Monday, June 6, 2016

Traditional Chinese Medicine Herbal Therapy - Popular Herbal Chinese Herbs – Bai Qian ( Rhizoma Cynanchi Stauntonii)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                             Bai Qian

Bai Qian is also known as Willowleaf Swallowwort Rhizome, the sweet, acrid and neutral herb has been used in TCM to cough due to influenza, bronchitis, asthma with abundance of phlegm, as it eliminates Phlegm, subdues Qi, calms cough, etc., by enhancing the function of lung channel.

Ingredients
1. Triterpenoid sapogenins
2. Hamcockinol
3. β-sitosterol
4. Fatty acids
5. Etc.

Health Benefits 
1. Antitussive, expectorant and anti-inflammatory effects
ethanol extract and ether extract from Bai Qian has demonstarted the activities of Antitussive, expectorant and anti-inflammatory effects, according to the study of “[Antitussive, expectorant and anti-inflammatory effects of rhizoma Cynanchi stauntonii].[Article in Chinese]” by Liang A, Xue B, Yang Q, Fu M, Wang J.(1).

2. Anti-influenza virus
volatile oil of the roots of Bai Qian (Cynanchum stauntonii) had exhibited the activities against influenza virus in vitro (IC50s=64 microg/ml). In in vivo experiment, it prevented influenza virus-induced deaths in a dose-dependent manner, according to the study of “Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus” by Zai-Chang Y, Bo-Chu W, Xiao-Sheng Y, Qiang W.(2).

3. Central Nervous system
the water and chloroform-extract compounds from Cynanchum has exerted the inhibitional effect on central nervous sytem.according to the study of “[Hypnotic effect of Chinese materia medica Cynanchum chinese in mice].[Article in Chinese]” by Peng XD, Yan QS, Wang R, Yang WD, Peng JZ.(3).

4. Anti-asthmatic effects
he water, ethanol and ether extracts from Cynanchum glaucescems has shown effectively prevent guinea pigs from asthma induced by acetulcholine and histamine mixture, according to the study of “[Antitussive, expectorant and anti-asthmatic effects of Cynanchum glaucescens (Decne.) Hand. -Mazz][Article in Chinese]” by Liang A, Xue B, Yang Q, Li Z.(4).

5. Analgesic,Anti-inflammatory and Anti-thrombotic Effects
Alcoholic extract of Rhizoma Cynanchi Stauntonii has prolonged the latent period of tail flip response to hot water stimulation and reduced acetic acid-induced writhing frequency,and inhibited xylene-induced swelling of the ear and carrageenin-induced swelling of the planta, according to the sudy of “Study on Analgesic,Anti-inflammatory and Anti-thrombotic Effects of Rhizoma Cynanchi Stauntoni” by Shanxi Academy of Traditional Chinese Medicine(5).
6. Etc.

Side Effects
1. Overdosing may cause stomach irritation
2. Since it has shown certain effect in lung, people who are takingasthma or other lung diseases
prescription should consult with their doctors or related field specialist before applying.
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=Rhizoma%20Cynanchi%20Stauntonii
(2) http://www.ncbi.nlm.nih.gov/pubmed/15975773
(3) http://www.ncbi.nlm.nih.gov/pubmed/17992999
(4) http://www.ncbi.nlm.nih.gov/pubmed?term=cynanchum%20glaucescens%20%28Decne.%29
(5) http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYA200101007.htm

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The General Approaches to prevent the unpreventable?

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

The General Approaches to prevent the unpreventable?

Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).
1. Healthy lifestyle(256)(257)(258)
According to Shahid Beheshti University of Medical Sciences, women with unhealthy life style are associated to increased risk of chronic diseases(260), including PCOs in comparison to those of healthy women(259), probably due to nutrient deficiency effects of immune functioning(261).

2. Balanced diet
Epidemiological data suggest that dietary patterns strongly affect inflammatoryprocesses(265).
Balancing diet(257)(258) with high in veggies and fruits(257) and less in meats not only provides sufficient nutrients to your body but also enhances the immunity in fighting against inflammatory diseases(264), including PCOs(264), irregular cell growth(263) and oxidative stress(262). Reduced intake of trans and saturated fats and increased intake of omega-3 and omega-9 fatty acids(257) and eating anti-inflammatory foods (fiber(272)(273), omega-3 fatty acids(269), vitamin E(270), and red wine(271) should also be emphasized(255)(265).

