Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
The Treatment
A. In conventional medicine perspective
The aim of treatment is to stop the progression and relieve the symptoms of the diseases
1. Non Medication
1.1. Physical therapy
Physical therapy with functions of re mediated impairments and promoted mobility, used conjunction with others including education, medical treatment,and occupational therapy may play an essential role for management of RA(172). In the treatment of patient with RA using the Whole-body cryotherapy (WBC) in supplement to physical therapy, Dr. combination and the research team at the joint study lead by the University School of Physical Education in Poznań said" (The combined therapies showed )improvement in pain, disease activity, fatigue, time of walking, and the number of steps over a distance of 50 m,...... similar significant reduction in IL-6 and TNF-α level (the inflammatory cytokines),...regardless of the kind of the applied physical procedure in patient with RA(173).
1.2. Relaxation therapy and biofeedback training
Relaxation and temperature biofeedback training as an adjunctive therapy has showed to alleviate both pain and stress-related symptoms as well as improvement of pain, tension, and sleep patterns. In fact, the therapy are found to induced higher physical/functional indices in comparison to physical therapy(174). Dr. Astin JA. and the research team at the University of Maryland School of Medicine suggested that psychological interventions such as relaxation, biofeedback, cognitive-behavioral therapy, may form an important part in may be important adjunctive therapies in the medical management of RA, especially for patients who have had the illness for shorter duration(175).In fact, a systematic review and meta-analysis of randomized controlled trials, also showed that psychological intervention improved both depressive symptoms and anxiety among patients with RA(176).
1.3. Low level laser therapy
Low level laser therapy may be beneficiary in modulated inflammatory response both in early as well as in late progression stages of RA, through its effects in significantly improved mononuclear inflammatory cells(177) as well as modulating inflammatory mediators (IL-1β, IL-6)(178). The study of 132 patients at the age varying from 18 to 85 years presenting with rheumatoid arthritis by Dr.Kulova LA, and Dr. Burduli NM also found thatn the therapy showed an improvement of the endothelial function and the microcirculation indices in patient with rheumatoid arthritis(179). But according to a randomized double-blind controlled trial laser therapy using low-level aluminum gallium arsenide was not effective at the wavelength, dosage, and power studied for the treatment of hands among patients with rheumatoid arthritis(180).
1.4. Occupational therapy
According to the Canadian association of occupation therapy, it is form of treatment to solve the problems that interfere with your ability to do the things that are important to you. It can also prevent a problem or minimize its effects(181). According to the Netherlands Institute for Health Services Research, in controlled (randomized and non-randomized) and other than controlled studies (OD) addressing OT for RA patients showed that occupation therapy improved outcome on functional ability, social participation and/or health related quality of life(182). Rheumatologically, occupation therapy in many cases has successfully improved and maintained functional capacity, prevented progression of deformities, ......... of that may require for the engagement of the individual in meaningful occupations, favoring autonomy and independence in self-care activities, employment, educational, social and leisure(183)
1.5. Prosorba column apheresis therapy (PCT)
Prosorba column apheresis therapy (PCT), a medical device containnig purified staphylococcal protein A covalently bound to a silica matrix has been used in many medical centers for treatment severerheumatoid arthritis (RA) since its approval in 1999(184) with some promising result(185).
The therapy showed a 52% improvement in joint tenderness, 40% improvement in swelling, 42% improvement in patient's pain, 38% improvement in patient's global response, and 48% improvement in physician's global scores 76% of responders, according to the study by Cypress Bioscience(184).
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(172) Juvenile rheumatoid arthritis: physical therapy and rehabilitation by Cakmak A1, Bolukbas N.(PubMed)
(173) Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy inRheumatoid Arthritis by Gizińska M1, Rutkowski R1, Romanowski W2, Lewandowski J3, Straburzyńska-Lupa A4.(PubMed)
(174) Rheumatoid arthritis: a study of relaxation and temperature biofeedback training as an adjunctive therapy by Achterberg J, McGraw P, Lawlis GF.(PubMed)
(175) Psychological interventions for rheumatoid arthritis: a meta-analysis of randomized controlled trials by Astin JA1, Beckner W, Soeken K, Hochberg MC, Berman B.(PubMed)
(176) Psychological interventions for rheumatoid arthritis: examining the role of self-regulation with a systematic review and meta-analysis of randomized controlled trials by Knittle K1, Maes S, de Gucht V.(PubMed)
(177) Low-level laser therapy in different stages of rheumatoid arthritis: a histological study by Alves AC1, de Carvalho PT, Parente M, Xavier M, Frigo L, Aimbire F, Leal Junior EC, Albertini R.(PubMed)
(178) Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation by Alves AC, Vieira R, Leal-Junior E, dos Santos S, Ligeiro AP, Albertini R, Junior J, de Carvalho P.(PubMed)
(179) [The influence of intravenous laser therapy on the endothelial function and the state of microcirculation in the patients presenting with rheumatoid arthritis].[Article in Russian] by Kulova LA, Burduli NM.(PubMed)
(180) Assessment of the effectiveness of low-level laser therapy on the hands of patients with rheumatoid arthritis: a randomized double-blind controlled trial by Meireles SM1, Jones A, Jennings F, Suda AL, Parizotto NA, Natour J.(PubMed)
(181) What is occupation therapy(Canadian association of occupation therapy)
(182) Occupational therapy for rheumatoid arthritis by Steultjens EM1, Dekker J, Bouter LM, van Schaardenburg D, van Kuyk MA, van den Ende CH.(PubMed)
(183) [Occupational therapy in rheumatoid arthritis: what rheumatologists need to know?].[Article in Portuguese] by de Almeida PH1, Pontes TB2, Matheus JP2, Muniz LF3, da Mota LM3.(PubMed)
(184) Effects of Prosorba column apheresis in patients with chronic refractory rheumatoid arthritis by
Roth S1(PubMed)
Tuesday, April 26, 2016
The Smoothies of Grape, Avocado and Green tea for Prevention a of Ectopic Pregnancy
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Ectopic pregnancy is defined as a condition in which the fertilized implant in somewhere else other than in the uterus. In most case, ectopic pregnancy occurs in the one of the Fallopian tube, causing tubal pregnancy. Ectopic pregnancy will end up in miscarriage as the fertilized can not survive outside of uterus.
Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as Green tea(1), Turmeric(3) and Olive(7) for reduced risk for
Women can not prevent ectopic pregnancy. but risk of the disease is reduced if you quit smoking, protect yourself from sexually transmitted infections (STIs) and pelvic inflammatory disease (PID). PID is a common cause of scar tissue in the fallopian tubes, which induce ectopic pregnancy.
