Medical Advisor Journals

Sunday, January 3, 2016

Most Common Diseases of elder: Respiratory Disease: Asthma - The Misdiagnosis

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

Misdiagnosis

According to the study by Scripps Memorial Hospital, two common reasons asthmatics fail standard therapy are incorrect diagnosis and failure to recognize underlying contributing factors(41), including 1. Vocal cord dysfunction
Vocal cord dysfunction (VCD) is a respiratory disorder characterized by paradoxical closure of the vocal cords during the respiratory cycle leading to obstructive airway symptoms. Misdiagnosis of VCD as asthma leads to inappropriate use of systemic steroids with its adverse effects, frequent emergency department visits, hospitalization, and, rarely, intubation and tracheostomy(42).

2. Respiratory bronchiolitis interstitial lung disease
Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) is a type of idiopathic interstitial pneumonia (IIP) found to be associated with smokers. Many patients with interstitial lung disease have their chronic cough mistakenly attributed to that condition when, in fact, the cough is due to more common disorders such as asthma, upper airway cough syndrome (previously referred to as postnasal drip syndrome), or gastroesophageal reflux disease(43).

3. Chronic obstructive pulmonary disease (COPD)
According to the study by National Jewish Medical and Research Center, despite the availability of consensus guideline diagnostic recommendations, diagnostic confusion between COPD and asthma appears common. Increased awareness of the differences between the two conditions is needed to promote optimal patient management and treatment(44).

4. Psychogenic cough
Psychogenic cough and its relationship to asthma and other asthma-like illnesses is complex since distinct maladies with similar features may coexist individually or in combination in any given patient. While chronic cough may occur as a sole presenting manifestation of bronchial asthma in all age groups, recent findings suggest that most children with persistent cough without other respiratory symptoms do not have asthma, according to the study by Ohio University(45).

5. Tracheobronchomalacia

There is a report of 62-year-old woman, diagnosed as bronchial asthma 3 years previously, was admitted due to acute severe dyspnea. Physical examination revealed saddle nose, flare/swelling of the ear auricles, and stridor. Computed tomography demonstrated thickening of tracheal/bronchial walls and stenosis of the lumen that deteriorated on expiration, suggesting tracheobronchomalacia(46).

6. Tracheal schwannoma
There is a report of a case of tracheal schwannoma in a female patient who presented with breathlessness and wheeze, and she was being treated for asthma(47).

Saturday, January 2, 2016

The Tasty Smoothie of Strawberry, broccoli and Green Tea for reducing risk and treatment of Colorectal Cancer

1/2 cup broccoli
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of colorectal cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Colorectal cancer is relatively very common and slowly growing and progress cancer and in predictable way. It is the third most commonly diagnosed cancer in developed countries, including US and Canada.

Fruits rich in bioactive phytochemicals including several classes of phenolic compounds such as flavonoids (anthocyanins, flavonols and flavanols) and phenolic acids (hydroxybenzoic and hydroxycinnamic acids) are associated to lower risk of cancer, including bowel cancer(1)(2).

Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae. The fruits have been grown all over the world in suitable climate for commercial profits and health benefits. Recent study by the Università Politecnica delle Marche, suggested that strawberry extracts expressed strongly anti oxidant effects and the capacity of promoting the action of antioxidant enzymes in protection against free radicals induced gastrointestinal disorders such as gastric ulcer, colorectal cancer and inflammatory bowel disease(4).

According to the University of California, berry extracts, particular strawberry containing major classes of berry phenolics expressed potential ability in inhibition of the growth of human colon (HT-29, HCT116) cancers through anti cell proliferation and modulate cellular proliferation and apoptosis of COX-2 expressing(3).

In support to the above claim, Dr. Wu QK and the research team at the University of Kuopio, berry extracts,(including strawberry) containing different phenolic profiles on cell viability and expression of markers of cell proliferation and apoptosis in human colon cancer HT-29 cells(5).

