Scientists may have found a natural whole food for the treatment of type II diabetes without inducing any side effects, some studies suggested,
Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The exact cause of type II diabetes is unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.
Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol and women with polycystic ovary syndrome.
Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications" and "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing the diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".
These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.
Medication including Alpha-glucosidase inhibitors. Thiazolidinediones (TZDs) Glucagonlike peptide–1 (GLP-1) agonists. Dipeptidyl peptidase IV (DPP-4) inhibitors used for the treatment of type II diabetes may be effective, however, they are to know to induce serious side effects such as low blood sugar, upset stomach, skin rash or itching, weight gain. kidney complications, upset stomach, tiredness or dizziness,... and metal taste.
If you are currently taking one of the above medicine, please make sure that you discuss the side effects with your doctor and know how to deal with them.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
Herbal medicine has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc..
The Chemical ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
In the study to examine the clinical effectiveness of aloe vera, a popular herbal remedy in the United Kingdom for the treatment of type II diabetes, researchers at the University of Exeter, launched a review by researching the database of MEDLINE, EMBASE, Biosis, and the Cochrane Library.
Only controlled clinical trials (on any indication) were included in the study.
There were no restrictions on the language of publication. All trials were read and data were extracted in a standardized, pre-defined manner.
After differentiating the 10 selected studies, researchers found that oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidemia.
However, the topical application of aloe vera was not an effective preventative for radiation-induced injuries.
Furthermore, Dr. Okyar A and colleagues, in clarifying the controversy over the past 15 years on the hypoglycemic activity of Aloe species, launched an investigation with separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats.
At the end of the experiment, researchers found that
* Application of Aloe vera A. vera leaf pulp and gel extracts were ineffective on lowering the blood sugar level of ND rats.
* A. vera leaf pulp extract showed hypoglycemic activity on IDDM and NIDDM rats, the effect being enhanced for type II diabetes in comparison with glibenclamide.
* On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats.
These results suggested, pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin dependent diabetes mellitus.
Taken all together Aloe Vera may be considered an adjunct therapy for treatment in patients non-insulin-dependent type 2 diabetes.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food Aloe vera during the course of the disease will be necessary to complete the picture of Aloe vera anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(2) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)
(3) Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)
(4) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)
Thursday, October 31, 2019
Navy Bean Promotes the Expression of Metabolite Markers that Improve Colon Health
Metabolite markers are the reaction of the metabolites that respond sensitively to phytochemical exposure.
Phytochemicals are plant-based natural components that form an important part in the human diet and animal feed. Synthetic phytochemicals are also commonly found in dietary supplements and pharmacological agents.
Phytochemicals are chemical compound produced by the plants to protect them against predators such as insects and bacteria and fungi. Some phytochemicals are also used in traditional medicine to combat diseases.
According to Prof. Chi Chen in the investigation of the metabolite markers of phytochemicals wrote, "the bidirectional interactions between phytochemicals and the metabolic system, such as the disposition of phytochemicals, the regulation of nutrient, antioxidant, and microbial metabolism, and overdose-induced toxicities".
In other words, phytochemicals including bioactive phytochemical play an essential role in regulating the metabolic system through many metabolic pathways.
Believe it or not, metabolic effects have a strong impact on phytochemicals on the digestion, absorption, distribution, and metabolism of nutrients and antioxidants.
On the digestive system, bioactive phytochemicals play an essential role in the human diet as a valuable source of many bioactive components: phenolic compounds, vitamins or bioactive peptides.
On chronic diseases, consumption of total phytochemical intake has been found to reduce the risk of cardiovascular disease, cancer, and neurodegenerative diseases.
On the metabolism of nutrients, gene-phytochemical interactions are individual differences depending on the individual genetic proposition, including the capacity to influence disease risk via several complementary and overlapping mechanisms.
More precisely, a person genetic variation in pathways has a strong effect on absorption, metabolism, and distribution of phytochemicals that expose at the tissue level or alter the biological response.
On antioxidant perspective, although phytochemicals and antioxidants are different, phytochemical antioxidants capacity demonstrated potential effects on oxidative status, that decrease the risk proteins, lipids, and cellular damage.
Collectively, by looking at the forms of metabolite markers, the tested assays after exposing to phytochemicals, researchers may know the inaction of the phytochemical and metabolic system.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
With an aim to find a natural compound for the promotion of gut health, researchers examined investigated metabolite markers of dry bean consumption in parallel human and mouse studies.
The study included 46 men who received dry bean enriched diet (250 g/day) for 4-weeks and 12 mice that received a standardized diet containing either 0 or 10% navy bean ethanol extract for 6 weeks.
According to the self-reported compared to the baseline, serum pipecolic acid (PA) and S-methyl cysteine (SMC) were elevated after dry bean consumption in human and mouse studies.
In other words, serum levels of pipecolic acid and S-methyl cysteine are metabolite markers that are useful to measure the amount of dry and navy bean consumption.
More precisely, according to the unpaired t-tests, a navy bean extract-enriched diet altered 26 metabolites (9% of analyzed metabolites) at P < 0.05 and 7 metabolites (2.4%) at q < 0.05 using unpaired t-tests; the most significant being PA, SMC, and NAO (all q < 0.003).
Furthermore, identified the biomarkers of dry (navy) bean intake may improve the understanding of the effect of navy bean in reducing the risk of colorectal cancer.
In intestinal microbial metabolism, the conversion of lysine to pipecolic acid (PA) may confer chemopreventive benefits for the human host because PA is a precursor of microbial compounds with anti-inflammatory property.
Taken altogether, the dry beans including navy bean may be considered a remedy for the improvement of colon health, through its metabolite markers, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies by Perera T1, Young MR, Zhang Z, Murphy G, Colburn NH, Lanza E, Hartman TJ, Cross AJ, Bobe G. (PubMed)
(2) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(3) Metabolite Markers of Phytochemicals by Prof. Chi Chen (Metabolites)
Phytochemicals are plant-based natural components that form an important part in the human diet and animal feed. Synthetic phytochemicals are also commonly found in dietary supplements and pharmacological agents.
Phytochemicals are chemical compound produced by the plants to protect them against predators such as insects and bacteria and fungi. Some phytochemicals are also used in traditional medicine to combat diseases.
According to Prof. Chi Chen in the investigation of the metabolite markers of phytochemicals wrote, "the bidirectional interactions between phytochemicals and the metabolic system, such as the disposition of phytochemicals, the regulation of nutrient, antioxidant, and microbial metabolism, and overdose-induced toxicities".
In other words, phytochemicals including bioactive phytochemical play an essential role in regulating the metabolic system through many metabolic pathways.
Believe it or not, metabolic effects have a strong impact on phytochemicals on the digestion, absorption, distribution, and metabolism of nutrients and antioxidants.
On the digestive system, bioactive phytochemicals play an essential role in the human diet as a valuable source of many bioactive components: phenolic compounds, vitamins or bioactive peptides.
On chronic diseases, consumption of total phytochemical intake has been found to reduce the risk of cardiovascular disease, cancer, and neurodegenerative diseases.
On the metabolism of nutrients, gene-phytochemical interactions are individual differences depending on the individual genetic proposition, including the capacity to influence disease risk via several complementary and overlapping mechanisms.
More precisely, a person genetic variation in pathways has a strong effect on absorption, metabolism, and distribution of phytochemicals that expose at the tissue level or alter the biological response.
On antioxidant perspective, although phytochemicals and antioxidants are different, phytochemical antioxidants capacity demonstrated potential effects on oxidative status, that decrease the risk proteins, lipids, and cellular damage.
Collectively, by looking at the forms of metabolite markers, the tested assays after exposing to phytochemicals, researchers may know the inaction of the phytochemical and metabolic system.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
With an aim to find a natural compound for the promotion of gut health, researchers examined investigated metabolite markers of dry bean consumption in parallel human and mouse studies.
The study included 46 men who received dry bean enriched diet (250 g/day) for 4-weeks and 12 mice that received a standardized diet containing either 0 or 10% navy bean ethanol extract for 6 weeks.
According to the self-reported compared to the baseline, serum pipecolic acid (PA) and S-methyl cysteine (SMC) were elevated after dry bean consumption in human and mouse studies.
In other words, serum levels of pipecolic acid and S-methyl cysteine are metabolite markers that are useful to measure the amount of dry and navy bean consumption.
More precisely, according to the unpaired t-tests, a navy bean extract-enriched diet altered 26 metabolites (9% of analyzed metabolites) at P < 0.05 and 7 metabolites (2.4%) at q < 0.05 using unpaired t-tests; the most significant being PA, SMC, and NAO (all q < 0.003).
Furthermore, identified the biomarkers of dry (navy) bean intake may improve the understanding of the effect of navy bean in reducing the risk of colorectal cancer.
In intestinal microbial metabolism, the conversion of lysine to pipecolic acid (PA) may confer chemopreventive benefits for the human host because PA is a precursor of microbial compounds with anti-inflammatory property.
Taken altogether, the dry beans including navy bean may be considered a remedy for the improvement of colon health, through its metabolite markers, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies by Perera T1, Young MR, Zhang Z, Murphy G, Colburn NH, Lanza E, Hartman TJ, Cross AJ, Bobe G. (PubMed)
(2) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(3) Metabolite Markers of Phytochemicals by Prof. Chi Chen (Metabolites)
Cranberry Arrests Breast Cancer Cells in Vitro
The women's breasts are made of tissues that produce milk (glandular tissue) and fat. The size of a woman's breast is totally depending on the amount of fat in the breast.
Cancer is a class of medical conditions associated with cell growth uncontrollably in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
Most common secondary cancers spread by primary breast cancer are bone, liver, lung and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime the risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue and smoking are some of the most prevalent factors that are found patient with the disease.
However, some researchers in the investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes the increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cell.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constant increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)
Cancer is a class of medical conditions associated with cell growth uncontrollably in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
Most common secondary cancers spread by primary breast cancer are bone, liver, lung and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime the risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue and smoking are some of the most prevalent factors that are found patient with the disease.