3. Moderate exercise(257)
Moderate exercise not only increases blood flow to strengthen the body tissues(274)(275) and organs(276), including the reproductive system but also enhances the immunity(277) in fighting against inflammatory process(277)(278) due to irregular cell growth(281)(282) and foreign invasion(279)(280).

4. Yoga
Yoga is a physical, mental, and spiritual practice in Hinduism, Buddhism.
According to studies holistic yoga therapy showed a significant effects in reducing anti-müllerian hormone (AMH-primary outcome), luteinizing hormone (LH), testosterone, hirsutism, and improving menstrual frequency, glucose, lipid, and insulin values(284) with nonsignificant changes in body weight, FSH, and prolactin in adolescent PCOS(283).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods LibraryEat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(260) The Science of Stress, Bad Habits, and Risk of Chronic Diseases
(261) The risks of poor nutrition(SA health)
(262) Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis by Murri M1, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF.(PubMed)
(263) The reproductive phenotype in polycystic ovary syndrome by Chang RJ1.(PubMed)
(264) Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential by Piltonen TT1, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice LC.(PubMed)
(265) Anti-inflammatory effects of plant-based foods and of their constituents by Watzl B1.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatorydiseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI1, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A1, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM1, Sumpter TL1, Turnquist HR2.(PubMed)
(269) Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease by Harbige LS1.(PubMed)
(270) Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunityand inflammatory parameters in adults with active rheumatoid arthritis: a randomized controlled trial by Aryaeian N1, Djalali M2, Shahram F3, Djazayery A4, Eshragian MR5.(PubMed)
(271) Red wine may be used in the therapy of myocarditis by Chen CJ1, Yu W, Wang W.(PubMed)
(272) High dietary fiber lowers systemic inflammation: potential utility in COPD and lung cancer by Young RP1, Hopkins RJ2.(PubMed)
(273) Dietary fibre linked to decreased inflammation in overweight minority youth by Miller SJ1, Batra AK, Shearrer GE, House BT, Cook LT, Pont SJ, Goran MI, Davis JN.(PubMed)
(274) Effects of high-intensity blood flow restriction exercise on muscle fatigue by Neto GR1, Santos HH2, Sousa JB3, Júnior AT4,(PubMed)
(275) Influence of Blood Flow Restriction During Low-intensity Resistance Exercise on the Post-exercise Hypotensive Response by Maior AS1, Simão R, Rocha Martins MS, Freitas de Salles B, Willardson JM. Araújo JP3, Aniceto RR5, Sousa MS3.(PubMed)
(276) Impact of exercise on muscle and nonmuscle organs by Boström PA1, Graham EL, Georgiadi A, Ma X.(PubMed)
(277) Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation by Benatti FB1, Pedersen BK2.(PubMed)
(278) The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases by Brandt C1, Pedersen BK.(PubMed)
(279) Enhanced follicular dendritic cell-B cell interaction in HIV and SIV infections and its potential role in polyclonal B cell activation by Rosenberg YJ1, Lewis MG, Kosco-Vilbois MH.(PubMed)
(280) THE FATE OF THE GIANT CELLS IN HEALING TUBERCULOUS TISSUE, AS OBSERVED IN A CASE OF HEALING TUBERCULOUS MENINGITIS by Hektoen L1.(PubMed)
(281) Cell-mediated immunity to mouse tumors: some recent findings. Hellström KE, Hellström I.(PubMed)
(282) Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors by Ngiow SF1, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ.(PubMed)
(283) Effects of a holistic yoga program on endocrine parameters in adolescents with polycystic ovarian syndrome: a randomized controlled trial by Nidhi R1, Padmalatha V, Nagarathna R, Amritanshu R.(PubMed)
(284) Effect of a yoga program on glucose metabolism and blood lipid levels in adolescent girls with polycystic ovary syndrome byNidhi R1, Padmalatha V, Nagarathna R, Ram A.(PubMed)
(285) Food, Immunity, and the Microbiome by Tilg H1, Moschen AR2.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Benign lung tumors - The Phytochemicals

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

Benign lung tumors, growth from many different structures in the lung, is defined as a conditions of abnormal cell growth with no tendency of spreading or masses that push normal cells out of the way rather than invading surrounding tissue restricted to a limited area in the lung. Approximately one out of 500 chest radiographs shows the incidental finding of a solitary pulmonary nodule and almost one half of these pulmonary lesions are caused by a tumor. Unfortunately, only 2% to 5% of alllung tumors are of benign origin, e. g. lipoma, fibroma, hamartoma, and chondroma, and the majority are malignant, most commonly primarylung cancer followed by metastases of extrapulmonary primary carcinomas. According to the study by Universitätsklinik für Pneumologie(a).

