Monday, February 1, 2016

The Incredible and Effective smoothie for reduced risk and treatment of Melanoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of melanoma

Yield: 2 servings (about 8 ounces each)
3/4 cup tomatoes
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of melanoma has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage. Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which are the cell produced dark pigment for the skin.

Recent reports from some well known institutions suggested that certain food sources such as green tea and tomato may be effective for reduced risk and treatment of basal cell cancer, one of most common type of skin cancer.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the University of Alabama at Birmingham, polyphenols from green tea inhibited the gene expression of protein HDAC in induction of DNA damage, in melanoma cell lines (A375, Hs294t, SK-Mel28 and SK-Mel119) through cell cycle arrest(1).

Another phytochemical, catechins also has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of induced cell migration(2).
The joint study lead by the National Taiwan Ocean University also support the notion of green tea intake and reduced risk of melanoma, attached EGCG to nanogold particles (EGCG-pNG) in various ratios showed improved anti-cancer efficacy in B16F10 murine melanoma cells(3).

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Its phytochemical lycopene, have demonstrated clear anticancer effects toward melanoma(4).
DR. Wu WB and colleagues at the Fu-Jen Catholic University said, " Lycopene, a natural carotenoid that is abundant in tomato,..... compromised melanoma-induced fibroblast migration and attenuated signalling transduction in fibroblasts simulated by melanoma-derived conditioned medium,... by acting as an inhibitor on stromal cells, tumour cells and their interactions, which may contribute to its anti-tumour activity.(5).
Furthermore, according to the National Institutes of Health, Bethesda, Diets consisting of foods rich in vitamin D and carotenoids and low in alcohol may lower the risk of melanoma(6).

Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey. Its phytochemical resveratrol, may consist an antioxidant effect in reduced melanoma risk(7).
According to the Duke University Medical Center, Durham, resveratrol (RESV) showed promise as a novel therapeutic in the management of melanoma through its cytotoxicity effect(8).
The combination of natural compounds ursolic acid (UA) and resveratrol (RES), according to the The University of Texas Health Science Center at San Antonio, also synergistically reduces the viability of B16F10 and A375 melanoma cells, through inhibition of autophagy(9).

The combination of Green tea, Tomato and Grape smoothie may hold a key to reduce risk for people who are at higher risk of  melanoma as well as for treatment of patient who have already developed the disease. People with  melanoma in any stage should drink as much as they can, depending to the digestive toleration..
Life style and diet pattern change are recommended

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage by Prasad R1, Katiyar SK2.(PubMed)
(2) Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition by Singh T1, Katiyar SK.(PubMed)
(3) Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanomacells by Chen CC1, Hsieh DS2, Huang KJ3, Chan YL4, Hong PD5, Yeh MK6, Wu CJ7.(PubMed)
(4) Nutrition: the future of melanoma prevention? by Tong LX1, Young LC2.(PubMed)
(5) Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer by Wu WB1, Chiang HS, Fang JY, Hung CF.(PubMed)
(6) Diet and melanoma in a case-control study by Millen AE1, Tucker MA, Hartge P, Halpern A, Elder DE, Guerry D 4th, Holly EA, Sagebiel RW, Potischman N.(PubMed)
(7) Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis by Murzaku EC1, Bronsnick T2, Rao BK1.(PubMed)
(8) Enhancing melanoma treatment with resveratrol by Osmond GW1, Augustine CK, Zipfel PA, Padussis J, Tyler DS.(PubMed)
(9) Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability by Junco JJ1, Mancha-Ramirez A, Malik G, Wei SJ, Kim DJ, Liang H, Slaga TJ.(PubMed)
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Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Prevention Diet

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                         Respiratory Disease 
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Chronic obstructive pulmonary disease (COPD))is the third leading cause of death in the United State.