1. The smoothie for reduced risk Ectopic Pregnancy caused by pelvic inflammatory disease
Yield: 2 serving (about 8 ounce each)
1 cup grape
1/4 cup avocado
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The finding the natural ingredients for treatment of pelvic inflammation disease is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Pelvic inflammation disease (PID) is defined as condition caused by inflammation or infection of the female uterus, fallopian tubes, and/or ovaries as a result of scars and adhesion in the pelvic which in turn may prevent the implantation of egg during natural pregnancy process. It affects over 1 million women in U.S. every month and most of them are in their teen and twenties and over 100,000 women become infertile in the US alone each year.
Recent studies reported by some well known institution, green tea, may process the anti inflammatory diseases, including inhibition of pelvic inflammation disease (PID), as pelvic inflammatory disease is
associated to increased expressions of Th1 cytokine IFN-gamma, and Th2 cytokine IL-5, related to pro inflammatory pathways(2).
Recent studies back by renowned institution suggested, Green tea(1), Grape(8) and Avocado(5) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression, recent studies suggested. According to The Catholic University of Korea, epigallocatechin-3-gallate attenuated the chronic inflammatory activities through educed the level of IFN-γ-induced priming signal in immune regulation via the down-regulation of pro-IL-1β and pro-capspase-1 in HEKn cell of proinflammatory cytokines(1).
Dr. and the colleagues at the Medical College of Ohio Ruppert proposed, theaflavins, amajor green constituent exhibited antioxidant, antineoplastic and antiinflammatory properties, including induction of IFNgamma mRNA of NF-kappaB for gene expression of pro - inflammatory pathway(3).Dr. Chen X, and professors Li W and Wang H.at the New York University School of Medicine, suggested that Green tea reduced endotoxin-induced release of (e.g., TNF, IL-1, and IFN-gamma) and (e.g., HMGB1) pro-inflammatory cytokines(4).
Avocado, a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae, is a commercially valuable fruit and cultivated in tropical climates throughout the world.
Omega-3 polyunsaturated fatty acids (PUFA) found abundantly in avocado may possess the most potent immunomodulatory activities, and among the omega-3 PUFA in reduced risk and treatment of inflammatory and auto immune diseases caused by the increased level of interleukin 1 (IL-1), a proinflammatory cytokine(5).
Dr. Calder PC. said, "n-3 PUFA can down regulate the activity of the nuclear transcription factor NFB" and "suppressed production of pro-inflammatory cytokines and can decrease adhesion molecule expression"(6).
According to Dr. Gouveia TL and research, omega 3 fatty acids plays an important role in activation of the immune system in the central nervous system in response to the release of pro inflammatory cytokines such as IL-1β, IL-6, and TNF-α(7) of which related to the occurance of pelvic inflammatory disease(2).
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also expressed the inhibition of cytokines involved the progression of pelvic inflammation disease (PID), according to Dr. Inoue H and Dr. Nakata R. said, "Resveratrol is as a phytoalexin, cyclooxygenase (COX) suppressor, and an activator of peroxisome proliferatoractivated receptor (PPAR) and SIRT1."(8).According to the, resveratrol intake ameliorated, in a dose-dependent manner, pro-inflammatory cytokines IL-1β, TNF-α and IL-6 mRNA expression and promote the release of anti-inflammatory interleukin (IL)-10(9). of that related to reduced risk and treatment of inflammatory diseases.
In fact the effectiveness of resveratrol in reduced risk and treatment of chronic inflammatory diseases may be due to promotion of anti inflammatory and reduction of pro inflammatory properties(10).
The combination of Green Tea, Grape and Avocado smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Pelvic inflammation disease (PID) without inducing adverse effects.
Women who are at increased risk of Pelvic inflammation disease (PID), due to family history,... should drink at least one cup daily. Women with Pelvic inflammation disease (PID) should drink as much as they can depending to the digestive toleration.
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape may also be effective in amelioration of sexual infectious diseases, including vaginal inflammation and infections(13), HIV/AIDS infection(14), herpes simplex virus vaginal infection(15), etc.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Ectopic pregnancy is defined as a condition in which the fertilized implant in somewhere else other than in the uterus. In most case, ectopic pregnancy occurs in the one of the Fallopian tube, causing tubal pregnancy. Ectopic pregnancy will end up in miscarriage as the fertilized can not survive outside of uterus.
Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as Green tea(1), Turmeric(3) and Olive(7) for reduced risk for
Women can not prevent ectopic pregnancy. but risk of the disease is reduced if you quit smoking, protect yourself from sexually transmitted infections (STIs) and pelvic inflammatory disease (PID). PID is a common cause of scar tissue in the fallopian tubes, which induce ectopic pregnancy.
1. The smoothie for reduced risk Ectopic Pregnancy caused by pelvic inflammatory disease
Yield: 2 serving (about 8 ounce each)
1 cup grape
1/4 cup avocado
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The finding the natural ingredients for treatment of pelvic inflammation disease is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Pelvic inflammation disease (PID) is defined as condition caused by inflammation or infection of the female uterus, fallopian tubes, and/or ovaries as a result of scars and adhesion in the pelvic which in turn may prevent the implantation of egg during natural pregnancy process. It affects over 1 million women in U.S. every month and most of them are in their teen and twenties and over 100,000 women become infertile in the US alone each year.
Recent studies reported by some well known institution, green tea, may process the anti inflammatory diseases, including inhibition of pelvic inflammation disease (PID), as pelvic inflammatory disease is
associated to increased expressions of Th1 cytokine IFN-gamma, and Th2 cytokine IL-5, related to pro inflammatory pathways(2).
Recent studies back by renowned institution suggested, Green tea(1), Grape(8) and Avocado(5) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression, recent studies suggested. According to The Catholic University of Korea, epigallocatechin-3-gallate attenuated the chronic inflammatory activities through educed the level of IFN-γ-induced priming signal in immune regulation via the down-regulation of pro-IL-1β and pro-capspase-1 in HEKn cell of proinflammatory cytokines(1).
Dr. and the colleagues at the Medical College of Ohio Ruppert proposed, theaflavins, amajor green constituent exhibited antioxidant, antineoplastic and antiinflammatory properties, including induction of IFNgamma mRNA of NF-kappaB for gene expression of pro - inflammatory pathway(3).Dr. Chen X, and professors Li W and Wang H.at the New York University School of Medicine, suggested that Green tea reduced endotoxin-induced release of (e.g., TNF, IL-1, and IFN-gamma) and (e.g., HMGB1) pro-inflammatory cytokines(4).
Avocado, a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae, is a commercially valuable fruit and cultivated in tropical climates throughout the world.
Omega-3 polyunsaturated fatty acids (PUFA) found abundantly in avocado may possess the most potent immunomodulatory activities, and among the omega-3 PUFA in reduced risk and treatment of inflammatory and auto immune diseases caused by the increased level of interleukin 1 (IL-1), a proinflammatory cytokine(5).
Dr. Calder PC. said, "n-3 PUFA can down regulate the activity of the nuclear transcription factor NFB" and "suppressed production of pro-inflammatory cytokines and can decrease adhesion molecule expression"(6).
