The Smoothie of Orange, Spinach and Grape Juice for Prevention and Treatment of Breast Hematoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Breast hematoma
1  cup of organic orange
1/2 spinach
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of  Breast hematoma has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(such as Ginger, Alfalfa Sprout  and Orange) for reduced risk and treatment of Breast hematoma.

Breast hematoma is a collection of blood due to bleeding within the breast. According to the Penn State Milton S. Hershey Medical Center, "The probability of development of a non-clinically significant hematoma was 21.6% for patients taking antithrombotics and 13.0% for those not taking antithrombotics"(1).

Vitamin K, found abundantly in spinach has exerted its coagulation effects in reduced risk of (subdural) hematoma, in a randomized trials identified from the Cochrane Central Register of Controlled Trials(2).

The Fuwai Hospital joint study also suggested, the favorite uninterrupted vitamin K antagonists (VKAs), in comparison to anticoagulation in catheter ablation (CA) of atrial fibrillation (AF) in occurrence of stroke or transient ischemic attacks and major bleeding in test subjects(3).

Dr. Levi M said, "Bleeding is the most important adverse effect of antithrombotic treatment and may be a major cause of morbidity, longstanding debilitation, and even mortality....... can be neutralized by the administration of vitamin K or prothrombin complex concentrates"(4).

Vitamin C, a water soluble vitamin found in orange may also benefit women with breast hematoma by preventing the breaking off  capillaries, the small vessels in the breast inducing bleeding(5).

According to the University Clinic Muenster, Vitamin C was shown to be cerebroprotective in several animal models of stroke, through the expression and transport activity of SVCT2, :key proteins for vitamin C uptake. in brain capillary endothelial cells after transhwaient ischemia in mice(6).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape may also reduced risk of complications caused by severe hemorrhagic injury, including the Lung(8), intestines(9), cystitis(10),.....through both pro and anti-inflammatory pathways(7).

The effectiveness of Orange, Spinach and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Breast hematoma with little or no adverse effects.

Women who are at increased risk of Breast hematoma due to family history, aging,.....may drink at least one serving daily and women with  Breast hematoma may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

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References
(1) Hematoma formation during breast core needle biopsy in women taking antithrombotic therapy by Chetlen AL1, Kasales C, Mack J, Schetter S, Zhu J.(PubMed)
(2) Vitamin K antagonists and risk of subdural hematoma: meta-analysis of randomized clinical trials by Connolly BJ1, Pearce LA1, Hart RG2.(PubMed)
(3) Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants Compared With UninterruptedVitamin K Antagonists in Patients Undergoing Catheter Ablation for Atrial Fibrillation. by Wu S1, Yang YM2, Zhu J1, Wan HB1, Wang J1, Zhang H1, Shao XH1.(PubMed)
(4) Emergency Reversal Strategies for Anticoagulation and Platelet Disorders by Levi M1.(PubMed)
(5) High-dose vitamin C treatment reduces capillary leakage after burn plasma transfer in rats by Kremer T1, Harenberg P, Hernekamp F, Riedel K, Gebhardt MM, Germann G, Heitmann C, Walther A.(PubMed)
(6) Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillaryendothelial cells after transient ischemia in mice by Gess B1, Sevimli S, Strecker JK, Young P, Schäbitz WR.(PubMed)
(7) Alteration of cytokine profile following hemorrhagic shock by Lu S1, Aguilar A1, Subramani K1, Poulose N1, Ayub A1, Raju R2.(PubMed)
(8) Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis by Lin ZS1,2, Ku CF1, Guan YF1, Xiao HT1, Shi XK1, Wang HQ2, Bian ZX1, Tsang SW1,3, Zhang HJ1.(PubMed)
(9) Effects of resveratrol on methotrexate-induced intestinal injury by Yulug E, Turedi S, Alver A, Turedi S, Kahraman C.(PubMed)
(10) Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna by Keles I1, Bozkurt MF, Cemek M, Karalar M, Hazini A, Alpdagtas S, Keles H, Yildiz T, Ceylan C, Buyukokuroglu ME.(PubMed)

Most common Diseases of 50plus: Obesity and Obesity's complication of Inguinal Hernia

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Inguinal hernia is defined as a condition of forming of a sac by the lining of the abdominal cavity (peritoneum) as a result of protrusion of abdominal-cavity contents through the inguinal canal. According to the statistics, the risk of Inguinal Hernia is higher in male, accounted for 27% and lower in female accounted for only 3% of the disease. If left untreated, it may be fatal to the host if the disease progress rapidly.

How Obesity associates with Inguinal Hernia
1, In the study of "Effect of body mass index on groin hernia surgery" by Rosemar A, Angerås U, Rosengren A, Nordin P., posted in PubMed, researchers filed the result that Of the 49,094 patients, 3.5% had a BMI <20 kg/m2 and 5.2% were obese. Altogether, women constituted only 7.7% of the studied group, but among patients with BMI <20 kg/m2 that had surgical procedures for femoralhernia, 81.4% were women. The relation between BMI and postoperative complications was U-shaped and after adjustment for age, gender, and emergency procedure, patients with BMI <20 and >25 had a significant increased risk when compared with patients with BMI from 20 to 25. Reoperation for recurrence of groinhernia has an increased hazard ratio of 1.20 (95% confidence interval, 1.00-1.40) in overweight, which was particularly evident after open suture and preperitoneal mesh techniques.

2. According to the abstract of the study of "Risk factors for inguinal herniaamong adults in the US population" by Ruhl CE, Everhart JE., posted inPubMed, researchers stated that among men in multivariate analysis, a higher incidence (p < 0.05) of inguinal hernia was associated with an age of 40-59 years (hazard ratio (HR) = 2.2, 95% confidence interval (CI): 1.7, 2.8), an age of 60-74 years (HR = 2.8, 95% CI: 2.2, 3.6), and hiatal hernia (HR = 1.8, 95% CI: 1.2, 2.7), while Black race (HR = 0.58, 95% CI: 0.42, 0.79), being overweight (HR = 0.79, 95% CI: 0.66, 0.95), and obesity (HR = 0.51, 95% CI: 0.36, 0.71) were associated with a lower incidence. Among women, older age, rural residence, greater height, chronic cough, and umbilical hernia were associated with inguinal hernia.