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

Isothiocyanates (ITCs) found in broccoli induced apoptosis in human colon cancer cell line SW480, through expression in some unkown potential pathways(6).

Sulforaphane, another natural product commonly found in broccoli, inhibited HCT116 human colon cancer cells angiogenesis and its progression through attenuating the expression of angiogenesis of tumors and mammalian development(HIF-1α) and migration and proliferation of endothelial cells(VEGF)(7).

Dr. Lippmann D and colleagues at the German Institute of Human Nutrition Potsdam-Rehbruecke said," High consumption of Brassica vegetables is considered to prevent especially colon carcinogenesis" and "GSLs(glucosinolates) can act anti-inflammatory and anti-carcinogenic but both effects depend on the specific amount and pattern of GSLs within a vegetable"(8).

According to the Saga University, drinking 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal cancer by 51.6% in patients after polypectomy(11) and an average of tumor volume by 70.3%(11).

In a cohort of 69,710 Chinese women aged 40 to 70 years, drink tea regularly at both the baseline and follow-up surveys are associated to reduced risk of colon and rectal cancer(9). According to the Shanghai Men's Health Study, regular consumption of green tea may reduce colorectal cancer risk among non-smokers but not smokers(10).

Dr. Núñez-Sánchez MA and colleagues at the Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain said," Preclinical studies using in vitro (cell lines) and animal models of CRC have reported anticancer effects for dietary phenolics through the regulation of different markers and signaling pathways" but " Overall, the clinical evidence of dietary phenolics against CRC is still weak and the amounts needed to exert some effects largely exceed common dietary doses"(12)

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References

(1) Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer by Brown EM1, Gill CI, McDougall GJ, Stewart D(PubMed)

(2) Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process by Duthie SJ1.(PubMed)

(3) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP1, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)

(4) Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase by Alvarez-Suarez JM1, Dekanski D, Ristić S, Radonjić NV, Petronijević ND, Giampieri F, Astolfi P, González-Paramás AM, Santos-Buelga C, Tulipani S, Quiles JL,Mezzetti B, Battino M.(PubMed)

(5) Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells by Wu QK1, Koponen JM, Mykkänen HM, Törrönen AR.(PubMed)

(6) Isothiocyanates from Broccolini seeds induce apoptosis in human colon cancer cells: proteomic and bioinformatic analyses by Yang Y1, Yan H, Li Y, Yang ST, Zhang X.(PubMed)

(7) Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells by Kim DH1, Sung B1, Kang YJ1, Hwang SY1, Kim MJ1, Yoon JH1, Im E1, Kim ND1.(PubMed)

(8) Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancerdifferently by Lippmann D1, Lehmann C, Florian S, Barknowitz G, Haack M, Mewis I, Wiesner M, Schreiner M, Glatt H, Brigelius-Flohé R, Kipp AP.(PubMed)

(9) Prospective cohort study of green tea consumption and colorectal cancer risk in women by Yang G1, Shu XO, Li H, Chow WH, Ji BT, Zhang X, Gao YT, Zheng W.(PubMed)

(10) Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study by Yang G1, Zheng W, Xiang YB, Gao J, Li HL, Zhang X, Gao YT, Shu XO.(PubMed)

(11) Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds by Fujiki H1, Sueoka E, Watanabe T, Suganuma M.(PubMed)

(12) Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs by Núñez-Sánchez MA1, González-Sarrías A1, Romo-Vaquero M1, García-Villalba R1, Selma MV1, Tomás-Barberán FA1, García-Conesa MT1, Espín JC1.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Complications

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Complications

1. Quality of life
In a cross-sectional study explored the relationships among family ritual meaning, cohesion, conflict, and health-related quality of life (both specific to chronic health conditions and in general), and the emotional and behavioral problems reported by youths with asthma, conducted by Faculty of Psychology and Educational Sciences, University of Coimbra, showed that stronger family ritual meaning predicted a more positive family environment (i.e., higher cohesion levels and lower conflict levels), better health-related quality of life, and fewer emotional and behavior problems in youths. Furthermore, family cohesion and conflict mediated the links between family ritual meaning and health-related quality of life, and emotional and behavioral problems(34). In 2007–08, people with asthma were more likely to have taken days off work, school or study in the last 12 months due to a long term condition than people without asthma (although these days off were not necessarily due to asthma). People with asthma rate their health worse than people without the condition, according to the data ofAIHW(35).