According to Dr. Gouveia TL and research, omega 3 fatty acids plays an important role in activation of the immune system in the central nervous system in response to the release of pro inflammatory cytokines such as IL-1β, IL-6, and TNF-α(7) of which related to the occurance of pelvic inflammatory disease(2).
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also expressed the inhibition of cytokines involved the progression of pelvic inflammation disease (PID), according to Dr. Inoue H and Dr. Nakata R. said, "Resveratrol is as a phytoalexin, cyclooxygenase (COX) suppressor, and an activator of peroxisome proliferatoractivated receptor (PPAR) and SIRT1."(8).According to the, resveratrol intake ameliorated, in a dose-dependent manner, pro-inflammatory cytokines IL-1β, TNF-α and IL-6 mRNA expression and promote the release of anti-inflammatory interleukin (IL)-10(9). of that related to reduced risk and treatment of inflammatory diseases.
In fact the effectiveness of resveratrol in reduced risk and treatment of chronic inflammatory diseases may be due to promotion of anti inflammatory and reduction of pro inflammatory properties(10).
The combination of Green Tea, Grape and Avocado smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Pelvic inflammation disease (PID) without inducing adverse effects.
Women who are at increased risk of Pelvic inflammation disease (PID), due to family history,... should drink at least one cup daily. Women with Pelvic inflammation disease (PID) should drink as much as they can depending to the digestive toleration.
2. The smoothie for reduced risk Ectopic Pregnancy caused by sexually transmitted infections (STIs)
1 cup grape
1/2 cup blueberry
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)
Sexually transmitted infections (STIs) is a disease can pass on from one to another after sexual contact, including vaginal intercourse, oral sex, and anal sex.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its antiaoxidants are best known for antimicrobial effect in prevention and treatment of sexual infectious diseases such as HPV and genital warts(11), HIV-1 infection(12),
1 cup grape
1/2 cup blueberry
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)
Sexually transmitted infections (STIs) is a disease can pass on from one to another after sexual contact, including vaginal intercourse, oral sex, and anal sex.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its antiaoxidants are best known for antimicrobial effect in prevention and treatment of sexual infectious diseases such as HPV and genital warts(11), HIV-1 infection(12),
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape may also be effective in amelioration of sexual infectious diseases, including vaginal inflammation and infections(13), HIV/AIDS infection(14), herpes simplex virus vaginal infection(15), etc.
The combination of Green Tea, Grape and Bueberry smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Ectopic Pregnancy induced by sexually transmitted infections (STIs) without inducing adverse effects.
Women who are at increased risk of Ectopic Pregnancy induced by sexually transmitted infections (STIs), due to sexual active,... should drink as much as they can, depending to the digestive toleration.
Women who are at increased risk of Ectopic Pregnancy induced by sexually transmitted infections (STIs), due to sexual active,... should drink as much as they can, depending to the digestive toleration.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes by Yun M1, Seo G1, Lee JY1, Chae GT1, Lee SB2.(PubMed)
(2) Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease by Chen KS1, Wang PH, Yang SF, Lin DB, Lin YJ, Kuo DY, Lin LY, Wu MT, Lin CW, Lee S, Chou MC, Tsai HT, Hsieh YS.(PubMed)
(3) Tea pigments inhibit the production of type 1 (T(H1)) and type 2 (T(H2)) helper T cell cytokines in CD4(+) T cells by Tomita M1, Irwin KI, Xie ZJ, Santoro TJ.(PubMed)
(4) More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines by Chen X1, Li W, Wang H.(PubMed)
(5) Omega-3 fatty acids in inflammation and autoimmune diseases by Simopoulos AP1.(PubMed)
(6) Dietary modification of inflammation with lipids by Calder PC1.(PubMed)
(7) High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? by Gouveia TL1, Vieira de Sousa PV1, de Almeida SS2, Nejm MB1, Vieira de Brito JM1, Cysneiros RM3, de Brito MV4, Salu BR4, Oliva ML4, Scorza FA1, Naffah-Mazzacoratti Mda G5.(PubMed)
(8) Resveratrol Targets in Inflammation by Inoue H1, Nakata R.(PubMed)
(9) IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. by Cianciulli A1, Dragone T1, Calvello R1, Porro C2, Trotta T2, Lofrumento DD3, Panaro MA4.(PubMed)
(10) Resveratrol differentially modulates inflammatory responses of microglia by Lu X1, Ma L, Ruan L, Kong Y, Mou H, Zhang Z, Wang Z, Wang JM, Le Y.(PubMed)
(11) Updates on human papillomavirus and genital warts and counseling messages from the 2010Sexually Transmitted Diseases Treatment Guidelines by Dunne EF1, Friedman A, Datta SD, Markowitz LE, Workowski KA.(PubMed)
(12) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(13) Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections by Jøraholmen MW1, Škalko-Basnet N2, Acharya G3, Basnet P4.(PudMed)
(14) Dawn of antioxidants and immune modulators to stop HIV-progression and boost the immune system in HIV/AIDS patients: An updated comprehensive and critical review by Singh G1, Pai RS2.d(PubMed)
(15) Effect of resveratrol on herpes simplex virus vaginal infection in the mouse by Docherty JJ1, Fu MM, Hah JM, Sweet TJ, Faith SA, Booth T.(PubMed)
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes by Yun M1, Seo G1, Lee JY1, Chae GT1, Lee SB2.(PubMed)
(2) Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease by Chen KS1, Wang PH, Yang SF, Lin DB, Lin YJ, Kuo DY, Lin LY, Wu MT, Lin CW, Lee S, Chou MC, Tsai HT, Hsieh YS.(PubMed)
(3) Tea pigments inhibit the production of type 1 (T(H1)) and type 2 (T(H2)) helper T cell cytokines in CD4(+) T cells by Tomita M1, Irwin KI, Xie ZJ, Santoro TJ.(PubMed)
(4) More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines by Chen X1, Li W, Wang H.(PubMed)
(5) Omega-3 fatty acids in inflammation and autoimmune diseases by Simopoulos AP1.(PubMed)
(6) Dietary modification of inflammation with lipids by Calder PC1.(PubMed)
(7) High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? by Gouveia TL1, Vieira de Sousa PV1, de Almeida SS2, Nejm MB1, Vieira de Brito JM1, Cysneiros RM3, de Brito MV4, Salu BR4, Oliva ML4, Scorza FA1, Naffah-Mazzacoratti Mda G5.(PubMed)
(8) Resveratrol Targets in Inflammation by Inoue H1, Nakata R.(PubMed)
(9) IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. by Cianciulli A1, Dragone T1, Calvello R1, Porro C2, Trotta T2, Lofrumento DD3, Panaro MA4.(PubMed)
(10) Resveratrol differentially modulates inflammatory responses of microglia by Lu X1, Ma L, Ruan L, Kong Y, Mou H, Zhang Z, Wang Z, Wang JM, Le Y.(PubMed)
(11) Updates on human papillomavirus and genital warts and counseling messages from the 2010Sexually Transmitted Diseases Treatment Guidelines by Dunne EF1, Friedman A, Datta SD, Markowitz LE, Workowski KA.(PubMed)
(12) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(13) Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections by Jøraholmen MW1, Škalko-Basnet N2, Acharya G3, Basnet P4.(PudMed)
(14) Dawn of antioxidants and immune modulators to stop HIV-progression and boost the immune system in HIV/AIDS patients: An updated comprehensive and critical review by Singh G1, Pai RS2.d(PubMed)
(15) Effect of resveratrol on herpes simplex virus vaginal infection in the mouse by Docherty JJ1, Fu MM, Hah JM, Sweet TJ, Faith SA, Booth T.(PubMed)
Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary arterial hypertension Treatment In herbal medicine perspective
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary arterial hypertension
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary arterial hypertension is a subgroup of a specific subgroup of pulmonary hypertension (PH) defined as a condition of slowly progressive disorder as a result of abnormally high blood pressure in the blood vessel, including pulmonary artery, pulmonary vein, or pulmonary capillaries, that carries blood from the heart to the lungs due to narrowing in diameter of most of the very small arteries throughout the lungs of that increased resistance to blood flow, leading to right heart failure and death. Because the phrase pulmonary arterial hypertension is long and pulmonary hypertension is a bit shorter the phrase pulmonary hypertension is often used in place of pulmonary arterial hypertension(a).According to statistic, approximately over 1,000 new cases of pulmonary arterial hypertension are diagnosed each year, In the United States alone.