3. In abstract of the study of "Risk factors for inguinal hernia in women: a case-control study. The Coala Trial Group" by Liem MS, van der Graaf Y, Zwart RC, Geurts I, van Vroonhoven TJ., posted in PubMed, researchers indicated in a hospital-based case-control study of 89 female patients with an incident inguinal hernia and 176 age-matched female controls. Activity since birth with two validated questionnaires was measured and smoking habits, medical and operation history, Quetelet index (kg/m2), and history of pregnancies and deliveries were recorded. Response for cases was 81% and for controls 73%. Total physical activity was not associated with inguinal hernia (univariate odds ratio (OR) = 0.8, 95% confidence interval (CI) 0.6-1.1), but high present sports activities was associated with lessinguinal hernia (multivariate OR = 0.2, 95% CI 0.1-0.7). Obesity (Quetelet index > 30) was also protective for inguinal hernia (OR = 0.2, 95% CI 0.04-1.0). Independent risk factors were positive family history (OR = 4.3, 95% CI 1.9-9.7) and obstipation (OR = 2.5, 95% CI 1.0-6.7).

4. In a study of "The effect of tobacco consumption and body mass index on complications and hospital stay after inguinal hernia surgery" by Lindström D, Sadr Azodi O, Bellocco R, Wladis A, Linder S, Adami J., posted in PubMed, researchers found that smoking increases the risk of postoperative complications even in minor surgery such as inguinal hernia procedures. Obesity increases hospitalization after inguinal hernia surgery. The Swedish version of oral moist tobacco, snus, does not seem to affect the complication rate after hernia surgery at all.

5. According to the study of "Inguinal hernia recurrence: classification and approach" by Campanelli G, Pettinari D, Nicolosi FM, Cavalli M, Avesani EC., posted in PubMed, researchers found that following a simple anatomo-clinical classification into three types that could be used to orient surgical strategy, were: type R1--first recurrence of "high" oblique external reducible hernia with small (<2 cm) defect in non-obese patients after pure tissue or mesh repair; type R2--first recurrence of "low" direct reducible hernia with small (<2 cm) defect in non-obese patients after pure tissue or mesh repair; and type R3--all other recurrences, including femoral recurrences, recurrent groin hernia with large defect (inguinaleventration), multi-recurrent hernias, non-reducible contralateral primary or recurrent hernia, and situations compromised by aggravating factors (e.g. obesity) or otherwise not easily included in R1 or R2 after pure tissue or mesh repair.

6. Etc.


Treatments of Obesity and Inguinal Hernia
1. According to the study of "Local anesthetic hernia repair in overweight and obese patients" by Reid TD, Sanjay P, Woodward A, posted in PubMed, researchers found that Local anesthetic inguinal hernia repair in the obese is safe and well tolerated. Use of a large volume local anesthetic mixture is recommended in overweight and obese patients.

2.In the study of "Factors determining the doses of local anesthetic agents in unilateral inguinal hernia repair" by Kulacoglu H, Ozyaylali I, Yazicioglu D., popsted in PubMed, researchers indicated that again, the feasibility of local anesthesia in elective inguinal hernia repair in all patient groups with different characteristics. The mean and maximum doses of local anesthetic agents were well within safety limits, even in recurrent and large hernias. Younger age, large hernias, recurrent hernias, omental mass in the hernia sac, high BMI, and duration of operation might be the factors affecting local anesthetic doses. The significant independent parameters in the multivariate analysis were duration of operation, sac content, and BMI for lidocaine dose, whereas the duration of operation and sac content were determinative for the sum volume of lidocaine and bupivacaine.

3. Etc.
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Most common Diseases Free and Longevity of 50 plus - Organic Soy Part A By Healthy Foods Tofu

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.

IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.


            Tofu or bean curd


Tofu or bean curd is soft white blocks made by coagulating soy milk with substance such as salt or acid or enzyne, a stable emulsion of oil, water, and protein that can be made into tofu, originated from Chinese and part of East and Southeast Asian. Since it is proven to be one of many healthy foods, it become synonymous with vegetarianism and others.

Nutrients
1. Protein
2. Carbohydrate
3. Omega 3 fatty acid
4. Vitamin A
5. B vitamin
6. Magnesium
7. Sodium
8. Manganese
9. Selenium
10. Copper
11. Phosphorus
12. Calcium
13. Potassium
14. Iron
15. Isoflavones
16. Etc.



I. Health benefits by Healthy food Tofu
A. Health benefits according to studies
1. Hair loss In the orally administered soymetide-4 (MITL), an immunostimulating peptide derived from soybean beta-conglycinin alpha' and it effect on hair loss found that PGE2, which is produced after activation of COX by soymetide-4, might suppress apoptosis of hair matrix cells and etoposide-induced alopecia by activating NF-kappaB, according to "Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin" by Tsuruki T, Takahata K, Yoshikawa M.(a)

b. Metabolic syndrome
In the assessment of the effect of low daily intake of soybeans in oxidative stress and it effects on the metabolic syndrome (MS) found that Low intake of soy protein for 90 days, besides being well tolerated by the patients, was able to improve several parameters related to the pathophysiology of MS, according to the study of "[Evaluation of the intake of a low daily amount of soybeans in oxidative stress, lipid and inflammatory profile, and insulin resistance in patients with metabolic syndrome].[Article in Portuguese] by Bahls LD, Venturini D, Scripes Nde A, Lozovoy MA, Simão TN, Simão AN, Dichi I, Morimoto HK.(b)

