Green Tea and Bioactive Saponin In Prevention and Treatment of Lymphoma

Lymphoma is a medical condition characterized by cell growth disorderly and uncontrollably in the lymph nodes. There were 661,996 people living with non-Hodgkin lymphoma in the United States, 2014.

According to the medical literature online, intake of green tea saponin and phenolic may have a strong influence in lymphoma oncogenesis through some certain aspects.

In EL4 cancer cells line, injection of green bioactive saponin stimulated the immunomodulatory activity in inhibited EL4 cell lines through regulated cytokine expression induced by inflammation and mitogen-activated protein kinases (MAPK) signaling pathway involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

Furthermore, injected saponin also reduced the expression of EL4 cells line in tumor proliferation by interrupting the process of sequence of mutated DNA transcript in mRNA expression in transmitting transcript by initiating production of inflammatory cytokines to reverse transcription-polymerase chain reaction in making copies of alternated gene, thus attenuating risk of tumor growth, tumor progression and immuno-suppression, activities in host anti-tumor response.


Treatment of green tea saponin also was found to induced cytotoxicity to EL4 cancer cell line without causing harm to healthy cells.

Additionally, the efficacy of tea saponin in inhibition of the proliferation and invasiveness of T-lymphoma (EL4) cells, may be also attributed to the effect of others inflammatory cytokines such as tumor necrosis factor-alpha TNF-α in induced cancer cells death and NF-κB in controlled transcription of DNA, cytokine production and cell survival through mediated the regulation of MAPK pathway in transduction (process by which foreign DNA is introduced into a cell by a virus or viral vector) and extracellular signals to cellular responses in induction of cell proliferation, differentiation, development, transformation, and apoptosis.

Tumor necrosis factor-alpha TNF-α, a pro-inflammatory cytokine plays an important role in the acute phase of inflammation with function in the regulation of biological processes including cell proliferation, differentiation, and apoptosis.

Nuclear factor-κB (NF-κB) is a transcription factor with function in the regulated expression of genes involving many biological processes including innate and adaptive immunity, inflammation and stress responses,

In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines Namalwa, RAP1-EIO and HS-Sultan, injection of green tea displayed significant inhibition of
50% of Namalwa tumors and RAP1-EIO and HS-Sultan tumor through paralyzed tumor invasive activities.

In compared to chemotherapy drug cyclophosphamide, green tea exhibited anti-angiogenic effect in induction of.frequency of apoptotic endothelial and tumor cell and promoted tumor shrinking by blocking the formation of new blood vessels in providing nutrients and fluid for tumor expansion.


Base on the information findings, researchers opinionated, "Further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression".


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(2) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)

Herbal Turmeric the Natural Prevention and treatment of Cholecystitis

Cholecystitis is the most common condition caused by the gallbladder stones blockage of the cystic duct, which carries bile from the gallbladder, leading to the inflammation of the gallbladder.


Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.

Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.


Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.

* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.

Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.


Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.


Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.

Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.

Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.


In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.

Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".

Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)

Green Tea and Green Tea Epigallocatechin‑3-O-gallate (EGCG) In Ameliorated Risk and Treatment of Leukemia

Leukemia is a malignant progressive disease characterized by irregular cell growth in the bone marrow and other blood-forming organs. According to the statistic, approximately Over 300 children with 0-14 years of age are diagnosed with leukemia each year in Canada alone.

In the review of the literature published online, green extract epigallocatechin‑3-O-gallate (EGCG) processed a significant anti-cancer effect in reduced chronic myeloid leukemia (CML) expansion in the myeloid cells through numbers of mechanisms.

Application of green tea epigallocatechin‑3-O-gallate (EGCG) in reduced risk of chronic myeloid leukemia (CML) was found to associate to the cellular process of cyclic guanosine monophosphate (cGMP)-dependent pathway and protein kinase Cδ expression to induce cancer cells apoptosis by increased acid sphingomyelinase (ASM) and lipid raft clustering in CML cells.


Acid sphingomyelinase (ASM), an enzyme plays an important role in normal membrane turnover.

Protein kinase Cδ expression plays a key role in signal transduction and are involved in the regulation of numerous cellular processes.


Cyclic guanosine monophosphate (cGMP)-is an important second messenger in many biological processes involved a series of molecular functions.

Further analysis also suggested that exhibited sGC function by injection of green tea EGCG may be an ideal approach to suppresses proliferation and survival of human CML

In other words, reduced expression of regulation of sGC caused by decreased NO production may initiate growth and survival advantage in CML tumor cells.


Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide.

Pharmacologically, pretreatment of soluble guanylate cyclase inhibitor NS-2028 decreased nitric oxide (NO)-stimulated sGC activity also reduced green tea polyphenol activities in activated sphingomyelinase (ASM) production.

NS-2028 is a specific inhibitor of soluble guanylyl cyclase.


In acute promyelocytic leukemia (APL), green tea (Camellia sinensis) catechin epigallocatechin-3-gallate (EGCG) displayed a strong and positive effect in elevating the expression of genes associated with cell cycle arrest and differentiation, including gene expression p27, PCAF, C/EBPα, and C/EBPɛ

P27, a cyclin-dependent kinase inhibitor 1B is an enzyme inhibitor and in elevation exerted positive regulation of cancer activity at the G1/S phase transition in cell division.

P300/CBP-associated factor (PCAF), is gene associated in binding to many sequence-specific factors involved in cell growth and/or differentiation.

Enhancer binding protein alphas/EBPα, with function in modulating the expression of genes involved in cell cycle regulation.


Enhancer binding protein epsilon (C/EBPɛ) is a protein composed of two polypeptide chains with function in binding to certain DNA regulatory regions.