However, some researchers in the investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes the increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cell.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constant increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)
Beware of Drug Interaction of Green tea and Green Tea Extract, Scientists Warn
Green may have processed a drug interaction property that inhibits the effect of conventional medicine, some scientists suggested.
Drug interactions are the greatest concern of some scientists, particularly in the pharmaceutical community as these effects can potentially reduce the desired effects for the treatment of certain diseases.
Intake of some drugs together, can reduce the absorption or increase the metabolism or elimination of other drugs treatment potential.
Some drugs interaction can cause an allergic reaction from skin rash and itching to a life-threatening anaphylactic reaction.
If you are taking some drugs for the treatment of certain diseases, please make sure that you know some may interact with the others.
The Havard health in the article "7 things you can do to avoid drug interactions"(4) suggested that you
1. Know why you are taking each medication
2. Know how to take the drug
3. Fill all your prescriptions at the same pharmacy
4. Are suspicious of supplements
5. Go easy on grapefruit juice
6. Limit intake of alcohol
7. Talk to your pharmacist
Green tea is a precious drink processed number of health benefits known to almost everyone in Asia and the Western world.
In the review the summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters, researchers at the Prince Sattam Bin Abdulaziz University, Al-Kharj suggested that
* Green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of the cytochrome P450 superfamily of enzymes of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. UGT1A1 and UGT1A4 but not the major cytochrome P450 enzyme, in vitro
Where cytochrome P450 enzymes have a unique function in metabolizing potentially toxic compounds, including drugs and products of endogenous metabolism.
* A clinical study, the organic anion transporting polypeptide 1A1 transporter with the potential role of liver transporters and bile acids is also inhibited by (-)-epigallocatechin-3-gallate while P-glycoprotein, the multidrug resistance protein 1 (MDR1) is unaffected
These results suggested that patients should be cautious that the consumption of significant amounts of green tea beverages or green tea extract may interact with the substrates of organic anion transporting polypeptide as mentioned above.
Further to investigate the effects of green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) on the pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes launched a study o the. male Sprague-Dawley rats.
The tested animals were given GTE (400 mg/kg), EGCG (150 mg/kg) or saline (control) by oral gavage, 30 min before a single intragastric administration of 10 mg/kg nadolol.
At the end of the experiment, researchers showed that
* Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, compared with control.
* EGCG alone significantly reduced Cmax and AUC of nadolol.
* The amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life of nadolol was not different among groups.
These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol, possibly through the inhibition of its intestinal absorption mediated by uptake transporters.
Taken all together, green tea, green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) can interact with the drug-metabolizing enzymes and drug transporters including nadolol.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats by Misaka S1, Miyazaki N, Fukushima T, Yamada S, Kimura J.(PubMed)
(2) An Appraisal of Drug-Drug Interactions with Green Tea Albassam AA1, Markowitz JS2.(PubMed)
(3) Effects of green tea extract on the pharmacokinetics of quetiapine in rats by Ezzeldin E1, Asiri YA2, Iqbal M1. (PubMed)
(4) 7 things you can do to avoid drug interactions by Harvard Health
Drug interactions are the greatest concern of some scientists, particularly in the pharmaceutical community as these effects can potentially reduce the desired effects for the treatment of certain diseases.
Intake of some drugs together, can reduce the absorption or increase the metabolism or elimination of other drugs treatment potential.
Some drugs interaction can cause an allergic reaction from skin rash and itching to a life-threatening anaphylactic reaction.
If you are taking some drugs for the treatment of certain diseases, please make sure that you know some may interact with the others.
The Havard health in the article "7 things you can do to avoid drug interactions"(4) suggested that you
1. Know why you are taking each medication
2. Know how to take the drug
3. Fill all your prescriptions at the same pharmacy
4. Are suspicious of supplements
5. Go easy on grapefruit juice
6. Limit intake of alcohol
7. Talk to your pharmacist
Green tea is a precious drink processed number of health benefits known to almost everyone in Asia and the Western world.
In the review the summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters, researchers at the Prince Sattam Bin Abdulaziz University, Al-Kharj suggested that
* Green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of the cytochrome P450 superfamily of enzymes of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. UGT1A1 and UGT1A4 but not the major cytochrome P450 enzyme, in vitro
Where cytochrome P450 enzymes have a unique function in metabolizing potentially toxic compounds, including drugs and products of endogenous metabolism.
* A clinical study, the organic anion transporting polypeptide 1A1 transporter with the potential role of liver transporters and bile acids is also inhibited by (-)-epigallocatechin-3-gallate while P-glycoprotein, the multidrug resistance protein 1 (MDR1) is unaffected
These results suggested that patients should be cautious that the consumption of significant amounts of green tea beverages or green tea extract may interact with the substrates of organic anion transporting polypeptide as mentioned above.
Further to investigate the effects of green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) on the pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes launched a study o the. male Sprague-Dawley rats.
The tested animals were given GTE (400 mg/kg), EGCG (150 mg/kg) or saline (control) by oral gavage, 30 min before a single intragastric administration of 10 mg/kg nadolol.
At the end of the experiment, researchers showed that
* Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, compared with control.
* EGCG alone significantly reduced Cmax and AUC of nadolol.
* The amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life of nadolol was not different among groups.
These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol, possibly through the inhibition of its intestinal absorption mediated by uptake transporters.
Taken all together, green tea, green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) can interact with the drug-metabolizing enzymes and drug transporters including nadolol.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats by Misaka S1, Miyazaki N, Fukushima T, Yamada S, Kimura J.(PubMed)
(2) An Appraisal of Drug-Drug Interactions with Green Tea Albassam AA1, Markowitz JS2.(PubMed)
(3) Effects of green tea extract on the pharmacokinetics of quetiapine in rats by Ezzeldin E1, Asiri YA2, Iqbal M1. (PubMed)
(4) 7 things you can do to avoid drug interactions by Harvard Health
Herbal Andrographis, the Natural Liver Protective Functional Remedy, Studies Found
Scientists may have found a herbal medicine which processes strong liver-protective effects, some studies suggested.
The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.
There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.
In the article on liver diseases, the 24 health also include autoimmune diseases that cause inflammation to the liver.
Sadly, according to the statistic, the mortality rate infected by viral hepatitis have increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.
Please check with your doctor to rule out the liver disease and damage possibility, if you are experiencing some of the above symptoms.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoids viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
As of today, despite enormous advances in modern medicine, conventional medicine can only focus to reduce symptoms of liver diseases. There is no completely effective medicine that can stimulate hepatic function, or offer complete protection of the organ, or help to regenerate hepatic cells.
In the finding of a natural hepatoprotective agent that can help to relieve the pressure of conventional medicine in patients with liver damage or diseases, researchers at the Vinayaka Missions University conducted a study to evaluate the liver protective activity of herbal Andrographis in liver injury in rats.
After subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks to induce chronic liver damage, the Male Wistar rats were treated with methanol and aqueous extracts of herbal Andrographis orally at a dose of 845 mg/kg/day.
At the end of the experiment, researchers found that* Herbal Andrographis extracts demonstrate clinically significant activity in comparison to a standard drug.
* Hepatic steatosis, hydropic degeneration and necrosis caused by the injection of the carbon tetrachloride were completely disappeared in the standard and extract-treated groups.
Further analysis also discovered, herbal Andrographis extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury.
Dr. Sangameswaran B, the lead author at the final report wrote, "The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent".
Additional investigation of the liver protective effect of Andrographolide (AN), a major bioactive compound isolated from herbal Andrographis, researchers at the Dr. Hari Singh Gour Central University, formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC) for enhancing absorption with carbon tetrachloride inducing hepatotoxicity rat model and compared.
The ANH showed a significant liver protective effect compared to the standard drug (Silymarin).
Application of ANH in an animal model has better bioavailability than those of AN observed by the statistics in vitro absorption and hence improved hepatoprotection as compared to plain AN at an equivalent dose.
Taken all together, herbal Andrographis and its bioactive ingredient Andrographolide (AN)may be considered an adjunct therapy in aiding the conventional medicine in providing the extra protection of the liver and treatment of liver damage and diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH. (PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. (PubMed)
The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.
There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.
In the article on liver diseases, the 24 health also include autoimmune diseases that cause inflammation to the liver.
Sadly, according to the statistic, the mortality rate infected by viral hepatitis have increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.
Please check with your doctor to rule out the liver disease and damage possibility, if you are experiencing some of the above symptoms.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
The Ingredients
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoids viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
As of today, despite enormous advances in modern medicine, conventional medicine can only focus to reduce symptoms of liver diseases. There is no completely effective medicine that can stimulate hepatic function, or offer complete protection of the organ, or help to regenerate hepatic cells.
In the finding of a natural hepatoprotective agent that can help to relieve the pressure of conventional medicine in patients with liver damage or diseases, researchers at the Vinayaka Missions University conducted a study to evaluate the liver protective activity of herbal Andrographis in liver injury in rats.
After subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks to induce chronic liver damage, the Male Wistar rats were treated with methanol and aqueous extracts of herbal Andrographis orally at a dose of 845 mg/kg/day.
At the end of the experiment, researchers found that* Herbal Andrographis extracts demonstrate clinically significant activity in comparison to a standard drug.
* Hepatic steatosis, hydropic degeneration and necrosis caused by the injection of the carbon tetrachloride were completely disappeared in the standard and extract-treated groups.
Further analysis also discovered, herbal Andrographis extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury.
Dr. Sangameswaran B, the lead author at the final report wrote, "The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent".
Additional investigation of the liver protective effect of Andrographolide (AN), a major bioactive compound isolated from herbal Andrographis, researchers at the Dr. Hari Singh Gour Central University, formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC) for enhancing absorption with carbon tetrachloride inducing hepatotoxicity rat model and compared.
The ANH showed a significant liver protective effect compared to the standard drug (Silymarin).
