Medical Advisor Journals

Monday, February 1, 2016

The Fabulous Smoothie of Tomato, Grape and Green Tea for Reduced Risk and Treatment of Bowen's disease (BD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of Bowen's disease (BD)

Yield: 2 serving (about 8 ounce each)
3/4 cup tomatoes
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Bowen's disease (BD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Bowen's disease (BD), an early stage of skin disease with characteristics of red, scaly patch on the skin. There is a suggestion that the diseases in early stage of skin cancer may be resulted of arsenic exposure causes of oxidative stress and alternation of DNA(2), in the groundwater of many under developed countries, affecting 200 million people(1).

It is hard to image that a curable smoothie with detoxified property may have a potential in reduced risk of the disease in people who constantly involved to the exposure to arsenic. But due to lack of knowledge of the progression of the diseases in early stage of skin cancer in general population, the finding of these natural ingredients has run into many obstacles.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. Its phytochemical curcumin exhibited anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against many types of cancers, including skin cancer(4).

In the phase I clinical trial, researchers suggested that curcumin may be the next potential in the chemoprevention of cancer due to its biologic effect(3).

When used conjunction with LED blue light united red light irradiation, curcumin induced a higher efficiency of regulating proliferation and apoptosis in skin keratinocytes in skin cancer(5).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects.

Its antioxidant (-)-Epigallocatechin-3-gallate (EGCG), has shown effectively in inhibited development of melanoma and nonmelanoma skin cancers(7), through its chemopreventive activity(8).
Dr. Katiyar SK, researcher at the Birmingham Veterans Affairs Medical Center said," The DNA repair by GTPs is mediated through the induction of interleukin (IL)-12(Pro inflammatory cytokine) which has been shown to have DNA repair ability"(6).

Myricetin is a flavonol, belongings to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, used in folk medicine as antioxidant to lower cholesterol, treat certain types of cancer, etc. According to the Kyungpook National University, the phytochemical inhibited the skin cancer formation through its effect on cancer cell cycle division in SKH1-Elite Mice model(9) as well as suppressing UVB-induced cyclooxygenase-2 (COX-2) expression of pain and inflammation of mouse skin epidermal JB6 P+ cells(10) in the early stage of non-melanoma skin cancer(11).

The effectiveness of Tomato, Grape and Green Tea phytochemicals on Bowen's disease (BD) may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk treatment of stroke with little or no adverse effects.
People who are at high risk of Bowen's disease (BD) due to family history, obesity,..... should drink at least one serving daily and people with Bowen's disease (BD) should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) The mechanistic basis of arsenicosis: pathogenesis of skin cancer by Hunt KM1, Srivastava RK2, Elmets CA2, Athar M3.(PubMed)

(2) Involvement of mtDNA damage elicited by oxidative stress in the arsenical skin cancers by Lee CH1, Wu SB, Hong CH, Chen GS, Wei YH, Yu HS.(PubMed)

(3) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions by Cheng AL1, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS,Pan MH, Wang YJ, Tsai CC, Hsieh CY.(PubMed)

(4) Biological and therapeutic activities, and anticancer properties of curcumin by Perrone D1, Ardito F1, Giannatempo G1, Dioguardi M1, Troiano G1, Lo Russo L1, DE Lillo A1, Laino L1, Lo Muzio L1.(PubMed)

(5) Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin by Niu T1, Tian Y2, Cai Q3, Ren Q3, Wei L3.(PubMed)

(6) Green tea prevents non-melanoma skin cancer by enhancing DNA repair by Katiyar SK1.(PubMed)

(7) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)

(8) (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity by Barthelman M1, Bair WB 3rd, Stickland KK, Chen W, Timmermann BN, Valcic S, Dong Z, Bowden GT.(PubMed)

(9) Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis by Kang NJ1, Jung SK, Lee KW, Lee HJ.(PubMed)

(10) Myricetin suppresses UVB-induced skin cancer by targeting Fyn by Jung SK1, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z.(PubMed)

(11) Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes by Kim W1, Yang HJ, Youn H, Yun YJ, Seong KM, Youn B.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Do and Do not's list