B. In Herbal medicine perspective
1. Radix Astragali
In the study of Sixty rats divided into three groups: hypoxia group, hypoxia + RA group and normal control group to observe the inhibitory effects of Radix Astragali (RA) on hypoxic structural remodeling of intraacinar pulmonary arteries (IAPA) and pulmonary hypertension (PHT), showe d that compared with the result of hypoxia + RA group, RA could relieve IAPA wall cell injuries and dilate the constricted IAPA induced by hypoxia. RA could also inhibit hypertrophic changes in the tunica media and proliferation of adventitial cells of the IAPA and muscularization of nonmuscular arteries(38).
2. Radix Peucedani
According to the study by the Department of Pathology, Cardiovascular Institute, RP could not only antagonize IAPA contraction caused by hypoxia and lower the resistance of pulmonary circulation, inhibit the cell proliferation and hypertrophy of adventitial cells of pulmonary artery, but also reverse the change in structure and function of pulmonary artery. It suggests that RA plays a key role in inhibiting hypoxic structural remodeling of IAPA and pulmonary hypertension(39).
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary arterial hypertension
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary arterial hypertension is a subgroup of a specific subgroup of pulmonary hypertension (PH) defined as a condition of slowly progressive disorder as a result of abnormally high blood pressure in the blood vessel, including pulmonary artery, pulmonary vein, or pulmonary capillaries, that carries blood from the heart to the lungs due to narrowing in diameter of most of the very small arteries throughout the lungs of that increased resistance to blood flow, leading to right heart failure and death. Because the phrase pulmonary arterial hypertension is long and pulmonary hypertension is a bit shorter the phrase pulmonary hypertension is often used in place of pulmonary arterial hypertension(a).According to statistic, approximately over 1,000 new cases of pulmonary arterial hypertension are diagnosed each year, In the United States alone.
The Treatment
B. In Herbal medicine perspective
1. Radix Astragali
In the study of Sixty rats divided into three groups: hypoxia group, hypoxia + RA group and normal control group to observe the inhibitory effects of Radix Astragali (RA) on hypoxic structural remodeling of intraacinar pulmonary arteries (IAPA) and pulmonary hypertension (PHT), showe d that compared with the result of hypoxia + RA group, RA could relieve IAPA wall cell injuries and dilate the constricted IAPA induced by hypoxia. RA could also inhibit hypertrophic changes in the tunica media and proliferation of adventitial cells of the IAPA and muscularization of nonmuscular arteries(38).
2. Radix Peucedani
According to the study by the Department of Pathology, Cardiovascular Institute, RP could not only antagonize IAPA contraction caused by hypoxia and lower the resistance of pulmonary circulation, inhibit the cell proliferation and hypertrophy of adventitial cells of pulmonary artery, but also reverse the change in structure and function of pulmonary artery. It suggests that RA plays a key role in inhibiting hypoxic structural remodeling of IAPA and pulmonary hypertension(39).
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Monday, April 25, 2016
Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Antioxidant
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
The Antioxidants
Antioxidants found abundantly in fruits and vegetables can enhance the immune system fighting against forming of free radicals causes of irregular cell growth and foreign invasion of inflammation and infection.
1. Vitamin C
Vitamin C, one of most powerful free radical scavengers, played an important role in prevention of domino effects of imbalance of estrogen may be a potent antioxidant effectively in normalization of the impaired oxidant/antioxidant system and delayed complication of RA(161). Dr, Al-Okbi SY in the study of elevated oxidative stress and inflammatory biomarkers suggested that vitamin C can be used as as complementary medicine to manage rheumatoid arthritis due to its anti-inflammatory and antioxidant activities(162).
But Dr. Rosenbaum CC and the research team at the the Bethesda North Hospital Pharmacy iunsisted that more high quality research are necessary before supplements including vitamin C can be effectively and safely recommended to reduce nonsteroidal antiinflammatory drug or steroid usage"(163)
2. Vitamin E
Low intake of vitamin E and selenium have been found to the RA elder patient(166).Vitamin E, another free radical scavenger may also be effective for patient with RA due to its positive effect on autoimmune disease by decreasing proinflammatory cytokines and lipid mediator(164). Dr. Aryaeian N. in the investigation of the effectiveness of supplements in RA, showed that the procession of property in promoted immunity and involvement of inflammatory parameters may put vitamin E in front of other rheumatoid arthritis (RA)management supplements(165).
3. Glucosamine
Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans may be another antioxidant used for management of symptoms of patient with RA, according to the study of 25 patients in the glucosamine group and 26 patients in the placebo group(167). Dr. Matsuno H. and the research team at the Matsuno Clinic for Rheumatic Diseases, said" (oral administration of) glucosamine-chondroitin-quercetin glucoside (GCQG) for 3 months showed a significant improvement in pain symptoms, daily activities (walking and climbing up and down stairs), and visual analogue scale, and changes in the synovial fluid properties"(168) in patient of OA and RA. Further more, the supplement also found to consist the therapeutic potential for arthritis by exerting antioxidative and immunomodulatory effects(169).