Application of ANH in an animal model has better bioavailability than those of AN observed by the statistics in vitro absorption and hence improved hepatoprotection as compared to plain AN at an equivalent dose.
Taken all together, herbal Andrographis and its bioactive ingredient Andrographolide (AN)may be considered an adjunct therapy in aiding the conventional medicine in providing the extra protection of the liver and treatment of liver damage and diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH. (PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. (PubMed)
Wednesday, October 30, 2019
Alfalfa, The Functional Herb Which Protects Our Body Against Type 2 Diabetes, Researchers Reveal
Diabetes is a chronic condition characterized by insufficient insulin entering the bloodstream to regulate glucose as a result of either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes may also be caused by allergic reactions of cells in the immune system.
The actual causes of diabetes inflammatory conditions are debatable.
Some researchers also do not know why some people without genetic mutations are susceptible to type 2 diabetes while others do not.
However, certain risk factors such as for overweight and obesity (overexpression of fatty tissue that causes insulin resistant), physical inactivity, family history, race,,,,, and age. ...
Women developed gestational diabetes, polycystic ovary syndrome,.... and high blood pressure is also some major risk factors associated to increase the risk of type 2 diabetes.
The first line medicine used for the treatment of type 2 diabetes is metformin which processes a significant effect in improving the body tissue sensitivity to insulin. In other words, metformin improves the body uses insulin more effectively. and lowers glucose production in the liver.
In stage prediabetes, patients may not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may increase the risk of cataracts and glaucoma, foot damage.
In the advance stage, untreated diabetes can also cause nerve damage or poor blood flow to the feet which in turn, increases the risk of various foot complications.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
It chemical constituents include flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein,.... and coumarin derivatives.
In the study to examine the Lucerne (alfalfa) effect by oral administrated the herbal extract through diet (62.5 g/kg) and drinking water (2.5 g/l) in reducing the hyperglycemia of streptozotocin-diabetic mice, researchers found
* Application of aqueous extract of lucerne exerts a significant stimulation of insulin secretion from the pancreatic B-cell line.
* Application of aqueous extract of lucern also promotes insulin-like activity in inhibited overexpression glucose.
* The sequential extraction with solvents revealed .higher insulin-releasing activity in both methanol and water fractions compared to one extract constituent.
Further analysis also suggested that the activity of the extract was found to be heat stable and enhanced by exposure to acid and alkali (0.1 M-HCl and NaOH).
Dr. Gray AM, the lead author at the final report wrote, "The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativa".
Additionally, in the study to reaffirm the effect herbal alfalfa against onset of diabetes researchers launched a study to compare alfalfa with other herbal medicine including dried leaves of agrimony (Agrimonia eupatoria), blackberry (Rubus fructicosus), celandine (Chelidonium majus), eucalyptus (Eucalyptus globulus), lady's mantle (Alchemilla vulgaris), and lily of the valley (Convallaria majalis); seeds of coriander (Coriandrum sativum); dried berries of juniper (Juniperus communis); bulbs of garlic (Allium sativum) and roots of liquorice (Glycyrhizza glabra).
In mice administrated by streptozotocin (200 mg/kg i.p.) to induce the development of hyperphagia, polydipsia, bodyweight loss, hyperglycemia, and hypoinsulinemia, researchers found that
* Herbal alfalfa exerts a strong effect in reduced the level of hyperglycemia during the development of streptozotocin diabetes compared to other herbs.
* Herbal alfalfa reduced polydipsia and a reduced rate of body weight loss.
* Alfalfa initially countered the hyperinsulinaemic effect of streptozotocin, without affecting the fall in plasma insulin.
Dr. said, after taking into account of other co and confounders, " The results suggest that certain traditional plant treatments for diabetes, namely alfalfa,.......can retard the development of streptozotocin diabetes in mice".
Taking all together, herbal alfalfa may be considered a functional herb for the prevention and treatment of type 2 diabetes.
However, additional data collection on large example size and multi-center clinical studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of alfalfa anti-type 2 diabetes possibilities.
And long-term multiple dietary supplement consumption of a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis should consult with their doctors or related field specialist before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM, Flatt PR. (PubMed)
(2) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. (PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)
In some cases, diabetes may also be caused by allergic reactions of cells in the immune system.
The actual causes of diabetes inflammatory conditions are debatable.
Some researchers also do not know why some people without genetic mutations are susceptible to type 2 diabetes while others do not.
However, certain risk factors such as for overweight and obesity (overexpression of fatty tissue that causes insulin resistant), physical inactivity, family history, race,,,,, and age. ...
Women developed gestational diabetes, polycystic ovary syndrome,.... and high blood pressure is also some major risk factors associated to increase the risk of type 2 diabetes.
The first line medicine used for the treatment of type 2 diabetes is metformin which processes a significant effect in improving the body tissue sensitivity to insulin. In other words, metformin improves the body uses insulin more effectively. and lowers glucose production in the liver.
In stage prediabetes, patients may not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may increase the risk of cataracts and glaucoma, foot damage.
In the advance stage, untreated diabetes can also cause nerve damage or poor blood flow to the feet which in turn, increases the risk of various foot complications.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
It chemical constituents include flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein,.... and coumarin derivatives.
In the study to examine the Lucerne (alfalfa) effect by oral administrated the herbal extract through diet (62.5 g/kg) and drinking water (2.5 g/l) in reducing the hyperglycemia of streptozotocin-diabetic mice, researchers found
* Application of aqueous extract of lucerne exerts a significant stimulation of insulin secretion from the pancreatic B-cell line.
* Application of aqueous extract of lucern also promotes insulin-like activity in inhibited overexpression glucose.
* The sequential extraction with solvents revealed .higher insulin-releasing activity in both methanol and water fractions compared to one extract constituent.
Further analysis also suggested that the activity of the extract was found to be heat stable and enhanced by exposure to acid and alkali (0.1 M-HCl and NaOH).
Dr. Gray AM, the lead author at the final report wrote, "The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativa".
Additionally, in the study to reaffirm the effect herbal alfalfa against onset of diabetes researchers launched a study to compare alfalfa with other herbal medicine including dried leaves of agrimony (Agrimonia eupatoria), blackberry (Rubus fructicosus), celandine (Chelidonium majus), eucalyptus (Eucalyptus globulus), lady's mantle (Alchemilla vulgaris), and lily of the valley (Convallaria majalis); seeds of coriander (Coriandrum sativum); dried berries of juniper (Juniperus communis); bulbs of garlic (Allium sativum) and roots of liquorice (Glycyrhizza glabra).
In mice administrated by streptozotocin (200 mg/kg i.p.) to induce the development of hyperphagia, polydipsia, bodyweight loss, hyperglycemia, and hypoinsulinemia, researchers found that
* Herbal alfalfa exerts a strong effect in reduced the level of hyperglycemia during the development of streptozotocin diabetes compared to other herbs.
* Herbal alfalfa reduced polydipsia and a reduced rate of body weight loss.
* Alfalfa initially countered the hyperinsulinaemic effect of streptozotocin, without affecting the fall in plasma insulin.
Dr. said, after taking into account of other co and confounders, " The results suggest that certain traditional plant treatments for diabetes, namely alfalfa,.......can retard the development of streptozotocin diabetes in mice".
Taking all together, herbal alfalfa may be considered a functional herb for the prevention and treatment of type 2 diabetes.
However, additional data collection on large example size and multi-center clinical studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of alfalfa anti-type 2 diabetes possibilities.
And long-term multiple dietary supplement consumption of a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis should consult with their doctors or related field specialist before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM, Flatt PR. (PubMed)
(2) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. (PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)
Herbal Aloe vera on Acne Vulgaris
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
There are many types of skin diseases in this world, the most common one is acne. Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin becomes the third source for cleansing the remainder of toxins.
The Ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
The benefits
Acne vulgaris, one of the skin diseases with areas of scaly red skin with seborrhea, blackheads, and whiteheads. Aloe vera one of many herbs has been studied and researched in the pharmaceutical world, because of its common problem to the young ages and commercial profits. The study to compare the efficacy and safety of the combination of tretinoin (TR) cream (0.05%) and Aloe vera topical gel (50%) with TR and vehicle, has been well-tolerated and significantly more effective than TR and vehicle for the treatment of mild to moderate acne vulgaris and with less side effects. Other researchers in the observation of traditional medicines of many cultures used to treat skin diseases, indicated that certain ingredients, including aloe vera, have been identified in the treatment of psoriasis and atopic dermatitis,
The Side effects
1. Hepatitis
Some researchers concerned that the overuse of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. by Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A.(PubMed)
(4) Innovations in natural ingredients and their use in skin care. by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
There are many types of skin diseases in this world, the most common one is acne. Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin becomes the third source for cleansing the remainder of toxins.
The Ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
The benefits
Acne vulgaris, one of the skin diseases with areas of scaly red skin with seborrhea, blackheads, and whiteheads. Aloe vera one of many herbs has been studied and researched in the pharmaceutical world, because of its common problem to the young ages and commercial profits. The study to compare the efficacy and safety of the combination of tretinoin (TR) cream (0.05%) and Aloe vera topical gel (50%) with TR and vehicle, has been well-tolerated and significantly more effective than TR and vehicle for the treatment of mild to moderate acne vulgaris and with less side effects. Other researchers in the observation of traditional medicines of many cultures used to treat skin diseases, indicated that certain ingredients, including aloe vera, have been identified in the treatment of psoriasis and atopic dermatitis,
The Side effects
1. Hepatitis
Some researchers concerned that the overuse of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause rheumatoid arthritis symptoms as a result of collagen in the plant
5. Etc.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. by Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A.(PubMed)
(4) Innovations in natural ingredients and their use in skin care. by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
Herbal Arnica, A Remedy Which Processes Anti-inflammatory Activity
Scientists may have herbal medicine which may reduce risk and treat diseases associated with inflammation, some studies suggested.
Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.
In the body tissue damage caused by physical impact or other sources, macrophages, the immune first ile of defense, stimulating the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.
