Alzheimer's disease is a chronic neurodegenerative disease caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages have Alzheimer's. 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time.
Although, less than 10% of patients with AD are associated with a genetic preposition. Patients with such a mutated gene are virtually guaranteed to develop the disease.
More precisely, any one of a number of different single-gene mutations on chromosomes 21, 14, and 1 was found to induce the onset of AD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of Alzheimer's disease (AD) investigated the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation and in vivo effects of this compound on AD pathogenesis.
In Neuro2a cells, injection of VMA inhibited the in vitro formation of Aβ peptide fibrils in the induction of neuron toxicity.
Furthermore, A diet containing 1% VMA prevented the cognitive degeneration was found in the tested AD mice.
Interestingly, this diet in the retention of cognitive ability was not accompanied by a reduction in the aggregate deposition in brains but rather, an increase in insoluble deposits, compared to control mice.
The results suggested that VMA shows a strong effect on Alzheimer's disease by altering the Aβ aggregation to a non-toxic form.
In order to reveal more information about bilberry anti AD activity, researchers elucidated the effects of different polyphenols on neuroprotection and APP processing under different in vitro stress conditions.
Injection of myricetin, quercetin or anthocyanin-rich extracts in a dose-dependent manner significantly inhibited the overexpression of free radicals caused by the application of Menadione.
APdE9 mice fed with anthocyanin-rich bilberry or blackcurrant extracts showed decreased APP C-terminal fragment levels, the amyloid precursor protein in the cerebral cortex, compared to APdE9 mice on the control diet.
Levels of soluble Aβ40 and Aβ42 levels were found to significantly decrease in bilberry-fed mice, compared to blackcurrant-fed mice.
Additionally, the bilberry diet also improved the spatial working memory of aged APdE9 mice, compared to mice on the control diet.
Based on the findings, Dr. Vepsäläinen S, the lead scientist wrote in the final report, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
Taken altogether, bilberry rich of anthocyanin may be considered a functional remedy for the prevention and treatment of Alzheimer's disease (AD), pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata Y. (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
Tuesday, December 31, 2019
Andrographis, The Best Anti Platelet Aggregation Herbal Medicine
A recent vitro study suggested that Andrographis paniculata exerted an enormous inhibitory effect on platelet aggregation.
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....
According to the Mahidol University, diterpenoids isolated from the plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.
The study also suggested that the effect of this action was attributed to the inhibition of the regulation of functions in differentiate cells.
Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".
In comparison to platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...
The study also proposed that the mechanism of these actions may be associated with the cardiovascular and antithrombotic activity compared to that of non-steroidal antiinflammatory drugs (NSAID),
Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.
Taking together, there is no doubt that herbal Andrographis processes an anti-Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorders should only take herbal medicine with the permission of related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)
Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....
According to the Mahidol University, diterpenoids isolated from the plant, including andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) in the thrombin-induced platelet aggregation, significantly inhibited blood clot a concentration-(1-100 microM) but not in higher doses, and time-dependent manner.
The study also suggested that the effect of this action was attributed to the inhibition of the regulation of functions in differentiate cells.
Due to inefficacy in applications of higher concentrations, Dr. said, "the extract with high level of AP(3) (Extract B) (IC(50) values=50-75 microg/ml) showed less inhibitory activity against thrombin than the extract with lower level of AP(3) (Extract A) (IC(50) values=25-50 microg/ml). These results indicate that the standardized A. paniculata extract may contain other antiplatelet compounds rather than AP(1) and AP(3), which contribute to high antiplatelet activity".
In comparison to platelet aggregation effects with non-steroidal antiinflammatory drugs (NSAID), treatment of the herbal medicine showed a strong influence on the biosynthesis of eicosanoids in cell signaling and the platelet-activating factor (PAF) with the ability to cause platelet aggregation, inflammation, and allergic response,...
The study also proposed that the mechanism of these actions may be associated with the cardiovascular and antithrombotic activity compared to that of non-steroidal antiinflammatory drugs (NSAID),
Other study insisted that the effects of andrographolide in platelet activation may be a result of reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet clumping formation of which decrease the platelet aggregation activity.
