Medical Advisor Journals

Wednesday, May 25, 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Diseases associated To

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Polymyalgia Arthritis (Rheumatica)

Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

Diseases associated with Polymyalgia Rheumatica(PMR)

1. Giant cell arteritis
Giant cell arteritis shares many similarities with Polymyalgia rheumatica, according to the statistics
Patient with Giant cell arteritis is associated to 50% higher risk of polymyalgia rheumatica. On the other hand, there are 20% risk of development of Giant cell arteritis in patient polymyalgia, rheumatica. But the clinical manifestations, the relationship between GCA and PMR is not yet clearly established(48).
Medication and therapies used for treatment of polymyalgia rheumatica are also found effectively for giant cell arteritis as well, including Corticosteroids and anti-interleukin-6 receptor therapy(50).

2. Autoimmune thyroid disease and thyroid diseases
Autoimmune thyroid disease is defined as a condition in which the immune system wrongly viewed the thyroid gland and hormones produced as a foreign substances, thereby, producing antibodies to destroy them. In a study of 250 patients with autoimmune thyroid disease, seven (2.8%) were found to have polymyalgia rheumatica. Female patient with age over 60 are found to have an increased risk of over 9.3% (49). Autoimmune thyroiditis is often related to Rheumatoid Arthritis due to other non-specific autoimmune organ diseases(51)
But according to the Service de Médecine Interne B, there is no evidences in support that the giant cell arteritis or polymyalgia rheumatica patients are at increased risk for hypothyroidism or hyperthyroidism(52)

3. Stroke
Besides cancer and heart diseases, stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or it's complications. The study of a total of 781 patients with PMR from the Taiwan Longitudinal Health Insurance Database between 2001 and 2005, patients with PMR are associated to an increased of stroke in comparison to controls(53).
Dr,.Hernández-Rodríguez J and the research team at the University of Barcelona suggested that Patients with GCA with apparently isolated PMR have a significant risk of developing ischemic complication(54).

4. Gastroesophageal reflux disease (GERD)
The prevalence of upper gastrointestinal (GI) diseases is increasing in subjects aged 65 years and over. Pathophysiological changes in esophageal functions that occur with aging may, at least in part, be responsible for the high prevalence of the disease. Use of medication of proton pump inhibitors (PPIs) are found to reduced risk of GERD in patient with polymyalgia rheumatica(55) in comparison to those without.

5. VasculitisVasculitis is diseases associated to the inflammation of blood vessels. Patient with Polymyalgia Rheumatica(PMR) may present together with large vessel vasculitis (LVV) as a result of the inflammatory impact(56). Tocilizumab showed to improve symptoms of disease and inhibit inflammatory markers(57).Methotrexate effectively reduces relapse rate and lowers the cumulative dose of glucocorticoid therapy in patient with Polymyalgia Rheumatica(PMR)(58).

6. Peripheral vascular disease
Patient with Polymyalgia rheumatica, the most common inflammatory rheumatologic conditions in older adults are associated with an excess risk of vascular disease in comparison to the onset of vascular event in patients with and without polymyalgia rheumatica(59). Dr. Warrington KJ and the research team at the Mayo Clinic, Rochester said. "Patients with PMR appear to have an increased risk of PAD" in an inception cohort of all Olmsted County, Minnesota residents diagnosed with PMR between 1 January 1970 and 31 December 1999(60).

7. Renal function impairment
Renal function impairment may associate rarely to patient with Polymyalgia Rheumatica(PMR). Only a few cases of AA amyloidosis secondary to PMR have been described in the literary data bases,according to the King's College Hospital NHS Foundation Trust(61). Dr. Escribá A and the research team at the Hospital Universitario 12 de Octubre, also expressed concerns of several cases of systemic amyloidosis associated with polymyalgia rheumatica (PMR) caused by massive amyloid deposition(62).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

REFERENCES
(48) Polymyalgia Rheumatica by Ehab R Saad, MD, MA, FACP, FASN; Chief Editor: Herbert S Diamond, MD(Medscape)
(49) Autoimmune thyroid disease and the polymyalgia rheumatica-giant cell arteritis syndrome by Dent RG, Edwards OM.(PubMed)
(50) Giant cell arteritis and polymyalgia rheumatica: an update by González-Gay MA1, Pina T.(PubMed)
(51) [Chronic autoimmune thyroiditis and connective tissue system diseases].[Article in Slovak]by Macejová Z1, Benhatchi K, Lazúrová I.(PubMed)
(52) [Prevalence of hypothyroidism and hyperthyroidism in temporal arteritis and rhizomelic pseudopolyarthritis. A controlled study of 104 cases].[Article in French] by Juchet H1, Labarthe MP, Ollier S, Vilain C, Arlet P.(PubMed)
(53) Polymyalgia rheumatica and the risk of stroke: a three-year follow-up study by Kang JH1, Sheu JJ, Lin HC.(PubMed)
(54) Development of ischemic complications in patients with giant cell arteritis presenting with apparently isolatedpolymyalgia rheumatica: study of a series of 100 patients by Hernández-Rodríguez J1, Font C, García-Martínez A, Espígol-Frigolé G, Sanmartí R, Cañete JD, Grau JM, Cid MC(PubMed)
(55) Estimation of the symptoms for GERD by GerdQ in the patients with rheumatic diseases by Nozaki Y1, Kinoshita K1, Ri J1, Sakai K1, Shiga T1, Hino S1, Hirooka Y1, Sugiyama M1, Funauchi M1, Matsumura I1.(PubMed)
(56) (18)F-FDG PET/CT for the detection of large vessel vasculitis in patients with polymyalgia rheumatica by Lavado-Pérez C1, Martínez-Rodríguez I2, Martínez-Amador N1, Banzo I1, Quirce R1, Jiménez-Bonilla J1, De Arcocha-Torres M1, Bravo-Ferrer Z1, Jiménez-Alonso M1, López-Defilló JL1, Blanco R3, González-Gay MA3, Carril JM1.(PubMed)
(57) Tocilizumab for the treatment of large-vessel vasculitis (giant cell arteritis, Takayasu arteritis) and polymyalgia rheumatica by Unizony S1, Arias-Urdaneta L, Miloslavsky E, Arvikar S, Khosroshahi A, Keroack B, Stone JR, Stone JH.(PubMed)
(58) Methotrexate treatment in large vessel vasculitis and polymyalgia rheumatica by Spies CM1, Burmester GR, Buttgereit F.(PubMed)
(59) Risk of vascular events in patients with polymyalgia rheumatica by Hancock AT1, Mallen CD2, Muller S1, Belcher J1, Roddy E1, Helliwell T1, Hider SL1.(PubMed)
(60) Increased risk of peripheral arterial disease in polymyalgia rheumatica: a population-based cohort study by Warrington KJ1, Jarpa EP, Crowson CS, Cooper LT, Hunder GG, Matteson EL, Gabriel SE.(PubMed)
(61) Rapid development of renal failure secondary to AA-type amyloidosis in a patient with polymyalgia rheumatica by Javaid MM1, Kamalanathan M, Kon SP.(PubMed)
(62) Secondary (AA-type) amyloidosis in patients with polymyalgia rheumatica by Escribá A1, Morales E, Albizúa E, Herrero JC, Ortuño T, Carreño A, Dominguez-Gil B, Praga M.(PubMed)