Phytochemicals to prevent benign lung tumors

1. Flavonoids
In the study to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for cancer prevention, found thatflavonoids are subdivided into subclasses including flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones. Epidemiological studies suggest dietary intake of flavonoids may reduce the risk of tumors of the breast, colon, lung, prostate, and pancreas. However, some studies have reported inconclusive or even harmful associations. A major challenge in the interpretation of epidemiological studies is that most of the data originate from case-control studies and retrospective acquisition of flavonoid intake. Differences in agricultural, sociodemographics, and lifestyle factors contribute to the heterogeneity in the intake of flavonoids among populations residing in the United States, Europe, and Asia. Dose and timing of exposure may influence the anticancer response to flavonoid-rich diets(22). Other study found that in vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior(23).

2. Triterpenoids and rexinoids
In the study to test the members of two noncytotoxic classes of drugs, synthetic oleanane triterpenoids and rexinoids, both as individual agents and in combination, for the prevention and treatment of carcinogenesis in a highly relevant animal model of lung cancer, found that triterpenoids and rexinoids are multifunctional, well-tolerated drugs that target different signaling pathways and are thus highly effective for prevention and treatment of experimental lung cancer(24).

3. Glyceollins
Glyceollins are a novel class of soybean phytoalexins with potential cancer-preventive and antiestrogenic effects. According to the study by the School of Life Sciences and Biotechnology, College of Natural Sciences, glyceollins, elicited ingredients of soy source, target the signaling pathways mediated by VEGF or bFGF, providing new perspectives into potential therapeutics for preventing and treating hypervascularized diseases including cancer(25).

4. Etc.


Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22753285
(22) http://www.ncbi.nlm.nih.gov/pubmed/22888839
(22a) http://www.ncbi.nlm.nih.gov/pubmed/22652763
(23) http://www.ncbi.nlm.nih.gov/pubmed/16097445
(24) http://www.ncbi.nlm.nih.gov/pubmed/19952361
(25) http://www.ncbi.nlm.nih.gov/pubmed/23229497

Anti Ageing Tips: Clinical proven in Rejuvenating of Your Arms(From Shoulder to Wrist)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The below tips have been proven through our clinical studies of over 400 subjects between age of 57 - 63. If you are in this age, you can expect the same results(a)(b)(c).

A. Dehydroascorbic acid (DHA) and vitamin E and A(1)
1. The chemical reaction of Dehydroascorbic acid (DHA)
Vitamin C + Water -----> Dehydroascorbic acid (DHA ) + 2e- +2H+
2. Vitamin E chemical structure


The α-tocopherol form of vitamin E
3. Vitamin A: C20H30O
The equipment and Preparation
1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A bottle of vitamin E purified oil (You can only buy it from any pharmacy for $10) (We used provitamin E produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects, You can also buy it at any pharmacy and super market for about $20 for a jar of 60ml)
3. A jar of provitamin A produced by Jamieson, due to complaints of irritation and stickiness of many tested subjects on vitamin A purofied oil, You can also buy it at any pharmacy and super market for about $15 for a jar of 120 ml)
4. A small bottle carries 100mL of warm tap water or still-water if desire.
5. A roll of bounty or a half hand size sponge.
6. A pair of plastic glove.

Please Note, Kyle J. Norton and Associates DO NOT receive funding from Jamieson(The giant vitamins company)

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration of Dehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to Rejuvenate of Your Arms(From Shoulder to Wrist)
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels.
Apply the solutions 3 times a days
Application first of Dehydroascorbic acid (DHA) 4% concentration to induce skin cleansing through its detoxified, antioxidant and cell and collagen regeneration effects by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Wait for 5 minutes then apply vitamin E directly and generously onto fingers and the back of your hands. Wait for 5 minutes, do the same with vitamin A.

After applying, clean the sponge if used and glove, return and store the bottle of solution and vitamin E. A into first aid box in room temperature. Replace the solution of Dehydroascorbic acid (DHA ) every ten days to retain accurate concentration.

