Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Over the years of research, 4 foods appeared mostly in medical studies in preventing and treating diseases, are Green Tea, Grape seed and skin, Turmeric and Organic Soy(Not for Western Women). All Right Reserved.
IV. Organic Soy
Soy foods, including tofu have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experience symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in older adult in Japan.(b)
The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidences could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.
Today, the promotion of soy is no longer existed, it may be results of discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce risk of certain mammary cancers and infertility. The publication of the result have drawn many criticisms. According to Thomas Badger, director and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a).Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by University of Goettingen may be interesting, as researchers said" Most importantly, there is dispute as to whether isoflavones derived from soyor red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancerpreventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".
Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.
Tofu or bean curd
Tofu or bean curd is soft white blocks made by coagulating soy milk with substance such as salt or acid or enzyne, a stable emulsion of oil, water, and protein that can be made into tofu, originated from Chinese and part of East and Southeast Asian. Since it is proven to be one of many healthy foods, it become synonymous with vegetarianism and others.
3. Omega 3 fatty acid
4. Vitamin A
5. B vitamin
I. Health benefits by Healthy food Tofu
A. Health benefits according to studies
1. Hair loss In the orally administered soymetide-4 (MITL), an immunostimulating peptide derived from soybean beta-conglycinin alpha' and it effect on hair loss found that PGE2, which is produced after activation of COX by soymetide-4, might suppress apoptosis of hair matrix cells and etoposide-induced alopecia by activating NF-kappaB, according to "Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin" by Tsuruki T, Takahata K, Yoshikawa M.(a)
b. Metabolic syndrome
In the assessment of the effect of low daily intake of soybeans in oxidative stress and it effects on the metabolic syndrome (MS) found that Low intake of soy protein for 90 days, besides being well tolerated by the patients, was able to improve several parameters related to the pathophysiology of MS, according to the study of "[Evaluation of the intake of a low daily amount of soybeans in oxidative stress, lipid and inflammatory profile, and insulin resistance in patients with metabolic syndrome].[Article in Portuguese] by Bahls LD, Venturini D, Scripes Nde A, Lozovoy MA, Simão TN, Simão AN, Dichi I, Morimoto HK.(b)
3. Cancer prevention
In the evaluation of Soy isoflavones and it effects on cancers found that Soy isoflavones, linked to reduced cancer risk in Asian epidemiology, may suppress cox-2 induction by activating ERbeta. In aggregate, these considerations suggest that a comprehensive lifestyle strategy targeting cox-2 expression and bioactivity may have tremendous potential for cancer prevention, according to "Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancerprevention" by McCarty MF.(c)
4. Lung cancer
In the Comparison to lung tumor nodules treated with soy isoflavones or radiation, lung tissues from mice found that Soy isoflavones augment destruction of A549 lung tumor nodules by radiation, and also mitigate vascular damage, inflammation and fibrosis caused by radiation injury to normal lung tissue. Soy could be used as a non-toxic complementary approach to improve RT in NSCLC., according to "Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury" by Hillman GG, Singh-Gupta V, Runyan L, Yunker CK, Rakowski JT, Sarkar FH, Miller S, Gadgeel SM, Sethi S, Joiner MC, Konski AA.(d)
5. Body weight and glycemic control
In the investigation of Soy isoflavones and it affects on plasma lipids, body weight, and insulin action, found that glucose tolerance tests in adult females were not significantly different with diet, but offspring eating TAD soy had increased glucose disappearance with overall lower glucose and insulin responses to the glucose challenge compared with typical American diet (TAD) casein, according to "Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring" by Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR.(e)
B. Health Benefits according to the concentration
Tryptophan is one of the 10 essential amino acids which the body uses to synthesize the proteins for brain cells need, thus enhancing the nerve cells in information transmitting between themselves and cells in the parts of the body that reduces the risk of anxiety and depression, according to the study of "The effects of tryptophan depletion on neural responses to emotional words in remitted depression" by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(1)
It is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(2)
Iron beside is important in enhance the oxygen absorption ti nourish the cells and organs in the body but also form a vital role in the effect of Erythropoietic Stimulating Agents (ESA) hyporesponsiveness, according to "Effects of IronSupplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents" by Karlsson T.(3)
In the evaluation of soy protein diet abd it effects on serum creatinine, found thatsoy feeding was associated with higher renal and hepatic linoleic acid content and higher hepatic alpha-linolenic acid, but lower hepatic arachidonic acid content. and concluded that Isocaloric soy protein feeding ameliorates both epithelial and interstitial changes in the Han:SPRD-cy rat independent of a hypocholesterolemic effect. The histologic benefit is associated with changes in polyunsaturated fatty acid metabolism that may influence both inflammatory and proliferative pathways, according to the study of "Modification of polycystic kidney disease and fatty acid status by soy protein diet" by Ogborn MR, Nitschmann E, Weiler HA, Bankovic-Calic N.(4)
C. Others Health benefit
Isoflavones is one of the most powerful phytoestrogen, which not only helps to reduce symptoms of peri-menopause and menopause due to decreasing of the reproduction of estrogen as aging ( in the evaluation of the effect of red clover isoflavone supplementation over vasomotor and overall menopausal symptoms in postmenopausal women, posted in PubMed(http://www.ncbi.nlm.nih.gov/pubmed/21870906) , researchers found that Red clover isoflavone supplementation was more effective than placebo in reducing daily vasomotor frequency and overall menopausal intensity in postmenopausal women.), it also helps to protect against the development of endometrial carcinoma as well as prolonging the menstrual cycle, ( according to the study of "The effect of phytoestrogens on the female genital tract" by Burton JL, Wells M., posted in PubMed, researchers found that this review will discuss the evidence from both animal studies and humans for an effect of these ubiquitous compounds on the development of the human female genital tract, in addition to prolonging the menstrual cycle, alleviating symptoms of the menopause, and protecting against the development of endometrial carcinoma.