Additionally, injection of EGCG also demonstrated a hugh effect against cancerous changes in gene expression and reduced expression of epigenetic modifiers DNMT1, HDAC1, HDAC2, and G9a.


DNA Methyltransferase, (DNMT1), Methylation of DNA is an important component of mammalian epigenetic gene regulation.


Histone deacetylase 1and 2 (HDAC1 and 2) are enzymes promote epigenetic repression and with function in transcriptional regulation, cell cycle progression and development.


Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a.is epigenetic modifier enzymes with function in regulating gene expression involved the functional role of cancer initiation and progression. Downregulation of G9a also decreased expression of histone H3K9 (H3K9me2) is inhibited cancer cells proliferation

Other, in the multicenter case-control study conducted in China, 2008-2013, comprising 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium by the University of Western Australia also confirmed the inverse association of green tea intake to adult leukemia risk.

Risk of leukemia adjusted odds ratios of 0.50 was found in green tea drinkers in compared to nondrinker, particularly in patients with GSTM1 and GSTP1 genotypes.

Dr. Liu P, the lead author said, "regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype".

Taking all together, green tea and epigallocatechin‑3-O-gallate (EGCG) intake may be considered as a secondary therapeutic application combined with standard therapy for the treatment of Leukemia regardless of polymorphic status.


For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(2) Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells by Borutinskaitė V1, Virkšaitė A1, Gudelytė G1, Navakauskienė R1.(PubMed)
(3) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)

Whole Food Tomato Promote the Ratio of Gut Microbiota For Optimal Health

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system

* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".


Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.

The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.

At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.

However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.


According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.


Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.



Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the gut health, pending to large sample size and multicenter human study.





Intake of polyphenols in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)

Green Tea and Its polyphenol (-)-epigallocatechin-3-gallate EGCG in Ameliorated Risk and Treatment of Endometrial Cancer

Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium. At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.

In the review of researcher papers online, the effects of green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in inhibition of endometrial cancer was expressed in various aspects.


In the experiment of green tea bioactive compound against the progression of tumor xenografts of human endometrial cancer, (-)-epigallocatechin-3-gallate EGCG demonstrated a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.

In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in activated transcription of many genes, in regulated cellular and systemic homeostatic response to external changes to tumor growth.

Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, in promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.


Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) is initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in regulated many cellular processes, including cell survival, proliferation, and growth.


After taking account of all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts including decreased cancer cell-secreted VEGFA but inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which acts indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1


The overexpression of cyclin D1 has been linked to the development and progression of cancer.

Proliferating cell nuclear antigen is a protein with function in cell cycle regulation and/or DNA replication and important for both DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down-expression of transcription factors fos and jun, the cellular immediate-early genes in induced transient cancer cell division and differentiation processes.

The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).


Bcl-2-associated X is a protein with function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.

B-cell lymphoma 2, a family protein with function in the regulation of cell apoptosis.

Cleavage of caspase-3 also is known as a critical executioner of apoptosis,

Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.

Implicitly, application of EGCG also increased the production of free radical expression in initiated the cytotoxicity effect by reduced levels of antioxidant glutathione levels and activated the p38 in cancer cells death without inducing toxicity to normal cells


P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses as well as in response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.


Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database upto February 2, 2015 , researchers indicated that green tea consumption was associated with a reduced risk of EC with a relative risk of .78 and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.

Particularly, the intake of green tea associated with attenuated risk of endometrial cancer was 84.33% in compared to 5.07 % of black tea.

Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reduced risk and treatment of endometrial cancer.

For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4.(PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)

Onion Blocks the Initiation of Prostate Cancer

The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The prostate gland is considered a reproductive organ in men.

Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.


At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.


Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.


According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.


The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk

*Age
The risk of developing prostate cancer increases with the age of over 45

* Family history
Statistic showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.

*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.

* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.


Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in pathology of prostate cancer.

* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.

* Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with a higher risk of prostate cancer as it interferes with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.

* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.

* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.

*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.



The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.


With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and vitro.


According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.
In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing the prostate cancer risk.
The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.

Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.






Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton

Green Tea Polyphenols in Attenuated Risk and Treatment of Bladder Cancer

Bladder cancer is a medical condition characterized by irregular cell growth in the tissues of the bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73


In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to numbers of mechanisms.

In T24 human bladder cancer cell line, application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in the activating Bcl-2 family proteins with function in regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in dose- and time-dependent manner.


The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.


Bcl-2 family proteins is a modulator responsible for the regulation of cell apoptosis.

In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached to the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti-cancer proliferation through induction of apoptosis.

This action of anti-cancer effect was attributed to a mechanism of EGCG-pNG in the activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with a function in control apoptosis by activating caspase proteases in the governing the space between outer and inner mitochondrial membrane.

Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending on the release of proteins from the intermembrane space of mitochondria.

Caspase cascade, family protease enzymes with function in programmed cell death and inflammation.

Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in the stimulated formation of a new blood vessel in provided nutrients and oxygen for the survival of cancer site in compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.



The vascular endothelial growth factor is a signal protein produced by cells in the stimulated formation of the blood vessel for cell division and site proliferation.


Based on information collected,, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumor in model mice.

More interestingly, bladder tumor induced by N-butyl-(-4-hydroxybutyl) nitrosamine (BBN) 0.05% solution on 8 week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significant lower rate of tumor invasive frequency of 23.8%; in group treated with both GTP and BBN in compared to 65.2% in group treated with BBN alone.



The tumor volume and microvascular density (MVD) as an independent predictor within a tumor and the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group were also significantly lower than in BBN treated mice.


Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect in suppressed the forming of the new blood vessel for the tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting the anti-carcinogenic effect.

Taken together, green tea extract polyphenols may be considered an adjunct therapy for reduced risk and used a combination with standard medicine for the treatment of bladder cancer.


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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ.(PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)