What to expect
1. In the first few days of application
The wrinkles, lines, creases, chapping of your skins begin to recede. Increased skin firming, smoothing, elasticity are at work in replacement of sagging skin.

2. In a few weeks
Depending to types of skin and severity of the effected areas, and according to our clinical study,
the combination of solution Rejuvenate of Your Arms(From Shoulder to Wrist) up to 90%. According to the study of ages between 57 - 62, approximately, 100% of tested subjects regain the youthfulness of Arms(From Shoulder to Wrist), achieve 80% in removal of skin chapping, lines, creases, etc., and 85% on reduced visibility of bulging veins and 100% of skin firming, smoothing, elasticity, probably through Dehydroascorbic acid (DHA) 4% concentration and vitamin E and A skin cleansing and detoxified, antioxidant and cell and collagen regeneration effects).




Millions have been spent in our studies, we provide this information free and do not ask for anything in return. You promise to tell everyone you know about this webpage and retweet it, so they do not waste any more money on ineffective commercial products.

Precautions
1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) and vitamin E for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration than that ofDehydroascorbic acid (DHA) 4% concentration has been shown to cause brownness on the finger nails.
3. The Dehydroascorbic acid (DHA) 4% concentration has been shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make that Dehydroascorbic acid (DHA) 4% concentration is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solutions get into your eyes, use tap water to clear them.
6. Do not attempt to make higher than Dehydroascorbic acid (DHA) 4% concentration solution, as it has not been tested.

7. Always shake well before using Dehydroascorbic acid (DHA) 4% concentration.

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying. If you have any questions about this article, please email at Kylenorton@live.ca

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer


References
(a) http://kylejnorton.blogspot.ca/2014/06/dehydroascorbic-acid-dhavitamin-c.html
(b) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html
(c) http://kylejnorton.blogspot.ca/2014/08/vitamin-dehydroascorbic-acid-dha-and.html
(1) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(2) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-points-of-view.html
(3) http://kylejnorton.blogspot.ca/2014/04/skin-aging-in-vitamin-e-points-of-view.html

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalgia Arthritis (Rheumatica): The Nuts and seeds Olive

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalgia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


                 Polymyalgia Arthritis (Rheumatica)


Polymalgia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                             Treatments


B. In herbal and traditional Chinese medicine perspective
3. Nuts and seeds Olive
Olive is belongs to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is also called the olive and the source of olive oil.

Olive Oil:
Fat Content
1. Saturated fats
a. Palmitic acid
b. Stearic acid
c. Arachidic acid
d. ehenic acid
e. Myristic acid
f. Lignoceric acid
2. Unsaturated fat3. Monounsaturated fats
a. Oleic acid
b. Palmitoleic acid
3. Polyunsaturated fats
a. Linoleic acid
b. Linolenic acid

Monounsaturated fatty acids found abundantly in olive oil, may be beneficiary for reduced inflammation and induced antioxidation(362,175).
In a pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee, conducted by Ardabil University of Medical Science, researchers showed use of olive oil in the experiment is more effective than medical gel for knee osteoarthritis, probably due to its phytochemiocals oleuropein and hydroxy tyroso(364,176).
Its omega-3 fatty acids component is also found to attenuate several inflammatory and degenerative diseases, through the expression of anti-inflammatory and immunomodulatory properties(177) of that may be potential effect for treatment of PMR, a low chronic inflammatory disease.
In chronic pain diseases, omega 3 fatty acids also exhibited anti analgesic property when it used either alone or in combination with morphine after acute and chronic administration in rats(178).
Dr. Ramsden CE and the research team lead by the National Institutes of Health suggested, with the biosynthetic precursors of endocannabinoids with antinociceptive, anxiolytic, and neurogenic, omega 3 fatty acids, could have physical and/or psychological pain modulating properties(179).