Most Common Diseases of 50plus: Diabetes(The Articles) ---How Diabetes Effect Men Sex Life

If you are diabetic, the chance that you are overweight and this increase the
chance of high cholesterol and high blood pressure. So, to control the
glucose in your blood stream, you might want to try high protein diet
together with fighting cholesterol and high blood pressure natural remedies.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Traditionally, diabetes is viewed as a failure of the pancreas to release
enough insulin for sugar metabolism. People with diabetes has grown
increasingly worse over last 10 years. The escalation in diabetes corresponds
to rise in heart disease, because of over weight, poor diet and lack of
exercise.

Diabetes can have an effect on sexual activity affecting both men and women, since diabetes effects the vessels and nerve systems involving normal function of the penis leading to various forms of sexual dysfunction.

Understanding Erection
With either mental or physical stimulation, your brain signals the nerve ending in the penis to release nitric oxide. Nitric oxide relaxes or dilates blood vessels, enabling them to open up and bringing more blood to the penis and helping to create an erection.

Sexual dysfunction occurs when a complication of diabetics resulting from poor blood sugar control, damages the nerves of the penis or there is plague building up in the arteries that feed blood into the penis causing vessels in the penis to be partially blocked preventing enough blood from getting into the penis.

To avoid sexual dysfunction, diabetics should actively work with their dietitian or nutritionist to create a healthy meal plan that is designed only for them. Delaying this step might cause high levels of glucose in the blood stream, resulting in high blood pressure and high cholesterol levels as well as
clogging up arteries and causing heart disease.This leads to blood vessels in the penis to be partially blocked causing sexual dysfunction.

Here are some natural remedies that will help to increase circulation of blood in your body:
1. Mistletoe extract or tea stimulates circulation and lower pressure of blood.
2.Ginkgo biloba aids small blood vessel circulation.
3. Arjuna is an Ayurvedic herb for improving circulation of blood and high blood pressure
You can buy these natural remedies at your local health food store. Be sure to read the recommended dosage.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Most Common Diseases of 50plus: Diabetes(The Recipes) --- A sauce for Asparagus and Artichokes

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

If you are diabetic, the chance that you are overweight and this increase the
chance of high cholesterol and high blood pressure. So, to control the
glucose in your blood stream, you might want to try high protein diet
together with fighting cholesterol and high blood pressure natural remedies.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The recipe of A sauce for Asparagus and Artichokes

Recipe contributed by Delicious dishes for diabetes by Robin Ellis, Published by Skyhorse publishing. Inc. You can view its website at www.skyhorsepublishing.com

This recipe, based on one by Geraldine Holt, is a tasty change from the more traditional vinaigrette to accompany welcome spring arrivals.
salt and pepper
1 tsp Dijon mustard
1 tsp white wine vinegar
4 tbsp olive oil
2 tbsp creme fraiche
1. Add a pinch of salt and pepper to a mixing bowl
2. Mix in the mustard and vinegar
3. Add oil gently - stirring to emulsfy
4. Fold in the creme.
5. taste for seasoning.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Food Therapy: Whole Grains - Brown rice

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Brown rice

Brown rice or unpolished rice is a kind of whole, natural grain with very brown color of which only the outermost layer of the rice kernel are removed, thus preventing the lost of nutrients

Nutrients
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (Vitamin B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12.Calcium
13. Iron
14. Magnesium
15. Manganese
16. Phosphorus
17. Potassium
18. Sodium
19. Zinc
20. Etc.

Health benefits
A. Health benefits according to studies
1. Diabetes
In the investigation of brown rice and white rice and theirs effect in diabetes found that Substitution of whole grains, including brown rice, for white rice may lower risk of type 2 diabetes. These data support the recommendation that most carbohydrate intake should come from whole grains rather than refined grains to help prevent type 2 diabetes, according to "White rice, brown rice, and risk of type 2 diabetes in US men and women" by Sun Q, Spiegelman D, van Dam RM, Holmes MD, Malik VS, Willett WC, Hu FB.(a)

2. Human serum albumin
Human serum albumin (HSA) and how to prevent the risk of risk of viral transmission from donors found that a rice seed bioreactor produces cost-effective recombinant HSA that is safe and can help to satisfy an increasing worldwide demand for human serum albumin, according to "Large-scale production of functional human serum albumin from transgenic rice seeds" by He Y, Ning T, Xie T, Qiu Q, Zhang L, Sun Y, Jiang D, Fu K, Yin F, Zhang W, Shen L, Wang H, Li J, Lin Q, Sun Y, Li H, Zhu Y, Yang D.(b)

