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Monday, June 6, 2016

Most Common Diseases of elder: Respiratory Disease: Benign lung tumors - The Phytochemicals

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

Benign lung tumors, growth from many different structures in the lung, is defined as a conditions of abnormal cell growth with no tendency of spreading or masses that push normal cells out of the way rather than invading surrounding tissue restricted to a limited area in the lung. Approximately one out of 500 chest radiographs shows the incidental finding of a solitary pulmonary nodule and almost one half of these pulmonary lesions are caused by a tumor. Unfortunately, only 2% to 5% of alllung tumors are of benign origin, e. g. lipoma, fibroma, hamartoma, and chondroma, and the majority are malignant, most commonly primarylung cancer followed by metastases of extrapulmonary primary carcinomas. According to the study by Universitätsklinik für Pneumologie(a).

Phytochemicals to prevent benign lung tumors

1. Flavonoids
In the study to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for cancer prevention, found thatflavonoids are subdivided into subclasses including flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones. Epidemiological studies suggest dietary intake of flavonoids may reduce the risk of tumors of the breast, colon, lung, prostate, and pancreas. However, some studies have reported inconclusive or even harmful associations. A major challenge in the interpretation of epidemiological studies is that most of the data originate from case-control studies and retrospective acquisition of flavonoid intake. Differences in agricultural, sociodemographics, and lifestyle factors contribute to the heterogeneity in the intake of flavonoids among populations residing in the United States, Europe, and Asia. Dose and timing of exposure may influence the anticancer response to flavonoid-rich diets(22). Other study found that in vitro work has concentrated on the direct and indirect actions of flavonoids on tumor cells, and has found a variety of anticancer effects such as cell growth and kinase activity inhibition, apoptosis induction, suppression of the secretion of matrix metalloproteinases and of tumor invasive behavior(23).

2. Triterpenoids and rexinoids
In the study to test the members of two noncytotoxic classes of drugs, synthetic oleanane triterpenoids and rexinoids, both as individual agents and in combination, for the prevention and treatment of carcinogenesis in a highly relevant animal model of lung cancer, found that triterpenoids and rexinoids are multifunctional, well-tolerated drugs that target different signaling pathways and are thus highly effective for prevention and treatment of experimental lung cancer(24).

3. Glyceollins
Glyceollins are a novel class of soybean phytoalexins with potential cancer-preventive and antiestrogenic effects. According to the study by the School of Life Sciences and Biotechnology, College of Natural Sciences, glyceollins, elicited ingredients of soy source, target the signaling pathways mediated by VEGF or bFGF, providing new perspectives into potential therapeutics for preventing and treating hypervascularized diseases including cancer(25).

4. Etc.


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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/22753285
(22) http://www.ncbi.nlm.nih.gov/pubmed/22888839
(22a) http://www.ncbi.nlm.nih.gov/pubmed/22652763
(23) http://www.ncbi.nlm.nih.gov/pubmed/16097445
(24) http://www.ncbi.nlm.nih.gov/pubmed/19952361
(25) http://www.ncbi.nlm.nih.gov/pubmed/23229497

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