3. Cancer prevention
In the evaluation of Soy isoflavones and it effects on cancers found that Soy isoflavones, linked to reduced cancer risk in Asian epidemiology, may suppress cox-2 induction by activating ERbeta. In aggregate, these considerations suggest that a comprehensive lifestyle strategy targeting cox-2 expression and bioactivity may have tremendous potential for cancer prevention, according to "Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancerprevention" by McCarty MF.(c)

4. Lung cancer
In the Comparison to lung tumor nodules treated with soy isoflavones or radiation, lung tissues from mice found that Soy isoflavones augment destruction of A549 lung tumor nodules by radiation, and also mitigate vascular damage, inflammation and fibrosis caused by radiation injury to normal lung tissue. Soy could be used as a non-toxic complementary approach to improve RT in NSCLC., according to "Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury" by Hillman GG, Singh-Gupta V, Runyan L, Yunker CK, Rakowski JT, Sarkar FH, Miller S, Gadgeel SM, Sethi S, Joiner MC, Konski AA.(d)

5. Body weight and glycemic control
In the investigation of Soy isoflavones and it affects on plasma lipids, body weight, and insulin action, found that glucose tolerance tests in adult females were not significantly different with diet, but offspring eating TAD soy had increased glucose disappearance with overall lower glucose and insulin responses to the glucose challenge compared with typical American diet (TAD) casein, according to "Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring" by Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR.(e)

6. Etc.

B. Health Benefits according to the concentration
1. Tryptophan

Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)

2. Manganese
It is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(2)

3. Iron
Iron beside is important in enhance the oxygen absorption ti nourish the cells and organs in the body but also form a vital role in the effect of Erythropoietic Stimulating Agents (ESA) hyporesponsiveness, according to "Effects of IronSupplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents" by Karlsson T.(3)

4. Protein
In the evaluation of soy protein diet abd it effects on serum creatinine, found thatsoy feeding was associated with higher renal and hepatic linoleic acid content and higher hepatic alpha-linolenic acid, but lower hepatic arachidonic acid content. and concluded that Isocaloric soy protein feeding ameliorates both epithelial and interstitial changes in the Han:SPRD-cy rat independent of a hypocholesterolemic effect. The histologic benefit is associated with changes in polyunsaturated fatty acid metabolism that may influence both inflammatory and proliferative pathways, according to the study of "Modification of polycystic kidney disease and fatty acid status by soy protein diet" by Ogborn MR, Nitschmann E, Weiler HA, Bankovic-Calic N.(4)
C. Others Health benefit
1. Isoflavones
Isoflavones is one of the most powerful phytoestrogen, which not only helps to reduce symptoms of peri-menopause and menopause due to decreasing of the reproduction of estrogen as aging ( in the evaluation of the effect of red clover isoflavone supplementation over vasomotor and overall menopausal symptoms in postmenopausal women, posted in PubMed(http://www.ncbi.nlm.nih.gov/pubmed/21870906) , researchers found that Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women.), it also helps to protect against the development of endometrial carcinoma as well as prolonging the menstrual cycle, ( according to the study of "The effect of phytoestrogens on the female genital tract" by Burton JL, Wells M., posted in PubMed, researchers found that this review will discuss the evidence from both animal studies and humans for an effect of these ubiquitous compounds on the development of the human female genital tract, in addition to prolonging the menstrual cycle, alleviating symptoms of the menopause, and protecting against the development of endometrial carcinoma.



2. Cardiovascular Benefits
Research found that protein of tofu significantly decreases the serum cholesterol by decreasing the levels of bad cholesterol (LDL) but leaving the good cholesterol (HDL) remain the same According to the study of "Effect of soy and milk proteinsupplementation on serum lipid levels: a randomized controlled trial" by Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS, Myers L, Xu J, Jones DW, Whelton PK, He J., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21952693)). It also benefits the cardiovascular health (according to the study of "Soy protein, isoflavones, andcardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee" by Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M; American Heart Association Nutrition Committee. posted PubMed (http://www.ncbi.nlm.nih.gov/pubmed/16418439)



3. Iron and copper
The ratio of iron and copper is essential to enhance the proper levels of hemoglobin in energy production by transporting and releasing oxygen throughout the body, according to the study of "Influence of copper, iron, zinc and fe (3) (+)haemoglobin levels on the etiopathogenesis of chronic calcific pancreatitis--a study in patients with pancreatitis" by Arumugam G, Padmanaban M, Krishnan D, Panneerselvam S, Rajagopal S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20809271, researchers found that the results of the present study revealed that the levels of copper and iron, the pro-oxidants and zinc and selenium may influence calcification process in CCP patients. Hypoxia-related tissue injury due to the formation of oxidised haemoglobin may also contribute to the pathogenesis of calcification in pancreas.



4. Superoxide dismutase
Superoxide dismutase are an important antioxidant defense in nearly all cells exposed to oxygen as a class of enzymes that catalyzes the dismutation of free radicals due to existence of copper and Zn in tofu (according to the study of "Cu,Zn-superoxide dismutase gene dosage and cell resistance to oxidative stress: a review" by Peskin AV., posted in Pubmed, researchers found that
There are data that increasing only Cu,Zn-SOD can be toxic, and the balance between Cu,Zn-SOD and peroxide-removing enzymes is supposed to be of prime importance in the antioxidant defence. Role of Cu,Zn-SOD deregulation in carcinogenesis is discussed.



5. Menstrual cramp and pain
The existence of Omega 3 fatty acid reduces the production of prostaglandin hormone, by balancing the ratio of Omega 3 and 6 fatty acids, resulting in lessening the movement of abdominal muscle that cause menstrual cramps and pain , according to the study of "Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea" by Moghadamnia AA, Mirhosseini N, Abadi MH, Omranirad A, Omidvar S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20795425), researchers found that There was also a marked reduction in low back pain and abdominal pain (P < 0.05), and participants needed significantly fewer rescue doses of ibuprofen while using fish oil.