However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells leading to tissue damage and the formation of abnormal scars after healing. The liver scar is one of the examples.
Some cytokines process such as interleukin-6 (IL-6) a duo function of pro and anti-inflammatory activity. Under normal conditions, the protein produces anti-inflammatory cytokines against substances that cause inflammation such as oxidative stress, however, in sensing of the bodily injury and damage, these proteins switch to produce proinflammatory cytokines.
Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune system response cannot destroy all pathogens in the acute phase of infection.
Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body's localized tissue, such as cancers and rheumatoid arthritis.
Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Inflammation is a condition of the Immune system self-protection to remove harmful ... from our body.
The ingredients
Beside containing helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative, etc.
In the study to reaffirm the traditional claim that herbal Arnica montana, in topical formulations process anti-inflammatory activity, researchers at the Pontificia Universidade Católica de Brasília, launched an investigation determine whether Arnica montana 6cH decreases acute and chronic inflammation in animal models.
In the acute, model, carrageenin-induced rat paw edema, the group treated with Arnica montana 6cH showed 30% inflammatory inhibition compared to control.
However, Treatment with Arnica 6cH, 30 min prior to carrageenan, did not produce any inhibition of the inflammatory process.
In the chronic model, Nystatin-induced edema, Arnica montana 6cH treatment after 3 days of injection of Nystatin, exerts a significantly reduced inflammation 6 h after the last dose of the inflammatory agent was applied compared to insignificant result when treatment was given 6 h after Nystatin treatment.
In a model based on the histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.
These results suggested that Arnica montana 6cH induce the anti-inflammatory effects in a dose and time-dependent manner.
Additionally, in the study to compare two types of gels and microemulsions used to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica Montana extract, and aloin, an anthrone-C-glucosyls with antibacterial activity present in aloe vera extract, researchers found that microemulsion can be a good vehicle to increase the permeation of helenalin, while the gel formulation, containing Sepigel 305, proved able to reduce the release and permeation of aloin, with a consequent activity limited to the surface of application, without any permeation. in a modified Franz cell and a porcine skin membrane.
These results suggested Arnica montana gel may be a good choice in reduced skin inflammation if it is used combined with a microemulsion, which processes the function in increasing the permeation of helenalin.
Taken all together, Herbal Arnica may be considered a functional food for the prevention and an adjunct therapy combined with primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(2) Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals by Macêdo SB, Ferreira LR, Perazzo FF, Carvalho JC. (PubMed)
(3) Effect of vehicles on topical application of aloe vera and arnica Montana components by Bergamante V, Ceschel GC, Marazzita S, Ronchi C, Fini A.(PubMed)
Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.
In the body tissue damage caused by physical impact or other sources, macrophages, the immune first ile of defense, stimulating the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.
However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells leading to tissue damage and the formation of abnormal scars after healing. The liver scar is one of the examples.
Some cytokines process such as interleukin-6 (IL-6) a duo function of pro and anti-inflammatory activity. Under normal conditions, the protein produces anti-inflammatory cytokines against substances that cause inflammation such as oxidative stress, however, in sensing of the bodily injury and damage, these proteins switch to produce proinflammatory cytokines.
Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune system response cannot destroy all pathogens in the acute phase of infection.
Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body's localized tissue, such as cancers and rheumatoid arthritis.
Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Inflammation is a condition of the Immune system self-protection to remove harmful ... from our body.
The ingredients
Beside containing helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative, etc.
In the study to reaffirm the traditional claim that herbal Arnica montana, in topical formulations process anti-inflammatory activity, researchers at the Pontificia Universidade Católica de Brasília, launched an investigation determine whether Arnica montana 6cH decreases acute and chronic inflammation in animal models.
In the acute, model, carrageenin-induced rat paw edema, the group treated with Arnica montana 6cH showed 30% inflammatory inhibition compared to control.
However, Treatment with Arnica 6cH, 30 min prior to carrageenan, did not produce any inhibition of the inflammatory process.
In the chronic model, Nystatin-induced edema, Arnica montana 6cH treatment after 3 days of injection of Nystatin, exerts a significantly reduced inflammation 6 h after the last dose of the inflammatory agent was applied compared to insignificant result when treatment was given 6 h after Nystatin treatment.
In a model based on the histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.
These results suggested that Arnica montana 6cH induce the anti-inflammatory effects in a dose and time-dependent manner.
Additionally, in the study to compare two types of gels and microemulsions used to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica Montana extract, and aloin, an anthrone-C-glucosyls with antibacterial activity present in aloe vera extract, researchers found that microemulsion can be a good vehicle to increase the permeation of helenalin, while the gel formulation, containing Sepigel 305, proved able to reduce the release and permeation of aloin, with a consequent activity limited to the surface of application, without any permeation. in a modified Franz cell and a porcine skin membrane.
These results suggested Arnica montana gel may be a good choice in reduced skin inflammation if it is used combined with a microemulsion, which processes the function in increasing the permeation of helenalin.
Taken all together, Herbal Arnica may be considered a functional food for the prevention and an adjunct therapy combined with primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(2) Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals by Macêdo SB, Ferreira LR, Perazzo FF, Carvalho JC. (PubMed)
(3) Effect of vehicles on topical application of aloe vera and arnica Montana components by Bergamante V, Ceschel GC, Marazzita S, Ronchi C, Fini A.(PubMed)
Herbal Bearberry Leaf Normalizes High Blood Pressure in Vivo, Scientists Find
Herbal Barberry may be considered as a functional food and natural alternative in the prevention and treatment of high blood pressure quickly with no adverse effects, some scientists suggested.
High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
The normal range of blood pressure is 120 over 80. The number in the top is systolic blood pressure, and the bottom is called the diastolic blood pressure.
Researchers do not know the exact causes of hypertension. However, researchers do know that certain preventable risk factors such as smoking, overweight or obese, physical inactivity,.... and excessive alcohol drinking are associated to increase risk of hypertension.
Prolong period of raising the pressure of the hear can lead to damage to the body in many ways.
Uncontrolled high blood pressure can lead to stroke heart disease by damaging and weakening your brain's blood vessels, a blood clot in the arteries.
An unhealthy diet high in salt, sugar, process products, genetic mutation, aging, family history,... and long-term stress also have a substantial impact on the onset of hypertension.
Dr. Kim EJ, the lead author in the study of the dietary effect in patients with borderline hypertension, suggested, " a short-term (12 weeks) lifestyle intervention had positive effects on blood pressure control and weight reduction in the subjects, but not on their blood levels of adipokines. It is interesting that the blood level of baseline leptin was negatively associated with the changes in blood pressure after this short-term intervention"(3).
The results showed that long-term dietary intervention should have a strong impact on keeping blood pressure in check.
Adipocytes found in the obese population may contribute to the high prevalence of hypertension.
Leptin, a chemical compound in the blood plays a critical role in regulation and arterial hypertension
Conventional blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they can induce serious side effects, including common gastrointestinal discomfort and psychological symptoms,
Lifelong intake of hypertension medicine can cause erectile dysfunction.
If you take the medicine in the long-term, please make sure you discuss the side effects with your doctor.
Bearberries are 3 species in the genus Arctostaphylos, belongings to the family Ericaceae, native to northern North America, Asia, and Europe.
The herbs have been used in traditional medicine as diuretic agents and to treat urinary problems, including bladder infections, kidney infection, kidney stones,.... and pelvic pain.
The Chemicals Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides,..... and flavonoids.
With the aim to find the possible hypotensive activity of aqueous extract of Vaccinium Arctostaphylos leaves, the Shiraz University of Medical Sciences conducted an experiment of rats with two-kidney, one-clip hypertension.
All Rat were subjected to a sham operation of the placement of Plexiglass clip-on left renal arteries.
After four weeks of surgery, renal artery clipped rats were either injected intravenously with different doses of the extract at 10, 25, or 75 mg/kg or normal saline.
The mean blood pressure and heart rate were measured before and 20, 40 and 60 minutes after vehicle or drug administration, researchers found that
* Group given normal saline has a significantly higher mean blood pressure, heart, and right kidney weights, lower left kidney weight and significantly indifferent heart rate.
* Treatment group with the injection of the extract at 75 mg/kg exerts a reduction of the mean blood pressure at 20, 40 and 60 minutes after administration without changing the heart rate.
* However, groups treated with doses of but 10 or 25 mg/kg show an insignificant change of mean blood pressure compared to group administrated with the extract at 75 mg/kg.
These results suggested that bearberry leaf extract has potential in reduced blood pressure in a dose depended manner.
Dr. Khalili A, the lead author at the final report, wrote, "... at a higher dose the extract did have hypotensive activity without changing the heart rate".
Truly, the Laboratoire de Pharmacognosy study of Arctostaphylos uva-ursi and hydroalcoholic extracts suggested that the test substances may process a pharmacological effect in reduced blood pressure through increasing urine flow and urinary sodium excretion in vitro.
Taking all together, herbal bearberry and its extract may be considered as a functional food for the treatment of high blood pressure.
However, further data collection on large example size and multi-centers studies performed with human consumption of the herbal leaf extract during the course of the disease will be necessary to complete the picture of bearberry hypotensive possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. The effects of aqueous extract of vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. by Khalili A, Khosravi MB, Nekooeian AA. (PubMed)
2. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats by Beaux D, Fleurentin J, Mortier F.(PubMed)
(3) Effects of a 12-week lifestyle intervention on health outcome and serum adipokines in middle-aged Korean men with borderline high blood pressure by Kim EJ1, Cho SW, Kang JY, Choi TI, Park YK(PubMed)
High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
The normal range of blood pressure is 120 over 80. The number in the top is systolic blood pressure, and the bottom is called the diastolic blood pressure.
Researchers do not know the exact causes of hypertension. However, researchers do know that certain preventable risk factors such as smoking, overweight or obese, physical inactivity,.... and excessive alcohol drinking are associated to increase risk of hypertension.
