A recent study conducted by a renowned institute suggested that Vitex agnus castus (Vac.) may have the potential in decreased overproduction of testosterone on male reproductive physiology.
Testosterone is a male steroid hormone played an important role in male reproductive organs and building bone and muscle mass as well as stimulating sexual desire in both sexes.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
In the study of hydroalcoholic Vac. extract (extraction by percolation technique) with the following doses: 65, 165, 265, 365 and 465 mg kg-', bromocriptine as a dopamine receptor agonist (5, 10, 20 mg kg(-1)) and haloperidol as a dopamine receptor antagonist (1, 1.5, 2, 2.5, 3 mg kg(-1)) injection male mice treated with chaste tree berry extract or combination of the extract showed a significant decrease of levels of testosterone in compared to other treatment groups.
Dr. Nasri S, the lead author said, ". LH and testosterone were measured by Radio Immuno Assay (RIA). LH and testosterone showed a significant decrease in the bromocriptine group and haloperidol increased these hormones. Vac. extract decreased significantly the LH and testosterone levels. The coadministration of Vac. extract and bromocriptine decreased LH and testosterone".
The study also found that Vitex agnus castus extract influences the neurotransmitters such as dopamine in regulated LH and testosterone secretion.
In confirming to the efficacy of chaste tree berry in reduced testosterone production, Vitex agnus castus L. (Vit.) fruit extract with 1650 mg/kg tested on male mice model with the doses (65, 165, 265, 365, 465 mg/kg) injected intraperitoneally for 30 days in 5 groups of animals, all tested mice showed a decreased testosterone levels in dose depending manner.
The researchers also insisted that through the Radio Immuno Assay (RIA), Vit. the fruit extract has an anti-androgenic effect and probably acts through the Hypothalamic-Pituitary-Gonadal (HPG) axis and the side effects only appear after a long time of their usage.
Dr Jillian Stansbury, not the author of the studies said, " (due to the effects of chaste tree berry in reduced LH levels and testosterone levels ) that Vitex may improve symptoms of high testosterone levels in men, including excessive libido, acne, and prostatic disease."
The reduced levels of testosterone of herbal medicine may be beneficial for patients with high levels of testosterone-induced of sexual libido, acne, and abnormal prostate expression.
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The effects of Vitex agnus castus extract and its interaction with dopaminergic system on LH and testosterone in male mice by Nasri S1, Oryan S, Rohani AH, Amin GR.(PubMed)
(2) The Effects of Vitex agnus castus L. Extract on Gonadotrophines and Testosterone in Male Mice(Researchgate)
(3) WOMEN’S HERBS” FOR MEN By Editor1 Posted November 8, 2010
In Botanical Medicine, Endocrinology, Fertility, Men's Health, Nature Cure, Oncology, Dr Jillian Stansbury
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