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Do and Do not's list

1. Quit smoking, if you don’t, do not try as smoking is the main cause of chronic obstructive pulmonary disease (COPD). People with low levels of the protein alpha-1 antitrypsin are susceptible to develop the disease. Tobacco smoke is a complex chemical aerosol containing at least 8000 chemical constituents, either tobacco derived or added by tobacco product manufacturers(29a)
2. If you working in the occupation in the environment exposure of exposures coal mine dust, silica, welding fume, textile dust, agricultural dust, cadmium fume, etc., please be cautious to avoid the development of the disease(30)
3. Prevent Vitamin D deficiency
In the study of the Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoimmune diseases, researchers at the School of Medicine, Semmelweis University, showed that VD supplementation in most related studies reduced the prevalence of asthma. VD supplementation may be useful in the prevention or adjunct treatment of chronic obstructive pulmonary disease(31).
4. Vitamin C, D, E, A, beta and alpha carotene
In the study of a systematic literature review performed on the association of vitamins and COPD. The role of vitamin supplements in COPD, showed that various vitamins (vitamin C, D, E, A, beta and alpha carotene) are associated with improvement in features of COPD such as symptoms, exacerbations and pulmonary function. High vitamin intake would probably reduce the annual decline of FEV1(32).
5. Antioxidants
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases that are characterized by systemic and chronic localized inflammation and oxidative stress. In the study to elevate amounts of reactive oxygen species (ROS) released from inflammatory cells, increased levels of ROS, either directly or via the formation of lipid peroxidation products, may play a role in enhancing the inflammatory response in both asthma and COPD, researchers at the Novartis Institutes for Biomedical Research, showed that a combination of antioxidants may be effective in the treatment of asthma and COPD(33).
6. Eat your vegetables and fruit
In the study to assess whether the risk of certain chronic diseases can be reduced by increased consumption of vegetables or fruit by the general public, and what strength of evidence has to be allocated to such an association, showed that increasing the consumption of vegetables and fruit lowers the risk of certain eye diseases, dementia and the risk of osteoporosis. Likewise, current data on asthma, COPD, and RA indicate that an increase in vegetable and fruit consumption may contribute to the prevention of these diseases(34). Guidelines from the US National Cancer Institute (103) recommend consumption of five servings of fruit and vegetables daily, corresponding to a vitamin C intake exceeding 200 mg. Dietary surveys carried out in the US population indicate that less than 12 percent of US children and adults meet this recommended level of intake (104). Diet appears to be an important cofactor in the development of obstructive lung disease, although data are still sparse(32a).
7. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://respiratory-research.com/content/13/1/116/abstract
(29a) http://www.ncbi.nlm.nih.gov/pubmed/23227851
(30) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513231/
(31) http://www.ncbi.nlm.nih.gov/pubmed/23234453
(32) http://www.ncbi.nlm.nih.gov/pubmed/21134250
(32a) http://www.ncbi.nlm.nih.gov/pubmed/12192737

The Incredible and Effective smoothie for reduced risk and treatment of Melanoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of melanoma

Yield: 2 servings (about 8 ounces each)
3/4 cup tomatoes
3/4 cup grape
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of melanoma has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage. Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which are the cell produced dark pigment for the skin.

Recent reports from some well known institutions suggested that certain food sources such as green tea and tomato may be effective for reduced risk and treatment of basal cell cancer, one of most common type of skin cancer.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the University of Alabama at Birmingham, polyphenols from green tea inhibited the gene expression of protein HDAC in induction of DNA damage, in melanoma cell lines (A375, Hs294t, SK-Mel28 and SK-Mel119) through cell cycle arrest(1).

Another phytochemical, catechins also has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of induced cell migration(2).

The joint study lead by the National Taiwan Ocean University also support the notion of green tea intake and reduced risk of melanoma, attached EGCG to nanogold particles (EGCG-pNG) in various ratios showed improved anti-cancer efficacy in B16F10 murine melanoma cells(3).

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Its phytochemical lycopene, have demonstrated clear anticancer effects toward melanoma(4).