6. Selenium
Selenium is classified as one of antioxidant trace mineral that helps to increase the immune function to fight the forming of free radicals, infection and inflammation caused by oxidation, irregular cells growth, virus and bacteria, etc., according tothe study of "Protective role of intraperitoneally administrated vitamin E and selenium on the levels of total lipid, total cholesterol, and fatty acid composition of muscle and liver tissues in rats" by Yilmaz O, Celik S, Cay M, Naziroğlu M., posted in PubMed, researchers found that the level of total lipid andcholesterol in muscle and liver tissues were reduced by administrating vitamin E and Se together. Additionally, the fatty acid synthesis in the muscle and liver tissues was decreased by this process) and prevent plague accumulated cause of Atherosclerosis (according to the study of 'Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials" by Bleys J, Miller ER 3rd, Pastor-Barriuso R, Appel LJ, Guallar E., posted inPubMed) thus reducing the risk of heart diseases and hypertension.



7. Etc.


Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/15808899
(b) http://www.ncbi.nlm.nih.gov/pubmed/22011856
(c) http://www.ncbi.nlm.nih.gov/pubmed/22001128
(d) http://www.ncbi.nlm.nih.gov/pubmed/22079530
(f) http://www.ncbi.nlm.nih.gov/pubmed/19484707
(1) http://www.ncbi.nlm.nih.gov/pubmed/19539268
(2) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(3) http://www.ncbi.nlm.nih.gov/pubmed/22111015

The Best Smoothie of Cooked Sweet Potato, Olive and Grape Juice for Prevention and Treatment of progressive kidney disease in Focal segmental glomerulosclerosis

Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Focal segmental glomerulosclerosis is scar tissues in the filtering unit of the kidney due to primary glomerular diseases in children and adolescents inducing edema and the loss of protein from the plasma into the urine. The syndrome may result of kidney failure when affected children and adolescents  grow into adulthood. According to Dr. Fogo AB, Focal segmental glomerulosclerosis (FSGS) has a common lesion in progressive kidney disease, and a disease characterized by marked proteinuria and podocyte injury(1).

The smoothie for prevention and treatment of  progressive in Chronic kidney disease
Yield: 2 servings (about 8 ounces each)

1/2 cup olive
1 cup cooked sweet potato
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Chronic Kidney Diseases(CKD)  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Chronic Kidney Diseases(CKD).

Chronic Kidney Diseases(CKD) is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled  effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat
modification in CKD patients, according to the Karolinska Institutet(5).
Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).
Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).
According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9).Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients(10).

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Albuminuria with little or no adverse effects.

People who are at high risk of Chronic Kidney Diseases(CKD) due to aging, weaken reno function... should drink at least one serving daily and People with Chronic Kidney Diseases(CKD) should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

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References
(*) Causes and pathogenesis of focal segmental glomerulosclerosis by Fogo AB1.(PubMed)
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)

Most Common Diseases of 50plus: Diabetes - Treatments In traditional Chinese medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

                               Treatments

C. In traditional Chinese medicine perspective
C.1. Causes
In traditional Chinese medicine, Diabetes mellitus is defined as a condition of the depletion-thirst disease, characterized by polydipsia, polyphagia, polyuria, and emaciation as a result of
1. Overeating causes of damage of spleen and stomach
2. Emotion effects anxiety, anger, mental depression, etc. such as causes of the liver qi stagnation
3. Intemperance in sexual life or congenital essence defect causes of the kidney qi deficiency.
C.2. Differentiation
In differentiation, diabetes is classified into 3 types
1. Upper-warmer depletion-thirst diseases
As a result of excessive heat of the lungs that deplete the lung’s yin with symptoms of thick nasal discharge, severe thirst accompanied by dryness of the mouth and tongue, reddened tip and margin of the tongue with thin, yellow coating, full and rapid pulse.
2. Middle-warmer depletion-thirst disease
As a result of excessive heat in the stomach deplete stomach yin with symptoms ofconstant hunger (Polyphagia), emaciation, painful, swollen, and/or bleeding gums, regurgitation, and/or vomiting after eating, burning sensation in the epigastrium,constipation, reddened tongue with dry, yellow coating, and slippery and strong pulse.
3. Lower-warmer depletion-thirst disease
As a result of excessive heat of the kidney consumes the kidney yin or yin & yang with symptoms of dizziness, vertigo, tinnitus, poor memory, deafness, night sweating, sore back, ache in bone, turbid urine, dry mouth, reddened tongue with little coating, and weak and rapid pulse.

C.3. TCM formulas in treating diabetes
According to the article of TREATMENT OF DIABETES WITH CHINESE HERBSby Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. The below formulas are recommended for diabetics depending to the differentiation(105).
1. Reducing Sugar Tablet A (Jiang Tang Jia Pian)
The formula includes the following herbs
astragalus, polygonatum, trichosanthes root, pseudostellaria, and rehmannia, and was recommended for people with low levels of insulin, but are still capable of producing insulin.
The herbs were administered as extracts in tablet form, with 2.3 grams raw material per tablet, 6 tablets each time, three times daily, for a total dose of over 40 grams per day (raw materials equivalent). The effects were said to be enhancing sugar tolerance and elevating the level of serum insulin. In the treatment of 405 cases of diabetes with this preparation at the Guanganmen Hospital, 76.5% of the patients had improved sugar tolerance. Among those patients who most closely fit the therapeutic pattern of the herbs-those with qi and yin deficiency-the effective rate was slightly higher, 81%.
2. Rehmannia Eight Formula was recommended for those patients who produced little or no insulin. This is for patients with advanced disease, representing a deficiency of yin and yang (the cinnamon bark and aconite added to Rehmannia Six Formula to produce Rehmannia Eight Formula are said to restore yang). In laboratory animal studies, use of this formula resulted in reduction of water demand (thirst), blood sugar, and sugar spill into the urine. As a result of positive reports resulting from use of this formula for diabetes in Japan, the current author recommended it for those with early-onset diabetes beginning in 1981, using mainly the patent medicine from China, variously called “Sexoton Pills” or “Golden Book Tea” which is the Rehmannia Eight Formula (Ba Wei Di Huang Wan). When consumed in the amount of 12 pills each time, three times daily, it could help reduce the fluctuations in blood sugar that were experienced by insulin-dependent patients who had difficulties gaining control of blood sugar levels. As a result, there was a slight reduction in total insulin usage, but the main benefit was more reliable effects of insulin.
3. Jade Spring Pill (Yu Quan Wan), a patent formula from China, is recommended for diabetes treatment in the dosage of 50 grams per day (the original form was large honey pills of about 6 grams each), for at least one month. In laboratory animal studies, this formula was shown to increase glycogen in liver cells (the single herb rehmannia also has this effect in laboratory animals). When the current author visited the Sichuan Province United Pharmaceutical Manufactory, a new product was presented: the second generation of “Yuechung Pills” (Jade Spring Pills), comprised of pueraria, trichosanthes root, rehmannia, licorice, schizandra, and other herbs not mentioned on the label. These pills are indicated in the package labeling for the “ill function of the islets of Langerhans.” The relatively small pills are packed into small bottles with a total of 6 grams each, and 20 bottles are packed in one box, accompanied by instructions to take one bottle each time, four times daily (the box is a five day supply at 24 grams/day). Compared to the first generation, it is said on the package insert, the new product had been clinically proved to have an improved rate of cure and that the dose had been reduced. Jade Spring Pill is useful for the early stage of diabetes, when yin deficiency and dryness dominate. In a recent clinical evaluation of a Chinese herb formula for diabetes, Jade Spring Pills, used for the control group, was reported to be effective in reducing blood sugar for 79% of cases treated (33).
If you need more information of above formulas, please visit the link (105).