2. Corticoid-associated complications
In the stduy to evaluate the frequency and type of side effects and complications of long-term corticosteroid therapy in the elderly, showed that infectious complications were found in 26 cases (39.3%), 11 cases (16.7%) of iatrogenic diabetes, arterial hypertension in 9 cases (13%), skeletal complications in both cases,psychiatric complications in two cases, ophthalmologic complications in one case(36).

3. Subcutaneous and mediastinal emphysema
There is a report of a case of a 21-year-old man admitted with asthma attack complicated by subcutaneous and mediastinal emphysema. Chest tomography confirmed the mediastinal emphysema and also revealed the epidural emphysema within the vertebral canal(37).

4. Pneumomediastinum
There is a report of a 17-year-old girl with severe asthma exacerbations. On admission to the intensive care unit, she manifested expiratory dyspnea, cyanosis, and an unproductive cough. Her chest x-rays showed extensive pneumomediastinum (PM), mild subcutaneous emphysema at the right anterior triangle of the neck, and right upper-lobe atelectasis(38).

5. Respiratory complicationsChildren with asthma are at increased risk for obstructive breathing during sleep. Adenotonsillectomy, the treatment of choice for obstructive breathing during sleep, is associated with significant postoperative respiratory morbidity. According to the study by Cincinnati Children’s Hospital, Cincinnati, in children with obstructive breathing during sleep, the presence of asthma is associated with an increased risk of respiratory complications after adenotonsillectomy(39). Other indicated that the frequency of perioperative bronchospasm and laryngospasm was surprisingly low in this cohort of persons with asthma. These complications did not lead to severe respiratory outcomes in most patients. The frequency of complications was increased in older patients and in those with active asthma(40).

6. Potentially (near) fatal asthma (PFA)
Potentially (near) fatal asthma (PFA) defines a subset of patients with asthma who are at increased risk for death from their disease. According to the study by the Northwestern University Feinberg School of Medicine, a diagnosis of PFA is made when any one of the following are present: (1) history of endotracheal intubation from asthma, (2) acute respiratory acidosis (pH < 7.35) or respiratory failure from acute severe asthma, (3) two or more episodes of acute pneumothorax or pneumomediastinumfrom asthma, (4) two or more episodes of acute severe asthma despite the use of long-term oral corticosteroids and other antiasthma medications.
In the UK in 2005, over 1300 people died from asthma, and on average one person dies from asthma every seven hours.
7. Etc.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Off er
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9643741
(35) http://www.aihw.gov.au/asthma-quality-of-life/
(36) http://www.ncbi.nlm.nih.gov/pubmed/23197053
(37) http://www.ncbi.nlm.nih.gov/pubmed/23182721
(38) http://www.ncbi.nlm.nih.gov/pubmed/20561891
(39) http://www.ncbi.nlm.nih.gov/pubmed/15945558
(40) http://www.ncbi.nlm.nih.gov/pubmed/8853074

Thursday, December 31, 2015

The smoothie tangerine peels, grape and cucumber for reduced risk and treatment of Acne

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk and treatment of Acne

Yield: 2 serving (about 8 ounce each)

1 medium tangerine peels

1 cup grapes
1/2 cup of cucumbers
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Combination of tangerine peel(5), grape(1) and cucumber(7)may consist a potential of pharmaceutical values as the ingredients are found effectively in reduced risk and Acne in recent studies.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins. It is the internal causes of acne.