DR. Wu WB and colleagues at the Fu-Jen Catholic University said, " Lycopene, a natural carotenoid that is abundant in tomato,..... compromised melanoma-induced fibroblast migration and attenuated signalling transduction in fibroblasts simulated by melanoma-derived conditioned medium,... by acting as an inhibitor on stromal cells, tumour cells and their interactions, which may contribute to its anti-tumour activity.(5).

Furthermore, according to the National Institutes of Health, Bethesda, Diets consisting of foods rich in vitamin D and carotenoids and low in alcohol may lower the risk of melanoma(6).

Grape is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey. Its phytochemical resveratrol, may consist an antioxidant effect in reduced melanoma risk(7).

According to the Duke University Medical Center, Durham, resveratrol (RESV) showed promise as a novel therapeutic in the management of melanoma through its cytotoxicity effect(8).

The combination of natural compounds ursolic acid (UA) and resveratrol (RES), according to the The University of Texas Health Science Center at San Antonio, also synergistically reduces the viability of B16F10 and A375 melanoma cells, through inhibition of autophagy(9).

The combination of Green tea, Tomato and Grape smoothie may hold a key to reduce risk for people who are at higher risk of melanoma as well as for treatment of patient who have already developed the disease. People with melanoma in any stage should drink as much as they can, depending to the digestive toleration..

Life style and diet pattern change are recommended

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage by Prasad R1, Katiyar SK2.(PubMed)
(2) Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition by Singh T1, Katiyar SK.(PubMed)
(3) Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanomacells by Chen CC1, Hsieh DS2, Huang KJ3, Chan YL4, Hong PD5, Yeh MK6, Wu CJ7.(PubMed)
(4) Nutrition: the future of melanoma prevention? by Tong LX1, Young LC2.(PubMed)
(5) Inhibitory effect of lycopene on PDGF-BB-induced signalling and migration in human dermal fibroblasts: a possible target for cancer by Wu WB1, Chiang HS, Fang JY, Hung CF.(PubMed)
(6) Diet and melanoma in a case-control study by Millen AE1, Tucker MA, Hartge P, Halpern A, Elder DE, Guerry D 4th, Holly EA, Sagebiel RW, Potischman N.(PubMed)
(7) Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis by Murzaku EC1, Bronsnick T2, Rao BK1.(PubMed)
(8) Enhancing melanoma treatment with resveratrol by Osmond GW1, Augustine CK, Zipfel PA, Padussis J, Tyler DS.(PubMed)
(9) Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability by Junco JJ1, Mancha-Ramirez A, Malik G, Wei SJ, Kim DJ, Liang H, Slaga TJ.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Prevention Diet

Respiratory Disease
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Chronic obstructive pulmonary disease (COPD))is the third leading cause of death in the United State.

Types of Chronic obstructive pulmonary disease (COPD)

1. Emphysema, a type of Chronic obstructive pulmonary disease (COPD), is defined as a long term and progressive condition cause of shortness of breath but depending to the stage of lung function as a result of damage to tissues of the air sacs (alveoli) in the lungs. In the study of 63 patients with stable COPD (spirometric GOLD stages 2–4) and 17 age- and comorbidity-matched controls, researchers found that in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum. The stage-dependent association with lung function supports the hypothesis that these platelet mediators may play a role in the pathogenesis of COPD(1). In some cases, but rarely, Emphysema is caused by Alpha-1 antitrypsin deficiency emphysema.

2. Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi cause of the increased production of mucus in the lung of that leading to difficult breathing.