  Types of Chronic obstructive pulmonary disease (COPD)


1. Emphysema, a type of Chronic obstructive pulmonary disease (COPD), is defined as a long term and progressive condition cause of shortness of breath but depending to the stage of lung function as a result of damage to tissues of the air sacs (alveoli) in the lungs. In the study of 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls, researchers found that in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD(1). In some cases, but rarely, Emphysema is caused by Alpha-1 antitrypsin deficiency emphysema.

2. Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi cause of the increased production of mucus in the lung of that leading to difficult breathing.

                                 The Prevention Diet

1. Neotropical blueberry and barley leaves
In the study of four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), isolated from the neotropical blueberry, using antioxidant activity-guided fractionation, found that he four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml(1).
2. Turmeric
Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. In the study of Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium, researchers found that the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation(2).
3. Oats, sweet corn and rice
Oats, sweet corn and rice contain measurable amounts of melatonin. In recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, pulmonary fibrosis, and asthma. In addition, lung and pulmonary fibroblasts secrete IL-8, which has a chemotactic effect on leukocytes, and which in turn, play a critical role in lung inflammation. Acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs. These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs(3).
4. Grape skin
In the study of the effects of grape skin in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD), showed that alteration of the oxidant-antioxidant balance is important in the pathogenesis of CS-induced ALI and suggests lung protective effects of GSE treatment in the mouse(4).
5. Grape skin, seed and red wine
In the study to investigate the effect of dexamethasone versus resveratrol on the release of COPD-related inflammatory mediators (IL-6, IL-8, GM-CSF and MCP-1) and matrix-metalloprotease-9 (MMP-9) from alveolar macrophages exposed to gram-negative bacterial endotoxin (lipopolysaccharide, LPS), found that resveratrol almost completely reduced the release of all cytokines and MMP-9 without significant differences between the cohorts. Our data provide evidence for a corticosteroid resistance of alveolar macrophage-dependent inflammatory responses induced by gram-negative bacteria in COPD and thus question the utility of corticosteroids in COPD therapy. Instead, resveratrol may prove an alternative(5).
6. Etc.
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Saturday, January 30, 2016

The Curable Smoothie of Tomato and Almond Milk for Reduced Risk and Treatment of Basal skin cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

 The Incredible and Effective smoothie for reduced risk and treatment Basal cell cancer

Yield: 2 serving (about 8 ounce each)
1 1/2 cup tomatoes
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of basal cell cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage. Basal cell cancer is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis. The cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.

Recent reports from some well known institutions suggested that certain food sources such as green tea and tomato may be effective for reduced risk and treatment of basal cell cancer, one of most common type of skin cancer. 
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.
According to the joint study lead by the University of Colorado Cancer Center, University of Colorado, green tea compound have been utilized in pre-clinical and/or clinical studies with promising results(1).
The early-onset basal cell carcinoma in a case-control study, lead by the Yale University School of Medicine, insisted that combined regular consumption of caffeinated coffee plus hot tea is inversely associated with early-onset BCC(2), particular the presence caffeine(3).
Dr. Song F and colleagues at the Harvard Medical School said, "Significant inverse association was also found between caffeinated coffee consumption and BCC risk" and "Compared with individuals who consumed caffeinated coffee less than 1 cup per month, women who consumed more than 3 cups/d had the lowest risk.."(4).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Its phytochemicals carotenoids, alpha-tocopherol and lycopene may be next potential target use for reduced risk and treatment of skin cancer(5), particular photo damage induced skin cancer (7). In fact, Topical application of lycopene hjas been used as antioxidants against depleted from the skin by UV radiation and achieve protection against premature aging and cancer(8).
Dr. Tong L and Dr. Young LC said, " ...., resveratrol, rosmarinic acid, lycopene,....have demonstrated clear anticancer effects toward melanoma(6).
Furthermore,  lycopene also was found to inhibit platelet-derived growth factor (PDGF)-BB-induced human Hs68 skin fibroblast migration on gelatin and collagen of that related to the benefit of anti melanoma growth, invasion, and metastasis(9).