Prolong period of raising the pressure of the hear can lead to damage to the body in many ways.
Uncontrolled high blood pressure can lead to stroke heart disease by damaging and weakening your brain's blood vessels, a blood clot in the arteries.
An unhealthy diet high in salt, sugar, process products, genetic mutation, aging, family history,... and long-term stress also have a substantial impact on the onset of hypertension.
Dr. Kim EJ, the lead author in the study of the dietary effect in patients with borderline hypertension, suggested, " a short-term (12 weeks) lifestyle intervention had positive effects on blood pressure control and weight reduction in the subjects, but not on their blood levels of adipokines. It is interesting that the blood level of baseline leptin was negatively associated with the changes in blood pressure after this short-term intervention"(3).
The results showed that long-term dietary intervention should have a strong impact on keeping blood pressure in check.
Adipocytes found in the obese population may contribute to the high prevalence of hypertension.
Leptin, a chemical compound in the blood plays a critical role in regulation and arterial hypertension
Conventional blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they can induce serious side effects, including common gastrointestinal discomfort and psychological symptoms,
Lifelong intake of hypertension medicine can cause erectile dysfunction.
If you take the medicine in the long-term, please make sure you discuss the side effects with your doctor.
Bearberries are 3 species in the genus Arctostaphylos, belongings to the family Ericaceae, native to northern North America, Asia, and Europe.
The herbs have been used in traditional medicine as diuretic agents and to treat urinary problems, including bladder infections, kidney infection, kidney stones,.... and pelvic pain.
The Chemicals Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides,..... and flavonoids.
With the aim to find the possible hypotensive activity of aqueous extract of Vaccinium Arctostaphylos leaves, the Shiraz University of Medical Sciences conducted an experiment of rats with two-kidney, one-clip hypertension.
All Rat were subjected to a sham operation of the placement of Plexiglass clip-on left renal arteries.
After four weeks of surgery, renal artery clipped rats were either injected intravenously with different doses of the extract at 10, 25, or 75 mg/kg or normal saline.
The mean blood pressure and heart rate were measured before and 20, 40 and 60 minutes after vehicle or drug administration, researchers found that
* Group given normal saline has a significantly higher mean blood pressure, heart, and right kidney weights, lower left kidney weight and significantly indifferent heart rate.
* Treatment group with the injection of the extract at 75 mg/kg exerts a reduction of the mean blood pressure at 20, 40 and 60 minutes after administration without changing the heart rate.
* However, groups treated with doses of but 10 or 25 mg/kg show an insignificant change of mean blood pressure compared to group administrated with the extract at 75 mg/kg.
These results suggested that bearberry leaf extract has potential in reduced blood pressure in a dose depended manner.
Dr. Khalili A, the lead author at the final report, wrote, "... at a higher dose the extract did have hypotensive activity without changing the heart rate".
Truly, the Laboratoire de Pharmacognosy study of Arctostaphylos uva-ursi and hydroalcoholic extracts suggested that the test substances may process a pharmacological effect in reduced blood pressure through increasing urine flow and urinary sodium excretion in vitro.
Taking all together, herbal bearberry and its extract may be considered as a functional food for the treatment of high blood pressure.
However, further data collection on large example size and multi-centers studies performed with human consumption of the herbal leaf extract during the course of the disease will be necessary to complete the picture of bearberry hypotensive possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. The effects of aqueous extract of vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. by Khalili A, Khosravi MB, Nekooeian AA. (PubMed)
2. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats by Beaux D, Fleurentin J, Mortier F.(PubMed)
(3) Effects of a 12-week lifestyle intervention on health outcome and serum adipokines in middle-aged Korean men with borderline high blood pressure by Kim EJ1, Cho SW, Kang JY, Choi TI, Park YK(PubMed)
Artichoke Kills Leukemic Cells Before They Can Spread, According to Studies
Artichoke may have a positive and profound effect in reducing risk and treatment of leukemia with no side effects, according to studies.
Leukemia is a medical condition arisen from the abnormal white blood cells produced by the bone marrow.
There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
CLL and AML are the most common cancers in adults and ALL are most common in children.
In contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.
According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.
And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.
Certain types of blood disorder, exposure to radioactive substances, and certain medication are some of the prevalent risks of cancer.
Some researchers suggested that cigarette smoking may contribute to the large part of AML onset compared to other subtypes.
Dr. Fircanis S in the study of "The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies" wrote in the final report, "current and ever smokers have 40% (RR 1.40, 95% CI 1.22-1.60; P < 0.001) and 25% (RR 1.25, 95% CI 1.15-1.36; P < 0.001) increased risk of developing AML when compared with non-smokers".
And, "Intensity of smoking of <10, 10-20, 20-30, and >30 cigarettes per day was associated with RRs of AML of 1.27, 1.36, 1.55, and 1.77, respectively (P < 0.001 for trend). Duration of smoking of <20 and >20 years was associated with RRs of 1.07 and 1.44, respectively (P < 0.001 for trend). Cumulative smoking of <10, 10-20, 20-30, and >30 pack-years was associated with RRs of 1.13, 1.23, 1.39, and 1.71, respectively (P < 0.001 for trend)".
The results strongly suggested that cigarette smoking is a major risk factor of acute myeloid leukemia and the risk of AML is increased depending on how many cigarettes that a person smokes a day.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural whole food for the treatment of leukemia against the overexpression of proinflammatory cytokines investigated the extract and 3 participating compounds of artichoke leaves (bracts on the human leukemia cell line.
Injection of the artichoke extract and compounds showed to modulate the lipopolysaccharide (LPS)-induced activation of proinflammatory protein (NF-κB) and the intracellular proinflammatory reactive oxygen species.
Low concentrations of the extract inhibited the enzyme AKR1B1 associated with the activation of NF-κB and the expression of pro-inflammatory genes.
The efficacy of the extract in the attenuation of the expression of the inflammation-related enzymes COX-2 and MMP-2 was attributed to the inhibiting activity of NF-κB.
In other words, artichoke reduced the production of inflammatory cytokines by inhibiting the levels of intracellular reactive oxygen species in the activation the protein NF-κB.
By suppressing the enzyme AKR1B1, artichoke reduced the inflammatory expression in facilitating the onset of leukemia.
Furthermore, in order to reveal more information about artichoke extract (CCE) against leukemia researchers evaluated the CCE effect on the growth of L1210 and HL-60 leukemia cells.
Injection with a variety of concentrations of CCE (500-2500 microg/microL) for 24 h resulted in dose-dependent inhibition of leukemia cell growth observed by the cell cycle arrest in S phase.
CCE also induced apoptosis of leukemia cells, detected by the sub-G(0) cell population and apoptotic DNA fragmentation.
The findings suggested that CCE inhibits leukemia cells through several mechanisms including the proteins associated with cell cycle division, inflammation, and cell degradation.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of leukemia, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells by Miláčková I1, Kapustová K1, Mučaji P1, Hošek J. (PubMed)
(2) Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases by Nadova S1, Miadokova E, Mucaji P, Grancai D, Cipak L. (PubMed)
(3) The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies by Fircanis S1, Merriam P, Khan N, Castillo JJ. (PubMed)
Leukemia is a medical condition arisen from the abnormal white blood cells produced by the bone marrow.
There are several forms of leukemia, including acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).
CLL and AML are the most common cancers in adults and ALL are most common in children.
In contrast to chronic leukemias that take months or years to develop, acute leukemias start and develop within days or weeks.
According to Leukemia Research, Leukemia causes the death of approximately 68,000 every year. Adults are 10 times more likely to develop the disease, compared to children.
And, Non-Hodgkin's lymphoma is the 7th most common cancer in the U.S. The 5-year survival rate for all subtypes of leukemia is 61.4 percent.
Certain types of blood disorder, exposure to radioactive substances, and certain medication are some of the prevalent risks of cancer.
Some researchers suggested that cigarette smoking may contribute to the large part of AML onset compared to other subtypes.
Dr. Fircanis S in the study of "The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies" wrote in the final report, "current and ever smokers have 40% (RR 1.40, 95% CI 1.22-1.60; P < 0.001) and 25% (RR 1.25, 95% CI 1.15-1.36; P < 0.001) increased risk of developing AML when compared with non-smokers".
And, "Intensity of smoking of <10, 10-20, 20-30, and >30 cigarettes per day was associated with RRs of AML of 1.27, 1.36, 1.55, and 1.77, respectively (P < 0.001 for trend). Duration of smoking of <20 and >20 years was associated with RRs of 1.07 and 1.44, respectively (P < 0.001 for trend). Cumulative smoking of <10, 10-20, 20-30, and >30 pack-years was associated with RRs of 1.13, 1.23, 1.39, and 1.71, respectively (P < 0.001 for trend)".
The results strongly suggested that cigarette smoking is a major risk factor of acute myeloid leukemia and the risk of AML is increased depending on how many cigarettes that a person smokes a day.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural whole food for the treatment of leukemia against the overexpression of proinflammatory cytokines investigated the extract and 3 participating compounds of artichoke leaves (bracts on the human leukemia cell line.
Injection of the artichoke extract and compounds showed to modulate the lipopolysaccharide (LPS)-induced activation of proinflammatory protein (NF-κB) and the intracellular proinflammatory reactive oxygen species.
Low concentrations of the extract inhibited the enzyme AKR1B1 associated with the activation of NF-κB and the expression of pro-inflammatory genes.
The efficacy of the extract in the attenuation of the expression of the inflammation-related enzymes COX-2 and MMP-2 was attributed to the inhibiting activity of NF-κB.
In other words, artichoke reduced the production of inflammatory cytokines by inhibiting the levels of intracellular reactive oxygen species in the activation the protein NF-κB.
By suppressing the enzyme AKR1B1, artichoke reduced the inflammatory expression in facilitating the onset of leukemia.
Furthermore, in order to reveal more information about artichoke extract (CCE) against leukemia researchers evaluated the CCE effect on the growth of L1210 and HL-60 leukemia cells.