The Prevention Diet

1. Neotropical blueberry and barley leaves
In the study of four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), isolated from the neotropical blueberry, using antioxidant activity-guided fractionation, found that he four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml(1).
2. Turmeric
Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. In the study of Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium, researchers found that the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation(2).
3. Oats, sweet corn and rice
Oats, sweet corn and rice contain measurable amounts of melatonin. In recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, pulmonary fibrosis, and asthma. In addition, lung and pulmonary fibroblasts secrete IL-8, which has a chemotactic effect on leukocytes, and which in turn, play a critical role in lung inflammation. Acrolein-induced IL-8 production was accompanied by increased levels of phosphorylation of Akt and extracellular signal-regulated kinases (ERK1/2) in HPFs, and that melatonin suppressed IL-8 production in HPFs. These results suggest that melatonin suppresses acrolein-induced IL-8 production via ERK1/2 and phosphatidylinositol 3-kinase (PI3K)/Akt signal inhibition in HPFs(3).
4. Grape skin
In the study of the effects of grape skin in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD), showed that alteration of the oxidant-antioxidant balance is important in the pathogenesis of CS-induced ALI and suggests lung protective effects of GSE treatment in the mouse(4).
5. Grape skin, seed and red wine
In the study to investigate the effect of dexamethasone versus resveratrol on the release of COPD-related inflammatory mediators (IL-6, IL-8, GM-CSF and MCP-1) and matrix-metalloprotease-9 (MMP-9) from alveolar macrophages exposed to gram-negative bacterial endotoxin (lipopolysaccharide, LPS), found that resveratrol almost completely reduced the release of all cytokines and MMP-9 without significant differences between the cohorts. Our data provide evidence for a corticosteroid resistance of alveolar macrophage-dependent inflammatory responses induced by gram-negative bacteria in COPD and thus question the utility of corticosteroids in COPD therapy. Instead, resveratrol may prove an alternative(5).
6. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=isoorientin%20and%20COPD
(2) http://www.ncbi.nlm.nih.gov/pubmed/22142850
(3) http://www.ncbi.nlm.nih.gov/pubmed/21951103
(4) http://www.ncbi.nlm.nih.gov/pubmed/21804454
(5) http://www.ncbi.nlm.nih.gov/pubmed/21447053

Saturday, January 30, 2016

The Curable Smoothie of Tomato and Almond Milk for Reduced Risk and Treatment of Basal skin cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment Basal cell cancer

Yield: 2 serving (about 8 ounce each)
1 1/2 cup tomatoes
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of basal cell cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage. Basal cell cancer is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis. The cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.

According to the joint study lead by the University of Colorado Cancer Center, University of Colorado, green tea compound have been utilized in pre-clinical and/or clinical studies with promising results(1).

The early-onset basal cell carcinoma in a case-control study, lead by the Yale University School of Medicine, insisted that combined regular consumption of caffeinated coffee plus hot tea is inversely associated with early-onset BCC(2), particular the presence caffeine(3).

Dr. Song F and colleagues at the Harvard Medical School said, "Significant inverse association was also found between caffeinated coffee consumption and BCC risk" and "Compared with individuals who consumed caffeinated coffee less than 1 cup per month, women who consumed more than 3 cups/d had the lowest risk.."(4).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Its phytochemicals carotenoids, alpha-tocopherol and lycopene may be next potential target use for reduced risk and treatment of skin cancer(5), particular photo damage induced skin cancer (7). In fact, Topical application of lycopene hjas been used as antioxidants against depleted from the skin by UV radiation and achieve protection against premature aging and cancer(8).
Dr. Tong L and Dr. Young LC said, " ...., resveratrol, rosmarinic acid, lycopene,....have demonstrated clear anticancer effects toward melanoma(6).

Furthermore, lycopene also was found to inhibit platelet-derived growth factor (PDGF)-BB-induced human Hs68 skin fibroblast migration on gelatin and collagen of that related to the benefit of anti melanoma growth, invasion, and metastasis(9).

Taking altogether, the combination of tomato and green tea may process the activities in reduced risk of the development and progression and treatment of patient with basal skin cancer.
People with higher risk of basal skin cancer due to family history, genetic mutation .... should drink 1 serving daily and people with basal skin cancer should drink as much as they can, depending to digestive toleration.
Life Style and diet pattern changed are recommended

References

(1) Chemopreventive opportunities to control basal cell carcinoma: Current perspectives by Tilley C1, Deep G1,2, Agarwal R1,2.(PubMed)

(2) Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study by Ferrucci LM1, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST.(PubMed)

(3) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin by Song F1, Qureshi AA, Han J(PubMed)

(4) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin by Song F1, Qureshi AA, Han J.(PubMed)

(5) Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer by Dorgan JF1, Boakye NA, Fears TR, Schleicher RL, Helsel W, Anderson C, Robinson J, Guin JD, Lessin S, Ratnasinghe LD, Tangrea JA.(PubMed)