3. Prebiotic
In the assessment of the prebiotic effects of brown rice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro and in healthy adults found that FBRA has the potentials as a prebiotic, however, we could not detect its effects on the intestinal environment in vivo. The results in a clinical study indicated that FBRA could be safely used for healthy adults, according to "Effects of fermentedbrown rice on the intestinal environments in healthy adult" by Nemoto H, Ikata K, Arimochi H, Iwasaki T, Ohnishi Y, Kuwahara T, Kataoka K.(c)

4. Lower weight gain and hepatic lipid
In the classification of the hydrolysates of white rice protein (WRP), brown riceprotein (BRP), and soy protein (SP) and its physiological effects found that animals fed the brown rice protein hydrolysate (BRPH)supplemented diet also had lower final body weight, liver weight, very low density lipoprotein cholesterol (VLDL-C), and liver cholesterol, and higher fecal fat and bile acid excretion than the control, according to "Lower weight gain and hepatic lipid content in hamsters fed high fat diets supplemented with white rice protein, brown rice protein, soy protein, and their hydrolysates" by Zhang H, Bartley GE, Mitchell CR, Zhang H, Yokoyama W.(d)

5. Hypercholesterolemia
In the experiment of white rice (WR), brown rice (BR), and germinated brown rice(GBR) and theirs effect in the progress of atherosclerosis found that rabbits fed a GBR diet demonstrated significantly lower levels of total cholesterol (TC), low-density lipoprotein (LDL), LDL/HDL, and atherogenic index (AI) and a higher level of high-density lipoprotein (HDL). Results from atherosclerotic plaque assessment, according to "Improving the lipid profile in hypercholesterolemia-induced rabbit by supplementation of germinated brown rice" by Mohd Esa N, Abdul Kadir KK, Amom Z, Azlan A.(e)

6. Etc.

B. Health benefits according to concentration
1. Manganese
It is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(I)

2. Selenium
Oat contains trace minerals selenium which is essential for the healthy function of the thyroid and immune system as it increases the antioxidant defense system by fighting against the forming of free radicals and reduce the risk of irregular cells growth causes of tumor and cancer, according to the study of "Selenium in theimmune system" by Arthur JR, McKenzie RC, Beckett GJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/12730442)

3. Magnessium
Magnesium not only important for bone health, according to the study of "Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis?" by Odabasi E, Turan M, Aydin A, Akay C, Kutlu M(II) but also play and important role in protecting against Alzheimer's disease, according to the study of "Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease" by Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ.(II)

4. Tryptophan
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(III)

5. Etc.

C. Other health benefits
1. Diabetes
Since it is a complex carbohydrate and contained high amount of fiber, it helps to release the glucose into blood stream slowly, thus decreasing the risk of insulin sensitive and type 2 diabetes, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F., posted in PubMed(1)

2. Antioxidants
Beside containing high levels of magnesium which is necessary for the synthesis of fatty acids to produce energy for our body needs, it also is one of the important component of antioxidant enzyme of which increases the body in fighting against the forming of free radical, according to the study of "Analysis of antioxidant enzyme activity and magnesium level in chronic obstructive pulmonary disease (COPD)" by Kurys E, Kurys P, Kuźniar A, Kieszko R., posted in PubMed(2)

3. Calcium
It also contains a variety of important nutrients, including calcium for the hair, teeth, nails, muscles and bones, according to the article of "Minerals" posted in VeganPeace(3)

4. . Heart diseases and strokeLignans have been shown to significantly lower the LDL (bad) cholesterol and triglyceride levels, thus reducing the risk of plaque building up on arterial wall and decreasing the risk of hypertension, leading heart diseases and stroke, according to the study of "Health effects of phytoestrogens" by Branca F, Lorenzetti S., posted in PubMed(4)

5. Cancer
High amount of selenium helps to repair and synthesis in damaged cells by eliminating worn out or abnormal cells, according to the study of "Effects of Selenium Supplements on Cancer Prevention: Meta-analysis of Randomized Controlled Trials" by Lee EH, Myung SK, Jeon YJ, Kim Y, Chang YJ, Ju W, Seo HG, Huh BY., posted in PubMed(5)

6. Etc.

Side effects
1. Arsenic
Long term exposure to arsenic can increase the risk of abnormal cell growth, leading to cancer risk.
2. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20548009
(b) http://www.ncbi.nlm.nih.gov/pubmed/22042856
(c) http://www.ncbi.nlm.nih.gov/pubmed/21921425
(d) http://www.ncbi.nlm.nih.gov/pubmed/21913675
(e) http://www.ncbi.nlm.nih.gov/pubmed/21682316

(I) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(II) http://www.ncbi.nlm.nih.gov/pubmed/21951617
(III) http://www.ncbi.nlm.nih.gov/pubmed/19539268

(1) http://www.ncbi.nlm.nih.gov/pubmed/20713332
(2) http://www.ncbi.nlm.nih.gov/pubmed/11977322
(3)http://www.veganpeace.com/nutrient_information/nutrient_info/minerals_info.htm
(4) http://www.ncbi.nlm.nih.gov/pubmed/15702593

Phytochemicals In Foods: The effects of Sulfides

Phytochemicals, the natural chemical constituents, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.

Sulfides are phytochemicals in a class of chemical compounds containing anion of sulfur in its lowest oxidation state of 2s, belonging to the group of Organosulfides found abundantly in Beer, cocktail mixes, wine, fresh potatoes, garlic oil, etc.