Taking altogether, the combination of tomato and green tea may process the activities in reduced risk of the development and progression and treatment of patient with basal skin cancer.
People with higher risk of basal skin cancer  due to family history, genetic mutation .... should drink 1 serving daily and people with basal skin cancer should drink as much as they can, depending to digestive toleration.
Life Style and diet pattern changed are recommended
(1) Chemopreventive opportunities to control basal cell carcinoma: Current perspectives by Tilley C1, Deep G1,2, Agarwal R1,2.(PubMed)
(2) Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study by Ferrucci LM1, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST.(PubMed)
(3) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin by Song F1, Qureshi AA, Han J(PubMed)
(4) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin by Song F1, Qureshi AA, Han J.(PubMed)
(5) Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer by Dorgan JF1, Boakye NA, Fears TR, Schleicher RL, Helsel W, Anderson C, Robinson J, Guin JD, Lessin S, Ratnasinghe LD, Tangrea JA.(PubMed)
(6) Nutrition: the future of melanoma prevention? by Tong LX1, Young LC2.(PubMed)
(7) Chemoprevention of photocarcinogenesis by lycopene by Ascenso A1, Ribeiro H, Marques HC, Oliveira H, Santos C, Simões S.(PubMed)
(8) A simple and rapid method to assess lycopene in multiple layers of skin samples by Lopes LB1, Reed R.(PubMed)
(9) Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB by Chiang HS1, Wu WB, Fang JY, Chen DF, Chen BH, Huang CC, Chen YT, Hung CF.(PubMed)
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Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Complications

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                         Respiratory Disease 
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Chronic obstructive pulmonary disease (COPD))is the third leading cause of death in the United State.

  Types of Chronic obstructive pulmonary disease (COPD)


1. Emphysema, a type of Chronic obstructive pulmonary disease (COPD), is defined as a long term and progressive condition cause of shortness of breath but depending to the stage of lung function as a result of damage to tissues of the air sacs (alveoli) in the lungs. In the study of 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls, researchers found that in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD(1). In some cases, but rarely, Emphysema is caused by Alpha-1 antitrypsin deficiency emphysema.

2. Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi cause of the increased production of mucus in the lung of that leading to difficult breathing.

                                  The Complications 


1. Thickening of airway wall
In the study to evaluate the relationship between small airway wall thickness and the lung function parameters in patients with asthma and COPD, shows that the thickening of airway wall in asthma is reflected by an increase in the indices of air trapping and in COPD this thickening results in a higher airway resistance and responsiveness. In COPD, the thickening of airway wall also is related to exposure to tobacco smoke(22).
2. Anatomic-functional alterations
Bronchial wall measurements differ between patients who have COPD with CB and those who have COPD without CB. The correlation between airway dimensions and indexes of airway obstruction in patients with COPD and CB indicates that the bronchial tree is the site of anatomic-functional alterations in this patient group(23).
3. Chronic hypoxia
Loss of body mass and exercise intolerance are common findings in chronic obstructive pulmonary disease and are often difficult to reverse despite optimal nutritional intake. In the study conducted by Department of Clinical Physiopathology, University of Florence, showed that malnutrition is a worsening factor in chronic obstructive pulmonary disease. Similarities between chronic obstructive pulmonary disease and altitude exposure point to the importance of hypoxia in this regard(24).
4. Infection
Chronic obstructive pulmonary disease (COPD), lower respiratory tract infections, both acute and chronic, occur with increased frequency. As these infections contribute considerably to the clinical course of the patient with COPD, they constitute a significant comorbidity in COPD. Recurrent acute infections by bacterial and/or viral pathogens are now clearly linked with the occurrence of exacerbations of COPD(25).