(6) Nutrition: the future of melanoma prevention? by Tong LX1, Young LC2.(PubMed)

(7) Chemoprevention of photocarcinogenesis by lycopene by Ascenso A1, Ribeiro H, Marques HC, Oliveira H, Santos C, Simões S.(PubMed)

(8) A simple and rapid method to assess lycopene in multiple layers of skin samples by Lopes LB1, Reed R.(PubMed)

(9) Lycopene inhibits PDGF-BB-induced signaling and migration in human dermal fibroblasts through interaction with PDGF-BB by Chiang HS1, Wu WB, Fang JY, Chen DF, Chen BH, Huang CC, Chen YT, Hung CF.(PubMed)

Most Common Diseases of elder: Chronic obstructive pulmonary disease (COPD) (Respiratory Disease): The Complications

The Complications

1. Thickening of airway wall
In the study to evaluate the relationship between small airway wall thickness and the lung function parameters in patients with asthma and COPD, shows that the thickening of airway wall in asthma is reflected by an increase in the indices of air trapping and in COPD this thickening results in a higher airway resistance and responsiveness. In COPD, the thickening of airway wall also is related to exposure to tobacco smoke(22).
2. Anatomic-functional alterations
Bronchial wall measurements differ between patients who have COPD with CB and those who have COPD without CB. The correlation between airway dimensions and indexes of airway obstruction in patients with COPD and CB indicates that the bronchial tree is the site of anatomic-functional alterations in this patient group(23).
3. Chronic hypoxia
Loss of body mass and exercise intolerance are common findings in chronic obstructive pulmonary disease and are often difficult to reverse despite optimal nutritional intake. In the study conducted by Department of Clinical Physiopathology, University of Florence, showed that malnutrition is a worsening factor in chronic obstructive pulmonary disease. Similarities between chronic obstructive pulmonary disease and altitude exposure point to the importance of hypoxia in this regard(24).
4. Infection
Chronic obstructive pulmonary disease (COPD), lower respiratory tract infections, both acute and chronic, occur with increased frequency. As these infections contribute considerably to the clinical course of the patient with COPD, they constitute a significant comorbidity in COPD. Recurrent acute infections by bacterial and/or viral pathogens are now clearly linked with the occurrence of exacerbations of COPD(25).

5. Pulmonary hypertension
Pulmonary hypertension (PH) is a common consequence of chronic obstructive pulmonary disease (COPD). There is a report of four patients with COPD and PH. Pulmonary arterial hypertension (PAH) associated diseases and pulmonary embolism were ruled out. PH persisted despite optimized treatment of underlying COPD and comorbidities(26).
6. Depression
In the study to evaluate the subjective assessment of sleep quality in stable COPD patients and its relationship with associated depression, found that the prevalence of poor sleep quality among COPD patients is high. Irrespective of severity of airflow obstruction, the presence of depression in COPD is a risk factor for poor sleep quality(27).
7. Heart diseases
In the study to explore the association of COPD and restrictive lung function impairment, respectively, with heart diseases in the general population, found that a strong association between COPD and cardiovascular diseases and indicates a strong association between restrictive lung function and heart diseases. Both obstructive and restrictive lung function impairments were common among subjects with heart diseases and vice versa(28).
8. Death
In the study of data measured change in six minute walk distance in the 12 month period before the event and also related change in six minute walk distance to lung function and St Georges Respiratory Questionnaire (health status), found that a fall in the six minute walk distance of 30m or more is associated with increased risk of death but not hospitalization due to exacerbation in patients with chronic obstructive pulmonary disease and represents a clinically significant minimally important difference(29).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.caSources
(1) http://respiratory-research.com/content/13/1/116/abstract
(22) http://www.ncbi.nlm.nih.gov/pubmed/20134043
(23) http://www.ncbi.nlm.nih.gov/pubmed/16304279
(24) http://www.ncbi.nlm.nih.gov/pubmed/15192444
(25) http://www.ncbi.nlm.nih.gov/pubmed/20513910
(26) http://www.ncbi.nlm.nih.gov/pubmed/23258580
(27) http://www.ncbi.nlm.nih.gov/pubmed/23243346
(28) http://www.ncbi.nlm.nih.gov/pubmed/23127573
(29) http://www.ncbi.nlm.nih.gov/pubmed/23262518