Health Benefits
1. Colon cancer
In the investigation of diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are presented in the Alliaceae family particularly in garlic and their effects on chemo-resistance of human cancer cells, a major obstacle in the treatment and management of malignant cancers, found that DADS and DATS induced Mdr1 and MRP1 gene expression (p<0.05). DADS promoted MRP3 gene expression (p<0.05) as well as DADS and DATS increased MRP4 and MRP6 gene expression (p<0.05) in the colo 205 xenograft mice. Based on our in vitro and in vivo results, diallyl polysulfides (DAS, DADS and DATS) affected the gene expression of the multidrug resistance in colo 205 human colon cancer cells in vitro and in vivo, according to 'Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo" by Lai KC, Kuo CL, Ho HC, Yang JS, Ma CY, Lu HF, Huang HY, Chueh FS, Yu CC, Chung JG.(1)

2. Skin cancer
In the investigation of Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracted from crushed garlic by steam-distillation and it anticancer activity in several cancer types, found that DATS revealed better growth inhibition of A375 and BCC cells than DADS and DAS did. Further demonstrated that DATS increased intracellular reactive oxygen species (ROS) generation, induced cytosolic Ca(2+) mobilization, and decreased mitochondrial membrane potential (DeltaPsim). Western blot results showed the concordance for the expression of molecules involved in G(2)/M arrest and apoptosis observed by cell cycle and cell viability analysis, according to "Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis" by

Wang HC, Yang JH, Hsieh SC, Sheen LY.(2)

3. Lung adenocarcinoma
In the valuation of the anticarcinogenic and antimutagenic effectsfrom DAS (diallyl sulfide), DADS (diallyl disulfide), and DATS (diallyl trisulfide), major oil-soluble allylsulfides (OAS) represent major garlic constituents, found that OASs DADS and DATS induce significant apoptosis in human lung adenocarcinoma A549 cells, whereas DAS does not. Differential modulation of reactive oxygen intermediates (ROI) and mitochondria membrane potential (MMP) may account for the apoptotic effects of DADS and DAT, according to "Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators" by Wu XJ, Hu Y, Lamy E, Mersch-Sundermann V.(3)

4. Cervical cancer
In the investigation of Diallyl sulfide (DAS), one of the main active constituents of garlic, for it inhibition of cancer cells in vitro and promotion of immune responses in vivo, found that DAS induced G0/G1 cell cycle arrest and apoptosis in HeLa cells through caspase- and mitochondria and p53 pathways providing further understanding of the molecular mechanisms of DAS action in cervical cancer, according to "Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways" by Wu PP, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(4)

5. Thyroid cancer
In the investigation of whetherDAS could induce growth inhibition and apoptosis in ATC cells. In MTT assay, DAS treatment inhibited the proliferation of ARO cells in a dose-dependent manner, showed that DAS-induced apoptosis was associated with a decrease in the level of Bcl-2 expression and an increase in the level of Bax expression, and cytochrome c was remarkably released from mitochondrial into the cytosol by DAS. Furthermore, caspase-9 and caspase-3 were activated by DAS, and DAS cleaved PARP. Taken together, DAS decreased cell proliferation and induced apoptosis via mitochondrial signaling pathway in ATC cells, according to "Diallyl sulfide induces growth inhibition and apoptosis of anaplastic thyroid cancer cells by mitochondrial signaling pathway" by Shin HA, Cha YY, Park MS, Kim JM, Lim YC.(5)

6. Antioxidants and inhibits inflammation
in the elucidation of the role of a transcription factor, Nuclear factor E2-related factor 2 (Nrf2) in inducing antioxidants and phase II enzymes during gentamicin toxicity in Wistar rats, showed that DAS enhances antioxidants and suppresses inflammatory cytokines through the activation of Nrf2, thereby protecting the cell against oxidative stress induced by gentamicin, according to "Diallyl sulfideenhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats.' by Kalayarasan S, Prabhu PN, Sriram N, Manikandan R, Arumugam M, Sudhandiran G.(6)

7. Joint inflammation
Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta), found that DAS prevents IL-1beta and MSU crystal induced COX-2 upregulation in synovial cells and chondrocytes and ameliorates crystal induced synovitis potentially through a mechanism involving NF-kappaB. Anti-inflammatory actions of DAS may be of value in treatment of joint inflammation, according to "Inhibition of cyclooxygenase 2 expression bydiallyl sulfide on joint inflammation induced by urate crystal and IL-1beta' by Lee HS, Lee CH, Tsai HC, Salter DM.(7)

8. Neuroprotective effects
In the investigation of Diallyl sulfide (DAS), the main organosulfur component of garlic neuroprotective effects against ischemia/reperfusion injury, showed that for animals with induced ischemia/reperfusion, those pretreated with 200 mg/kg DAS showed an infarct volume (22.36 ± 0.67%) significantly lower than that of the non-treated ischemia/reperfusion group (38.23 ± 0.72%), and the percentage of terminal dUTP nick-end labeling-positive cells (23.46 ± 1.02%) of the DAS-pretreated group was also significantly decreased compared to non-treated (36.41 ± 1.58%). Fluorescence immunohistochemistry staining and western blot analysis indicated that DAS reduced caspase-3 expression and increased Bcl-2 expression, according to "Neuroprotective effects of diallyl sulfide against transient focal cerebral ischemia via anti-apoptosis in rats" by Lin X, Yu S, Chen Y, Wu J, Zhao J, Zhao Y.(8)

9. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources

(1) http://www.ncbi.nlm.nih.gov/pubmed/22397993
(2) http://www.ncbi.nlm.nih.gov/pubmed/20459099
(3) http://www.ncbi.nlm.nih.gov/pubmed/19197990
(4) http://www.ncbi.nlm.nih.gov/pubmed/21424116
(5) http://www.ncbi.nlm.nih.gov/pubmed/20219414
(6) http://www.ncbi.nlm.nih.gov/pubmed/19374873
(7) http://www.ncbi.nlm.nih.gov/pubmed/18573668
(8) http://www.ncbi.nlm.nih.gov/pubmed/22196859

Most Common Diseases of 50plus: Diabetes(The Recipes) --- Leeks in White Wine and Butter

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

If you are diabetic, the chance that you are overweight and this increase the
chance of high cholesterol and high blood pressure. So, to control the
glucose in your blood stream, you might want to try high protein diet
together with fighting cholesterol and high blood pressure natural remedies.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The recipe of Leeks in White Wine and Butter

Recipe contributed by Delicious dishes for diabetes by Robin Ellis, Published by Skyhorse publishing. Inc. You can view its website at www.skyhorsepublishing.com

Serves 4
Simple and delicious
2 large leeks- just the white part- check for residue, then cut into cork tube-shape
salt and pepper
glass of white wine
3 tbsp water
50 g /2 oz. butter

1. Place the leek pieces in the shallow pan. Season with salt and pepper.
2. Pour into wine and pepper, then add the butter. Put on the lid and bring up to a simmer. Cook over the low heat for about 20 minutes p the leeks should be beautiful tender.