5. Pulmonary hypertension
Pulmonary hypertension (PH) is a common consequence of chronic obstructive pulmonary disease (COPD). There is a report of four patients with COPD and PH. Pulmonary arterial hypertension (PAH) associated diseases and pulmonary embolism were ruled out. PH persisted despite optimized treatment of underlying COPD and comorbidities(26).
6. Depression
In the study to evaluate the subjective assessment of sleep quality in stable COPD patients and its relationship with associated depression, found that the prevalence of poor sleep quality among COPD patients is high. Irrespective of severity of airflow obstruction, the presence of depression in COPD is a risk factor for poor sleep quality(27).
7. Heart diseases
In the study to explore the association of COPD and restrictive lung function impairment, respectively, with heart diseases in the general population, found that a strong association between COPD and cardiovascular diseases and indicates a strong association between restrictive lung function and heart diseases. Both obstructive and restrictive lung function impairments were common among subjects with heart diseases and vice versa(28).
8. Death
In the study of data measured change in six minute walk distance in the 12 month period before the event and also related change in six minute walk distance to lung function and St Georges Respiratory Questionnaire (health status), found that a fall in the six minute walk distance of 30m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference(29).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.caSources
(1) http://respiratory-research.com/content/13/1/116/abstract
(22) http://www.ncbi.nlm.nih.gov/pubmed/20134043
(23) http://www.ncbi.nlm.nih.gov/pubmed/16304279
(24) http://www.ncbi.nlm.nih.gov/pubmed/15192444
(25) http://www.ncbi.nlm.nih.gov/pubmed/20513910
(26) http://www.ncbi.nlm.nih.gov/pubmed/23258580
(27) http://www.ncbi.nlm.nih.gov/pubmed/23243346
(28) http://www.ncbi.nlm.nih.gov/pubmed/23127573
(29) http://www.ncbi.nlm.nih.gov/pubmed/23262518
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The Natural Smoothie of Green Tea, Blueberry for Prevention and Treatment of Herpes Simplex

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of Herpes simplex

Yield: 2 servings (about 8 ounces each)
1 3/4 cups blueberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  herpes simplex has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Herpes simplex is an infectious skin disease caused by herpes simplex virus due to skin-to-skin contact, mouth contact, or sexual contact.
The recent studies from numbers of respectable institutions insisted that green tea,
may be a potential target for next generation in  production of a natural sources in reduced risk and treatment of herpes simplex  without induced any side effects.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. Its phytochemicals epigallocatechin-3-gallate used topically inhibited herpes simplex labialis infection with clinical significance(1).
Theaflavin-3,3'-digallate (TF3) in Catechin, a major phytochemical constituent found in green tea, inhibited HSV-1 production in both Vero and A549 cells(2), according to the joint study from Seton Hall University.
Dr. de Oliveira A and colleagues in the study of the effect of green tea against herpes simplex, suggested that Green tea polyphenol epigallocatechin gallate (EGCG), may be a potent inhibitor of herpes simplex virus 1 (HSV-1) by blocking the production of infectious HSV-1 particles(3).

Resveratrol, found abundantly in blueberry is a phytochemical in the class of Stilbenoids may also be a potential agent for reduced risk and treatment of  Herpes simplex(4).
According to the Nanjing University School of Medicine and Jiangsu Laboratory of Molecular Medicine, Stilbenoids including resveratrol with basic structural unit of 1,2-diphenylethylene, have demonstrated potent biological activities in against HSV-1 and HSV-2 infection(5), through inhibited the production of reactive oxygen species(ROS).
Dr. Faith SA and researchers at the Northeastern Ohio Universities College of Medicine, also suggested, resveratrol suppressed nuclear factor-kappaB in regulating the immune response to infection in herpes simplex virus infected cells in the all stages of impairs expression of HSV genes and synthesis of viral DNA.(6).

Anthocyanidins‎, another flavonoid found in blueberry also demonstrated a strong antiviral activity in a plaque reduction assay through its cytopathic effect (CPE)(7).
In support of the effectiveness of flavonoid against herpes simplex infection, Dr. Lin LC and researchers at the National Research Institute of Chinese Medicine said, " (All compounds)showed an inhibitory effects on herpes simplex virus type-1 (HSV-1) replication in Vero cells. Both compounds (-)-epigallocatechin 3-O-gallate (1), samarangenin B (2) exhibited potent inhibitory activities in HSV-1 replication"(8).