Acne is most common type of skin, affecting billions of people all over world. The dream of finding natural sources for reducing risk and treatment of acne may induce billions and billions dollars of commercial profits of discovered pharmaceutical companies,

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape, as an antimicrobial and anti-inflammatory substances may speed acne recovery from invaded and progression of acne(1), according to the University of Catania,

The phytochemical also has been found effectively in treating acne vulgaris due to its suppression of sebaceous growth by suppressing survival and growth in response to extracellular signals(2).

Dr. Taylor EJ and the research at the David Geffen School of Medicine, said," The ...antibacterial activity and reduced cytotoxicity.....demonstrated by resveratrol.... highlight its potential as a novel therapeutic option or adjuvant therapy in the treatment of acne vulgaris"(3).

Furthermore, resveratrol in the extracts from some herbal medicines also exhibited antibiofilm activity by inhibited the antimicrobial susceptibility of biofilm-associated cells induced the pathogenesis of acne vulgaris(4).

Tangerines, an orange-colored citrus fruit, a type of, mandarin orange originated to Tangier, Morocco, are now cultivated all over the world in suitable climate for commercial profits due to their health effects.
Nobiletin, a phytochemical compound from the group of flavonoid found abundantly in the citrus peels of tangerine exhibited the similar function of acne drugs 13-cis retinoic acid and all-trans retinoic acid(5), may be an effective candidate for acne therapy through reduction of sebocyte proliferation, sebum production and progression of cell apoptosis by suppressing survival and growth in response to extracellular signals(5).

Cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. Due to its silica in skin promotion health benefits, the fruits have been added to some cosmetic gel for treatment of skin diseases(6).According to the Harvard Medical School, topical silica–gold nanoshells at 800 nm exhibited mild anti inflammatory effects and decrease the pathophysiology of acne vulgaris in regulation of sebaceous gland of that induced an effective treatment of moderate-to-severe facial acne, depending to the assessments of disease severity(7).

In support to the above, the University of California study using 150nm silica-gold nanoshell, reduced the acne expression through inducing photothermal disruption of sebaceous glands without damaging collateral skin(8).

Acne Support Group. said,",,, used Silicol Skin for 6 weeks, ...statistically significant 86% overall improvement was reported, with most participants citing the chin as showing the greatest change"(9).

Taking altogether, smoothie with combine of Tangerine peel, grape and cucumber may be effective in reduced risk of the development and progression and treatment of patient with acne.

People with higher risk of acne due to family history, .... should drink 1 serving daily and people with acne should drink as much as they can depending to digestive toleration.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

References

(1) Cosmetics for acne: indications and recommendations for an evidence-based approach by Dall'oglio F1, Tedeschi A, Fabbrocini G, Veraldi S, Picardo M, Micali G.(PubMed)

(2) Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway by Kim SY1, Hyun MY2, Go KC1, Zouboulis CC3, Kim BJ1.(PubMed)

(3) Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro by Taylor EJ1, Yu Y, Champer J, Kim J.(PubMed)

(4) Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin,resveratrol and salidroside as active compounds by Coenye T1, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(PubMed)

(5) A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters by Sato T1, Takahashi A, Kojima M, Akimoto N, Yano M, Ito A.(PubMed)
(6) Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice by Hirai T1, Yoshioka Y2,3,4, Takahashi H5,6, Ichihashi K7, Udaka A8, Mori T9, Nishijima N10, Yoshida T11, Nagano K12, Kamada H13,14, Tsunoda S15,16, Takagi T17,18, Ishii KJ19,20, Nabeshi H21, Yoshikawa T22, Higashisaka K23,24, Tsutsumi Y(PubMed)
(7) Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles by Paithankar DY1, Sakamoto FH2, Farinelli WA2, Kositratna G2, Blomgren RD1, Meyer TJ1, Faupel LJ1, Kauvar AN3, Lloyd JR4, Cheung WL5, Owczarek WD6,Suwalska AM6, Kochanska KB6, Nawrocka AK6, Paluchowska EB6, Podolec KM7, Pirowska MM7, Wojas-Pelc AB7, Anderson RR2.(PubMed)
(8) Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic by Paithankar D1, Hwang BH2, Munavalli G3, Kauvar A4, Lloyd J5, Blomgren R6, Faupel L6, Meyer T6, Mitragotri S7.(PubMed)
(9) The effects of Silicol Skin on moderate to severe acne: UK field survey by Acne Support Group(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Diagnosis