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References
(156) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(157) Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica by Gabriel SE1, Sunku J, Salvarani C, O'Fallon WM, Hunder GG.(PubMed)
(362,175) Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression by Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni P.(PubMed)
(364,176) A pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee.in Bohlooli S1, Jastan M, Nakhostin-Roohi B, Mohammadi S, Baghaei Z.(PubMed)
(177) An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases by Lorente-Cebrián S1, Costa AG, Navas-Carretero S, Zabala M, Laiglesia LM, Martínez JA, Moreno-Aliaga MJ.(PubMed)
(178) Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy withomega-3 fatty acids by Escudero GE1, Romañuk CB2, Toledo ME1, Olivera ME2, Manzo RH2, Laino CH1.(PubMed)
(179) Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress by Ramsden CE1, Zamora D2, Makriyannis A3, Wood JT3, Mann JD4, Faurot KR2, MacIntosh BA5, Majchrzak-Hong SF6, Gross JR7, Courville AB8, Davis JM9,Hibbeln JR6.(PubMed)

The Obesity' Article: The Effective of Foods on Obesity's Weight Loss

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The prevalence of extreme overweight and obesity has caused concerns of scientific community in the South East Asian population, due unhealthy diet and life style change over 2 decades of economic prosperity. Overweight and obesity have reached epidemic proportions in many Asian countries, affecting even younger age than in Western populations with economic burden in the development of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1). One of six Malaysian are either extreme overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and according to global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of global DALYs are caused by overweight or obesity, worldwide(2).
Epidemiological studies, linking herbal medicine, foods and vitamins in preventing and treating these diseases have been inconclusive(a)
Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression. According to the Georgetown University Medical Center, average daily food intake was decreased only with the herbal formulation, not the phenylpropanolamine (PPA) at the low and high doses, in comparison of the effectiveness among herbal formulation and a commonly available(3). Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated with herbal products attributed with weight-reducing properties(4)(5)(6)(7). The College of Medicine, The Ohio State University insisted that various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.
Epidemiological studies, linking certain foods in reduced weight loss for obese individual have produced certain positive results, but researchers emphasized that weight loss can not be in the expenses of intake of nutrients(30a).
1. Oats
Oat is a species of cereal grain grown for its seed and was first cultivated in Europe but is now grown all over the world, especially in Scotland and England. It is one of good crop to plant in the poor soil after crops are harvested in the Fall(30).
Oat, rich in beta-glucan, may hold a magic power in regulation of metabolism and liver-protecting effect. According to Chung-Shan Medical University, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions with no adverse effects(31). Whole-grain ready-to-eat oat cereal, in a randomized study of 144 Free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL, had favorable effects on fasting lipid levels and waist circumference(32). Other study suggested that at-derived beta-glucan, combined with moderate exercise also improved lipid profile and caused a decrease in weight(33).

2. Salmon
Salmon is the common name for Salmonidae. They are anadromous, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die(34).
Dietary salmon oil, in rat study showed to reduced weight loss of CXB-E and -H tested mice, but induced with weight gain in recombinant inbred strains. This findings may suggested that body weight response to salmon oil feeding is controlled by multiple genes(35). A novel oral form of salmon calcitonin (sCT), according to the study at 1Nordic Bioscience, also showed to improve fasting and postprandial glycemic control and insulin sensitivity and may be considered as a promising agent for the treatment of obesity-related insulin resistance and type 2 diabetes patients(36)(37).

3. Brown rice
Brown rice or unpolished rice is a kind of whole, natural grain with very brown color of which only the outermost layer of the rice kernel are removed, thus preventing the lost of nutrients(38).
The study of the weigh effect of brown rice on metabolic parameters in type 2 diabetes, showed a positive effect of consumption of the brown rice (LB) in association with a decreased waist circumference in type 2 diabetic patients(39). Other randomized study of forty women between 20 and 35 years of age in the comparison of white rice and mixed rice of weight control, including brown rice, indicated that meal replacement with mixed rice was superior to replacement with white rice in weight control, improving antioxidant enzyme activity(40).

4. Chicken
Chicken are domesticated fowl belonging to the subspecies of Gallus domesticus and is raised all over the world for its delicious meats and eggs. It can be roasted, broiled, grilled or poached into a very delicious, tasteful and nutritious meal(41).
In the comparison of weight loss and total lipid profile changes in overweight women consuming beef or chicken, researchers at 1Rippe Lifestyle Institute, Shrewsbury showed a interest result of weight loss and improved lipid profile can be accomplished through diet and exercise, regardless to dietary protein source including lean beef or chicken(42). But the study at University of Navarra, showed a opposite result in the study of frequent consumption of selenium-enrichedchicken meat(43), it may be the result of the presence of antioxidant selenium in the meat.