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Most common Diseases Free and Longevity of 50 plus - Grape Seeds and Skins Part B By Phytochemicals in Foods

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

II. Grape Seeds and Skins
Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey.

B. By Phytochemicals in Foods
B.1. Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc.
1. Anti cancers
In the review of resveratrol and it effects as a chemopreventive agent, tumor initation, promotion, and progression via multiple pathways, indicated thatresveratrol exerts antioxidant activities, hence contributing to the prevention of tumor initiation. Growing or metastasizing carcinomas are inhibited by resveratrolthrough prevention of angiogenesis by inhibiting VEGF and matrix metalloproteases. Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins, according to "Fighting cancer with red wine? Molecular mechanisms ofresveratrol" by Kraft TE, Parisotto D, Schempp C, Efferth T.(1)

2. Anti cancers and anti inflammatory effects
In the observation of Resveratrol's effects in exhibition of several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans, found that Anticancer activity of this compound is mainly due to induction of apoptosis via several pathways, as well as alteration of gene expressions, all leading to a decrease in tumor initiation, promotion, and progression. Resveratrol exhibits anti-inflammatory activity through modulation of enzymes and pathways that produce mediators of inflammation and also induction of programmed cell death in activated immune cells. Resveratrolhas been shown to produce no adverse effects, even when consumed at high concentrations, according to "Potential of resveratrol in anticancer and anti-inflammatory therapy" by Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ.(2)

3. Prostate cancer
In the evaluation of the tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) in tumor development and progression in prostate carcinogenesis, found that resveratrolmay act as potential adjunctive treatment for late-stage hormone refractory prostate cancer. More importantly, for the first time, our study demonstrates the mechanism by which AR regulates PTEN expression at the transcription level, indicating the direct link between a nuclear receptor and the PI3K/AKT pathway, according to "Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines' by
Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(3)

4. Cardiovascular diseases
In the revie of reviews some of the key studies, and the known mechanisms for these beneficial effects. Evidence from different experimental studies, including from the authors' laboratories, and the beneficial effects of polyphenols found in red wine, especially resveratrol in grape skins.
found that Resveratrol benefits include a reduction in cardiovascular morbidity and mortality, lung cancer and prostate cancer by approximately 30% to 50%, 57% and 50%, respectively. Polyphenols possess antioxidant, superoxide-scavenging, ischemic-preconditioning and angiogenic properties. Some of these properties of polyphenols may explain their protective effects on the cardiovascular system, as well as other body organs, according to "Significance of wine and resveratrol incardiovascular disease: French paradox revisited" byVidavalur R, Otani H, Singal PK, Maulik N.(4)

5. Cardiovascular health
In the review of Resveratrol (3,4',5-trihydroxystilbene), a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems, indicated that Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases, according to "Resveratroland cardiovascular health" by Das M, Das DK.(5)

6. Anti inflammatory effects
In the study of implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanism, found that resveratrolremarkably inhibited hepatic retention and metastatic growth of melanoma cells by 50% and 75%, respectively. The mechanism involved IL-18 blockade at three levels: First, resveratrol prevented IL-18 augmentation in the blood of melanoma cell-infiltrated livers. Second, resveratrol inhibited IL-18-dependent expression of VCAM-1 by tumor-activated hepatic sinusoidal endothelium, preventing melanoma cell adhesion to the microvasculature. Third, resveratrol inhibited adhesion- and proliferation-stimulating effects of IL-18 on metastatic melanoma cells through hydrogen peroxide-dependent nuclear factor-kappaB translocation blockade on these cells, according to "Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18" by Salado C, Olaso E, Gallot N, Valcarcel M, Egilegor E, Mendoza L, Vidal-Vanaclocha F.(6)

7. Oxidative stress and endothelial dysfunction
In the investiagtion of the role of S6K1 in aging-associated endothelial dysfunction and effects of the polyphenol resveratrol on S6K1 in aging endothelial cells, wrote that our data demonstrate a causal role of the hyperactive S6K1 in eNOS uncoupling leading to endothelial dysfunction and vascular aging. Resveratrolimproves endothelial function in aging, at least in part, through inhibition of S6K1. Targeting S6K1 may thus represent a novel therapeutic approach for aging-associated vascular disease, according to "Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition byresveratrol" by Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z.(7)

8. Insulin resistance
In the evaluation of the effects of Res on insulin sensitivity and the underlying mechanism, insulin-resistant KKA(y) mice were treated with 2 and 4 g/kg diets of Res for 12 weeks, found that Res intervention reduces blood glucose and serum insulin levels, improves insulin and glucose tolerance, increases serum adiponectin and adiponectin mRNA levels in epididymal adipose tissues, and more importantly, elevates Sirt1, p-AMPK, p-IRS1, and p-AKT levels in liver and soleus muscles, according to "Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice" by Chen S, Li J, Zhang Z, Li W, Sun Y, Zhang Q, Feng X, Zhu W.(8)

9. Propionibacterium acnes
In the investigation of whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved, found that out of 119 plant in the study, researchers identified five with potent antibiofilm activity against P. acnes (extracts from Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab). We subsequently identified icariin,resveratrol and salidroside as active compounds in three of these extracts. Extracts from E. brevicornum and P. cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked antibiofilm activity when used in subinhibitory concentrations, indicating that killing of microbial cells is not their only mode of action, accoridng to "Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds" by Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(9)