Taking together, there is no doubt that herbal Andrographis processes an anti-Platelet Aggregation through exhibiting the functions of various mechanisms. People with bleeding disorders should only take herbal medicine with the permission of related field specialists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation by Thisoda P1, Rangkadilok N, Pholphana N, Worasuttayangkurn L, Ruchirawat S, Satayavivad J.(PubMed)
(2) Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation by Amroyan E1, Gabrielian E, Panossian A, Wikman G, Wagner H.(PubMed)
(3) A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of plateletactivation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP by Lu WJ1, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.(PubMed)
Aloe Vera, the Natural Whole Food in Inhibited HSV-1(Herpes simplex)
Aloe vera may be the next potential topical medicine used for the treatment of oral HSV-1 infections without exerting any toxicity, the study by the renowned institute suggested.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits, used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Herpes simplex is a contagious disease caused by human herpesvirus 1 and 2, the 2 members of the herpes virus family.
According to the joint study lead by the Shiraz University of Medical Sciences, gel extraction with concentrations of Aloe vera (0.2, 0.5, 1, 2, and 5%) exhibited anti-HSV-1 activity assessed by plaque reduction assay.
Dr. Rezazadeh F, the lead author of the study said, "The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between the two serial concentrations".
Acemannan, an extracted polysaccharide from Aloe vera, has shown to exhibited antiviral activities against herpes simplex virus type 1 (HSV-1), in vivo through activation of immune responses.
A combination with azidothymidine(an antiretroviral medication) and acyclovir(an antiviral medication) administration acted synergistically to inhibit the replication of HIV-1 and herpes simplex virus type 1 (HSV-1), respectively.
In fact, the effects of the combination against U1 cells infected with HIV-1, are also attributed to the function of blocking the potentiate of virus replication without inducing toxicity.
Although Aloe Vera has shown to inhibit the replication of HSV-1 activity through its antiviral property, a more precise understanding of the biological activities is necessary before developing Aloe vera as a pharmaceutical source.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study by Rezazadeh F1, Moshaverinia M1, Motamedifar M2, Alyaseri M3.(PubMed)
(2) Acemannan, an extracted polysaccharide from Aloe vera: A literature review by Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A.(PubMed)
(3) In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir by Kahlon JB1, Kemp MC, Yawei N, Carpenter RH, Shannon WM, McAnalley BH.(PubMed)
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits, used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Herpes simplex is a contagious disease caused by human herpesvirus 1 and 2, the 2 members of the herpes virus family.
According to the joint study lead by the Shiraz University of Medical Sciences, gel extraction with concentrations of Aloe vera (0.2, 0.5, 1, 2, and 5%) exhibited anti-HSV-1 activity assessed by plaque reduction assay.
Dr. Rezazadeh F, the lead author of the study said, "The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between the two serial concentrations".
Acemannan, an extracted polysaccharide from Aloe vera, has shown to exhibited antiviral activities against herpes simplex virus type 1 (HSV-1), in vivo through activation of immune responses.
A combination with azidothymidine(an antiretroviral medication) and acyclovir(an antiviral medication) administration acted synergistically to inhibit the replication of HIV-1 and herpes simplex virus type 1 (HSV-1), respectively.
In fact, the effects of the combination against U1 cells infected with HIV-1, are also attributed to the function of blocking the potentiate of virus replication without inducing toxicity.
Although Aloe Vera has shown to inhibit the replication of HSV-1 activity through its antiviral property, a more precise understanding of the biological activities is necessary before developing Aloe vera as a pharmaceutical source.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study by Rezazadeh F1, Moshaverinia M1, Motamedifar M2, Alyaseri M3.(PubMed)
(2) Acemannan, an extracted polysaccharide from Aloe vera: A literature review by Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A.(PubMed)
(3) In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir by Kahlon JB1, Kemp MC, Yawei N, Carpenter RH, Shannon WM, McAnalley BH.(PubMed)
Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health
Gut microbiota or gastrointestinal microbiota is the complex community of over 10 trillions microorganisms living in our digestive tracts.
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement of nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in the colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement of nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in the colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Monday, December 30, 2019
Bromelain Promotes and Removes Eschar In Burn Wounds, Human Trials Show
Eschar is a dry, dark scab of dead skin associated with a certain skin condition.