The Natural Smoothie of Green Tea, Blueberry for Prevention and Treatment of Herpes Simplex

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Incredible and Effective smoothie for reduced risk and treatment of Herpes simplex

Yield: 2 servings (about 8 ounces each)
1 3/4 cups blueberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of herpes simplex has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Herpes simplex is an infectious skin disease caused by herpes simplex virus due to skin-to-skin contact, mouth contact, or sexual contact.
The recent studies from numbers of respectable institutions insisted that green tea,
may be a potential target for next generation in production of a natural sources in reduced risk and treatment of herpes simplex without induced any side effects.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. Its phytochemicals epigallocatechin-3-gallate used topically inhibited herpes simplex labialis infection with clinical significance(1).

Theaflavin-3,3'-digallate (TF3) in Catechin, a major phytochemical constituent found in green tea, inhibited HSV-1 production in both Vero and A549 cells(2), according to the joint study from Seton Hall University.

Dr. de Oliveira A and colleagues in the study of the effect of green tea against herpes simplex, suggested that Green tea polyphenol epigallocatechin gallate (EGCG), may be a potent inhibitor of herpes simplex virus 1 (HSV-1) by blocking the production of infectious HSV-1 particles(3).

Resveratrol, found abundantly in blueberry is a phytochemical in the class of Stilbenoids may also be a potential agent for reduced risk and treatment of Herpes simplex(4).

According to the Nanjing University School of Medicine and Jiangsu Laboratory of Molecular Medicine, Stilbenoids including resveratrol with basic structural unit of 1,2-diphenylethylene, have demonstrated potent biological activities in against HSV-1 and HSV-2 infection(5), through inhibited the production of reactive oxygen species(ROS).

Dr. Faith SA and researchers at the Northeastern Ohio Universities College of Medicine, also suggested, resveratrol suppressed nuclear factor-kappaB in regulating the immune response to infection in herpes simplex virus infected cells in the all stages of impairs expression of HSV genes and synthesis of viral DNA.(6).

Anthocyanidins‎, another flavonoid found in blueberry also demonstrated a strong antiviral activity in a plaque reduction assay through its cytopathic effect (CPE)(7).

In support of the effectiveness of flavonoid against herpes simplex infection, Dr. Lin LC and researchers at the National Research Institute of Chinese Medicine said, " (All compounds)showed an inhibitory effects on herpes simplex virus type-1 (HSV-1) replication in Vero cells. Both compounds (-)-epigallocatechin 3-O-gallate (1), samarangenin B (2) exhibited potent inhibitory activities in HSV-1 replication"(8).

Rich sources of Catechin, Resveratrol and Anthocyanidins found in green tea and blueberry may process a potential benefit for reduced risk and treatment of Herpes simplex infection. The smoothie containing these ingredients in high amount should also mimic the similar effects in chronic use.
People at higher risk of Herpes simplex infection due to genetic mutation, immune disorder,..... should drink at least one serving daily and people with the disease should drink as much as they can, depending to the toleration of digestive system.

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References

(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)

(2) Antiviral activity of theaflavin digallate against herpes simplex virus type 1 by de Oliveira A1, Prince D1, Lo CY2, Lee LH3, Chu TC4.(PubMed)

(3) Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by de Oliveira A1, Adams SD, Lee LH, Murray SR, Hsu SD, Hammond JR, Dickinson D, Chen P, Chu TC.(PubMed)

(4) Natural polyphenols: potential in the prevention of sexually transmitted viral infections by Date AA1, Destache CJ2.(PubMed)

(5) Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation by Chen X1, Qiao H, Liu T, Yang Z, Xu L, Xu Y, Ge HM, Tan RX, Li E.(PubMed)

(6) Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells by Faith SA1, Sweet TJ, Bailey E, Booth T, Docherty JJ.(PubMed)

(7) Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro by Lyu SY1, Rhim JY, Park WB.(PubMed)

(8) Anti-herpes simplex virus type-1 flavonoids and a new flavanone from the root of Limonium sinense by Lin LC1, Kuo YC, Chou CJ.(PubMed)