The Effects of Herbal Cascara Sagrada (Rhamnus purshiana) om Type 2 Diabetes

Herbal Cascara sagrada may process a strong and positive effect on reducing the risk and treatment of type 2 diabetes, according to studies.

Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with insufficient insulin entering the bloodstream to regulate the glucose, caused by either cell in the pancreas died off or receptor sites clogged up by fat and cholesterol.

Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to the epidemiological studies.

Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.

Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.


The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.

Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia as follows deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".


And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.

Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.

Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) which plays a role in activating the glucose and fatty acid uptake.

Furthermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.

In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.

According to the insulin tolerance test, the administration of emodin also increased insulin sensitivity after daily injection for 8 days.

Dr. the lead scientists said, "emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".

In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.

Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome.

Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.

Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.


In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.

The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.

Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska1 and Małgorzata Godziejewska-Zawada. (PMC)

Aloe Vera, the Natural Antioxidant Whole Food

Aloe Vera has shown to express to the antibacterial infection and scavenging properties with the rate of over 75% compared to ascorbic acid (92%) a renowned institute suggested.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorroeaceae, native to Sudan used in herbal medicine in treating many kinds of diseases, including wound and burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. The plant is very popular for commercial cultivation due to its health benefits,

Antioxidants are the set of molecules with functions in binding the production of free radicals causes of oxidative stress to the body and fighting against the invasion of bacterial organisms.

According to Monash University Malaysia, Aloe vera bioactive compounds exerted inhibited effects against numbers of bacterial strands, particular in Bacillus (20.7%), Pseudomonas (20.7%) and Enterobacter (13.8%).

Dr. Akinsanya MA, the lead author in the joint study suggested that the efficacy of Aloe Vera is the result of the production of bioactive compounds with high DPPH, (an organic chemical compound with) scavenging properties (75-88%).

In fact, in vitro, the testing various phytochemicals such as total phenolic content antioxidant activity, A. vera methanolic leaf extracts exhibited a strong antioxidant activity in free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay.

Although, Aloe Vera may have significant antioxidant property different agro-climatic conditions may affect the total phenolic content (TPC) and antioxidant potential of the plant.


The findings that Aloe Vera has exerted the antioxidant effects in various aspects, but intake of the large amounts should be taken with care.

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Sources
(1) Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera by Akinsanya MA1, Goh JK2, Lim SP2, Ting AS3.(PubMed)
(2) Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f by Kumar S1, Yadav A1, Yadav M1, Yadav JP2.(PubMed)

Herbal Artichoke, the Best Anti-Aging Functional Remedy

Skin aging is a natural process that can not be stopped. However, some people may look younger compared to their biological age.

According to the prominent oxidative stress theory, long-term accumulation of cell damage due to overexpression of free radicals in the skin can lead to early skin aging.

The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.

Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".

Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.


In other words, long-term unhealthy lifestyles such as excessive alcohol drinking, substance abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.


The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.

Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.


In other words, the polyphenolic artichoke extracts exhibited an anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radicals and depletion of antioxidant enzymes produced by the host.


The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.

Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.

On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.

Furthermore, in UVB-induced photoaging, researchers examined the antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemicals in the artichoke.


Cynaropicrin (Cyn) attenuated UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.

In other words, in an anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.

Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

Herbal Cascara Sagrada (Rhamnus purshiana), the Anti Viral Herbal Medicine

Herbal Cascara sagrada may be the next generation of the natural vaccine in reducing risk and treatment of viral infection, according to studies.imilar to

Similar to bacterial infection, both infections shared common characteristics by spreading through coughing and sneezing by and contact with infected people, especially through kissing and sex.

However, the virus may also cause infection by entering the body through wound and cut. Most viruses are killed in the acute phase of the infection.

During this phase, the immune system stimulates the constriction of blood vessels in speeding up the production of blood palette to cover the wound and production of inflammatory cytokines to the site of infection to fight off the bacterial and viral invasion.

The most common viruses that cause infection are hepatitis A, B, human papillomavirus (HPV) influenza. mumps, and rubella. People with a weakened immune system are susceptible to acute and chronic viral infections.
According to the article immune factor allows viral infections to become chronic by the University of Bonn, many viral diseases tend to become chronic, including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently".

Some researchers argued that the chronic infectious diseases may be a result of a weakened immune system which can not kill off the virus with the set period of time during the acute phase of infection, leading to the adaptation of the change, thus reducing the helper T cells in the secretion of inflammatory messengers and reduced function of the tumor necrosis factor in chronic infection compared to the acute phase of infection.


Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Researchers on finding a natural compound for the treatment of viral infection examined the effects of emodin, active ingredients from Rheum tanguticum (R. tanguticum, one of the Chinese Rhubarb) and Cascara Sagrada against HSV infection in tissue culture cells and in a mouse model.

Emodin displayed significant inhibition of the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with an antiviral index of 2.07 and 3.53, respectively.

Emodin treatment also increased the survival rate of HSV-infected mice, prolonged survival time and showed higher efficacy of HSV elimination from brain, heart, liver, and ganglion, compared to the controls.