Most cases of eschar are associated with burning or cauterizing that stop bleeding, or prevent the spread of infection.
Most common causes of eschar are burned, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.
Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of is red, painful, dry, and with no blisters on the affected site.
* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, and swollen and painful on the affected site.
* Third-degree burns not only to destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to completely damage of the nerves in the area.
Believe it or not, 10 percent burns of a child's body and 15 to 20 percent burns of an adult's body are considered to be major injuries and require medical attention and hospitalization.
The most common types of burns are* Thermal burns caused by external heat sources.
* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.
* Chemical burns caused by acids, alkalies, detergents, or solvents.
* Electrical burns caused by electrical current.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full-thickness burns.
According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.
In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scab or falling away of dead skin due to surgical tangential excision of deep dermal and full-thickness burns.
Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".
Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.
More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.
After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care
Most cases of eschar are associated with burning or cauterizing that stop bleeding, or prevent the spread of infection.
Most common causes of eschar are burned, a condition that causes severe skin damage. Burn wound can recover without serious health consequences in a few days or weeks depending on the size of the burns.
Burns depending on the severity can be classified into
* First-degree burns affect only the epidermis or outer layer of the skin accompanied by the symptoms of is red, painful, dry, and with no blisters on the affected site.
* Second-degree burns affect the epidermis and part of the dermis layer of the skin accompanied by the symptoms of red, blistered, and swollen and painful on the affected site.
* Third-degree burns not only to destroy the epidermis and dermis but also damage the underlying bones, muscles, and tendons accompanied by no symptoms due to completely damage of the nerves in the area.
Believe it or not, 10 percent burns of a child's body and 15 to 20 percent burns of an adult's body are considered to be major injuries and require medical attention and hospitalization.
The most common types of burns are* Thermal burns caused by external heat sources.
* Radiation burns caused by prolonged exposure to ultraviolet rays of the sun or radiotherapy.
* Chemical burns caused by acids, alkalies, detergents, or solvents.
* Electrical burns caused by electrical current.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of diabetic foot burns, researchers examined the effect of bromelain-based enzymatic debridement with Nexobrid® (Mediwound) on surgical tangential excision of deep dermal and full-thickness burns.
According to the retrospective case series that identified four patients with diabetic foot burns,
Nexobrid® debridement showed significant activity in the development of further eschar and deepening of their wounds a few days after NexoBrid was applied.
In other words, Nexobrid® debridement protects the skin against the formation of dry, dark scab or falling away of dead skin due to surgical tangential excision of deep dermal and full-thickness burns.
Based on the finding, Dr. Berner JE, the lead scientist said, "We would recommend judicious use of this new product in patients with diabetic foot wounds".
Moreover, the joint study led by the University of Heidelberg based on the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists suggested that the degree of consensus was remarkably high, with a unanimous consensus in 88.2% of statements, and the lowest degree of consensus of 70% in only 3 statements.
More precisely, most patients support the use of Nexobrid® debridement for the treatment of removed eschar in burn wounds and reduced blood loss.
After taking other factors into account, Dr. Hirche C, the lead researcher wrote, "This consensus document may serve as a preliminary guideline for the use of enzymatic debridement with user-oriented recommendations until further evidence and systematic guidelines are available".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of eschar in burn wounds, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Limitations to the use of bromelain-based enzymatic debridement (NexoBrid®) for treating diabetic foot burns: a case series of disappointing results by Berner JE1,2, Keckes D1, Pywell M1, Dheansa B. (PubMed)
(2) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(3) Burn Stages and Types of burn by the Stanford Health Care
Bilberry, Protects the Heart and Blood Vessels Against Cardiovascular Diseases
Scientists may have found a whole fruit for the prevention and treatment of cardiovascular diseases, according to studies.
Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.
According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.
The most common risk factors associated with CVD are an unhealthy diet, physical inactivity, smoking, and excessive alcohol drinking.
Patients with CVD mostly were found to have some intermediate conditions such as high blood pressure, cholesterol, and glucose and being overweight and obese.