5. Water
According to Virginia Tech, consuming 500 ml water prior to each main meal may lead to greater weight loss than a hypocaloric diet alone in middle-aged and older adults, because of it acutely reduces meal energy intake(EI)(44) but not younger subjects(45). The Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial, suggested that replacing caloric beverages with water or diet beverages induced 2% to 2.5% weight loss(46).

6. Nuts
Dietary consumption of nuts with rich sources of multiple nutrients is associated with health benefits and weight loss,epidemiologically. but in well-controlled nut-feeding trials, no changes in body weight were observed(47). Pistachio nuts, a member of the cashew family, can be consumed as a portion-controlled snack for individuals restricting calories to lose weight without concern that pistachios will cause weight gain(48).

7. Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
According to Maastricht University, caffeine intake and green tea supplementation are associated to improved weight maintenance, partly through thermogenesis and fat oxidation, in a randomized placebo-controlled double blind parallel trial in 76 overweight and moderately obese subjects(49). Catechins the antioxiands found abundantly in green tea, significantly decreased body weight and significantly maintained body weight after a period of weight loss, depending to the moderators of habitual caffeine intake and ethnicity(50). In a high-protein diet, green tea-caffeine mixture, failed to exert the same effect on body weight maintenance(51).

8. Coffee
Coffee made from the roasted seeds of the genus Coffee, belonging to the family Rubiaceae native to southern Arabia. Coffee may consist certain substances.
In a randomized, double-blind, placebo-controlled, linear dose, crossover study, green coffee extract, consistent with human and animal studies and a meta-analysis may be an effective nutraceutical in reducing weight in preobese adults(52). Mannooligosaccharides (MOS), extracted from coffee, exhibited a potential functional use for weight management and improvement in adipose tissue distribution, but varying in gender(53)
Unfortunately, green coffee extract (GCE), according to University of Exeter, in reviews of the effect against weight loss of existed data, showed a significant poor methodological quality and suggested that more rigorous trials are needed to assess the usefulness of GCE as a weight loss tool(54). Other study, reported a case of Brazil Potent Slimming Coffee and possibly also other weight-lossproducts may be contaminated with sibutramine and as a result cause severe adverse reactions after stabbing herself in the stomach with a knife(55).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight lossand improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(30) #Healthy #Foods - Oats ((Avena sativa) (Health tips for better living and living health)
(31a) Association between mood and diet quality in subjects with metabolic syndrome participating in a behavioural weight-loss programme: A cross-sectional assessment by Perez-Cornago A, Zulet MA, Martinez JA.(PubMed)
(31b) Dietary quality-adherence to the dietary guidelines in Tehranian adolescents: Tehran Lipid and Glucose Study by Mirmiran P1, Azadbakht L, Azizi F.(PubMed)
(31) Oat prevents obesity and abdominal fat distribution, and improves liver function in humans by Chang HC1, Huang CN, Yeh DM, Wang SJ, Peng CH, Wang CJ.(PubMed)
(32) Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods by Maki KC1, Beiseigel JM, Jonnalagadda SS, Gugger CK, Reeves MS, Farmer MV, Kaden VN, Rains TM.(PubMed)
(33) Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia, Reyna-Villasmil N1, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernández-Hernández R, Valasco M, Arraiz N.(PubMed)
(34) #Healthy #Foods - Seafoods - Salmon (Healthy tips for better living and living health)
(35) Genetically determined body weight loss in mice fed diets containing salmonoil by LeBoeuf RC1, Veldee MS.(PubMed)
(36) Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats by Feigh M1, Nielsen RH, Hansen C, Henriksen K, Christiansen C, Karsdal MA.(PubMed)
(37) A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats by Feigh M1, Henriksen K, Andreassen KV, Hansen C, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA.(PubMed)
(38) #Healthy #Foods - Whole Grain - Brown rice or Hulled rice's(Health tips for beter living and living health)
(39) Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes by Kim TH1, Kim EK, Lee MS, Lee HK, Hwang WS, Choe SJ, Kim TY, Han SJ, Kim HJ, Kim DJ, Lee KW.(PubMed)
(40) Meal replacement with mixed rice is more effective than white rice in weightcontrol, while improving antioxidant enzyme activity in obese women by Kim JY1, Kim JH, Lee da H, Kim SH, Lee SS.(PubMed)
(41) #Healthy #Foods - Chicken (Gallus gallus domesticus)(Health tips for btter living and living health)
(42) Weight loss and total lipid profile changes in overweight women consuming beef or chicken as the primary protein source by Melanson K1, Gootman J, Myrdal A, Kline G, Rippe JM.(PubMed)
(43) Frequent consumption of selenium-enriched chicken meat by adults causesweight loss and maintains their antioxidant status by Navas-Carretero S1, Cuervo M, Abete I, Zulet MA, Martínez JA.(PubMed)
(44) Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults by Dennis EA1, Dengo AL, Comber DL, Flack KD, Savla J, Davy KP, Davy BM(PubMed)
(45) Pre-meal water consumption reduces meal energy intake in older but not younger subjects by