In vivo, researchers found that emodin demonstrates the antiviral activity similar to that of acyclovir, an antiviral medication.

Compared to the efficacy of antiviral activity of nucleoside analogs against herpes simplex virus (HSV) infections, injection of emodin specifically inhibited the nuclease activity of HSV-1 UL12 alkaline nuclease, which is necessary for the production of viral DNA according to the biochemical assay.

Emodin reduced the plaque formation or cell to cell infection with an EC50 of 21.5±4.4 μm, according to the plaque reduction assay.


Emodin also inhibited the accumulation of viral nucleocapsids in the nucleus in the initiation of viral transcription and replication in a dose-dependent manner.

Dr. C-Y Hsiang and colleagues suggested that emodin is a potent anti-HSV agent via the suppression of a novel target, UL12.

Taken altogether, herbal Cascara Sagrada processed abundantly bioactive ingredient emodin may be considered a functioning remedy for the prevention and combined with primary medicine for the treatment of viral infection, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299


References
(1) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by C-Y Hsiang1 and T-Y Ho. (PMC)
(2) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR1, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(3) Immune factor allows viral infections to become chronic. Study may lead the way to new therapeutic approaches by Science Daily

Herbal Calendula Which Processes Anti-Plaque and Gingivitis Activity, revealed by Human Studies

Scientists may have found a natural ingredient that has a potential effect against the onset of gingivitis, according to studies.

Gingivitis is a condition of the inflammation of the gum. The most common cause of the disease is poor hygiene in the induction of bacterial biofilms attached to tooth surfaces.

Gingivitis is an early stage of gum disease, leading to the inflammation in inducing plaque buildup at the gumline. Daily brushing and flossing in most cases can remove the plaque, without the assistance of the dentist.

However, if daily brushing and flossing can not remove the plaque, please check with your dentist.

Untreated gingivitis can weaken the bone and connective tissue that hold the teeth in place, causing to periodontitis and the loss of tooth or teeth.

Besides poor hygiene, smoking or chewing tobacco, medical conditions such as diabetes, long-term intake of certain medications such as oral contraceptives, steroids, anticonvulsants, a denture that fit poorly, broken fillings, pregnancy, and genetic deposition are some risk factors associated with the onset of gingivitis.

Dr. Nascimento GG, the lead scientist, in the concern of widespread obesity in the risk of gingivitis launched a study of a total of 1211 children aged 8- to 12-year old from the public and private schools in Southern Brazil by a two-stage cluster method.

In the oral examination, the presence of plaque and gingival bleeding were found in 34.6% in Obese/overweight children, compared to the mean and median values of gingival bleeding sites were 3.10 and 2.0 respectively in the group.

According to the In the sex-stratified analysis, researchers said, "overweight/obese boys presented a greater risk for gingivitis".


The discovery strongly suggested there is a closed link between gingivitis and people who are obese.


Calendula is also known as pot marigold, the annual perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-

Researchers on finding natural ingredients for the prevention and treatment of with no side effects examined the herbal Calendula officinalis anti-plaque and anti-gingivitis activity.

240 patients having gingivitis (probing depth (PD) ≤3 mm), with a complaint of bleeding gums within the age group of 20-40 years enrolled with their informed consent were included in this study.

The subjects were randomly assigned into two groups - test group (n = 120) and control group (n = 120).


All the test group patients were advised to dilute 2 ml of tincture of calendula with 6 ml of distilled water and rinse their mouths once in the morning and once in the evening for six months. Similarly, the control group patients were advised to use 8 ml distilled water (placebo) as a control mouthwash and rinse mouth twice daily for six months.


In the absence of scaling (that is, between the first and second visit), the test group showed a statistically significant reduction in the scores of plaque index (PI), gingival index (GI), sulcus bleeding index (SBI), and oral hygiene index-simplified (OHI-S) compared to the control group when the baseline scores were compared with the third-month scores.


However, when scaling was performed during the third month (second visit), there was a statistically significant reduction in the scores of all parameters when the third-month scores were compared with the sixth-month scores in both groups, but the test group showed a significantly greater reduction in the PI, GI, SBI, and OHI-S scores compared to that of the control group.

These results clearly suggested that calendula mouthwash is effective in reducing dental plaque and gingivitis adjunctive to scaling, according to the researchers.

In order to reveal more information about herbal Calendula anti-gingivitis effects, researchers investigated the effects of a topic gel containing clobetasol propionate and Calendula officinalis L in an acetate tray over two years.

The study included 2 patients with a diagnosis of lichen planus presenting as DG, researchers found that the symptomatic outbreaks were delayed and presented as less severe symptoms in the two years follow-up.

The findings indicated the topic of gel treatment reduces the length and severity of symptomatic outbreaks desquamative gingivitis.