Most common symptoms of CVD include persistent chest pain, chest tightness, chest pressure and chest discomforts, and conditions associated with lower blood circulation due to narrowing blood vessels such as shortness of breath, numbness, weakness or coldness in your legs or arms.
Some people before having a CVD may also experience symptoms of pain in the neck, jaw, throat, upper abdomen or back.
If you experience some of the symptoms aforementioned, please check with your doctor to rule out the possibility.
Some researchers suggested that people inherited the mutated gene from the parent are also at a higher risk of CVD.
Dr. Sunil K. Nadar the lead scientist in the investigation of the genetics of CVD wrote, "The term ‘cardiovascular disease’ (CVD) encompasses a wide spectrum of diseases—including ischaemic heart disease (IHD), congenital structural heart disease and various inherited arrhythmias and cardiomyopathies—each of which has its own etiology and pathogenesis".
And, "Our present understanding seems to suggest that it is not one gene on its own that leads to CVD, but rather an interaction between the effects of various genes".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the differentiation of natural compounds for the treatment of cardiovascular disease (CVD), researchers in a joint study led by the Slovak University of Agriculture in Nitra examined the effects of regular consumption of bilberries on CVD risk reduction.
Women (n=25) and men (n=11) included in the study were asked to consume 150 g of frozen stored bilberries 3 times a week for 6 weeks.
At the end of the study, the consumption of bilberries showed a significant decrease of risk factors associated with the onset of CVD, including total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044).
In men, larger favorable changes were found in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C (P=.009) compared to women.
Interestingly, the injection of bilberry over the period was not induced favorable change but an increase of LDL-C.
Dr, Habanova M, the lead scientist after taking into co and confounders, said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Furthermore, in order to find more information about the bilberry anti CVD effects, researchers investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).
The randomized controlled trial included participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.
Injection of bilberry juice resulted in a significant decrease in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG).
However, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) involved in the acute phase of systematic inflammation was also observed in the bilberry group.
Bilberry juice exerted a significant effect in modulating the protein associated with pro-inflammatory cytokines, through activation of a transcription factor, a crucial protein (nuclear factor- kappa B (NF-kappaB)) associated with chronic inflammatory diseases.
Interestingly, injection of bilberry juice did not induce the change of other clinical parameters, including oxidative stress or antioxidant status.
The findings suggested that bilberry reduced risk CVD by modulating the inflammation processes.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD by Karlsen A1, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. (PubMed)
(3) Genes and Cardiovascular Disease. Where do we go from here? by Sunil K. Nadar1,* and Kully Sandhu. (PMC)
Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.
According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.
The most common risk factors associated with CVD are an unhealthy diet, physical inactivity, smoking, and excessive alcohol drinking.
Patients with CVD mostly were found to have some intermediate conditions such as high blood pressure, cholesterol, and glucose and being overweight and obese.
Most common symptoms of CVD include persistent chest pain, chest tightness, chest pressure and chest discomforts, and conditions associated with lower blood circulation due to narrowing blood vessels such as shortness of breath, numbness, weakness or coldness in your legs or arms.
Some people before having a CVD may also experience symptoms of pain in the neck, jaw, throat, upper abdomen or back.
If you experience some of the symptoms aforementioned, please check with your doctor to rule out the possibility.
Some researchers suggested that people inherited the mutated gene from the parent are also at a higher risk of CVD.
Dr. Sunil K. Nadar the lead scientist in the investigation of the genetics of CVD wrote, "The term ‘cardiovascular disease’ (CVD) encompasses a wide spectrum of diseases—including ischaemic heart disease (IHD), congenital structural heart disease and various inherited arrhythmias and cardiomyopathies—each of which has its own etiology and pathogenesis".
And, "Our present understanding seems to suggest that it is not one gene on its own that leads to CVD, but rather an interaction between the effects of various genes".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the differentiation of natural compounds for the treatment of cardiovascular disease (CVD), researchers in a joint study led by the Slovak University of Agriculture in Nitra examined the effects of regular consumption of bilberries on CVD risk reduction.
Women (n=25) and men (n=11) included in the study were asked to consume 150 g of frozen stored bilberries 3 times a week for 6 weeks.
At the end of the study, the consumption of bilberries showed a significant decrease of risk factors associated with the onset of CVD, including total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044).