4. Methylsulfonylmethane
Methylsulfonylmethane (MSM), an antioxidant with organosulfur compound has shown to involve in reduced the progression of inflammatory processes in RA patient(170). The Jazan University study in the comparison of the effectiveness of Echinacea extract and composite glucosamine, chondroitin and methyl sulfonyl methane supplements, showed that both ingredient exhibit anti inflammation, oedema and mild proliferation of synovial cells activities, through reduced cartilage damage and bone density of that may be a promising light on arthritis treatment(171)
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(161) Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model by Meki AR1, Hamed EA, Ezam KA(PubMed)
(162) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis.
Al-Okbi SY1(PubMed)
(163) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(164) Effects of diets containing fish oil and vitamin E on rheumatoid arthritis. by Tidow-Kebritchi S1, Mobarhan S.(PubMed)
(165) Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunity and inflammatory parameters in adults with active rheumatoid arthritis: a randomized controlled trial. by Aryaeian N1, Djalali M2, Shahram F3, Djazayery A4, Eshragian MR5(PubMed)
(166)Intake of antioxidants in patients with rheumatoid arthritis by Silva BN1, Araújo ÍL1, Queiroz PM2, Duarte AL3, Burgos MG4.(PubMed)
(167) Effects of glucosamine administration on patients with rheumatoid arthritis by Nakamura H1, Masuko K, Yudoh K, Kato T, Kamada T, Kawahara T.(PubMed)
(168) Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis by Matsuno H1, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y.(PubMed)
(169) The anti-arthritic and immune-modulatory effects of NHAG: a novel glucosamine analogue in adjuvant-induced arthritis by Shah SU1, Jawed H, Awan SI, Anjum S, Simjee SU.(PubMed)
(170) The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis by Notarnicola A1, Tafuri S, Fusaro L, Moretti L, Pesce V, Moretti B.(PubMed)
(171) The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model by Arafa NM1, Hamuda HM, Melek ST, Darwish SK.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
The Antioxidants
Antioxidants found abundantly in fruits and vegetables can enhance the immune system fighting against forming of free radicals causes of irregular cell growth and foreign invasion of inflammation and infection.
1. Vitamin C
Vitamin C, one of most powerful free radical scavengers, played an important role in prevention of domino effects of imbalance of estrogen may be a potent antioxidant effectively in normalization of the impaired oxidant/antioxidant system and delayed complication of RA(161). Dr, Al-Okbi SY in the study of elevated oxidative stress and inflammatory biomarkers suggested that vitamin C can be used as as complementary medicine to manage rheumatoid arthritis due to its anti-inflammatory and antioxidant activities(162).
But Dr. Rosenbaum CC and the research team at the the Bethesda North Hospital Pharmacy iunsisted that more high quality research are necessary before supplements including vitamin C can be effectively and safely recommended to reduce nonsteroidal antiinflammatory drug or steroid usage"(163)
2. Vitamin E
Low intake of vitamin E and selenium have been found to the RA elder patient(166).Vitamin E, another free radical scavenger may also be effective for patient with RA due to its positive effect on autoimmune disease by decreasing proinflammatory cytokines and lipid mediator(164). Dr. Aryaeian N. in the investigation of the effectiveness of supplements in RA, showed that the procession of property in promoted immunity and involvement of inflammatory parameters may put vitamin E in front of other rheumatoid arthritis (RA)management supplements(165).
3. Glucosamine
Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans may be another antioxidant used for management of symptoms of patient with RA, according to the study of 25 patients in the glucosamine group and 26 patients in the placebo group(167). Dr. Matsuno H. and the research team at the Matsuno Clinic for Rheumatic Diseases, said" (oral administration of) glucosamine-chondroitin-quercetin glucoside (GCQG) for 3 months showed a significant improvement in pain symptoms, daily activities (walking and climbing up and down stairs), and visual analogue scale, and changes in the synovial fluid properties"(168) in patient of OA and RA. Further more, the supplement also found to consist the therapeutic potential for arthritis by exerting antioxidative and immunomodulatory effects(169).
4. Methylsulfonylmethane
Methylsulfonylmethane (MSM), an antioxidant with organosulfur compound has shown to involve in reduced the progression of inflammatory processes in RA patient(170). The Jazan University study in the comparison of the effectiveness of Echinacea extract and composite glucosamine, chondroitin and methyl sulfonyl methane supplements, showed that both ingredient exhibit anti inflammation, oedema and mild proliferation of synovial cells activities, through reduced cartilage damage and bone density of that may be a promising light on arthritis treatment(171)
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) 8 Areas of Age-Related Change(NIH)
(2) Arthritis-Related Statistics(CDC)
(3) Valgus deformities of the feet and characteristics of gait in patients who have rheumatoid arthritis by Keenan MA1, Peabody TD, Gronley JK, Perry J.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(4a) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(161) Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model by Meki AR1, Hamed EA, Ezam KA(PubMed)
(162) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis.
Al-Okbi SY1(PubMed)
(163) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(164) Effects of diets containing fish oil and vitamin E on rheumatoid arthritis. by Tidow-Kebritchi S1, Mobarhan S.(PubMed)
(165) Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunity and inflammatory parameters in adults with active rheumatoid arthritis: a randomized controlled trial. by Aryaeian N1, Djalali M2, Shahram F3, Djazayery A4, Eshragian MR5(PubMed)
(166)Intake of antioxidants in patients with rheumatoid arthritis by Silva BN1, Araújo ÍL1, Queiroz PM2, Duarte AL3, Burgos MG4.(PubMed)
(167) Effects of glucosamine administration on patients with rheumatoid arthritis by Nakamura H1, Masuko K, Yudoh K, Kato T, Kamada T, Kawahara T.(PubMed)
(168) Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis by Matsuno H1, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y.(PubMed)
(169) The anti-arthritic and immune-modulatory effects of NHAG: a novel glucosamine analogue in adjuvant-induced arthritis by Shah SU1, Jawed H, Awan SI, Anjum S, Simjee SU.(PubMed)
(170) The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis by Notarnicola A1, Tafuri S, Fusaro L, Moretti L, Pesce V, Moretti B.(PubMed)
(171) The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model by Arafa NM1, Hamuda HM, Melek ST, Darwish SK.(PubMed)
The Fabulous Green Tea and Grape for reducded rsik and Treatment of Impetigo
Kyle J. Norton(Scholar, master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for Reduced risk and Treatment of Impetigo
Yield: 2 serving (about 8 ounce each)
1 cup Blueberry
1/4 cup avocado
1/4 cup raw flax seed
1 cup of rice milk
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The dream of finding the natural ingredient for prevention and treatment of infectious skin diseases, such as Impetigo, without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard because of not achieving the same potent results in human trials.
Scientist community may have found the smoothie(combined ingredients of garlic, olive and coconut oils) with potential and therapeutic value for reduced risk and treatment of Impetigo without adverse effects.
Impetigo is a contagious skin disease infection affecting mostly children and infants.
According to the recent studies by the well known institutions, green tea(3) and Grapes(1) , may hold a key for potential and therapeutic values for attenuated symptoms and treatment of Impetigo.
