
Carvacrol, a monoterpenoid phenol phytochemical found in oregano oil inhibited the growth of several bacteria strains(285), including candida albicans due to its antimicrobial properties that disrupt the bacteria membrane(286).
5. Cinnamon
Cinnamon is a spice obtained from the inner bark of trees from the genus Cinnamomum, belongings to the family Lauraceae, used in traditional medicine to treat digestive system disorder(287)(289), insulin sensitive(288)(290) and enhance the immune system in regulated cells growth due to its antioxidant activity(290).
The cinnamon essential oil has antimicrobial properties(291)(292), which can prevent, limit or destroy the fungal overgrowth(293).
6. Allspice
Allspice also called Jamaica pepper is a spice of dried unripe fruit of Pimenta dioica, belongings to the family Myrtaceae, native to southern Mexico and Central America. The herb has been used in folk medicine in relieving indigestion and gas(294) and as a deodorant.
Phenylpropene found in allspice volatile oils has shown to exhibit an antimicrobial property(295), including Candida albicans(296)
7. Lavender(Lavandula angustifolia)
The lavender is a genus Lavandula of flowering plants in the mint family Lamiaceae, originated in Asia, used in herbal medicine to treat the microbial infection(297) for the skin and reduce inflammation(298)(299).
Its essential oil components linalool and linalyl acetate showed both fungistatic and fungicidal activity(300)(301) against C. albicans strains in reducing fungal progression and the spread of infection in host tissue(301).
8. Chamomile
Chamomile is a common name for several daisy-like plants, genus Matricaria belongings to the family Asteraceae, native to Europe and western Asia used in traditional medicine to aid sleep(302), treat diarrhea(303) and reduce oxidative stress(304). Chamomile containing the high amount of flavonoids is best known for its antioxidant(303), such as antiseptic and antibiotic properties against virus bacteria invasion(305)(306(307)) including candida ablicans(308).
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)
(b) Effect of diallyldisulphide on an antioxidant enzyme system in Candida species by Yousuf S1, Ahmad A, Khan A, Manzoor N, Khan LA(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)
(270) Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla by Freile ML1, Giannini F, Pucci G, Sturniolo A, Rodero L, Pucci O, Balzareti V, Enriz RD.(PubMed)
(271) Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. Musumeci R1, Speciale A, Costanzo R, Annino A, Ragusa S, Rapisarda A, Pappalardo MS, Iauk L.(PubMed)
(272) In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects. Abd El-Wahab AE, Ghareeb DA1, Sarhan EE, Abu-Serie MM, El Demellawy MA.(PubMed)
(273) Inhibition of biofilm formation and lipase in Candida albicans by culture filtrate of Staphylococcus epidermidis in vitro. Bhattacharyya S1, Gupta P2, Banerjee G2, Jain A2, Singh M2.(PubMed)
(274) Differential Candida albicans lipase gene expression during alimentary tract colonization and infection. Schofield DA1, Westwater C, Warner T, Balish E.(PubMed)
(275) Medicinal Plants in Australia Volume 4: An Antipodean Apothecary
(276) Ellagitannin(Wikipedia)
(2377) Oil of clover(Wikipedia)
(278) Anti-virulence potential of eugenyl acetate against pathogenic bacteria of medical importance by Musthafa KS1, Voravuthikunchai SP.(PubMed)
(279) Immunomodulatory activity of geranial, geranial acetate, gingerol, and eugenol essential oils: evidence for humoral and cell-mediated responses. Farhath S1, Vijaya P1, Vimal M2.(PubMed)
(280) Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni by Cwikla C1, Schmidt K, Matthias A, Bone KM, Lehmann R, Tiralongo E.(PubMed)
(281) Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in ratsby Yamaura K1, Shimada M, Nakayama N, Ueno K.(PubMed)
(282) In vitro antifungal activity of the berberine and its synergism with fluconazole by Iwazaki RS1, Endo EH, Ueda-Nakamura T, Nakamura CV, Garcia LB, Filho BP.(PubMed)