Taken altogether, herbal Calendula may be used as a mouthwash or topical gel for the prevention and treatment of gingivitis with no side effects, pending the result of a larger and multicenter human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent by Khairnar MS, Pawar B, Marawar PP, Mani A.(PubMed)
(2) Management of two cases of desquamative gingivitis with clobetasol and Calendula officinalis gel by Machado MA1, Contar CM, Brustolim JA, Candido L, Azevedo-Alanis LR, Gregio AM, Trevilatto PC, Soares de Lima AA. (PubMed)
(3) Are obesity and overweight associated with gingivitis occurrence in Brazilian schoolchildren by Nascimento GG1, Seerig LM, Vargas-Ferreira F, Correa FO, Leite FR, Demarco FF. (PubMed)

Herbal Ashwagandha the Anti Rheumatoid Arthritis Herbal Medicine

Rheumatoid Arthritis, a type of musculoskeletal disorders (MSDs) is a chronic disorder characterized by inflammation of the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 50, causing the diminished quality of life of many elders.

Musculoskeletal disorders (MSDs) are medical conditions mostly caused by work-related occupations and working environments, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time.

According to a community sample of 73 females and 32 males aged 85 and over who underwent a standardized examination at home, musculoskeletal pain was reported by 57% of those interviewed.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affects over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot. The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...

Long-term bone damage and the prolonged onset of the disease can induce deformities of hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.

Dr. Motl RW and Dr. McAuley E. in the assessment of chronic diseases said, " The rationale and the associated onset of chronic disease conditions that influence function, disability, and quality of life (QOL) are embedded in the "Graying of America""(29), including patients with RA.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of arthritis, researchers examined the effect of Cannabis sativa, Prunella vulgaris, and Withania somnifera) possess anti-inflammatory, and-rheumatic arthritis properties.

According to the tested analysis, the tested medical plants showed a significant effect on RA by targeting TNF-α through its anti-inflammatory activity.

More precisely, twenty unique molecules found in the medical plants including Withania somnifera were attributed to the utmost binding affinity, least binding energies associated with the interaction of receptor-ligand interactions of residues against RA.


Based on the findings, researchers said, " the RA patients should use reported compounds for the prescription of RA by targeting TNF-α. This report is opening new dimensions for designing innovative therapeutic targets to cure RA.".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of RA, pending to the result of larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparative in silico analyses of Cannabis sativa, Prunella vulgaris and Withaniasomnifera compounds elucidating the medicinal properties against rheumatoid arthritis by Zaka M1, Sehgal SA2, Shafique S3, Abbasi BH. (PubMed)
(2) Most Common Diseases of elder: The Clinical Trials and Studies of musculoskeletal disorders: Osteoporosis - The Symptoms by Kyle J. Norton
(3) Physical activity, disability, and quality of life in older adults by Motl RW1, McAuley E. (PubMed)

Cat's Claw, the Best Whole Herb medicine for Treatment of Type I Diabetes

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Progression of immune-mediated diabetes or Type 1 diabetes mellitus is a chronic T cell-mediated disease resulting from autoimmune destruction of pancreatic beta-cells.

A recent study suggested that Cat's Claw may be effective for the treatment of diabetes-induced by Th1/Th2 (T cell) cytokine production.


In vivo, immunotoxicity testing, BALB/c male mice treated once a day with 125, 500 or 1250 mg/kg of U. tomentosa extract for 28 days, increased the number of T helper lymphocytes and B lymphocytes. The whole herb medicine also significantly exerted a large stimulatory effect on lymphocyte(a form of small white blood cell) viability.

Other study involved C57BL/6 male mice injected with MLDS (40 mg/kg) orally treated with UT at 10-400mg/kg during 21 days, showed to express a significant protection against the loss of insulin-secreting presented β-cells, through modulated the production of two helper T cell classes, known as Th1 and Th2, with increased levels of type-2 T helper cells and mast cells, known as IL-5 and the protein regulated activities of white blood cells known as IL-2.

Further linking Interleukin-2 effected on type I diabetes, the study of Interleukin-2 and type 1 diabetes and several autoimmune diseases suggested that depended on interleukin-2 (IL-2) in proliferating and controlling the T effector cells (Teff) reaction, low dose IL-2 treatment at the initial time of diabetes can rescue insulin secretion by restoring proteins expression.


Dr. Rosenzwajg M, the lead author said, " Regulatory T cells (Tregs) play a major role in controlling effector T cells (Teffs) responding to self-antigens, which cause autoimmune diseases.,....and expanding/activating Tregs with low-dose interleukin-2 (IL-2) could provide immunoregulation without immunosuppression"

Cat's Claw may be effective in protein regulated activities of white blood cells, known as IL-2 through the improvement of immune function in induced immunosuppression cause of Type I diabetes, but the quantity intake should only be prescribed by professional herbalist to prevent toxicity.


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Sources
(1) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both? by Domingues A1, Sartori A, Golim MA, Valente LM, da Rosa LC, Ishikawa LL, Siani AC, Viero RM.(PubMed)
(2) Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile by Domingues A1, Sartori A, Valente LM, Golim MA, Siani AC, Viero RM.(PubMed)
(3) Interleukin-2 and type 1 diabetes: new therapeutic perspectives by Hartemann A1, Bourron O.(PubMed)
(4) Interleukin 2 in the pathogenesis and therapy of type 1 diabetes by Rosenzwajg M1, Churlaud G, Hartemann A, Klatzmann D.(PubMed)