 Rich sources of Catechin, Resveratrol and Anthocyanidins found in green tea and blueberry may  process a potential  benefit for reduced risk and treatment of Herpes simplex infection. The smoothie containing these ingredients in high amount should also mimic the similar effects in chronic use.
People at higher risk of Herpes simplex infection due to genetic mutation, immune disorder,..... should drink at least one serving daily and people with the disease should drink as much as they can, depending to the toleration of digestive system.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) Antiviral activity of theaflavin digallate against herpes simplex virus type 1 by de Oliveira A1, Prince D1, Lo CY2, Lee LH3, Chu TC4.(PubMed)
(3) Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by de Oliveira A1, Adams SD, Lee LH, Murray SR, Hsu SD, Hammond JR, Dickinson D, Chen P, Chu TC.(PubMed)
(4) Natural polyphenols: potential in the prevention of sexually transmitted viral infections by Date AA1, Destache CJ2.(PubMed)
(5) Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation by Chen X1, Qiao H, Liu T, Yang Z, Xu L, Xu Y, Ge HM, Tan RX, Li E.(PubMed)
(6) Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells by Faith SA1, Sweet TJ, Bailey E, Booth T, Docherty JJ.(PubMed)
(7) Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro by Lyu SY1, Rhim JY, Park WB.(PubMed)
(8) Anti-herpes simplex virus type-1 flavonoids and a new flavanone from the root of Limonium sinense by Lin LC1, Kuo YC, Chou CJ.(PubMed)
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Friday, January 29, 2016

The Curable Smoothie of Tomato and Almond Milk for Reduced Risk and Treatment of Alopecia areata

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for Reduced Risk and Treatment of Alopecia Areata 

Yield: 2 serving (about 8 ounce each)
1 3/4 cup tomatoes
1 cup almond milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of alopecia areata has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Alopecia areata is a auto immune skin disease due to genetic mutation in which the immune system attacked the hair follicle, affecting unpredictable hair loss.
Strong evidences of number of renowned institutions suggested that natural sources, including carotenoids from tomatoes(3), and vitamin E from almond(7) may be a combination ingredients for reduced risk and treatment of alopecia areata(1) through their effects in influence in the reduction of  oxidative stress(1)(2) various pathways.

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.
Carotenoids, a major chemical compound found in tomato, in animal model, may be used for unraveling the pathogenesis of AA including the role of retinoic acid metabolism in the severity of disease and hair shaft proteins(3) and treatment of Alopecia areata(6). 
The Ohio State University study reveal the important of genes related retinoic acid (RA) synthesis causes of alopecia areata, and suggested that increased intake of vitamin A may reduce the cytokines and chemokines involved the hair loss progression(5).
Dr. Holler PD and Dr. Cotsarelis G. said," Hypovitaminosis A from inadequate vitA intake causes hair loss" and "dietary vitA may have a role in precipitating and maintaining alopecias as well"(4).

Almond consists of an outer hull and a hard shell with the seed (nut) inside is native to the Middle East and widely cultivated seed in the world for it economic and health benefit. According to Cairo University, vitamin E found abundantly in almond exhibited anti oxidative effect against auto immune disease induced the loss the follicle alopecia areata(7). 

Taking altogether, the combination of tomato and almond may process the activities in reduced risk of development and progression and treatment of Alopecia areata
People with higher risk of alopecia areata  due to family history, genetic mutation .... should drink 1 serving daily and people with alopecia areata should drink as much as they can, depending to digestive toleration.
Life Style and diet pattern changed are recommended