If you are experience some of the above symptoms and if your doctor suspects that you have asthma, after recording your family history and completing the physical exam, the test which your doctor orders include
1. Chest X-Ray
In the study of the medical records of 58 patients aged 18-40 with the diagnosis of mild to moderate asthmato assess the value of the chest X-ray in helping to make the diagnosis of asthma at the primary care level, researchers at theHarvard University Health Services, showed that the number of asthmatic patients with CXR+ and SPI – (n = 23) was significantly larger than the number with CXR- and SPI+ (n = 10), which indicates that for mild asthma the chest X-ray may be more sensitive than spirometry even though not as specific(28). Other suggested that the X-ray request was an action not based on sound clinical judgement. Cost savings and a reduction in radiation exposure can be made by eliminating unnecessary chest X-ray requests(29).
2. Spirometry
Spirometry is a lung (or pulmonary) function test to measure the lung function in studying the air volume and flow rate within the lungs. According to the study by Department of Community Medicine, University of Tromsø the ability of GPs to differentiate between asthma and COPD seems to have considerably improved during the last decade, probably due to the dissemination of spirometry and guidelines for COPD diagnosis(30).
3. Peak Flow Testing –
Peak Flow Testing is a self-assessment to evaluate lung function The peak expiratory flow (PEF), also known as peak expiratory flow rate (PEFR) is to measure the airway
obstruction.
4. Impulse oscillometry (IOS)
Impulse oscillometry is a noninvasive and rapid technique requiring only passive cooperation by the patient. Pressure oscillations are applied at the mouth to measure pulmonary resistance and reactance. It is employed by health care professionals to help diagnose pediatric pulmonary diseases such asthma and cystic fibrosis; assess therapeutic responses; and measure airway resistance during provocation testing(31).In the study to to evaluate whether impulse oscillometry, an easy-to-perform technique, can detect asthmatic airway obstruction stage, researchers at the Shanghai Pudong New Area People’s Hospital, found that IOS provides an accurate, reliable, and patient-friendly technique for classifying asthmatic airway obstruction(32).

5. Allergy Tests for Asthma
if you doctor suspects that your asthma may be triggered as a result of an allergic reaction. Allergy tests may be ordered to determine the exact cause of your allergy and asthma. In the study to determine the predictive value of allergy and pulmonary function tests for the diagnosis of asthma in athletes, showed that positive prick tests were recorded in 44.4% of athletes (in 60.5% of asthmatics, in 95.2% of rhinitics and in 21.0% of nonasthmatic – nonrhinitic subjects). Skin-tests positivity was not related to the abnormal spirometric data found in individual cases. Provocation tests with bronchodilators or exercise did not appear sensitive enough to diagnose mild forms of asthma in subjects with normal basal spirometric values(33).

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9643741
(29) http://www.ncbi.nlm.nih.gov/pubmed/8311783
(30) http://www.ncbi.nlm.nih.gov/pubmed/22135492
(31) http://www.ncbi.nlm.nih.gov/pubmed/21354020
(32) http://www.ncbi.nlm.nih.gov/pubmed/23189951
(33) http://www.ncbi.nlm.nih.gov/pubmed/17845586

Wednesday, December 30, 2015

The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Bone cancer

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of Bone Cancer and Bone Cancer

Yield: 2 serving (about 8 ounce each)
1 1/2 cups blackberry
1/3 tsp cucumin
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of ovarian cancer has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Blackberry(1), green tea and turmeric may be the next generation of pharmaceutical ingredients for reduced risk and treatment of bone cancer, recent study suggested

Bone cancer is an abnormal growth of cells within the bone that have became cancerous. Bone cancer may be classified as primary canceroriginated in the bone, and secondary cancer originated from elsewhere.