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Sources
(105) http://www.itmonline.org/arts/diabherb.htm

General Health: Candida Albicans: What happen if candida become fungus

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth results in candidiasis. Non-albicansCandida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candidaresistance toward antifungal agents.


What happen if candida become fungus

When Candida growth becomes uncontrolled and become fungus, its metabolites and/or toxins(117)(118) interfere with the functioning of nutrient-uptake(107)(108) and penetrate into the bloodstream, causing
a) Neuro effects
Candida produces toxins(acetaldehyde and ethanol)(112)(113) in large quantity that affect our brain and interfere with our biochemical processes, leading to upset levels of hormones and many key chemicals(109), resulting in symptoms of fatigue, aggression, depression and toxicity and schizophrenia(110)(111).

b) Permeability
As the innermost membrane of the four coats of the intestinal wall becomes permeable due to fungus(114)(115), partially digested foods, toxins produced by fungus and chemical molecules can enter the bloodstream and reach organs that suppress their normal functions, causing immune dysfunction(116)(117) in a long run and many kinds of chronic illness(118)(119).

c) Reproductive dysfunction
Overgrowth candida can cause the reproductive tract infection(120). For female, it leads to infections of the upper reproductive tract (fallopian tubes, ovary and uterus)(123), and/or the lower reproductive tract(124) (vagina, cervix and vulva)(121)(122), for male, it is at the penis(127), testicles, urethra(128) or the sperm tube(125), causing reproductive dysfunction, including infertility(126).

d) Premenstrual syndrome
As over growth candida binding to hormones(130), it alters the pathway and their shape by preventing them entering the target receptor sites, that make certain hormones inactive, leading to estrogen and progesterone effected cell growth, morphology and virulence(131), in regulating blood sugar(132) and endocrine disruptor causes of premenstrual syndrome(129).

e) Autoimmune disorders
e.1. After entering blood stream, it causes allergies reaction of the immune system(133)(134), but some of antigens' molecules are similar to molecules of human tissue(135), resulting of immune system attacking both the antigens and the body's healthy tissues, leading to autoimmune disorders(136).

e. 2. The main target of candida target
The main target of candida is to evade the body's immune system for their forever survival in the host body by targeting the immune system response in fighting against invading organism(137) as they change the receptors of foreign organism or theirs' form which are displaying(138), making them difficult for the body's immune cells to react appropriately(19)(140).

e.3. Digestive track colonization
The main purpose of Candida is trying to invade the intestinal wall by suppressing immune system responds(142) with inflammation(141), leading to prolong inflammation, (the prolonged inflammation is called ulceration colitis if it occurs in the large intestine(143)(144) and it is called Crohn's disease if it occurs in the small intestine(145)(146)147) that can cause of digestive track colonization of the host body.

e.4. The mind and emotion
If candida overgrowth, it produces toxins (canditoxin and ethanol) that affect our brain and it releases metabolites that interfere with our biochemical processes in hormone production(109), leading to fatigue, aggression, depression and toxicity(110)(111).