10. Healthy heart and longevity
In the review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action,
found that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice, according to "Resveratrol and red wine, healthy heart and longevity" by Das DK, Mukherjee S, Ray D.(10)

11. Antioxidants
In the assessment of the effects of the antioxidants resveratrol and quercetin on frozen-thawed ram sperm, found that Semen samples (which exceeded minimum standards) from four mature crossbreed Santa Inês rams were pooled and aliquots of each pool were diluted in Tris-egg yolk-glycerol, with the addition of 0, 5, 10, 15, and 20 μg/mL of resveratrol and quercetin in Experiment 1 and Experiment 2, respectively. In Experiment 1, the proportion of sperm with a high mitochondrial membrane potential was greater (P < 0.02) in the control group than in resveratrol20 μg/mL group. In Experiment 2, the proportion of sperm with high mitochondrial membrane potential was greater in the control group (P < 0.0001) than in the other experimental groups, and greater in the quercetin 5 μg/mL group (P < 0.05) than in the other quercetin-treated groups, according to "Effect of antioxidantsresveratrol and quercetin on in vitro evaluation of frozen ram sperm" by Silva EC, Cajueiro JF, Silva SV, Soares PC, Guerra MM.(11)

12. Incision-induced acute and chronic pain
In the searching for more efficacious treatments in inhibition of incision-induced pain and prevention of the transition to chronic pain following surgery, found that local injection of resveratrol around the surgical wound strongly attenuates incision-induced allodynia. Intraplantar IL-6 injection and plantar incision induces persistent nociceptive sensitization to PGE2 injection into the affected paw after the resolution of allodynia to the initial stimulus. We further show that resveratroltreatment at the time of IL-6 injection or plantar incision completely blocks the development of persistent nociceptive sensitization consistent with the blockade of a transition to a chronic pain state by resveratrol treatment, according to "Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" by Tillu DV, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ.(12)

13. Anti diabetes
In the evaluation of resveratrol, a polyphenolic SIRT1 activator and its SIRT1 activation in an in vitro fluorescent based assay (EC(50) : 7 μM) and the efficacy of resveratrol was also evaluated in ob/ob mice for its antidiabetic and associated metabolic effects, found that a significant improvement observed in the glucose excursion in the oral glucose tolerance test performed for 120 min; although an insignificant improvement in the triglycerides, total cholesterol, adiponectin and free fatty acid levels was observed at different doses of resveratrol tested. The present findings suggest that resveratrol is an antihyperglycemic agent and drugs similar to resveratrol can be considered as an effective therapeutic adjuvant for the current treatment of diabetes mellitus, according to "Antidiabetic activity ofresveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes" by Sharma S, Misra CS, Arumugam S, Roy S, Shah V, Davis JA, Shirumalla RK, Ray A.(13)

14. Neuroprotective effects
In the elucidation of the neuroprotective effect and influence of resveratrol on the extracellular levels of neurotransmitter and neuromodulator during ischemia/reperfusion in rats,
found that chronic treatment with resveratrol remarkably reduced the release of excitatory neurotransmitter glutamate, aspartate and neuromodulator d-Serine during ischemia and reperfusion; and significantly increased the basal extracellular levels of inhibitory neurotransmitter gamma-amino-n-butyric acid, glycine and taurine. Chronic treatment with resveratrol also ameliorated O-phosphoethanolamine levels and excitotoxic index during ischemia and reperfusio, according to "Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats" by Li C, Yan Z, Yang J, Chen H, Li H, Jiang Y, Zhang Z(14)

15. Neuroprotective effects
In the investigation of the neuroprotective properties of resveratrol found thatResveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy, according to "Neuroprotective properties of resveratrol in different neurodegenerative disorders" by Albani D, Polito L, Signorini A, Forloni G.(15)

16. Etc.

B.2. Pterostilbene
Pterostilbene is a phytochemical in the class of Stilbenoids, found abundantly in grapes, blueberries, etc.
1. Colon cancer
In the identification of the chemopreventive potential of pterostilbene with colonic tumor formation as an end point and further to evaluate the mechanistic action ofpterostilbene during colon carcinogenesis, found that Colon tumors frompterostilbene-fed animals showed reduced expression of inflammatory markers as well as nuclear staining for phospho-p65, a key molecule in the nuclear factor-kappaB pathway. In HT-29 cells, pterostilbene reduced the protein levels of beta-catenin, cyclin D1 and c-MYC, altered the cellular localization of beta-catenin and inhibited the phosphorylation of p65, according to "Dietary intake ofpterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats' by Paul S, DeCastro AJ, Lee HJ, Smolarek AK, So JY, Simi B, Wang CX, Zhou R, Rimando AM, Suh N.(1)

2. Antioxidant effect
In the study of the antioxidant activities of trans-resveratrol, pterostilbene and quercetin, and the effect of their combination were investigated in human erythrocytes in vitro, found that Resveratrol was significantly less effective. However, the three compounds protected the erythocytes against hemolysis and GSH (reduced glutathione) depletion to the same extent. Combinations consisting of two compounds (molar ratio 1:1) influenced lipid peroxidation in a concentration-dependent manner. At lower concentrations, resveratrol with quercetin orpterostilbene inhibited synergistically the oxidative injury of membrane lipids At higher concentrations, an additive effect was observed, according to "Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro" by Mikstacka R, Rimando AM, Ignatowicz E.(2)

3. Breast cancer
In the study of receptor pathways- estrogen receptor (ER) and tyrosine kinase receptors, especially the epidermal growth factor receptor (EGFR) family and theirs effects on cell-proliferation and in the development of both primary and recurrent breast cancer,
indicated that there is strong evidence to show that several phytochemicals present in berries such as cyanidin, delphinidin, quercetin, kaempferol, ellagic acid, resveratrol and pterostilbene, interact with and alter the effects of these pathways, according to " Influence of Berry-Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention" by Aiyer H, Warri AM, Woode DR, Hilakivi-Clarke L, Clarke R.(3)