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. According to the, it extract has exhibited weak antibacterial effect of amoxicillin in methicillin-resistant Staphylococcus aureus infected mice(3). But its polyphenols (TPP), showed a significant effects in the same methicillin-resistant Staphylococcus aureus (MRSA, the bacteria also responsible for induction of Impetigo in children and infants) through regulating the expression of various proteins in Staphylococcus aureus (MRSA)(4).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for Reduced risk and Treatment of Impetigo
Yield: 2 serving (about 8 ounce each)
1 cup Blueberry
1/4 cup avocado
1/4 cup raw flax seed
1 cup of rice milk
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The dream of finding the natural ingredient for prevention and treatment of infectious skin diseases, such as Impetigo, without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard because of not achieving the same potent results in human trials.
Scientist community may have found the smoothie(combined ingredients of garlic, olive and coconut oils) with potential and therapeutic value for reduced risk and treatment of Impetigo without adverse effects.
Impetigo is a contagious skin disease infection affecting mostly children and infants.
According to the recent studies by the well known institutions, green tea(3) and Grapes(1) , may hold a key for potential and therapeutic values for attenuated symptoms and treatment of Impetigo.
Against streptococcus pyogenes, one of bacteria induced contagious skin infection, Epigallocatechin Gallate (EGCG) isolated from green tea, displayed antimicrobial properties at various concentrations, through effectively reduced GAS bacteria cellular attachment and induced GAS cell death(5).
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape inhibited also methicillin-resistant Staphylococcus aureus through disturbing the expression of genes related to QS in bacterial density(6), through its antioxidant activity(1). According to the joint study by the Capital Medical University, resveratrol of the polyphenols, inhibited the methicillin-resistant Staphylococcus aureus (MRSA), determined by the checkerboard agar dilution method(7).
Dr. Sakagami Y and colleagues at the Kinki University said" Two resveratrol trimers, gnemonol B isolated from Gnetum gnemon and gnetin E,....exhibit strong antibacterial activities against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA)" and ",(may be used) alone or in combination with antibiotics might be useful in controlling and treating VRE and MRSA infections"(2).
Taking altogether, intake of combination of green tea and grape may as a cornerstone for further investigation of the validation.
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) New stilbene derivatives from Calligonum leucocladum by Okasaka M1, Takaishi Y, Kogure K, Fukuzawa K, Shibata H, Higuti T, Honda G, Ito M, Kodzhimatov OK, Ashurmetov O.(PubMed)
(2) Antibacterial activity of stilbene oligomers against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics by Sakagami Y1, Sawabe A, Komemushi S, All Z, Tanaka T, Iliya I, Iinuma M.(PubMed)
(3) Green tea extract weakens the antibacterial effect of amoxicillin in methicillin-resistant Staphylococcus aureus infected mice by Peng Q1, Huang Y, Hou B, Hua D, Yao F, Qian Y.(PubMed)
(4) Antibacterial effects of green tea polyphenols on clinical isolates of methicillin-resistant Staphylococcus aureus by Cho YS1, Schiller NL, Oh KH.(PubMed)
(5) Evaluation of the antimicrobial efficacy of green tea extract (egcg) against streptococcus pyogenes in vitro - biomed 2011 by Hull Vance S1, Tucci M, Benghuzzi H.(PubMed)
(6) RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol by Qin N1, Tan X2, Jiao Y3, Liu L4, Zhao W5, Yang S6, Jia A7.(PubMed)
(7) Studies of the in vitro antibacterial activities of several polyphenols against clinical isolates of methicillin-resistant Staphylococcus aureus by Su Y1, Ma L2, Wen Y3, Wang H4, Zhang S5.(PubMed)
Most Common Diseases of 50plus: Pulmonary vascular disease(Respiratory disease): Pulmonary arterial hypertension Treatment In conventional medicine perspective
Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary arterial hypertension
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary arterial hypertension is a subgroup of a specific subgroup of pulmonary hypertension (PH) defined as a condition of slowly progressive disorder as a result of abnormally high blood pressure in the blood vessel, including pulmonary artery, pulmonary vein, or pulmonary capillaries, that carries blood from the heart to the lungs due to narrowing in diameter of most of the very small arteries throughout the lungs of that increased resistance to blood flow, leading to right heart failure and death. Because the phrase pulmonary arterial hypertension is long and pulmonary hypertension is a bit shorter the phrase pulmonary hypertension is often used in place of pulmonary arterial hypertension(a).According to statistic, approximately over 1,000 new cases of pulmonary arterial hypertension are diagnosed each year, In the United States alone.
A. In conventional medicine perspective
Treatment of pulmonary arterial hypertension (group 1 of clinical classification) has been recently characterized by important progresses, particularly in pharmacological therapy. According to the study by Azienda Ospedaliero-Universitaria,
1. Only until few years ago, patients with pulmonary arterial hypertension were treated with non-specific drugs, such as diuretics and digoxin for right heart failure and calcium-channel blockers in the minority of cases, responders to the acute vasoreactivity test. In addition, use of oral anticoagulant treatment was supported by uncontrolled studies.
2. In the last 15 years (in particular in the last 8 years) different randomized controlled trials assessing the functional, clinical and hemodynamic efficacy of three classes of targeted drugs (prostanoids, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors) with pulmonary vascular dilating and antiproliferative effects have been performed.
a. Treatment starts with general measures (physical activity, fertility control, respiratory tract infection, etc.) and supportive therapy (anticoagulant therapy, diuretics, oxygen, digoxin). Patients who respond to the acute vasoreactivity test (10% of idiopathic form) are treated with high doses of calcium-channel blockers, non-responders with targeted therapies either on monotherapy or combination.
b. Usually an oral active drug is initiated and a second compound of a different class is combined in case of non-satisfactory response to the first treatment
c. Combination therapy should be performed only in specialized centers with large experience on use of targeted therapies and their relevant side effects.
d. In case of failure of medical therapy, possible options are balloon atrial septostomy and/or listing for lung or heart-lung transplantation. As available treatments do not constitute a cure for pulmonary arterial hypertension, further progresses are expected in the near future(37).
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Respiratory Disease
Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc,.
Pulmonary vascular disease: Pulmonary arterial hypertension
Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary arterial hypertension is a subgroup of a specific subgroup of pulmonary hypertension (PH) defined as a condition of slowly progressive disorder as a result of abnormally high blood pressure in the blood vessel, including pulmonary artery, pulmonary vein, or pulmonary capillaries, that carries blood from the heart to the lungs due to narrowing in diameter of most of the very small arteries throughout the lungs of that increased resistance to blood flow, leading to right heart failure and death. Because the phrase pulmonary arterial hypertension is long and pulmonary hypertension is a bit shorter the phrase pulmonary hypertension is often used in place of pulmonary arterial hypertension(a).According to statistic, approximately over 1,000 new cases of pulmonary arterial hypertension are diagnosed each year, In the United States alone.