(283) Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents by Park KD1, Lee JH, Kim SH, Kang TH, Moon JS, Kim SU.(PubMed)
(284) Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans by Dhamgaye S1, Devaux F2, Vandeputte P3, Khandelwal NK4, Sanglard D3, Mukhopadhyay G5, Prasad R4.(PubMed)
(285) Effect of two monoterpene phenols on antioxidant defense system in Candida albicans by Khan A1, Ahmad A2, Ahmad Khan L3, Padoa CJ4, van Vuuren S5, Manzoor N6.(PubMed)
(286) Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candidaby Ahmad A1, Khan A, Akhtar F, Yousuf S, Xess I, Khan LA, Manzoor N.(PubMed)
(287) Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage by Ozbayer C1, Kurt H, Ozdemir Z, Tuncel T, Moheb Saadat S, Burukoglu D, Senturk H, Degirmenci I, Gunes HV.(PubMed)
(288) Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients by Askari F1, Rashidkhani B2, Hekmatdoost A3.(PubMed)
(289) Regular ingestion of cinnamon cortex pulveratus offers gastroprotective activity in mice by Tankam JM1, Sawada Y, Ito M.(PubMed)
(290) An overview on chemical composition, bioactivity, and processing of leaves of Cinnamomum tamala by Sharma V1, Rao LJ.(PubMed)
(291) Antimicrobial activities of commercial essential oils and their components against food-borne pathogens and food spoilage bacteria by Mith H1, Duré R2, Delcenserie V2, Zhiri A3, Daube G2, Clinquart A2.(PubMed)
(292) The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants by Miller AB1, Cates RG, Lawrence M, Soria JA, Espinoza LV, Martinez JV, Arbizú DA.(PubMed)
(293) Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis by Pires RH1, Montanari LB, Martins CH, Zaia JE, Almeida AM, Matsumoto MT, Mendes-Giannini MJ.(PubMed)
(294) Properties and Uses for Herbs and Spices
(295) Fumigant activity of (E)-anethole identified in Illicium verum fruit against Blattella germanica by Chang KS1, Ahn YJ.(PubMed)
(296) Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens by Botelho MA1, Nogueira NA, Bastos GM, Fonseca SG, Lemos TL, Matos FJ, Montenegro D, Heukelbach J, Rao VS, Brito GA.(PubMed)
(297) Hydrolates from lavender (Lavandula angustifolia) - their chemical composition as well as aromatic, antimicrobial and antioxidant properties by Prusinowska R1, Śmigielski K, Stobiecka A, Kunicka-Styczyńska A.(PubMed)
(298) Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romania by Spiridon I1, Colceru S, Anghel N, Teaca CA, Bodirlau R, Armatu A.(PubMed)
(299) Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma by Ueno-Iio T1, Shibakura M2, Yokota K1, Aoe M1, Hyoda T1, Shinohata R1, Kanehiro A3, Tanimoto M3, Kataoka M1.(PubMed)
(300) Lavandula luisieri essential oil as a source of antifungal drugs by Zuzarte M1, Gonçalves MJ, Cruz MT, Cavaleiro C, Canhoto J, Vaz S, Pinto E, Salgueiro L.(PubMed)(301) Antifungal activity of phenolic-rich Lavandula multifida L. essential oil by Zuzarte M1, Vale-Silva L, Gonçalves MJ, Cavaleiro C, Vaz S, Canhoto J, Pinto E, Salgueiro L.(PubMed)
(302) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
(303) Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats by Sebai H1, Jabri MA2, Souli A3, Rtibi K3, Selmi S3, Tebourbi O4, El-Benna J5, Sakly M4.
(PubMed)
(304) Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress by Bhaskaran N1, Shukla S, Kanwal R, Srivastava JK, Gupta S.(PubMed)
(305) Study of antimicrobial activity of chamomile oil by Aggag ME, Yousef RT.(PubMed)
(306) Phenolic acids profile, antioxidant and antibacterial activity of chamomile, common yarrow and immortelle (Asteraceae)by Mekinić IG, Skroza D, Ljubenkov I, Krstulović L, Možina SS, Katalinić V.(PubMed)
(307) A novel colorimetric broth microdilution method to determine the minimum inhibitory concentration (MIC) of antibiotics and essential oils against Helicobacter pylori by Weseler A1, Geiss HK, Saller R, Reichling J.(PubMed)
(308) All-natural composite wound dressing films of essential oilsencapsulated in sodium alginate with antimicrobial properties by Liakos I1, Rizzello L2, Scurr DJ3, Pompa PP2, Bayer IS4, Athanassiou A5.(PubMed)
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