4. Anti-adipogenic effects
In the assessment of the effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells, found that garcinol and pterostilbene caused an inhibition of lipid accumulation in the 3T3-L1 adipocyte differentiation phase. Garcinol and pterostilbene also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin, resistin, and fatty acid synthase (FAS) in 3T3-L1 adipocyte differentiation. In 3T3-L1 adipocytes, garcinol significantly down-regulated the protein expressions of PPARγ and FAS as well as up-regulated the protein expressions of adipose triglyceride lipase (ATGL) and adiponectin, according to "Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells" by Hsu CL, Lin YJ, Ho CT, Yen GC.(4)

5. Aging and Alzheimer's disease
In the investigation of resveratrol and pterostilbene, a resveratrol derivative, in the protection against age-related diseases including Alzheimer's disease (AD), found that two months of pterostilbene diet but not resveratrol significantly improved radial arm water maze function in SAMP8 compared with control-fed animals. Neither resveratrol nor pterostilbene increased sirtuin 1 (SIRT1) expression or downstream markers of sirtuin 1 activation. Importantly, markers of cellular stress, inflammation, and AD pathology were positively modulated by pterostilbene but not resveratrol and were associated with upregulation of peroxisome proliferator-activated receptor (PPAR) alpha expression, according to "Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease" by Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G.(5)

6. Cholesterol
In the investigation of whether resveratrol and its three analogues (pterostilbene, piceatannol, and resveratrol trimethyl ether) would activate the peroxisome proliferator-activated receptor alpha (PPARalpha) isoform, found that the maximal luciferase activity responses to pterostilbene were higher than those obtained with the hypolipidemic drug, ciprofibrate (33910 and 19460 relative luciferase units, respectively), at 100 microM. Hypercholesterolemic hamsters fed withpterostilbene at 25 ppm of the diet showed 29% lower plasma low density lipoprotein (LDL) cholesterol, 7% higher plasma high density lipoprotein (HDL) cholesterol, and 14% lower plasma glucose as compared to the control group. The LDL/HDL ratio was also statistically significantly lower for pterostilbene, as compared to results for the control animals, at this diet concentration, according to "Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters" by Rimando AM, Nagmani R, Feller DR, Yokoyama W.(6)

7. Atherosclerosis
In the determination of the effect of Pterostilbene (PT) on Vascular endothelial cell (VEC) apoptosis, the main event occurring during the development of atherosclerosis, found that Cotreatment with PT and siRNA of LOX-1 synergistically reduced oxLDL-induced apoptosis in HUVECs. Overexpression of LOX-1 attenuated the protection by PT and suppressed the effects of PT on oxLDL-induced oxidative stress. PT may protect HUVECs against oxLDL-induced apoptosis by downregulating LOX-1-mediated activation through a pathway involving oxidative stress, p53, mitochondria, cytochrome c and caspase protease. PT might be a potential natural anti-apoptotic agent for the treatment of atherosclerosis, according to "Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo" by Zhang L, Zhou G, Song W, Tan X, Guo Y, Zhou B, Jing H, Zhao S, Chen L.(7)

8. Adjuvant arthritis
In the evaluation of the effects of pinosylvin (PIN) and pterostilbene (PTE), natural substances from the stilbenoid group, on the development of adjuvant arthritis in rats, found that the effect of PTE on CL was only partial. PIN, on the other hand, had a beneficial anti-inflammatory and antioxidant effect on oxidative stress induced biochemical changes occurring in AA, as determined by all three functional parameters, according to "In vivo effect of pinosylvin andpterostilbene in the animal model of adjuvant arthritis" by Macickova T, Drabikova K, Nosal R, Bauerova K, Mihalova D, Harmatha J, Pecivova J.(8)

9. Bladder cancer
In the study of Pterostilbene (PT), a naturally occurring phytoalexin, and its effects in a variety of pharmacologic activities, including antioxidant, cancer prevention activity and cytotoxicity to many cancers, found that PT causes autophagy in cancer cells and suggests that PT could serve as a new and promising agent for the treatment of sensitive and chemoresistant bladder cancer cells, according to "Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells" by Chen RJ, Ho CT, Wang YJ.(9)

10. Anti-inflammatory effects
In the examination of the molecular mechanisms of the action of pterostilbene in colon cancer,
indicated that A combination of cytokines (tumor necrosis factor-alpha, IFN-gamma, and bacterial endotoxin lipopolysaccharide) induced inflammation-related genes such as inducible nitric oxide synthase and cyclooxygenase-2, which was significantly suppressed by treatment with pterostilbene. We further identified upstream signaling pathways contributing to the anti-inflammatory activity ofpterostilbene by investigating multiple signaling pathways, including nuclear factor-kappaB, Janus-activated kinase-signal transducer and activator of transcription, extracellular signal-regulated kinase, p38, c-Jun NH(2)-terminal kinase, and phosphatidylinositol 3-kinase, according to "Anti-inflammatory action ofpterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells" by Paul S, Rimando AM, Lee HJ, Ji Y, Reddy BS, Suh N.(10)

11. Etc.

B.3. Piceatannol
Piceatannol is a phytochemical in the class of Stilbenoids, found abundantly in grapes, etc.
1. Anti cancers
In the determination of the apoptotic effects of piceatannol and myricetin, naturally occurring polyphenols in red wine, alone or in combination, in two human cell lines: HL-60 (leukemia) and HepG2 (hepatoma), found that on the signaling pathways responsible for induction of HO-1 expression.found that piceatannol or myricetin alone induced apoptotic cell death in a concentration- and time-dependent manners in HL-60 cells. Furthermore, in combined treatment the percentage of apoptotic HL-60 cells was significantly higher. Nevertheless, the percentage of TUNEL positive HepG2 cells only was significant after piceatannol treatment and in combined treatment was even lower than in cells treated with piceatannol alone, according to "Selective apoptotic effects of piceatannol and myricetin in human cancer cells" by Morales P, Haza AI.(1)

