Vitamin B12 and Endometrial Cancer

Kyle J. Norton

The incidence of endometrial cancer among white women are higher in comparison of black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin, found abundantly in a variety of foods, such as fish, shellfish, meat, eggs, dairy products, etc. and plays an important role in regulating the functions of nervous system and formation of blood.

Epidemiological studies, focusing vitamin B12 in reduced risk of endometrial cancer have produced inconsistent results, but in certain studies, vitamin B12 composted with other micro nutrients was found to be effective. Neurotoxicity caused by Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) may induce peripheral neuropathy, the study of Goshajinkigan (a traditional Japanese herbal medicine) composed with vitamin B12, showed to inhibit the progression of peripheral neuropathy, thus alleviating the symptoms of endometrial cancer(1). One-carbon metabolism, vitamin B12 showed no influence endometrial cancer risk but for women with with the MTHFR 677 TT or MTHFR 1298 CC genotype, the dietary factors including vitamin B12 are associated to the protective effect against endometrial cancer(2). Due to the influence of Folate, methionine, vitamin B(6) and vitamin B(12)  in the one-carbon metabolism pathway which is critical for DNA synthesis, methylation and repair some researchers suggested that intake of these nutrients may be associated with an reduced risk of breast, colon and endometrial cancers(3).

Taking altogether. without going into reviews, vitamin B12 composed with other micronutrients may be efective in reduced risk and treatment of endometrial cancer but large example size are necessary to validate their claims. Over doses of the vitamin may induce symptoms of toxicity, including headache, giddiness and abnormal heart functioning, etc., please make sure to follow the guideline of the Institute of Medicine of the National Academies.

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References
(1) Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative study by Kaku H¹, Kumagai S, Onoue H, Takada A, Shoji T, Miura F, Yoshizaki A, Sato S, Kigawa J, Arai T, Tsunoda S, Tominaga E, Aoki D, Sugiyama T.(PubMed)
(2) One-carbon metabolism factors and endometrial cancer risk by Liu JJ¹, Hazra A, Giovannucci E, Hankinson SE, Rosner B, De Vivo I.(PubMed)
(3) Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk by Harris HR¹, Cramer DW, Vitonis AF, DePari M, Terry KL.(PubMed)