Van Walleghen EL1, Orr JS, Gentile CL, Davy BM.(PubMed)
(46) Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial by Tate DF1, Turner-McGrievy G, Lyons E,Stevens J, Erickson K, Polzien K, Diamond M, Wang X, Popkin B.(PubMed)
(47) Nut consumption and body weight by Sabaté J.(PubMed)
(48) Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program by Li Z1, Song R, Nguyen C, Zerlin A, Karp H, Naowamondhol K, Thames G, Gao K, Li L, Tseng CH, Henning SM, Heber(PubMed)
(48) Impact of peanuts and tree nuts on body weight and healthy weight loss in adults by Mattes RD1, Kris-Etherton PM, Foster GD.(PubMed)
(49) Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation by Westerterp-Plantenga MS1, Lejeune MP, Kovacs EM.(PubMed)
(50) The effects of green tea on weight loss and weight maintenance: a meta-analysis by Hursel R1, Viechtbauer W, Westerterp-Plantenga MS.(PubMed)
(51) Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss by Hursel R1, Westerterp-Plantenga MS.(PubMed)
(52) Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects by Vinson JA1, Burnham BR, Nagendran MV.(PubMed)
(53) A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women, by St-Onge MP1, Salinardi T, Herron-Rubin K, Black RM.(PubMed)
(54) The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(55) [Life-threatening psychosis caused by using sibutramine-contaminated weight-loss coffee].

[Article in Dutch] by Bertholee D1, ter Horst PG, Wieringa A, Smit JP.(PubMed)

Phytochemicals In Foods: The effects of Ursolic acid

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                         Ursolic acid

Ursolic acid is a phytochemincal in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

Health Benefits
1. Multi-drug resistance cancers
In the study of the proliferation-inhibiting and apoptosis-inducing effects of ursolic acid (UA) and oleanolic acid (OA) on multi-drug resistance (MDR) cancer cells in vitro, indicated that Both UA and OA have antitumor effects on cancer cells with MDR, and the optimal effect is shown by UA on colonic cancer cells. Also, UA shows cell apoptosis-inducing effect on SW480, possibly by way of down-regulating the expressions of apoptosis antagonistic proteins, Bcl-2, Bcl-xL, and surviving, according to "Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro" by Shan JZ, Xuan YY, Ruan SQ, Sun M.(1)

2. Skin fibroblast cells
In the observation of how ursolic and oleanolic acids can be used for the purpose of quality control of natural products used in dermatocosmetology as well as of various other therapeutic preparations, showed that Of the two isomeric compounds, UA showed a higher cytotoxic activity against HSF cells than did OA. Our investigations showed that OA, in view of its non-toxic nature, may be used as a supplementary factor for dermal preparations, according to "The effect of ursolic and oleanolic acids on human skin fibroblast cells" by Wójciak-Kosior M, Paduch R, Matysik-Woźniak A, Niedziela P, Donica H.(2)

3. Antibiotic resistance
In the investigation of antibiotic resistance effects of oleanolic acid (OA) and ursolic acid (UA), among bacterial pathogens (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus and Staphylococcus epidermidis), found that Using FICI value estimation and the time-kill method it was demonstrated that in some combinations, the tested compounds acted in synergy to lower the susceptibility of S. aureus, S. epidermidis and L. monocytogenes to ampicillin and oxacillin, but no synergy was observed for P. aeruginosa, according to "Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid" by Kurek A, Nadkowska P, Pliszka S, Wolska KI.(3)