Injection with a variety of concentrations of CCE (500-2500 microg/microL) for 24 h resulted in dose-dependent inhibition of leukemia cell growth observed by the cell cycle arrest in S phase.
CCE also induced apoptosis of leukemia cells, detected by the sub-G(0) cell population and apoptotic DNA fragmentation.
The findings suggested that CCE inhibits leukemia cells through several mechanisms including the proteins associated with cell cycle division, inflammation, and cell degradation.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of leukemia, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells by Miláčková I1, Kapustová K1, Mučaji P1, Hošek J. (PubMed)
(2) Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell cycle arrest, cytochrome c release and activation of caspases by Nadova S1, Miadokova E, Mucaji P, Grancai D, Cipak L. (PubMed)
(3) The relation between cigarette smoking and risk of acute myeloid leukemia: an updated meta-analysis of epidemiological studies by Fircanis S1, Merriam P, Khan N, Castillo JJ. (PubMed)
Tuesday, October 29, 2019
Healthy Food Tomato, the Natural and Potential Anti-Inflammatory Remedy
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
In other words, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of palette to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases on infection are stopped at the acute phase. The wound or injury are slowly recovered.
However, in severe cases, particularly in people with the weakened immune system, the inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, leading to low-grade chronic inflammation.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Dr. Roma Pahwa in the classification of chronic inflammation wrote, "Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage".
And, "(The causes of chronic inflammation are) Failure of eliminating the agent causing acute inflammation, ..., Exposure to a low level of a particular irritant or foreign materials,...An autoimmune disorder,... Recurrent episodes of acute inflammation,... Inflammatory and biochemical inducers"
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a potential compound for the treatment of inflammatory diseases researchers examined the effect of tomato ketchup extracts and bioactives from tomato ketchup on human monocytes and vascular endothelial cells (HUVEC).
HUVEC selected to the study were pre-treated for 1 h with either individual bioactives (7.5 µM lycopene, 1.4 µM α-tocopherol or 55 µM ascorbic acid) or a combination of these three compounds, or with the hydrophilic or lipophilic tomato ketchup extracts or with the two extracts combined.
According to the tested assays, tomato ketchup extracts significantly reduced gene expression and pro-inflammatory cytokines TNF-α and IL-8 in HUVEC after inducing inflammation.
Furthermore, levels of anti-inflammatory release were increased observed by the expression of anti-inflammatory cytokine IL-10.
The effects were correlated with the reduction of IL-8 production in the presence of the test compounds and extracts.
In other words, lycopene found in the tomato extract is one of the major bioactive compounds that induce the anti-inflammatory effect and α-tocopherol and ascorbic acid appeared to strengthen the anti-inflammatory effect of lycopene.
In order to obtain more information about tomato anti-inflammatory activity, researchers analyzed the potential protective effects of phytochemicals in tomatoes on inflammation.
According to the nitric oxide (NO) assay, tomato extract exhibited anti-inflammatory effect by inhibiting the NO production in LPS-stimulated RAW264 macrophages.
Levels of pro-inflammatory cytokines were significantly decreased after injection of tomatoes.
The efficacy of tomato was attributed to the bioactive compound RF52 in the inhibition of the production of these proinflammatory mediators.
Dr. Kim YI, the lead scientist said, "These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages".
Taken altogether, tomatoes may be considered functional food for the prevention and treatment of inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protection against chemotaxis in the anti-inflammatory effect of bioactives from tomato ketchup by Hazewindus M1, Haenen GR1, Weseler AR1, Bast A. (PubMed)
(2) Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages by Kim YI1, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
In other words, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of palette to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases on infection are stopped at the acute phase. The wound or injury are slowly recovered.
However, in severe cases, particularly in people with the weakened immune system, the inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, leading to low-grade chronic inflammation.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Dr. Roma Pahwa in the classification of chronic inflammation wrote, "Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage".
And, "(The causes of chronic inflammation are) Failure of eliminating the agent causing acute inflammation, ..., Exposure to a low level of a particular irritant or foreign materials,...An autoimmune disorder,... Recurrent episodes of acute inflammation,... Inflammatory and biochemical inducers"
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a potential compound for the treatment of inflammatory diseases researchers examined the effect of tomato ketchup extracts and bioactives from tomato ketchup on human monocytes and vascular endothelial cells (HUVEC).
HUVEC selected to the study were pre-treated for 1 h with either individual bioactives (7.5 µM lycopene, 1.4 µM α-tocopherol or 55 µM ascorbic acid) or a combination of these three compounds, or with the hydrophilic or lipophilic tomato ketchup extracts or with the two extracts combined.
According to the tested assays, tomato ketchup extracts significantly reduced gene expression and pro-inflammatory cytokines TNF-α and IL-8 in HUVEC after inducing inflammation.
Furthermore, levels of anti-inflammatory release were increased observed by the expression of anti-inflammatory cytokine IL-10.
The effects were correlated with the reduction of IL-8 production in the presence of the test compounds and extracts.
In other words, lycopene found in the tomato extract is one of the major bioactive compounds that induce the anti-inflammatory effect and α-tocopherol and ascorbic acid appeared to strengthen the anti-inflammatory effect of lycopene.
In order to obtain more information about tomato anti-inflammatory activity, researchers analyzed the potential protective effects of phytochemicals in tomatoes on inflammation.
According to the nitric oxide (NO) assay, tomato extract exhibited anti-inflammatory effect by inhibiting the NO production in LPS-stimulated RAW264 macrophages.
Levels of pro-inflammatory cytokines were significantly decreased after injection of tomatoes.
The efficacy of tomato was attributed to the bioactive compound RF52 in the inhibition of the production of these proinflammatory mediators.
Dr. Kim YI, the lead scientist said, "These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages".
Taken altogether, tomatoes may be considered functional food for the prevention and treatment of inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protection against chemotaxis in the anti-inflammatory effect of bioactives from tomato ketchup by Hazewindus M1, Haenen GR1, Weseler AR1, Bast A. (PubMed)
(2) Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages by Kim YI1, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Herbal Star Anise (Illicium verum), The Natural Depressant Alternative
Star Anise may be used as an antidepressant to treat diseases associated with the central nervous system,, some scientists suggested.
The central nervous system is a part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.
Antidepressants are a class of conventional medication used for the treatment of major depressive disorder and other psychological conditions, including anxiety depression disorders.
Neurotoxicity is a form of toxicity that affects the structure or function of the central and/or peripheral nervous system, leading to damage of neuron and brain cells of the central nervous system.
In some cases, neurotoxicity can induce unpleasant symptoms of weakness in the limbs. altered sensation, tingling, and numbness in the limbs, headache, and loss of certain types of acute cognitive function.
However, in severe cases, neurotoxicity can cause vision loss, complete loss of memory and reduced cognitive function.
Some patients with neurotoxicity also experience uncontrollable obsessive and/or compulsive behavior and sexual dysfunction.
Dr. Bateman DN the lead scientists in the concern of "Antidepressant use and risk of central nervous system toxicity metastasis" launched an investigation to examine "Tricyclic antidepressant poisoning: central nervous system effects and management" wrote, " All tricyclic drugs are potentially able to cause the main acute CNS toxic syndromes of coma and convulsions" and
"Coma is the most useful sign indicative of toxic risk and appears to predict severe toxic complications (fits and arrhythmias) more reliably than ECG changes".
The finding clearly suggested that the use of antidepressants should be taken with extreme care as the medicine may cause neurotoxicity similar to those of the overdose of Star Anise.
Ba Jiao Hui Xiang also known Chinese Star Anise is a spice that has been used in traditional Chinese cooking for thousands of years from a small evergreen tree, native in southwest China.
The acrid and warm herb has been used in TCM as an antibiotic agent and to treat a hernia, chronic lower back pain, vomiting due to coldness in stomach, pain, and coldness in the stomach. etc. as it disperses cold moves qi and calms pain by enhancing the functions of liver, kidney, spleen, stomach channels.
Besides the main ingredient Anethole, star Anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Dr. Li J, the lead scientist at the Huaqiao University, in the finding a natural ingredient or whole food with a therapeutic function similar to those of conventional antidepressants with little or no side effects evaluated the behavioral and biochemical effects of macranthol, a triphenyl lignan isolated from Illicium dunnianum (Star Anise).
Depressed mice treated at different doses of macranthol (10, 20 and 40 mg/kg) are subjected to the forced swimming test, tail suspension test and chronic unpredictable mild stress.
One day of the acute treatment of macranthol significantly increased the mobility time in the forced swimming test and tail suspension test.
Chronic (5-week) treatment of macranthol reversed the reduction of sucrose preference induced by chronic unpredictable mild stress.
Where the sucrose preference test is a useful tool to investigate anhedonia (inability to feel pleasure).
Futhermore, the application of macranthol completely ameliorated the corticosterone hypersecretion associated with patients with depression observed by acute swim stress or chronic unpredictable mild stress.
Also, the chronic macranthol treatment exerted a significant effect in attenuating the reduction of serotonergic neurotransmission in brain regions of the frontal cortex and hippocampus.
Where low serotonin levels have been linked to depression.
These results strongly indicated that Star Anise produced an antidepressant-like effect mediated by the serotonergic and neuroendocrine system.
After taking into account co and confounder and additional observation, the team wrote in the final report, "the finding that only chronic but not acute treatment enhanced brain-derived neurotrophic factor (BDNF) expression".
More importantly, with the concern that injection of Star Anise may induce acute toxicity, Dr. Chouksey D, the herb research team conducted an experiment to test the chemical component of fruit extracts and its action on the central nervous system.
The selected Male albino rats and mice were trained for seven days prior to the experiments and divided into five groups with six animals in each, prior to the drug administered by intraperitoneal route according to body weight.
At a dose of 200 mg of phenobarbitone, before injection of Star Anise, tested subjects showed a prolonged sleeping time, an alteration in general behavior pattern, reduced locomotor activity and anxiolytic effects without significant altering muscles coordination activity.