e.5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicansisolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicansby Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistantCandida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(107) Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Paillaud E1, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN.(PubMed)
(108) Nutritional factors and oral candidosis. Samaranayake LP (PubMed)
(109) Relative risk of vaginal candidiasis after use of antibiotics compared with antidepressants in women: postmarketing surveillance data in England. Wilton L1, Kollarova M, Heeley E, Shakir S.(PubMed)
(110) Effect of antibiotics on vulvovaginal candidiasis: a MetroNet study. Xu J1, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD.(PubMed)
(111) Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three-dimensional ultrasound. Deb S1, Campbell BK, Pincott-Allen C, Clewes JS, Cumberpatch G, Raine-Fenning NJ.(PubMed)
(112)[Oral contraception and carbohydrate metabolism--the physiopathological explanation].[Article in French], Hilal M.(PubMed)
(113) PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination. Lefèvre L1, Galès A, Olagnier D, Bernad J, Perez L, Burcelin R, Valentin A, Auwerx J, Pipy B, Coste A.(PubMed)
(114) The epidemiology of vaginal colonisation with group B streptococci in a sexually transmitted disease clinic.Honig E1, Mouton JW, van der Meijden WI.(PubMed)
(115)Risk factors for Salmonella infection. Loss of gastric acid linked tocandidiasis. Larner AJ.(PubMed)
(116)Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. Brzozowski T1, Zwolinska-Wcislo M, Konturek PC, Kwiecien S, Drozdowicz D, Konturek SJ, Stachura J, Budak A, Bogdal J, Pawlik WW, Hahn EG.(PubMed)
(117) Growth limitation in Candida lipolytica cultures and supersynthesis ofmetabolites]. [Article in Russian] Lozinov AB, Finogenova TV, Glazunova LM, Illarionova VI.(PubMed)
(118) Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. Brosnahan AJ1, Merriman JA, Salgado-Pabón W, Ford B, Schlievert PM.(PubMed)
(119) The Toxic Effects of Yeast OvergrowthPosted by SoundHealth, in Disease
(120) Mercury Poisoning, Candida Yeast, Or Is It Both?
(11=21) Relation of blood acetaldehyde level to clinical symptoms in the disulfiram-alcohol reaction.
RABY K.(PubMed)
(122) Biofuels. Engineering alcohol tolerance in yeast. Lam FH1, Ghaderi A2, Fink GR3, Stephanopoulos G4.(PubMed)
(123 Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells. Elamin E1, Masclee A2, Troost F2, Dekker J3, Jonkers D2.(PubMed)
(124) Effect of corilagin on membrane permeability of Escherichia coli, Staphylococcus aureus and Candida albicans. Li N1, Luo M, Fu YJ, Zu YG, Wang W, Zhang L, Yao LP, Zhao CJ, Sun Y.(PubMed)
(125)A new look at the antibiotic amphotericin B effect on Candida albicans plasma membrane permeability and cell viability functions. Chudzik B1, Koselski M, Czuryło A, Trębacz K, Gagoś M.(PubMed)
(126) New insights into innate immune control of systemic candidiasis. Lionakis MS(PubMed)
(127 )Immunogenetics of type 1 diabetes mellitus. Morran MP1, Vonberg A1, Khadra A2, Pietropaolo M3.(PubMed)
(128) Burden of Fungal Disease - Ireland. Dorgan E1, Denning DW2, McMullan R3.(PubMed)
(129) Burden of serious fungal infections in Spain.
Rodriguez-Tudela JL1, Alastruey-Izquierdo A2, Gago S3, Cuenca-Estrella M2, León C4, Miro JM5, Nuñez Boluda A6, Ruiz Camps I7, Sole A8, Denning DW9; University of Manchester in association with the LIFE program at. Electronic address: http://www.LIFE-worldwide.org.(PubMed)
(130) Prevalence study of genital tract infections in pregnant women referred to health centers in Iran.
Mobasheri M, Saeedi Varnamkhast N, Karimi A, Banaeiyan S.(PubMed)
(131)Vaginal infections among pregnant women at Omdurman Maternity Hospital in Khartoum, Sudan.
Abdelaziz ZA1, Ibrahim ME, Bilal NE, Hamid ME.(PubMed)
(132) Reproductive tract infections among married women in Upper Egypt. Sullam SA1, Mahfouz AA, Dabbous NI, el-Barrawy M, el-Said MM.(PubMed)
(133) Characterization of low molecular weight antimicrobial peptide from human female reproductive tract. Sharma S1, Sethi S, Prasad R, Samanta P, Rajwanshi A, Malhotra S, Sharma M.(PubMed)
(134) Lower genital tract infections in infertile Nigerian women compared with controls.Okonofua FE1, Ako-Nai KA, Dighitoghi MD.(PubMed)
(135) ion of oocyte fertilization by assisted reproductive techniques and increased sperm DNA fragmentation in the presence of Candida albicans: a case report. Burrello N1, Calogero AE, Perdichizzi A, Salmeri M, D'Agata R, Vicari E.(PubMed)
(136) Studies on the significance of positive bacterial semen cultures in malefertility in Nigeria.Onemu SO1, Ibeh IN.(PubMed)
(137) Mycetomatoid infection of the penis by Candida albicans. Mastrolorenzo A1, Giomi B, Cipollini EM, Tammaro R, Decarli N, Cammelli D, Fabiani Tropeano F, Tiradritti L, Difonzo EM, Zuccati G.(PubMed)
(138) Candida albicans epididymo-orchitis and fungemia in a patient with chronic myelogenous leukemia Mark Pimentel, MD, Lindsay E Nicolle, MD FRCPC, and Salman Qureshi, MD FRCPC(PubMed)
(139) Normocalcemic tetany and candidiasis. Galland L.(PubMed)
(140) Interaction of Candida albicans with genital mucosa: effect of sex hormoneson adherence of yeasts in vitro. Kalo A1, Segal E.(PubMed)
(141) Response of pathogenic and non-pathogenic yeasts to steroids. Prasad R1, Devaux F, Dhamgaye S, Banerjee D.(PubMed)
(142)Evaluation of the influence of blood glucose level on oral candidal colonization in complete denture wearers with Type-II Diabetes Mellitus: An in vivo Study. Ganapathy DM1, Joseph S, Ariga P, Selvaraj A.(PubMed)
(143)Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Cenci E1, Romani L, Vecchiarelli A, Puccetti P, Bistoni F.(PubMed)
(144)[Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect].[Article in German] Kübler A1, Ziegler C, Barth T, Zöller J.(PubvMed)
(145)Immune thrombocytopaenic purpura: an autoimmune cross-link between infections and vaccines.
Rinaldi M1, Perricone C, Ortega-Hernandez OD, Perricone R, Shoenfeld Y.(PubMed)
(146)Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.Kamikawa Y1, Mori Y, Nagayama T, Fujisaki J, Hirabayashi D, Sakamoto R, Hamada T, Sugihara K.(PubMed)
(147)Oxidative and nitrosative stress on phagocytes' function: from effective defense to immunity evasion mechanisms. Ferrari CK1, Souto PC, França EL, Honorio-França AC.(PubMed)
(148)IL-17 signaling in host defense against Candida albicans. Gaffen SL1, Hernández-Santos N, Peterson AC.(PubMed)
(149)Th17 cells in immunity to Candida albicans. Hernández-Santos N1, Gaffen SL.(PubMed)
(150)The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Bishu S1, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL(PubMed)
(151)Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk. Cohen-Kedar S1, Baram L, Elad H, Brazowski E, Guzner-Gur H, Dotan I.(PubMed)
(152)Innate immunity induced by fungal β-glucans via dectin-1 signaling pathway.
Lee DH1, Kim HW2.(PubMed)
(153)[Candidiasis in the experimental model of ulcerative colitis].[Article in Polish] Zwolińska-Wcisło M1, Sliwowski Z, Drozdowicz D, Kwiecień S, Mazurkiewicz-Janik M, Trojanowska D, Rudnicka-Sosin L, Mach T, Budak A, Brzozowski T, Konturek SJ, Pawlik WW.(PubMed)
(154)Effect of Candida colonization on human ulcerative colitis and the healing of inflammatory changes of the colon in the experimental model of colitis ulcerosa. Zwolinska-Wcislo M1, Brzozowski T, Budak A, Kwiecien S, Sliwowski Z, Drozdowicz D, Trojanowska D, Rudnicka-Sosin L, Mach T, Konturek SJ, Pawlik WW.(PubMed)
(155)Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease.Standaert-Vitse A1, Jouault T, Vandewalle P, Mille C, Seddik M, Sendid B, Mallet JM, Colombel JF, Poulain D.(PubMed)
(156)Candida albicans colonization and ASCA in familial Crohn's disease. Standaert-Vitse A1, Sendid B, Joossens M, François N, Vandewalle-El Khoury P, Branche J, Van Kruiningen H, Jouault T, Rutgeerts P, Gower-Rousseau C, Libersa C, Neut C, Broly F, Chamaillard M, Vermeire S, Poulain D, Colombel JF.(PubMed)
(157)Effect of strain of Staphylococcus aureus on synergism with Candidaalbicans resulting in mouse mortality and morbidity. Carlson E.(PubMed)
(158)Lesson of the month 2: toxic shock syndrome.
Shalaby T1, Anandappa S2, Pocock NJ2, Keough A2, Turner A2.(PubMed)
(159)Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. Kulhankova K1, King J, Salgado-Pabón W.(PubMed)