4. Cytotoxic activites
In the evaluation of the anti-proliferative capability of the derivatives of C-3 and C-28 positions of ursolic acid (UA). against HepG2, AGS, HT-29 and PC-3 cells by the MTT assay, showed the cytotoxic capacity of the compounds was: Group I
5. Hepatocellular carcinoma
In the study of the inhibitory effect and mechanisms of UA on the human hepatoma cell line SMMC-7721, indicated that the proliferation of SMMC-7721 cells was significantly inhibited in a dose- and time-dependent manner after UA treatment. UA induced cell cycle arrest and apoptosis. The DNA microarray analysis indicated that 64 genes were found to be markedly up- or down-expressed, including GDF15, SOD2, ATF3, and fos, according to "Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway" by Yu YX, Gu ZL, Yin JL, Chou WH, Kwok CY, Qin ZH, Liang ZQ.(5)

6. Bladder cancer
In the investigation of Ursolic acid (UA) anti-tumor properties against bladder cancer, found that the ceramide level was increased after UA treatment in T24 cells, and UA-induced AMPK activation and T24 cell apoptosis were inhibited by ceramide synthase inhibitor fumonisin B1, and was enhanced by exogenously adding cell permeable short-chain ceramide (C6), suggesting that ceramide might serve as an upstream signal for AMPK activation. Further, activation of AMPK by UA promoted c-Jun N-terminal kinase (JNK) activation, but inhibited mTOR complex 1 (mTORC1) signaling to cause survivin down-regulation, according to "Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells" by Zheng QY, Yao C, Jin F, Zhang Y, Zhang GH.(6)

7. Anti cancers
In the investigation of QSAR models for predicting the activities of ursolic acid analogs against human lung (A-549) and CNS (SF-295) cancer cell lines, indicated that The QSAR study indicated that the LUMO energy, ring count, and solvent-accessible surface area were strongly correlated with anticancer activity. Similarly, the QSAR model for cytotoxic activity against the human CNS cancer cell line (SF-295) also showed a high correlation (r (2) = 0.99 and rCV(2) = 0.96), and indicated that dipole vector and solvent-accessible surface area were strongly correlated with activity. Ursolic acid analogs that were predicted to be active against these cancer cell lines by the QSAR models were semisynthesized and characterized on the basis of their (1)H and (13)C NMR spectroscopic data, and were then tested in vitro against the human lung (A-549) and CNS (SF-295) cancer cell lines. The experimental results obtained agreed well with the predicted values, according to "Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity" by Kalani K, Yadav DK, Khan F, Srivastava SK, Suri N.(7)

8. Hippocrates, "Let food be thy medicine and medicine be thy food"
In the determination of the traditional medicine and diet on mankind through the ages for prevention and treatment of most chronic diseases, found that suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents ( avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide) that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer, according to "Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer" by Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB.(8)

9. Photoprotection
Inn the evaluation of photoprotective effects of against UVAR of triterpenoids, indicated that natural material-derived triterpenoids such as oleanolic acid can abrogate UVA-induced gene expression by raft stabilization. This effect depends on the structure of the molecule, because its isomer ursolic acid also integrates within the rafts without inhibiting ceramide formation and upregulation of gene expression, according to "Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure" by Bayer M, Proksch P, Felsner I, Brenden H, Kohne Z, Walli R, Duong TN, Götz C, Krutmann J, Grether-Beck S.(9)

10. Cardiotonic and antidysrhythmic effects
In the study of the cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive (Olea europaea, subsp. africana) as well as methyl maslinate (MM) isolated from the leaves of Olea europaea (Cape cultivar), found that OA and UV isolated from wild African olive leaves, or crude extract containing all components, can provide a cheap and accessible source of additive to conventional treatment of hypertension, complicated by stenocardia and cardiac failure, according to "Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol" by Somova LI, Shode FO, Mipando M.(10)

11. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21799944
(2) http://www.ncbi.nlm.nih.gov/pubmed/22252762
(3)
(4) http://www.ncbi.nlm.nih.gov/pubmed/22370266
(5) http://www.ncbi.nlm.nih.gov/pubmed/20819578
(6) http://www.ncbi.nlm.nih.gov/pubmed/22387548
(7) http://www.ncbi.nlm.nih.gov/pubmed/22271093
(8) http://www.ncbi.nlm.nih.gov/pubmed/22069560
(9) http://www.ncbi.nlm.nih.gov/pubmed/21824200
(10) http://www.ncbi.nlm.nih.gov/pubmed/15070161
(11) http://www.ncbi.nlm.nih.gov/pubmed/12648829