The Treatment
Treatment of pulmonary arterial hypertension (group 1 of clinical classification) has been recently characterized by important progresses, particularly in pharmacological therapy. According to the study by Azienda Ospedaliero-Universitaria,
1. Only until few years ago, patients with pulmonary arterial hypertension were treated with non-specific drugs, such as diuretics and digoxin for right heart failure and calcium-channel blockers in the minority of cases, responders to the acute vasoreactivity test. In addition, use of oral anticoagulant treatment was supported by uncontrolled studies.
2. In the last 15 years (in particular in the last 8 years) different randomized controlled trials assessing the functional, clinical and hemodynamic efficacy of three classes of targeted drugs (prostanoids, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors) with pulmonary vascular dilating and antiproliferative effects have been performed.
a. Treatment starts with general measures (physical activity, fertility control, respiratory tract infection, etc.) and supportive therapy (anticoagulant therapy, diuretics, oxygen, digoxin). Patients who respond to the acute vasoreactivity test (10% of idiopathic form) are treated with high doses of calcium-channel blockers, non-responders with targeted therapies either on monotherapy or combination.
b. Usually an oral active drug is initiated and a second compound of a different class is combined in case of non-satisfactory response to the first treatment
c. Combination therapy should be performed only in specialized centers with large experience on use of targeted therapies and their relevant side effects.
d. In case of failure of medical therapy, possible options are balloon atrial septostomy and/or listing for lung or heart-lung transplantation. As available treatments do not constitute a cure for pulmonary arterial hypertension, further progresses are expected in the near future(37).
All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Rheumatoid Arthritis: The Phytochemicals
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
The Phytochemicals
1. Curcumin
Curcumin is a phytochemical found abundantly in Turmeric, principal curcuminoid of the popular Indian spice
1.1. Anti-inflammatory agentCurcumin (diferuloyl methane) may be used as nonsteroidal anti-inflammatory drugs (NSAIDs for treatment of rheumatoid arthritis(143). Dr. Sarker MR and the research team at the University of North Texas Health Science Center in the study of animal model, suggested that dietary curcumin amy have a positive effects on improved anti-inflammatory or antioxidant actions(144).
1.1. Antioxidants
Curcumin, one of most powerful antioxidant found in foods was found epidemiologically as a proven antioxidant for its anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects(145). The antioxidant is also considered as a novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease by the Western Sydney University(146).
In rheumatoid arthritis patients, oral administration of curcumin sginificantly improved the American College of Rheumatology (ACR) DAS scores in reduction in tenderness and swelling of joint and and other arthritic conditions(147) such as dramatic amelioration of arthritis symptoms(148).
2. Gingerol
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger.
2.1. Antioxidants and Anti-inflammatory effectsCrude ginger and rosemary extracts showed to inhibit the production of pro-inflammatory cytokines due ot its function as an inflammatory mediators with high antioxidant activity(149). The comparison of different ginger constituents, such as [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol, 6-Shogaol has found to be most potent antioxidant and anti-inflammatory phytochemical due the presence of alpha,beta-unsaturated ketone moiety(150).
Dr. Masuda Y. and the research team at the Osaka City University said" antioxidants isolated from the rhizomes of ginger,....the antioxidant activity might be due to not only radical scavenging activity of antioxidants but also their affinity of the antioxidants to the substrates"(151).
2.2. Rheumatoid arthritis
In rheumatoid arthritis, ginger-turmeric rhizomes mixture on animal model, may be effective against rheumatoid arthritis (RA) severity and complications, through the mediation of decreasing the systemic inflammation that occur at the appearance of polyarthritis, oxidative stress and dyslipidemia(152). According to DR. Ramadan G1 and the research team at the King Faisal University, the anti-inflammatory/anti-oxidant activity of ginger is less potent than turmeric but constitute to some beneficial effects against rheumatoid arthritis onset/progression(153).
3. Quercetin
Quercetin is a member of flavonoids, found in fruits, vegetables, leaves and grains with anti inflammatory and antioxidant property(154)(155). which have been found effectively in reduce the early onset and stop the progression of rheumatoid arthritis.In rat adjuvant arthritis, an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days,quercetin lowered levels of pro inflammatory cytokines, interleukin-1β, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity(156), . Dr.Ji JJ and the research team at the Dalian Medical University, suggested that quecetin may be a potent agent for treatment of symptoms of RA such as disabling joint disease involved hands, wrists, feet and other small joints, through its anti inflammatory and antioxidant effects(157).
4. Epigallocatechin-3-gallate (EGCG) Epigallocatechin-3-gallate (EGCG) found in green tea has been found to process antitumor,anti-Alzheimer, and anti-aging properties throguh epidemiological studies(158). According to the joint study lead by the Zhejiang University, Epigallocatechin-3-gallate (EGCG) improved anti-oxidant defense enzyme, reduced mitochondrial oxidative stress, through its antioxidants and inflammatory effects which may contribute to the treatment of rheumatoid arthritis(159).
In rheumatoid arthritis, Epigallocatechin-3-gallate (EGCG) may have a beneficiary effects for treatment of RA due to its suppressed autoimmune arthritis activity(160), also through vary antioxidant and anti inflammatory pathways.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(143) Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation by Satoskar RR, Shah SJ, Shenoy SG.(PubMed)
(144) Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity by Sarker MR1, Franks S2, Sumien N1, Thangthaeng N1, Filipetto F2, Forster M1.(PubMed)
(145) Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease by Venigalla M1, Gyengesi E2, Münch G3(PubMed)
(146) Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease by Venigalla M1, Gyengesi E2, Sharman MJ3, Münch G4(PubMed)
(147) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis by Chandran B1, Goel A.(PubMed)
(148) Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine by Yang Y1, Wu X2, Wei Z2, Dou Y2, Zhao D3, Wang T2, Bian D2, Tong B2, Xia Y2, Xia Y4, Dai Y5(PubMed)
(149) Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type by Justo OR1, Simioni PU2, Gabriel DL2, Tamashiro WM2, Rosa Pde T3, Moraes ÂM4.(PubMed)
(150) Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol by Dugasani S1, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN.(PubMed)
(151) Antioxidant properties of gingerol related compounds from ginger by Masuda Y1, Kikuzaki H, Hisamoto M, Nakatani N.(PubMed)
(152) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O.(PubMed)
(153) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM.(PubMed)
(154) Antioxidant and Anti-Inflammatory Activity Determination of One Hundred Kinds of Pure Chemical Compounds Using Offline and Online Screening HPLC Assay by Lee KJ1, Oh YC1, Cho WK1, Ma JY1.(PubMed)
(155) Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters by Murakami Y1, Kawata A2, Ito S3, Katayama T2, Fujisawa S2(PubMed)
(156) Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis by Gardi C1, Bauerova K2, Stringa B3, Kuncirova V4, Slovak L4, Ponist S4, Drafi F4, Bezakova L5, Tedesco I6, Acquaviva A3, Bilotto S6, Russo GL7.(PubMed)
(157) Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis by Ji JJ1, Lin Y, Huang SS, Zhang HL, Diao YP, Li K.(PubMed)
(158) Green tea polyphenols and their potential role in health and disease by Afzal M1, Safer AM, Menon M.(PubMed)
(159) Mitochondrial modulation by Epigallocatechin 3-Gallate ameliorates cisplatin induced renal injury through decreasing oxidative/nitrative stress, inflammation and NF-kB in micebyPan H1, Chen J2, Shen K3, Wang X1, Wang P1, Fu G1, Meng H1, Wang Y1, Jin B1.(PubMed)
(160) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)
(161) Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model by Meki AR1, Hamed EA, Ezam KA(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).
Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders(1). According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). Rheumatoid Arthritis can induced bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).
The Phytochemicals
1. Curcumin
Curcumin is a phytochemical found abundantly in Turmeric, principal curcuminoid of the popular Indian spice
1.1. Anti-inflammatory agentCurcumin (diferuloyl methane) may be used as nonsteroidal anti-inflammatory drugs (NSAIDs for treatment of rheumatoid arthritis(143). Dr. Sarker MR and the research team at the University of North Texas Health Science Center in the study of animal model, suggested that dietary curcumin amy have a positive effects on improved anti-inflammatory or antioxidant actions(144).
1.1. Antioxidants
Curcumin, one of most powerful antioxidant found in foods was found epidemiologically as a proven antioxidant for its anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects(145). The antioxidant is also considered as a novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease by the Western Sydney University(146).
In rheumatoid arthritis patients, oral administration of curcumin sginificantly improved the American College of Rheumatology (ACR) DAS scores in reduction in tenderness and swelling of joint and and other arthritic conditions(147) such as dramatic amelioration of arthritis symptoms(148).
2. Gingerol
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger.
2.1. Antioxidants and Anti-inflammatory effectsCrude ginger and rosemary extracts showed to inhibit the production of pro-inflammatory cytokines due ot its function as an inflammatory mediators with high antioxidant activity(149). The comparison of different ginger constituents, such as [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol, 6-Shogaol has found to be most potent antioxidant and anti-inflammatory phytochemical due the presence of alpha,beta-unsaturated ketone moiety(150).
Dr. Masuda Y. and the research team at the Osaka City University said" antioxidants isolated from the rhizomes of ginger,....the antioxidant activity might be due to not only radical scavenging activity of antioxidants but also their affinity of the antioxidants to the substrates"(151).
2.2. Rheumatoid arthritis
In rheumatoid arthritis, ginger-turmeric rhizomes mixture on animal model, may be effective against rheumatoid arthritis (RA) severity and complications, through the mediation of decreasing the systemic inflammation that occur at the appearance of polyarthritis, oxidative stress and dyslipidemia(152). According to DR. Ramadan G1 and the research team at the King Faisal University, the anti-inflammatory/anti-oxidant activity of ginger is less potent than turmeric but constitute to some beneficial effects against rheumatoid arthritis onset/progression(153).
3. Quercetin
Quercetin is a member of flavonoids, found in fruits, vegetables, leaves and grains with anti inflammatory and antioxidant property(154)(155). which have been found effectively in reduce the early onset and stop the progression of rheumatoid arthritis.In rat adjuvant arthritis, an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days,quercetin lowered levels of pro inflammatory cytokines, interleukin-1β, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity(156), . Dr.Ji JJ and the research team at the Dalian Medical University, suggested that quecetin may be a potent agent for treatment of symptoms of RA such as disabling joint disease involved hands, wrists, feet and other small joints, through its anti inflammatory and antioxidant effects(157).
4. Epigallocatechin-3-gallate (EGCG) Epigallocatechin-3-gallate (EGCG) found in green tea has been found to process antitumor,anti-Alzheimer, and anti-aging properties throguh epidemiological studies(158). According to the joint study lead by the Zhejiang University, Epigallocatechin-3-gallate (EGCG) improved anti-oxidant defense enzyme, reduced mitochondrial oxidative stress, through its antioxidants and inflammatory effects which may contribute to the treatment of rheumatoid arthritis(159).
In rheumatoid arthritis, Epigallocatechin-3-gallate (EGCG) may have a beneficiary effects for treatment of RA due to its suppressed autoimmune arthritis activity(160), also through vary antioxidant and anti inflammatory pathways.
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(143) Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation by Satoskar RR, Shah SJ, Shenoy SG.(PubMed)
(144) Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity by Sarker MR1, Franks S2, Sumien N1, Thangthaeng N1, Filipetto F2, Forster M1.(PubMed)
(145) Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease by Venigalla M1, Gyengesi E2, Münch G3(PubMed)
(146) Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease by Venigalla M1, Gyengesi E2, Sharman MJ3, Münch G4(PubMed)
(147) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis by Chandran B1, Goel A.(PubMed)
(148) Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine by Yang Y1, Wu X2, Wei Z2, Dou Y2, Zhao D3, Wang T2, Bian D2, Tong B2, Xia Y2, Xia Y4, Dai Y5(PubMed)
(149) Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type by Justo OR1, Simioni PU2, Gabriel DL2, Tamashiro WM2, Rosa Pde T3, Moraes ÂM4.(PubMed)
(150) Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol by Dugasani S1, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN.(PubMed)
(151) Antioxidant properties of gingerol related compounds from ginger by Masuda Y1, Kikuzaki H, Hisamoto M, Nakatani N.(PubMed)
(152) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O.(PubMed)
(153) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM.(PubMed)
(154) Antioxidant and Anti-Inflammatory Activity Determination of One Hundred Kinds of Pure Chemical Compounds Using Offline and Online Screening HPLC Assay by Lee KJ1, Oh YC1, Cho WK1, Ma JY1.(PubMed)
(155) Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters by Murakami Y1, Kawata A2, Ito S3, Katayama T2, Fujisawa S2(PubMed)
(156) Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis by Gardi C1, Bauerova K2, Stringa B3, Kuncirova V4, Slovak L4, Ponist S4, Drafi F4, Bezakova L5, Tedesco I6, Acquaviva A3, Bilotto S6, Russo GL7.(PubMed)
(157) Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis by Ji JJ1, Lin Y, Huang SS, Zhang HL, Diao YP, Li K.(PubMed)
(158) Green tea polyphenols and their potential role in health and disease by Afzal M1, Safer AM, Menon M.(PubMed)
(159) Mitochondrial modulation by Epigallocatechin 3-Gallate ameliorates cisplatin induced renal injury through decreasing oxidative/nitrative stress, inflammation and NF-kB in micebyPan H1, Chen J2, Shen K3, Wang X1, Wang P1, Fu G1, Meng H1, Wang Y1, Jin B1.(PubMed)
(160) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)
(161) Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model by Meki AR1, Hamed EA, Ezam KA(PubMed)
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