Black berry, a edible fruit produced species in the Rubus genus in the Rosaceae family has found to consist a various health effects including suppressing tumor growth through its antioxidants flavonols and ellagitannins(1). According to the joint study lead by the Universidade Estadual Paulista-UNESP, DNA damage in bone marrow and peripheral blood cells and chromosomal aberrations, was significant reduced in a 2000 mg/kg dose due to the presence of its phytochemical compounds tormentic acid, stigmasterol, quercitinglucoronide (miquelianin) and niga-ichigoside F1 (2).

Dr. Dai J and colleagues at the niversity of Kentucky, in support of the berry;s antiproliferative and anti-inflammatory properties disclosed," in a concentration-dependent manner, total anthocyanin concentrations in the range of 0-40 microg/mL suppressed both high-dose (10 microg/mL) and low-dose (0.1 microg/mL) lipid A-induced interleukin-12 release from mouse bone marrow-derived dendritic cells"(3).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

Curcumin, the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma, by inhibiting the over-expression of gene (Notch1) associated with tumor progression, according to Dr. Li Y, and scientists at the Qilu Hospital, Shandong University(4).

In chondrosarcoma, a soft tissue sarcoma, curcumin, an active compound induced tumor apoptosis and inhibited tumor proliferation, invasion, angiogenesis, and metastasis of cancer cells, through protein in regulated cell cycle and tumor suppression gene p53(5).

The joint study in support of the effect of curcumin in reduced risk and treatment of bone cancer, said," IL-1 signaling(in the regulation of immune and inflammatory responses) and VEGF-A expression(involved progression and prognosis of cancer) are blocked by Curcumin in chondrosarcoma cells" and "Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression" of that "may be an additional treatment option in chondrosarcoma"(6).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-gallate, the major ingredient found in green tea may be a potential anti-TNFα(inflammatory cytokine) as a therapeutic option for osteolytic painas it attenuated symptom of pain in bone cancer through inhibiting the pro inflammatory cytokines(7).

Dr. Jeong JY and the research team at the joint study by the National Institute of Animal Science discovered that Epigallocatechin-3-gallate (EGCG) inhibited the expression levels of various genes and proteins involved in adipogenesis of which involved the reduction of cell viability and arrested the cell cycle at the gap 2/mitosis phase in bone-marrow mesenchymal stem cells(8).

Furthermore, in support of the green tea effects on bone cancer cells, the University of Madras showed that Green tea, polyphenol exhibited antioxidant effect through a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity(9).

Taking altogether people who are at increased risk of Bone cancer due to family history or gene mutation .....should drink at least one serving daily and people with bone cancer should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

References

(1) The blackberry fruit: a review on its composition and chemistry, metabolism and bioavailability, and health benefits by Kaume L1, Howard LR, Devareddy L. (PubMed)

(2) In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage by Tolentino F1, Araújo PA1, Marques Ede S1, Petreanu M2, Andrade SF2, Niero R2, Perazzo FF3, Rosa PC4, Maistro EL5(PubMed)(3) Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. by Dai J1, Patel JD, Mumper RJ.(PubMed)
(4) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling by Li Y1, Zhang J, Ma D, Zhang L, Si M, Yin H, Li J.(PubMed)
(5) Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway by Lee HP1, Li TM, Tsao JY, Fong YC, Tang CH.(PubMed)
(6) Curcumin blocks interleukin-1 signaling in chondrosarcoma cells by Kalinski T1, Sel S2, Hütten H3, Röpke M4, Roessner A1, Nass N1.(PubMed)
(7) Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model by Li Q1, Zhang X2.(PubMed)
(8) Epigallocatechin-3-gallate-induced free-radical production upon adipogenic differentiation in bovine bone-marrow mesenchymal stem cells by Jeong JY1,2, Park MN2, Cho ES3, Jang HJ4, Park S5, Lee HJ6.(PubMed)
(9) Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats by Pandurangan AK1, Periasamy S, Anandasadagopan SK, Ganapasam S, Srinivasalu SD.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Causes