In men, larger favorable changes were found in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C (P=.009) compared to women.
Interestingly, the injection of bilberry over the period was not induced favorable change but an increase of LDL-C.
Dr, Habanova M, the lead scientist after taking into co and confounders, said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Furthermore, in order to find more information about the bilberry anti CVD effects, researchers investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).
The randomized controlled trial included participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.
Injection of bilberry juice resulted in a significant decrease in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG).
However, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) involved in the acute phase of systematic inflammation was also observed in the bilberry group.
Bilberry juice exerted a significant effect in modulating the protein associated with pro-inflammatory cytokines, through activation of a transcription factor, a crucial protein (nuclear factor- kappa B (NF-kappaB)) associated with chronic inflammatory diseases.
Interestingly, injection of bilberry juice did not induce the change of other clinical parameters, including oxidative stress or antioxidant status.
The findings suggested that bilberry reduced risk CVD by modulating the inflammation processes.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD by Karlsen A1, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. (PubMed)
(3) Genes and Cardiovascular Disease. Where do we go from here? by Sunil K. Nadar1,* and Kully Sandhu. (PMC)
Herbal Ashwagandha inhibits the Risk of Pancreatic Cancer
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA. Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts in the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obesity, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistics, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men. Pancreatic cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancer, researchers examined the withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera in human pancreatic cancer cells.
According to the tested analysis, the extract significantly increased the cells spherical structure with double-layer membranes degraded by autophagy through cleaning out damaged cells in normal cells.
However, in human pancreatic cancer (PC) cells, withanolide extract also blocked the degradation of autophagy by inhibiting SNARE protein in the the-mediated fusion of autophagosomes and lysosomes which contains degradative enzymes enclosed in a membrane.
In other words, in human pancreatic cancer (PC) cells, the extract promotes the cancer cell degradation by autophagy to induce apoptosis.
More precisely, WA induced ER stress-mediated apoptosis. by promoting the accumulation of ubiquitinated proteins, associated with degradation via the proteasome, a protein involved in degrading unneeded or damaged proteins.
In vivo, combining WA with a series of ER stress aggravators enhanced apoptosis synergistically in tumor growth in PC xenografts.
Based on the findings, researchers said, "simultaneous suppression of 2 key intracellular protein degradation systems rendered PC cells vulnerable to ER stress, which may represent an avenue for new therapeutic combinations for this disease".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of pancreatic cancer, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells by Li X1, Zhu F1, Jiang J2, Sun C3, Zhong Q4, Shen M1, Wang X1, Tian R1, Shi C1, Xu M1, Peng F1, Guo X1, Hu J5, Ye D6, Wang M1, Qin R. (PubMed)
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts in the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obesity, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistics, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men. Pancreatic cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancer, researchers examined the withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera in human pancreatic cancer cells.
According to the tested analysis, the extract significantly increased the cells spherical structure with double-layer membranes degraded by autophagy through cleaning out damaged cells in normal cells.
However, in human pancreatic cancer (PC) cells, withanolide extract also blocked the degradation of autophagy by inhibiting SNARE protein in the the-mediated fusion of autophagosomes and lysosomes which contains degradative enzymes enclosed in a membrane.
In other words, in human pancreatic cancer (PC) cells, the extract promotes the cancer cell degradation by autophagy to induce apoptosis.
More precisely, WA induced ER stress-mediated apoptosis. by promoting the accumulation of ubiquitinated proteins, associated with degradation via the proteasome, a protein involved in degrading unneeded or damaged proteins.
In vivo, combining WA with a series of ER stress aggravators enhanced apoptosis synergistically in tumor growth in PC xenografts.
Based on the findings, researchers said, "simultaneous suppression of 2 key intracellular protein degradation systems rendered PC cells vulnerable to ER stress, which may represent an avenue for new therapeutic combinations for this disease".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of pancreatic cancer, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells by Li X1, Zhu F1, Jiang J2, Sun C3, Zhong Q4, Shen M1, Wang X1, Tian R1, Shi C1, Xu M1, Peng F1, Guo X1, Hu J5, Ye D6, Wang M1, Qin R. (PubMed)
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