Most Common Diseases of 50plus: Diabetes Treatment In conventional medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

                                            Treatments

A. In conventional medicine perspective
The aim of the treatment is to prolonged life, relieve symptoms and prevent complication as well as enhancing the life quality
A. 1. Life style management
According to the study by Diakonissen-Krankenhaus Salzburg, Salzburg, Österreich, aiabetes education, nutritional advice, exercise recommendations and training for smoking cessation comprise the mainstay of diabetes treatment before starting drug therapy. Prevention as well as treatment of diabetes mellitus is positively influenced by life-style modification(71). Other in the study of The sample aged 53.5±6.6 years, 72.7% aged 50 to 59 years; 45.3% were women; an average of 8±2.08 years in the disease’s evolution. suggested that it is necessary to improve life styles on physical activity, self-esteem, diet and attachment to the treatment(72). And in a cross-sectional correlational study indicate that poor metabolic control of diabetic patients has a detrimental effect on quality of life, and when diabetic patients use more self-control skills, they may achieve better quality of life(73).

A.2. Non medication therapy
1. Exercise
Along with diet and medication, exercise is the third cornerstone of type 2 diabetes treatment. Persons with type 2 diabetes should perform at least 90 min per week of vigorous (> 65% of VO (2)max) aerobic exercise or 150 min per week of moderate-intensity (40-65% of VO (2)max) aerobic physical activity. Performing at least 240 min of physical activity per week is associated with greater cardiovascular disease risk reductions as well as with less cardioÂ-vascular events compared with lower volumes of activity, according to the study by Abteilung Bewegung und Gesundheit, Erlangen(74).

2. Diet therapy
Low-carbohydrate and low-fat calorie-restricted diets are recommended for weight loss in overweight and obese people with type 2 diabetes. In the study of 215 overweight people with newly diagnosed type 2 diabetes who were never treated with antihyperglycemic drugs and had hemoglobin A(1c) (HbA(1c)) levels less than 11%, found that after 4 years, 44% of patients in the Mediterranean-style diet group and 70% in the low-fat diet group required treatment (absolute difference, -26.0 percentage points [95% CI, -31.1 to -20.1 percentage points]; hazard ratio, 0.63 [CI, 0.51 to 0.86]; hazard ratio adjusted for weight change, 0.70 [CI, 0.59 to 0.90]; P < 0.001). Participants assigned to the Mediterranean-style diet lost more weight and experienced greater improvements in some glycemic control and coronary risk measures than did those assigned to the low-fat diet and concluded that compared with a low-fat diet, a low-carbohydrate, Mediterranean-style diet led to more favorable changes in glycemic control and coronary risk factors and delayed the need for antihyperglycemic drug therapy in overweight patients with newly diagnosed type 2 diabetes(75).

A.3. Medication
A.3.1. Oral administration
1. Beta-blocker therapy
In the study to determine the use and association with one-year mortality of beta-blocker therapy for the treatment of acute myocardial infarction (AMI) in elderly diabetic patients and to examine whether beta-blocker therapy was associated with increased rates of hospital readmission for diabetic complications traditionally associated with beta-blockers, researchers showed that Beta-blockers are associated with a lower one-year mortality rate for elderly diabetic patients to a similar extent as for nondiabetics, without increased risk of readmission for diabetic complications. Increasing the use of beta-blockers in elderly diabetic patients represents an opportunity to improve the care and outcomes of these patients after AMI(76). Major side effects include the precipitation or worsening of congestive heart failure, and significant negative(77).