2. Breast cancer
found that PIC inhibited migration and anchorage-independent growth of human mammary epithelial cells (MCF-10A) treated with the prototypic tumor promoter, 12-O-tetradecanoylphorbol-13-aceate (TPA). PIC treatment suppressed the TPA-induced activation of NF-kappaB and expression of cyclooxygenase-2 (COX-2) in MCF-10A cells. We speculate that an electrophilic quinone formed as a consequence of oxidation of PIC bearing the catechol moiety may directly interact with critical cysteine thiols of IKKbeta, thereby inhibiting its catalytic activity "Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target" by Son PS, Park SA, Na HK, Jue DM, Kim S, Surh YJ.(2)

3. Anti-inflammatory activities and cardioprotective effect
In the investigation of the modulation of inflammation by resveratrol and its metabolites by determining the expression and release of chemokine, eotaxin-1, in cultured human pulmonary artery endothelial cells, found that piceatannol showed potency similar to resveratrol. We propose that control of eotaxin-1 expression and release by proinflammatory cytokines in HPAEC may be considered as an in vitro model for screening and discovering polyphenols with anti-inflammatory activities and cardioprotective potentials, according to "Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells" by Yang CJ, Lin CY, Hsieh TC, Olson SC, Wu JM.(3)

4. Alzheimer's disease
In the demonstration of the presence of autoantibodies to ecto-F1-ATPase (ASabs) in sera and cerebrospinal fluids from patients with Alzheimer's disease (AD), found that ASabs, unlike irrelevant antibodies, can increase cellular uptake of HDL, a risk factor for the development of AD, via a mechanism involving the prototypical function of ecto-F1-ATPase: the generation of ADP due to the hydrolysis of ATP. Piceatannol, a specific inhibitor ecto-F1-ATPase, completely hindered these effects. We hypothesize that ASabs could exert a pathogenetic role in AD, according to "Anti-ATP synthase autoantibodies from patients with Alzheimer's disease reduce extracellular HDL level" by Vacirca D, Barbati C, Scazzocchio B, Masella R, Rosano G, Malorni W, Ortona E.(4)

5. Prostate cancer
In the determination of whether piceatannol inhibits the lung metastasis of prostate cancer cells, MAT-Ly-Lu (MLL) rat prostate cancer cells expressing luciferase were injected into the tail veins of male nude mice, found that Piceatannol increased the protein levels of tissue inhibitor of metalloproteinase-2 in a concentration-dependent fashion. Additionally, piceatannol inhibited the phosphorylation of signal transducer and activator of transcription (STAT) 3. Furthermore, piceatannoleffected reductions in both basal and EGF-induced interleukin (IL)-6 secretion. An IL-6 neutralizing antibody inhibited EGF-induced STAT3 phosphorylation and EGF-stimulated migration of DU145 cells. Interleukin-6 treatment was also shown to enhance the secretion of uPA and VEGF, STAT3 phosphorylation and the migration of DU145 cells; these increases were suppressed by piceatannol. These results demonstrate that the inhibition of IL-6/STAT3 signaling may constitute a mechanism by which piceatannol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells, according to "Piceatannolinhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling" by Kwon GT, Jung JI, Song HR, Woo EY, Jun JG, Kim JK, Her S, Park JH.(5)

6. Antiallergic and radical scavenging activities
In the assessment of the methanolic extract of the whole plant of Cyperus longus originating in Egypt and its antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice,
found that Among the isolates, longusol B (IC(50)=96 µM), luteolin (3.0 µM), resveratrol (17 µM), piceatannol (24 µM), and cassigarols E (84 µM) and G (84 µM) were found to inhibit the release of β-hexosaminidase, as a marker of antigen-induced degranulations, in rat basophilic leukemia (RBL-2H3) cells, accoridng to "Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus" by Morikawa T, Xu F, Matsuda H, Yoshikawa M.(6)

7. Anti aging
In the review of the cellular senescence, characterized by cellular hypertrophy: cell growth in the absence of cell division, indicated that the genes that regulate this process can be activated or inactivated by numerous plant polyphenols such as resveratrol, quercetin, butein, fistein, piceatannol, curcumin. Many of these substances have been shown to lengthen the lifespan of invertebrates. Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents, according to "The potential influence of plant polyphenols on the aging process" by Cherniack EP.(7)

8. Melanogenesis and collagen synthesis
In the evaluation of The effect of passion fruit, the fruit of Passiflora edulis , on melanin inhibition and collagen synthesis, using cultured human melanoma and fibroblast cells, found that treatment of melanoma cells with PF-S led to inhibition of melanogenesis. In addition, the production of total soluble collagen was elevated in dermal fibroblast cells cultured in the presence of PF-S. PF-R and PF-P did not yield these effects. Furthermore, the removal of polyphenols from PF-S led to the abolishment of the effects described above. We discovered thatpiceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is present in passion fruit seeds in large amounts and that this compound is the major component responsible for the PF-S effects observed on melanogenesis and collagen synthesis, according to "Extract of Passion Fruit ( Passiflora edulis ) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen Synthesis" by Matsui Y, Sugiyama K, Kamei M, Takahashi T, Suzuki T, Katagata Y, Ito T.(8)

9. Colitis
In the investigation of the possible protective effects of resveratrol and piceatannolagainst dextran sulfate sodium (DSS)-induced inflammation in mouse colonic mucosa, found that oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK, according to "Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis" by Youn J, Lee JS, Na HK, Kundu JK, Surh YJ.(9)

10. Etc.

Side Effects
1. Overdose may cause headache, itchy scalp, dizziness, and nausea, abdominal pain etc.
2. Do not take the herbs if you have high blood pressure
3. Grape seed extract may interact with other medication, such blood thinner, NSAID painkiller, etc.
4. Do not take the herb in children or if you are pregnant without approval of the related field specialist.
5. etc.