2. Cardiovascular Benefits
Research found that protein of tofu significantly decreases the serum cholesterol by decreasing the levels of bad cholesterol (LDL) but leaving the good cholesterol (HDL) remain the same According to the study of "Effect of soy and milk proteinsupplementation on serum lipid levels: a randomized controlled trial" by Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS, Myers L, Xu J, Jones DW, Whelton PK, He J., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21952693)). It also benefits the cardiovascular health (according to the study of "Soy protein, isoflavones, andcardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee" by Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M; American Heart Association Nutrition Committee. posted PubMed (http://www.ncbi.nlm.nih.gov/pubmed/16418439)
3. Iron and copper
The ratio of iron and copper is essential to enhance the proper levels of hemoglobin in energy production by transporting and releasing oxygen throughout the body, according to the study of "Influence of copper, iron, zinc and fe (3) (+)haemoglobin levels on the etiopathogenesis of chronic calcific pancreatitis--a study in patients with pancreatitis" by Arumugam G, Padmanaban M, Krishnan D, Panneerselvam S, Rajagopal S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20809271, researchers found that the results of the present study revealed that the levels of copper and iron, the pro-oxidants and zinc and selenium may influence calcification process in CCP patients. Hypoxia-related tissue injury due to the formation of oxidised haemoglobin may also contribute to the pathogenesis of calcification in pancreas.
4. Superoxide dismutase
Superoxide dismutase are an important antioxidant defense in nearly all cells exposed to oxygen as a class of enzymes that catalyzes the dismutation of free radicals due to existence of copper and Zn in tofu (according to the study of "Cu,Zn-superoxide dismutase gene dosage and cell resistance to oxidative stress: a review" by Peskin AV., posted in Pubmed, researchers found that
There are data that increasing only Cu,Zn-SOD can be toxic, and the balance between Cu,Zn-SOD and peroxide-removing enzymes is supposed to be of prime importance in the antioxidant defence. Role of Cu,Zn-SOD deregulation in carcinogenesis is discussed.
5. Menstrual cramp and pain
The existence of Omega 3 fatty acid reduces the production of prostaglandin hormone, by balancing the ratio of Omega 3 and 6 fatty acids, resulting in lessening the movement of abdominal muscle that cause menstrual cramps and pain , according to the study of "Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea" by Moghadamnia AA, Mirhosseini N, Abadi MH, Omranirad A, Omidvar S., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20795425), researchers found that There was also a marked reduction in low back pain and abdominal pain (P < 0.05), and participants needed significantly fewer rescue doses of ibuprofen while using fish oil.
Selenium is classified as one of antioxidant trace mineral that helps to increase the immune function to fight the forming of free radicals, infection and inflammation caused by oxidation, irregular cells growth, virus and bacteria, etc., according tothe study of "Protective role of intraperitoneally administrated vitamin E and selenium on the levels of total lipid, total cholesterol, and fatty acid composition of muscle and liver tissues in rats" by Yilmaz O, Celik S, Cay M, Naziroğlu M., posted in PubMed, researchers found that the level of total lipid andcholesterol in muscle and liver tissues were reduced by administrating vitamin E and Se together. Additionally, the fatty acid synthesis in the muscle and liver tissues was decreased by this process) and prevent plague accumulated cause of Atherosclerosis (according to the study of 'Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials" by Bleys J, Miller ER 3rd, Pastor-Barriuso R, Appel LJ, Guallar E., posted inPubMed) thus reducing the risk of heart diseases and hypertension.
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