2. Metformin
The oral antidiabetic medicine is the first for patient of type II diabetes, in particular, in overweight and obese people and those with normal kidney function by improving your body responds to insulin to reduce high blood sugar levels with side effect ot limit to nausea, diarrhea, and gas. Over doses can cause vomiting, diarrhea, abdominal pain, tachycardia, drowsiness, and, rarely, hypoglycemia or hyperglycemia, according to the study by Jeffrey R. Suchard, MD and Thomas A. Grotsky, MD(78).

3. Sulfonylurea
The medaction helps to increase the amount of insulin made by your body makes, and lower blood sugar levels. Unfortunately, Patients with type 2 diabetes exposed to sulfonylureas and exogenous insulin had a significantly increased risk of cancer-related mortality compared with patients exposed to metformin(79). Other study indicated that they did not identify an increased mortality risk among the different combinations of sulfonylureas and metformin, suggesting that overall mortality is not substantially influenced by the choice of sulfonylurea(80).

Side effects are not limit to Sweating, Shaking, Feeling hungry and anxious, etc.

4. Thiazolidinediones
The medicine lower blood sugar levels by increasing the body’s sensitivity to insulin. Unfortunately, it can causes liver cancer and colorectal cancer in type 2 diabetes mellitus, according to the study of a total of 606,583 type 2 diabetic patients, age 30 years and above, without a history of cancer were identified from the Taiwan National Health Insurance claims database during the period between January 1 2000 and December 31 2000, by Department of Internal Medicine, National Taiwan University Hospital(81). Other suggested that it may cause bone loss(82) and bladder cancer(83). Side effects of Thiazolidinediones are not limit to
heart failure, weight gain, fluid tetention and risk of bone fracture, etc.

5. Insulin
The aim of insulin therapy is to treat diabetes by controlling the amount of sugar (glucose) in the blood. BIAsp 30, a biphasic insulin, has been shown to be more effective in terms of glycaemic control than standard biphasic human insulin 30 (BHI 30). In the study by Institute of Biomedical Research, University of Birmingham, a strong evidence was provided for better glycaemic control with BIAsp 30 without increases in the incidence of major hypoglycaemia or nocturnal hypoglycaemic episodes. Overall, weight gain with BIAsp 30 was minimal and not significantly greater than with basal insulin or BHI 30. The reported efficacy and tolerability of BIAsp 30 in the treatment of diabetes based on a variety of clinical endpoints is supported by a good body of evidence relating to its use in different dosage regimens and in comparison with other insulin treatment regimens(84). Side effects are rare, but allergic reactions can be severe and pose a significant risk to health(85).

6. DPP-IV Inhibitors
The medicine helps to lower glycated hemoglobin, fasting and postprandial glucose levels, with a low incidence of hypoglycemia and no weight gain and only given to patient can not tolerate first line medicine. There is a trend towards increasing use of DPP-IV inhibitors, which are no less efficacious and safe in Asians than Caucasians and may have some advantages over existing oral antidiabetic agents, particularly for certain high-risk groups(86). Clinical trials have shown that vildagliptin is effective in significantly lowering glycosylated hemoglobin (HbA1c), fasting plasma glucose, and prandial glucose levels. beta-cell function may also be improved. The drug has placebo like tolerability and rate of hypoglycemia events. Vildagliptin expands non-injectable treatment options available for management of T2DM patients, who are poorly controlled with monotherapy(87). Other study suggeested that Vildagliptin represents a safe and effective new approach to targeting GLP-1 deficiencies in patients with type 2 diabetes by inhibiting DPP IV(88). Side effects are not limit to incidences of hypoglycemia increased with longer duration and optimal results with minimal adverse effects were achieved with 25 mg twice daily and 50 mg once daily doses(89).

7. Etc.

A.3.2. Insulin or insulin and oral medication therapy
The conbination of GLP-1 analogues and isulin may be effective in the treatment of type 2 diabetes mellitus, as GLP-1 stimulate insulin production and secretion, and suppress glucagon secretion, depending on the blood glucose level and have an effect on the brain, enhancing satiety, and on the gut, where they delay gastric emptying(90).
Unfortunately, In a 136 insulin-naïve respondents (57% female, 69% Latino, mean age 51.1±10.3 years; $200-$1000 median monthly household income; grade 8-12 median education) revealed a 48% prevalence of complete unwillingness to begin insulin, researchers found that Latino respondents were younger, lived fewer years in the U.S., had less education, were more likely unwilling to use insulin (53% vs. 30%, p=0.03), and reported a more negative attitude to 8 of 9 PIR domains (p≤0.01 for each). Fewer years in the U.S. predicted greater unwillingness and a more negative attitude on 8 of 9 PIR domains (p≤0.03 for each); and less education predicted greater feelings of unfairness (p=0.01)(91).

A.4. Surgery
Although surgery is rare and only in nonmorbidly obese patients with uncontrolled type 2 diabetes
1. In this randomized, nonblinded, single-center trial, we evaluated the efficacy of intensive medical therapy alone versus medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy in 150 obese patients with uncontrolled type 2 diabetes, showed that in obese patients with uncontrolled type 2 diabetes, 12 months of medical therapy plus bariatric surgery achieved glycemic control in significantly more patients than medical therapy alone(92). Other indicated that clinical and laboratory manifestations of type 2 diabetes are resolved or improved in the greater majority of patients after bariatric surgery; these responses are more pronounced in procedures associated with a greater percentage of excess body weight loss and is maintained for 2 years or more(93).
Laparosopic gastric sleeve gastrectomy resulted in remission of poorly controlled nonmorbidly obese T2DM patients up to 50% at 1 year after operation. The effect is related more to the decreasing of insulin resistance because of calorie restriction and weight loss rather than to the increasing of insulin secretion. C-peptide >3 ng/mL is the most important predictor for a successful treatment(94). But other indicated that Laparoscopic ileal interposition associated with a sleeve gastrectomy (LII-SG) is a safe and effective operation for the treatment of type 2 diabetic (T2DM) patients with BMI below 35. As the clamp technique, II-SG significantly improved IS and β-cell function as early as 30 days postoperatively in a T2DM population with a BMI of 21.9-33.8.(95).

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