The application of Star Anise strongly inhibited the complication induced by the injection of phenobarbitone.
Compared to the efficacy of three extracts of Star Anise at the dose of 200 mg, methanol extract was found to produce more prominent effects, then hexane and ethyl acetate extracts.
The results of the observation firmly indicated that the extracts of Star Anise possess potent CNS depressant action and anxiolytic effect without interfering with motor coordination.
Taken altogether, Star Anise may have a depressant like effect, comparable to those of the conventional antidepressants. However, intake of Star Anise extract or whole herb should only be prescribed by the related field specialist, as acute toxicity has been detected at the dose over 2 000 mg/kg.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Central nervous system activity of Illicium verum fruit extracts by Chouksey D, Upmanyu N, Pawar RS. (PubMed)
(2) Antidepressant-like effect of macranthol isolated from Illiciumdunnianum tutch in mice by Li J, Geng D, Xu J, Weng LJ, Liu Q, Yi LT. (PubMed)
The central nervous system is a part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.
Antidepressants are a class of conventional medication used for the treatment of major depressive disorder and other psychological conditions, including anxiety depression disorders.
Neurotoxicity is a form of toxicity that affects the structure or function of the central and/or peripheral nervous system, leading to damage of neuron and brain cells of the central nervous system.
In some cases, neurotoxicity can induce unpleasant symptoms of weakness in the limbs. altered sensation, tingling, and numbness in the limbs, headache, and loss of certain types of acute cognitive function.
However, in severe cases, neurotoxicity can cause vision loss, complete loss of memory and reduced cognitive function.
Some patients with neurotoxicity also experience uncontrollable obsessive and/or compulsive behavior and sexual dysfunction.
Dr. Bateman DN the lead scientists in the concern of "Antidepressant use and risk of central nervous system toxicity metastasis" launched an investigation to examine "Tricyclic antidepressant poisoning: central nervous system effects and management" wrote, " All tricyclic drugs are potentially able to cause the main acute CNS toxic syndromes of coma and convulsions" and
"Coma is the most useful sign indicative of toxic risk and appears to predict severe toxic complications (fits and arrhythmias) more reliably than ECG changes".
The finding clearly suggested that the use of antidepressants should be taken with extreme care as the medicine may cause neurotoxicity similar to those of the overdose of Star Anise.
Ba Jiao Hui Xiang also known Chinese Star Anise is a spice that has been used in traditional Chinese cooking for thousands of years from a small evergreen tree, native in southwest China.
The acrid and warm herb has been used in TCM as an antibiotic agent and to treat a hernia, chronic lower back pain, vomiting due to coldness in stomach, pain, and coldness in the stomach. etc. as it disperses cold moves qi and calms pain by enhancing the functions of liver, kidney, spleen, stomach channels.
Besides the main ingredient Anethole, star Anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Dr. Li J, the lead scientist at the Huaqiao University, in the finding a natural ingredient or whole food with a therapeutic function similar to those of conventional antidepressants with little or no side effects evaluated the behavioral and biochemical effects of macranthol, a triphenyl lignan isolated from Illicium dunnianum (Star Anise).
Depressed mice treated at different doses of macranthol (10, 20 and 40 mg/kg) are subjected to the forced swimming test, tail suspension test and chronic unpredictable mild stress.
One day of the acute treatment of macranthol significantly increased the mobility time in the forced swimming test and tail suspension test.
Chronic (5-week) treatment of macranthol reversed the reduction of sucrose preference induced by chronic unpredictable mild stress.
Where the sucrose preference test is a useful tool to investigate anhedonia (inability to feel pleasure).
Futhermore, the application of macranthol completely ameliorated the corticosterone hypersecretion associated with patients with depression observed by acute swim stress or chronic unpredictable mild stress.
Also, the chronic macranthol treatment exerted a significant effect in attenuating the reduction of serotonergic neurotransmission in brain regions of the frontal cortex and hippocampus.
Where low serotonin levels have been linked to depression.
These results strongly indicated that Star Anise produced an antidepressant-like effect mediated by the serotonergic and neuroendocrine system.
After taking into account co and confounder and additional observation, the team wrote in the final report, "the finding that only chronic but not acute treatment enhanced brain-derived neurotrophic factor (BDNF) expression".
More importantly, with the concern that injection of Star Anise may induce acute toxicity, Dr. Chouksey D, the herb research team conducted an experiment to test the chemical component of fruit extracts and its action on the central nervous system.
The selected Male albino rats and mice were trained for seven days prior to the experiments and divided into five groups with six animals in each, prior to the drug administered by intraperitoneal route according to body weight.
At a dose of 200 mg of phenobarbitone, before injection of Star Anise, tested subjects showed a prolonged sleeping time, an alteration in general behavior pattern, reduced locomotor activity and anxiolytic effects without significant altering muscles coordination activity.
The application of Star Anise strongly inhibited the complication induced by the injection of phenobarbitone.
Compared to the efficacy of three extracts of Star Anise at the dose of 200 mg, methanol extract was found to produce more prominent effects, then hexane and ethyl acetate extracts.
The results of the observation firmly indicated that the extracts of Star Anise possess potent CNS depressant action and anxiolytic effect without interfering with motor coordination.
Taken altogether, Star Anise may have a depressant like effect, comparable to those of the conventional antidepressants. However, intake of Star Anise extract or whole herb should only be prescribed by the related field specialist, as acute toxicity has been detected at the dose over 2 000 mg/kg.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Central nervous system activity of Illicium verum fruit extracts by Chouksey D, Upmanyu N, Pawar RS. (PubMed)
(2) Antidepressant-like effect of macranthol isolated from Illiciumdunnianum tutch in mice by Li J, Geng D, Xu J, Weng LJ, Liu Q, Yi LT. (PubMed)
Herbal Arctostaphylos uva-ursi, The Potential and Natural Antibiotics Alternative
Arctostaphylos uva-ursi may be the next target to identify the single ingredient as the natural antibiotic for the treatment of bacterial infection with no side effects, some scientists suggested.
Infection is a result of pathogens entering the human body that starts to multiply. In the acute phase of infection, the white blood calls in the immune first line of defense stimulate the production of inflammatory cytokines to the site with an aim to kill off the invaded bacteria.
During the battle normally won by the immune system, the overexpression of inflammatory cytokine can cause symptoms of skin redness, swelling and fever as well as damaging to the nearby cells, leading healthy cell death and improper healing with the formation of irreversible scars.
Normally, the immune system can kill off the foreign bacteria within 3 -8 weeks. However, if the immune fails to destroy all the pathogens with that time frame, it will adapt to the change, leading to chronic inflammatory diseases such as RA and diabetes.
The microorganism infection can be broken down to many stages
* In the first stage, a new host is exposed to infectious particles shed by an infected individual.
*In the second stage of contact between the host and the infectious particles may be through the skin or the internal mucosal surfaces of the respiratory, gastrointestinal, and urogenital tracts.
* In the stage of finding the focus site to establish infection. Most pathogens start this stage by adhering to the epithelial surface, and then colonizing it, or penetrating it to replicate in the tissues. In this stage, the foreign pathogens are at the risk to be expelled by the natural immune defenses.
Dr.Janeway CA Jr, the lead author in the article "Immunobiology: The Immune System in Health and Disease. 5th edition" wrote, "Only when a microorganism has successfully established a site of infection in the host does disease occur, and little damage will be caused unless the agent is able to spread from the original site of infection or can secrete toxins that can spread to other parts of the body".
"Extracellular pathogens spread by direct extension of the focus of infection through the lymphatics or the bloodstream.". and "Obligate intracellular pathogens must spread from cell to cell; they do so either by direct transmission from one cell to the next or by release into the extracellular fluid and reinfection of both adjacent and distant cells".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
Herbal Arctostaphylos uva-ursi contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the finding, a natural or natural whole for the replacement of conventional antibiotics which not only has developed resistance to most antimicrobial agents but also induce significant side effects, researchers at the University of Ottawa examine the ethanolic extracts of 14 Canadian botanicals, analyzed by high-performance liquid chromatography.
Extracts of Arctostaphylos uva ursi (kinnikinnick or bearberry) inhibited the growth of all Neisseria gonorrhoeae (Ng) isolated with minimum inhibitory concentrations of 32 μg/mL compared to higher doses of other botanical plants.
After comparing the antibacterial efficacy of all selected herbal plant in the study, researchers suggested that herbal Arctostaphylos uva-ursi represents a potential source of novel compounds which inhibit Ng, including isolates resistant to antibiotics.
Futhermore, in the testing, the antibacterial activity of the new discovery of two novels acylated caprylic alcohol glycosides (1, 2) isolated by Arctostaphylos pumila using the High-throughput isolation, purification, and analysis methods.
Both new compounds showed to exert a significant inhibitory effect against resistance and nonresistance bacteria.
More precisely, compounds 1 and 2 exhibited antibacterial activity against Gram-positive methicillin-resistant Staphylococcus aureus with a MIC of 128 microg/mL and 64 microg/mL, respectively.
The finding suggested that the extracts and a bioactive compound of Arctostaphylos uva ursi process a strong antibacterial activity similar to those of conventional antibiotics with no side effects.
However, intake of the extracts or supplements should be taken with extreme care to prevent overdoses of acute toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles. by Cybulska P, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA. (PubMed)
(3) Miniaturization of the structure elucidation of novel natural products--two trace antibacterial acylated caprylic alcohol glycosides from Arctostaphylos pumila by Hu JF, Yoo HD, Williams CT, Garo E, Cremin PA, Zeng L, Vervoort HC, Lee CM, Hart SM, Goering MG, O'Neil-Johnson M, Eldridge GR.(PubMed)
(4) Immunobiology: The Immune System in Health and Disease. 5th edition by Janeway CA Jr, Travers P, Walport M, et al.
Infection is a result of pathogens entering the human body that starts to multiply. In the acute phase of infection, the white blood calls in the immune first line of defense stimulate the production of inflammatory cytokines to the site with an aim to kill off the invaded bacteria.
