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By Kyle J. Norton Health article writer and researcher; Over 10.000
articles and research papers have been written and published on line,
including world wide health, ezine articles, article base, healthblogs,
selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is the
loss of mental ability, severe enough to interfere with people's every
life and Alzheimer's disease is the most common type of dementia in
aging people.
V. Treatments
C. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records. causes of dementia are the results of (*)
C.5. According to TCM philosophy, dementia is also to be
induced by the combination/or of Kidney essence vacuity and toxin (turbid phlegm).
C.5.1. Dementia due to toxins accumulation
Toxins
accumulation in internal organs disturbed the balance of
immunity(1213)(1214) may cause impairment of food intake
regulation(1215), exhibition of phlegm(1208)(1208)(1210), retention of
fluid(1211)(1212) and blood statsis(1209) induced early the onset of
dementia, in aging population with depletion of
kidney-essence(1208)(1209), according to traditional Chinese medicine.
Herbal Medicine for toxins elimination
Chinese Herbal medicine for toxins elimination
1. Shui Fei Zi or Milk thistle (Silybum marianum)
Shui fei zi, the bitter and cold herb, is also known as milk thistle, native to Western Europe and northern Africa, used in traditional Chinese medicine to improve liver function(1193)(1194)(1210), promote the flow of breast milk(1207), bile secretion(1200),
anti depression(1201) and anti tumors(1196)(1197)(1198), inhibit
allergic effects(1195)(1199), treat hepatitis C(1202)(1203),
cirrhosis(1205) and liver fibrosis(1206), by enhancing function of liver and gallbladder channels(1204)
Phytochemicals
1. Flavonoid
2. Fumaric acid
3. Silymarin
4. Isosilybin,
5. Dehydrosilybin,
6. Silydianin
7. Silychristin
8. Cinnamic acid
9. Myristic acid
10. Palmitelaidic acid
10. Arachidic acid
11. Etc.
Shui Fei Zi or Milk thistle used in the treatment and prevention of dementia(1218)
in traditional Chinese medicine, may be due to its effectiveness of
phytochemicals Silymarin and Silibinin in ameliorated amyloid pathology(1216) and oxidative stress(1216)(1217) through attenuated levels of lipid peroxidation (malondialdehyde) and antioxidant (glutathione) in the hippocampus(1217).
1.1. In Alzheimer's disease
Alzheimer disease
(AD). a neurodegenerative disorders is the most prevalent diseases in
the United States, in aging population(1219). Silymarin, a phytochemical
found abundantly in milk thistle, in age related disorders like
neurodegenerative diseases improved locomotion rate, higher response to
stimuli and tolerance to stress, in C.elegans Alzheimer's Model, through delayed paralysis via enhanced resistance to oxidative stress(1220). In rat induced Alzheimer's disease
model, the phytochemical also inhibited amyloid formation(1222) and
suppressed amyloid protein precursor (APP) expression(1222)and reduced
neurotoxicity in PC12 cells(1222) in improvement memory(1223) and
learning function(1221).
1.2. In Parkinson disease
In a mouse model of Parkinson's disease, causes
of mitochondrial dysfunction and selective cells death of
dopaminergic neurons, silibinin, derivative of silymarin, protected
mitochondria through attenuated motor deficit and dopaminergic neuronal
loss(1224) and anti oxidative and anti inflammatory pathways(1225).
1.3. In neuroprotective effects
In focal cerebral ischemia, silymarin (SM), a mixture of flavonolignans extracted from the milk thistle exerted it neuroprotective effects, in
upregulating the antioxidant status and lowering the apoptotic response
in slowing down the progression of neurodegeneration(1226) and
preventing inflammation-related neurodegenerative disease(1227) and ROS
causs of oxidative damage to macromolecules in the brain(1230).
1.4. In cognitive impairment
In cognitive deficit mice model, silibinin exhibited its anti cognitive impairment effects through amelioration
of decreases in dopamine and serotonin levels in the prefrontal cortex
and hippocampus, (1228). In amyloid
beta peptide-induced memory impairment, the chemicals also improve
cognitive memory deficits through attenuated the Abeta(25-35)-
accumulation of malondialdehyde and depletion of glutathione in the
hippocampus(1229).
Reprinted from Norton Journal, Volume
I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of
Central Nervous system(CNS): Dementia - Treatments in Traditional
Chinese Herbal Medicine by Kyle J. Norton.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(1193) http://www.ncbi.nlm.nih.gov/pubmed/9468229
(1194) http://www.ncbi.nlm.nih.gov/pubmed/20564545
(1195) http://www.ncbi.nlm.nih.gov/pubmed/23121838
(1196) http://www.ncbi.nlm.nih.gov/pubmed/23879966
(1197) http://www.ncbi.nlm.nih.gov/pubmed/24574320
(1198) http://www.ncbi.nlm.nih.gov/pubmed/25242120
(1199) http://www.ncbi.nlm.nih.gov/pubmed/23701595
(1200) http://www.ncbi.nlm.nih.gov/pubmed/17692492
(1201) http://www.ncbi.nlm.nih.gov/pubmed/25431050
(1202) http://www.ncbi.nlm.nih.gov/pubmed/25247194
(1203) http://www.ncbi.nlm.nih.gov/pubmed/22797645
(1204) http://alternativehealing.org/shui_fei_ji.htm
(1205) http://www.ncbi.nlm.nih.gov/pubmed/15277093
(1206) http://www.ncbi.nlm.nih.gov/pubmed/22087179
(1207) http://www.ncbi.nlm.nih.gov/pubmed/23468043
(1208) http://www.ncbi.nlm.nih.gov/pubmed/24187864
(1209) http://www.ncbi.nlm.nih.gov/pubmed/22500712
(1210) http://www.ncbi.nlm.nih.gov/pubmed/24155069
(1211) http://www.ncbi.nlm.nih.gov/pubmed/25155658
(1212) http://www.ncbi.nlm.nih.gov/pubmed/25162367
(1213) http://www.ncbi.nlm.nih.gov/pubmed/24719080
(1214) http://www.ncbi.nlm.nih.gov/pubmed/22866982
(1215) http://www.ncbi.nlm.nih.gov/pubmed/16769094
(1216) http://www.ncbi.nlm.nih.gov/pubmed/21185897
(1217) http://www.ncbi.nlm.nih.gov/pubmed/19552690
(1218) http://www.ncbi.nlm.nih.gov/pubmed/21071836
(1219) http://www.ncbi.nlm.nih.gov/pubmed/25696782
(1220) http://www.ncbi.nlm.nih.gov/pubmed/25613505
(1221) http://www.ncbi.nlm.nih.gov/pubmed/24460990
(1222) http://www.ncbi.nlm.nih.gov/pubmed/21071836
(1223) http://www.ncbi.nlm.nih.gov/pubmed/19638571
(1224) http://www.ncbi.nlm.nih.gov/pubmed/25677261
(1225) http://www.ncbi.nlm.nih.gov/pubmed/24660866
(1226) http://www.ncbi.nlm.nih.gov/pubmed/21840019
(1227) http://www.ncbi.nlm.nih.gov/pubmed/20833521
(1228) http://www.ncbi.nlm.nih.gov/pubmed/19857526
(1229) http://www.ncbi.nlm.nih.gov/pubmed/19552690
(1230) http://www.ncbi.nlm.nih.gov/pubmed/19647779
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