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Causes

1. Smoking and second hand smoke
Smoking is considered as one of major cause of lung diseases, including asthma. According to the study by Texas Tech University Health Science Center, Airway mucosal permeability is increased in smokers, which could lead to increased clearance of inhaled corticosteroids from the airways. Smokers also have decreased histone deacetylase activity, which is necessary for corticosteroids to fully suppress cytokine production, and can lead to corticosteroid resistance. The study also indicated that In asthmatic patients who smoke, disease control is poorer than in asthmatic nonsmokers. Of all forms of SHS, maternal exposure seems to have the largest impact on asthma by increasing the frequency and severity of the disease and decreasing lung function. Asthmatic children exposed to multiple household smokers face an increased risk for respiratory illness-related absences from school, and these effects persist during adolescence but weaken during adulthood(6).
2. Allergies
People who are sufferred from alergies are most likely to develop asthma. The allergic march is a progression of atopic disease from eczema to asthma, and then to allergic rhinoconjunctivitis. It appears to be caused by a regional allergic response with breakdown of the local epithelial barrier that initiates systemic allergic inflammation. Genetic and environmental factors predispose to developing the allergic march, according to the study by Department of Surgery, Cape Cod Hospital, Hyannis(7). Other indicated that Allergen exposure contributes to the risk of asthma exacerbations, but other precipitating factors, such as viruses, can interact and increase the risk. According to the study by hôpitaux universitaires de Strasbourg, deteriorating asthma can be related to increased exposure to allergens, particularly allergens from house dust mite, cockroach, cat, rodent, mold or pollen. Several studies have demonstrated that sensitization to respiratory allergens and allergen exposure increases the risk of exacerbation of asthma. When asthma exacerbations are work-related, occupational allergens may be implicated(8).

3. Occupational and environmental exposures
Occupational and exposure history may increase the risk of respiratory problems. According to a report by Dr, Hoy RF., there is a case of a man, 23 years of age and previously well, presents with 2 months of cough, shortness of breath and weight loss. Occupational and exposure history identifies him as commencing work at a mushroom farm 12 months ago where he is exposed to dust from the mixing of mushroom compost. He is not required to use respiratory protection at work. His cough and chest tightness usually start in the afternoon at work and persist into the evening. Some of the effects of exposures may be immediate, whereas others such as asbestos-related lung disease may not present for many decades. Airborne contaminants may be the primary cause of respiratory disease or can exacerbate pre-existing respiratory conditions such as asthma and chronic obstructive pulmonary disease(9).

4. Obesity
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. In the study to to examine the relationship between central obesity and asthma outcomes in a group of Iranian asthma patients, researchers showed that there is a significant association of WHR-based central obesity with forced expiratory volume in 1 s (FEV(1)) (β = -9.04; p-value = .044) and forced vital capacity (FVC) (β = -10.52; p-value = .012). Logistic regression analysis showed a significant increased risk of asthma attacks in 3 months with Asian WC-based central obesity [odds ratio (OR) = 6.31, 95% confidence interval (CI): 1.16-34.41]; emergency room (ER) visits with NIH WC-based (OR = 5.15, 95% CI: 1.36-19.55) and Asian WC-based (OR = 18.72, 95% CI: 1.92-182.63) central obesity; and hospitalization in 1 year with NIH WC-based (OR = 5.28, 95% CI: 1.28-21.84) and Asian WC-based (OR = 12.39, 95% CI: 1.29-119.53) central obesity(10).
Some study suggested that asthma in the obese patient might be more responsive to leukotriene modifiers, orchestrated by leptin and/or adiponectin derived from adipose tissue, than to inhaled corticosteroids, possibly reflecting differences in the underlying airway inflammation in obese vs. non-obese asthmatics(11).

