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By Kyle J. Norton Health article writer and researcher; Over 10.000
articles and research papers have been written and published on line,
including world wide health, ezine articles, article base, healthblogs,
selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
V. Treatments
C. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.5. According to TCM philosophy, dementia is also to be
induced by the combination/or of Kidney essence vacuity and toxin
(turbid phlegm).
C.5.1. Dementia due to toxins accumulation
Toxins accumulation in internal organs disturbed the balance of
immunity(1213)(1214) may cause impairment of food intake
regulation(1215), exhibition of phlegm(1208)(1208)(1210), retention of
fluid(1211)(1212) and blood statsis(1209) induced early the onset of
dementia, in aging population with gradual depletion of
kidney-essence(1208)(1209), according to traditional Chinese medicine.
Herbal Medicine for toxins elimination
Chinese Herbal medicine for toxins elimination
3. Da Suan(Garlic) used in the treatment of symptoms of dementia(1283)(1284)(1285), including Alzheimer's
pathophysiology(1288)(1289) in traditional Chinese medicine, may be due
to its effectiveness of phytochemicals aged garlic extract and S-allyl-L-cysteine and extracts(1284) in oxidative
stress inhibition(1284) and anti progression involved association of
degeneration and neuro inflammatory activity(1286) through neuro
protection against amyloid-beta peptide-induced apoptosis(1285) and toxicity(1287).
3.1. In Alzheimer's disease
Strong evidences suggested that deposited amyloid-beta(Abeta) has shown
to associated to the progression in Alzheimer's disease
(AD)(1290)(1291)(1292), In mouse model induced by neurotoxic amyloid
beta protein (Aβ), ethyl acetate fractions of garlic extract exhibited
high levels of radical scavenging activity involved cognitive impairment
against Aβ-induced neuronal deficit and Aβ-induced learning and memory
deficits in vivo(1293). According to Indiana University School of
Medicine, the extracts also attenuated synaptic degeneration and
neuroinflammatory pathways associated with AD, through major
phytochemical S-allyl-L-cysteine (SAC) (1294), including oxidative
insults to neurons(1295). In Alzheimer's transgenic model Tg2576,
dietary aged garlic extract (AGE) (2%)
showed to exhibited anti-amyloidogenic, anti-inflammatory and
anti-tangle effects also through its phytochemicals S-allyl-cysteine
(SAC) (20 mg/kg) and di-allyl-disulfide (DADS)(1296) without without
interfering with its antibiotic activity in ameliorate gentamicin
(GM)effectiveness(1297).
3.2. In Parkinson disease
Olfactory dysfunction(1298)(1299) in non-motor functioning and
hyposmia(1300)(1301)/anosmia(1302)(1303) are common manifestation in
some neurodegenerative disorders caused by oxidative stress (OS) and
inflammatory insults(1305), including Parkinson disease. Dietary
supplement S-methyl-L-cysteine, a substrate in the catalytic
antioxidant system mediated by MSRA showed to protect cells from
oxidative damage through its antioxidative effect(1304) when used
conjunction with methionine sulfoxide reductase A in Parkinson's-like symptoms(1304).
3.3. In Cognitive impairment
In early cognitive deficits caused by gradually of accumulation of
beta-amyloid peptide (Abeta) oligomers of Abeta42 species, aged garlic
extract, in mice model, prevented progressive behavioral
impairment, slowed plaque development, through protection against
deterioration of hippocampal based memory(1306), In Alzheimer's disease
induced mice model, S-allyl cysteine, a component of aged garlic
extract, ameliorated cognitive deficits and oxidative damage in the
hippocampus of intracerebroventricular streptozotocin (ICV-STZ)(1308).
According to Gyeongsang National University, the effectiveness of aged garlic extracts, in neurodegenerative disorders, notably Alzheimer's disease(AD), may be due to its antioxidant activities in improvement of cognitive impairment against Aβ-induced neuronal deficit(1307).
3.4. In learning and memory
Acute and chronic oral administration of aged garlic extract, in mice using step down latency (SDL) by passive avoidance response and transfer latency (TL) using elevated plus maze, improved learning and memory probably due to cortical acetylcholinesterase (AchE) and reduced glutathione (GSH) levels activities and anti-oxidant property(1309). In oxidative damage and spatial learning and memory
deficits induced mice model, S-allylcysteine exerted its protective
effect against reactive oxygen species. Abeta(25-35)-induced hippocampal
toxicity and learning deficits, through its free radical scavenging and ameliorated lipid peroxidation activities(1310).
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
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(1310) http://www.ncbi.nlm.nih.gov/pubmed/15087243
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