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

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References
(1) Oxidative stress and autoimmune skin disease by Shah AA1, Sinha AA.(PubMed)
(2) Oxidative stress in alopecia areata: a case-control study by Bakry OA1, Elshazly RM, Shoeib MA, Gooda A.(PubMed)
(3) Alopecia areata: updates from the mouse perspective by Sundberg JP1, Berndt A, Silva KA, Kennedy VE, Sundberg BA, Everts HB, Rice RH, King LE Jr.(PubMed)
(4) Retinoids putting the "a" in alopecia by Holler PD1, Cotsarelis G.(PubMed)
(5) Endogenous retinoids in the pathogenesis of alopecia areata by Duncan FJ1, Silva KA, Johnson CJ, King BL, Szatkiewicz JP, Kamdar SP, Ong DE, Napoli JL, Wang J, King LE Jr, Whiting DA, McElwee KJ, Sundberg JP,Everts HB.(PubMed)
(6) [Treatment of alopecia areata with vitamin A acid].[Article in German] by Much Th.(PubMed)
(7) The antioxidant role of paraoxonase 1 and vitamin E in three autoimmune diseases by Ramadan R1, Tawdy A, Abdel Hay R, Rashed L, Tawfik D.(PubMed)


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Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Chronic obstructive pulmonary disease (COPD))is the third leading cause of death in the United State.
             Types of Chronic obstructive pulmonary disease (COPD)
                                
1. Emphysema, a type of Chronic obstructive pulmonary disease (COPD), is defined as a long term and progressive condition cause of shortness of breath but depending to the stage of lung function as a result of damage to tissues of the air sacs (alveoli) in the lungs. In the study of 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls, researchers found that in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD(1). In some cases, but rarely, Emphysema is caused by Alpha-1 antitrypsin deficiency emphysema.

2. Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi cause of the increased production of mucus in the lung of that leading to difficult breathing.

                        Diagnosis and tests

If you are smokers and have the above symptoms and your doctor may suspect that you have developed the chronic obstructive pulmonary disease (COPD). After a complete physical exam and recording the family history of the diseases, the tests which your doctor orders may include
1. Spirometry
Spirometryis one of the best test for patient who is suspected to have developed chronic obstructive pulmonary disease (COPD). In this test, you are asked to breath into a instrument connected to a spirometer for the evaluation of the function of your lung including the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled. In the study Of the 12,491 patients with a primary or secondary COPD diagnosis between 1994 and 2006, with 1520 continuously enrolled patients, showed that among the 648 eligible records from patients with evidence of a pulmonary function test, 366 were identified by spirometry as having COPD of GOLD stage I or higher (average percentage of predicted forced expiratory volume in 1 second: 60%): 19% were diagnosed at the stage of mild disease (GOLD stage I); 50% at moderate disease (GOLD stage II); and 31% at severe or very severe disease (GOLD stage III or IV, respectively). The majority of patients in these groups were not receiving maintenance treatment(17).
2. Stethoscope
Stethoscope is medical device used by tour doctor to listen to the internal sounds of your lung. According to the study by the University of Colorado Medical Center, the stethoscope and spirometer became important early tools in diagnosis and assessment. Spirometry remains the most effective means of identification and assessment of the course of COPD and responses to therapy, and is grossly underused for this purpose(18).
3. Exercise intolerance tests
Walking tests, such as the “shuttle” incremental walking test (SWT) and the 6-min walking test (6′WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. According to the study by University of Rome La Sapienza, the two walking protocols reveal substantial differences in pathophysiologic adaptations and provide evidence that SWT is more accurate than the 6′WT in the evaluation of maximal exercise tolerance in COPD patients(19).
4. Exercise for desaturation test
In the study to to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation, researchers found that for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD(20).
5. Arterial blood gases
The blood test is to measure the levels of oxygen and carbon dioxide in the blood.
6. Etc.
D. Misdiagnosis
Chronic obstructive pulmonary disease (COPD) or Asthma
Chronic obstructive pulmonary disease (COPD) is often misdiagnosed as asthma, leading to inappropriate treatment and suboptimal patient outcomes. Despite the availability of consensus guideline diagnostic recommendations, diagnostic confusion between COPD and asthma appears common. Increased awareness of the differences between the two conditions is needed to promote optimal patient management and treatment, according to the National Jewish Medical and Research Center(21). 
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