During the battle normally won by the immune system, the overexpression of inflammatory cytokine can cause symptoms of skin redness, swelling and fever as well as damaging to the nearby cells, leading healthy cell death and improper healing with the formation of irreversible scars.
Normally, the immune system can kill off the foreign bacteria within 3 -8 weeks. However, if the immune fails to destroy all the pathogens with that time frame, it will adapt to the change, leading to chronic inflammatory diseases such as RA and diabetes.
The microorganism infection can be broken down to many stages
* In the first stage, a new host is exposed to infectious particles shed by an infected individual.
*In the second stage of contact between the host and the infectious particles may be through the skin or the internal mucosal surfaces of the respiratory, gastrointestinal, and urogenital tracts.
* In the stage of finding the focus site to establish infection. Most pathogens start this stage by adhering to the epithelial surface, and then colonizing it, or penetrating it to replicate in the tissues. In this stage, the foreign pathogens are at the risk to be expelled by the natural immune defenses.
Dr.Janeway CA Jr, the lead author in the article "Immunobiology: The Immune System in Health and Disease. 5th edition" wrote, "Only when a microorganism has successfully established a site of infection in the host does disease occur, and little damage will be caused unless the agent is able to spread from the original site of infection or can secrete toxins that can spread to other parts of the body".
"Extracellular pathogens spread by direct extension of the focus of infection through the lymphatics or the bloodstream.". and "Obligate intracellular pathogens must spread from cell to cell; they do so either by direct transmission from one cell to the next or by release into the extracellular fluid and reinfection of both adjacent and distant cells".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
Herbal Arctostaphylos uva-ursi contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the finding, a natural or natural whole for the replacement of conventional antibiotics which not only has developed resistance to most antimicrobial agents but also induce significant side effects, researchers at the University of Ottawa examine the ethanolic extracts of 14 Canadian botanicals, analyzed by high-performance liquid chromatography.
Extracts of Arctostaphylos uva ursi (kinnikinnick or bearberry) inhibited the growth of all Neisseria gonorrhoeae (Ng) isolated with minimum inhibitory concentrations of 32 μg/mL compared to higher doses of other botanical plants.
After comparing the antibacterial efficacy of all selected herbal plant in the study, researchers suggested that herbal Arctostaphylos uva-ursi represents a potential source of novel compounds which inhibit Ng, including isolates resistant to antibiotics.
Futhermore, in the testing, the antibacterial activity of the new discovery of two novels acylated caprylic alcohol glycosides (1, 2) isolated by Arctostaphylos pumila using the High-throughput isolation, purification, and analysis methods.
Both new compounds showed to exert a significant inhibitory effect against resistance and nonresistance bacteria.
More precisely, compounds 1 and 2 exhibited antibacterial activity against Gram-positive methicillin-resistant Staphylococcus aureus with a MIC of 128 microg/mL and 64 microg/mL, respectively.
The finding suggested that the extracts and a bioactive compound of Arctostaphylos uva ursi process a strong antibacterial activity similar to those of conventional antibiotics with no side effects.
However, intake of the extracts or supplements should be taken with extreme care to prevent overdoses of acute toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles. by Cybulska P, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA. (PubMed)
(3) Miniaturization of the structure elucidation of novel natural products--two trace antibacterial acylated caprylic alcohol glycosides from Arctostaphylos pumila by Hu JF, Yoo HD, Williams CT, Garo E, Cremin PA, Zeng L, Vervoort HC, Lee CM, Hart SM, Goering MG, O'Neil-Johnson M, Eldridge GR.(PubMed)
(4) Immunobiology: The Immune System in Health and Disease. 5th edition by Janeway CA Jr, Travers P, Walport M, et al.
Bromelain Kills Leukemia Cancer Cells
Leukemia is a medical and chronic condition that affects the blood and bone marrow associated with the production of immature white blood cells that can not function properly.
Leukemia can be classified into 2 types
A. Acute leukemia
Acute leukemia is a condition of the rapid increase in the numbers of extreme immature white blood cells that appear in the bloodstream and other parts of the body, including tissue and organs.
* Acute lymphocytic leukemia (ALL) is a type of cancer caused by the abnormal growth of extreme immature lymphocytes by the bone marrow and/or lymphatic system. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia, accounting for 80% of all cases.
* Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells.
B. Chronic leukemia
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells.
* Chronic lymphocytic leukemia (CLL) is a condition caused by slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies.
* Chronic myelogenous leukemia (CML) is a condition caused by slow growth and spreading of abnormal granulocytes.
The exact causes of leukemia are unidentified. Researchers do not know the exact factors that cause the alternation of cell DNA that promotes the abnormal growth of white blood cells.
However, they do know aging, family factors, male, smoking, long-term exposure to certain chemicals, chemo and radiation therapies, genetic proposition and certain types of blood disorder are associated with the increased risk of the disease.
Leukemia shared all general symptoms with other types of cancer such as unintended weight loss, loss of appetite, gastrointestinal discomforts and persistent fatigue accompanied by specific symptoms of bleeding or bruising, recurrent nosebleeds, tiny red spots in your skin, excessive sweating, and hight time bone pain or tenderness.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound or whole food for the treatment of leukemia, researchers investigated a panel of cancer cell lines with bromelain in the presence or absence of peroxidase.
Bromelain combined with peroxidase (BM-PR) showed significant inhibition of acute myeloid (K562) cell proliferation and altered the morphological features.
The combination not only exhibited pro-apoptosis against the cancer cell line but also interfered with the cell cycle division through cell cycle arrest.
BM-PR also increased the expression of intracellular ROS level in the induction of cytotoxicity and altered the mitochondrial membrane potential, against the tested cancer cells.
According to the Western blot analysis, BM-PR increased the levels of proteins associated with the activity of proapoptosis and tumor suppression.
Compared to the treatment of bromelain, researchers said, "These results suggest that BM-PR from pineapple induces apoptosis better than the only bromelain in acute myeloid leukemia cells possibly via mitochondria-dependent pathway".
In CD44 cell surface proteins involved in leukocyte binding to endothelium and the metastatic spread of tumor cells, injection of bromelain inhibited the human leukemia Molt 4/8 cells growth by reducing CD44 receptor density.
The most active in reducing CD44 receptor density of bromelain was a half-maximal value of 1.9 mu g/ml and 2.3 mu g/ml.
Based on the findings, bromelain inhibited the progression of leukemia via the reduced CD44 receptor density.
Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain with peroxidase from pineapple are more potent to target leukemiagrowth inhibition - A comparison with only bromelain by Debnath R1, Chatterjee N2, Das S3, Mishra S4, Bose D4, Banerjee S4, Das S4, Saha KD5, Ghosh D6, Maiti D. (PubMed)
(2) Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemiaand sk-mel-28 melanoma-cells in-vitro by Harrach T1, Gebauer F, Eckert K, Kunze R, Maurer H. (PubMed)
Leukemia can be classified into 2 types
A. Acute leukemia
Acute leukemia is a condition of the rapid increase in the numbers of extreme immature white blood cells that appear in the bloodstream and other parts of the body, including tissue and organs.
* Acute lymphocytic leukemia (ALL) is a type of cancer caused by the abnormal growth of extreme immature lymphocytes by the bone marrow and/or lymphatic system. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia, accounting for 80% of all cases.
* Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells.
B. Chronic leukemia
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells.
* Chronic lymphocytic leukemia (CLL) is a condition caused by slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies.
* Chronic myelogenous leukemia (CML) is a condition caused by slow growth and spreading of abnormal granulocytes.
The exact causes of leukemia are unidentified. Researchers do not know the exact factors that cause the alternation of cell DNA that promotes the abnormal growth of white blood cells.
However, they do know aging, family factors, male, smoking, long-term exposure to certain chemicals, chemo and radiation therapies, genetic proposition and certain types of blood disorder are associated with the increased risk of the disease.
Leukemia shared all general symptoms with other types of cancer such as unintended weight loss, loss of appetite, gastrointestinal discomforts and persistent fatigue accompanied by specific symptoms of bleeding or bruising, recurrent nosebleeds, tiny red spots in your skin, excessive sweating, and hight time bone pain or tenderness.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound or whole food for the treatment of leukemia, researchers investigated a panel of cancer cell lines with bromelain in the presence or absence of peroxidase.
Bromelain combined with peroxidase (BM-PR) showed significant inhibition of acute myeloid (K562) cell proliferation and altered the morphological features.
The combination not only exhibited pro-apoptosis against the cancer cell line but also interfered with the cell cycle division through cell cycle arrest.
BM-PR also increased the expression of intracellular ROS level in the induction of cytotoxicity and altered the mitochondrial membrane potential, against the tested cancer cells.
According to the Western blot analysis, BM-PR increased the levels of proteins associated with the activity of proapoptosis and tumor suppression.
Compared to the treatment of bromelain, researchers said, "These results suggest that BM-PR from pineapple induces apoptosis better than the only bromelain in acute myeloid leukemia cells possibly via mitochondria-dependent pathway".
In CD44 cell surface proteins involved in leukocyte binding to endothelium and the metastatic spread of tumor cells, injection of bromelain inhibited the human leukemia Molt 4/8 cells growth by reducing CD44 receptor density.
The most active in reducing CD44 receptor density of bromelain was a half-maximal value of 1.9 mu g/ml and 2.3 mu g/ml.
Based on the findings, bromelain inhibited the progression of leukemia via the reduced CD44 receptor density.
Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain with peroxidase from pineapple are more potent to target leukemiagrowth inhibition - A comparison with only bromelain by Debnath R1, Chatterjee N2, Das S3, Mishra S4, Bose D4, Banerjee S4, Das S4, Saha KD5, Ghosh D6, Maiti D. (PubMed)
(2) Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemiaand sk-mel-28 melanoma-cells in-vitro by Harrach T1, Gebauer F, Eckert K, Kunze R, Maurer H. (PubMed)
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