5. Exercise-Induced Asthma
Vigorous exercise can cause a narrowing of the airways in asthma patient.There is a report of a 44-year-old man with a history of seasonal allergic rhinitis but no asthma, who reported difficulty breathing when playing tennis and a 45-year-old woman who presented with persistent, generally well-controlled asthma, who was now experiencing bouts of coughing and wheezing during exercise. EIB is a frequently encountered problem among patients presenting to primary care specialists. Affected patients should be made aware of the importance of proactive treatment with a short-acting beta agonist before initiating any exercise(12).

6. Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. It is considered as one the causes of asthma. There is a report of an 11-year-old boy who was referred to a pediatric respiratory clinic for asthma that was not responsive to inhaled medications. The child presented with a one-year history of dyspnea on exertion, cough and wheeze. He also complained of chronic dyspepsia. The presence of GI symptoms, in addition to abnormalities on chest radiograph and spirometry, suggested the presence of achalasia(13).

7. Sinusitis
Sinusitis is defined as a condition of inflammation of the paranasal sinuses of which can develop headache as a result of exposure to a cold or flu virus, or an allergic reaction to pollen, mold, dust or smoke, etc..Sinusitisaffects 37 million people each year. Some researchers suggested that there is a close relationship between allergic rhinitis and asthma, food allergy, and atopic dermatitis. Rhinitis and sinusitis often coexist and are commonly referred to with the term rhinosinusitis. These conditions are also linked in the so-called atopic march, which is the sequential appearance of atopic manifestations starting with atopic dermatitis and later followed by food allergy, allergic rhinitis, and asthma(14).

8. Upper Respiratory Infections
upper respiratory viral infections are strongly associated in time with hospital admissions for asthma in children and adults. Rhinoviruses were the major pathogen implicated, and the majority of viral infections and asthma admissions occurred during school attendance, according to the study by the Department of Medical Statistics and Computing, University of Southampton(15).

9. Irregular Mentruation
Irregular menstruation are associated with asthma. In the study of a total of 8588 women (response rate 77%) participated in an 8 year follow up postal questionnaire study of participants of the ECRHS stage I in Denmark, Estonia, Iceland, Norway, and Sweden. Only non-pregnant women not taking exogenous sex hormones were included in the analyses (n = 6137), showed that Irregular menstruation was associated with asthma (OR 1.54 (95% CI 1.11 to 2.13)), asthma symptoms (OR 1.47 (95% CI 1.16 to 1.86)), hay fever (OR 1.29 (95% CI 1.05 to 1.57)), and asthma preceded by hay fever (OR 1.95 (95% CI 1.30 to 2.96)) among women aged 26-42 years(16).

10. Sulphite additives
Topical, oral or parenteral exposure to sulphites (mainly from the consumption of foods and drinks that contain these additives) has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions(16a).

11. Cold air
Endurance athletes show an increased prevalence of airway hyperresponsiveness. In the study of a total, 64 elite athletes (32 swimmers and 32 cold-air athletes), 32 mild asthmatic subjects and 32 healthy controls underwent allergy skin prick testing, methacholine challenge and induced sputum analysis found that there is a significant airway inflammation only in competitive athletes with airway hyperresponsiveness. However, the majority of elite athletes showed evidence of bronchial epithelial damage that could possibly contribute to the development of airway hyperresponsiveness(17a).
11. Etc.

Medical Advisor Journals

Pages

Natural Medicine for Fatty Liver And Obesity Reversal

Sunday, January 3, 2016

Most Common Diseases of elder: Respiratory Disease: Asthma - The Misdiagnosis

Saturday, January 2, 2016

The Tasty Smoothie of Strawberry, broccoli and Green Tea for reducing risk and treatment of Colorectal Cancer

Most Common Diseases of elder: Respiratory Disease: Asthma - The Complications

Thursday, December 31, 2015

The smoothie tangerine peels, grape and cucumber for reduced risk and treatment of Acne

Most Common Diseases of elder: Respiratory Disease: Asthma - The Diagnosis

Wednesday, December 30, 2015

The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Bone cancer

Most Common Diseases of elder: Respiratory Disease: Asthma - The Causes