Saturday, September 3, 2016

Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Ma Qian Zi (Semen Strychnotis)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
          Ma Qian Zi (Semen Strychnotis)




Ma Qian Zi or Fan Mu Bie is also known as Nux Vomica.. The bitter, cold and very toxic herb has been used in TCM to treat Bell’s palsyma, myasthenia gravis, tuberculosis, cervical erosion, rheumatoid arthritis,injuries,boils and swellings,sequelae from polio of children,impotence,etc., as it promotes circulation in the channels and collaterals, dissolves nodules, resolves oedema, calms pain, etc., by enhancing the functions of liver and spleen channels.

Ingredients
1. Strychnine
2. brucine
3. vomicine
4. pseudostrychnine
5. pseudobrucine
6. (a-Colubrine
7. β-Colubrine
8. loganin
9. chlorogenic acid
10. palmitic acid
11. Etc

Health Benefits
1. Human gastric carcinoma AGS cells
In the study to examine whether and how the water extract of Strychni Semen (ESS) treatment would affect the growth of AGS human gastric carcinoma cells, found that ESS inhibits the growth of AGS cells in a concentration-dependent manner. Cell cycle analysis showed G2/M phase arrest and apoptosis in AGS cells following ESS treatment. ESS-mediated G2/M arrest was found to be associated with up-regulation of cyclin A, Cdc2, tumor suppressor p53 and cyclin dependent kinase (Cdk) inhibitor p21(WAF1/CIP1), whereas the expressions of other G2/M regulatory proteins, including cyclin B1 and Cdk2, were down-regulated compared with the control. The induction of apoptotic cell death by ESS was associated with down-regulation of anti-apoptotic Bcl-2 and up-regulation of pro-apoptotic Bax expression(1).

2. Ovalbumin-specific IgE antibody response
In the study to investigate Strychnos nux-vomica Linn. (SNV; Loganiaceae) possible immunomodulatory effect on induction of ovalbumin (OVA)-specific IgE antibody response in a murine model, indicated that revealed no significant change in the total IgG antibody response against OVA, as evaluated by ELISA. These results confirm the suppressive activity of S. nux-vomica on allergen-specific IgE antibody response and suggest its possible application in allergic conditions(2).

3. Antisnake venom activity
Scientist at the Department of Physiology, University of Calcutta indictaed that the whole seed extract of S. nux vomica (in low doses) effectively neutralized Daboia russelii venom induced lethal, haemorrhage, defibrinogenating, PLA2 enzyme activity and Naja kaouthia venom induced lethal, cardiotoxic, neurotoxic, PLA2 enzyme activity. An active compound (SNVNF) was isolated and purified by thin layer chromatography and silica gel column chromatography, which effectively antagonised D. russelii venom induced lethal, haemorrhagic, defibrinogenating, oedema, PLA2 enzyme activity and N. kaouthia induced lethal, cardiotoxic, neurotoxic, PLA, enzyme activity. Polyvalent snake venom antiserum action was significantly potentiated by the active compound. Spectral studies revealed it to be a small, straight chain compound containing methyl and amide radicals. Detailed structure elucidation of the compound (SNVNF) is warranted before its clinical trials as a snake venom antagonist.(3).

4. Etc.

Side Effects
1. Since the herb is very toxic, overdose can cause spasm of the jaw and neck muscles, difficulty in swallowing, the whole body is uncomfortable, then extreme contraction of the muscles and tetany, etc.
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.


Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18446845
(2) http://www.ncbi.nlm.nih.gov/pubmed/19069846
(3) http://www.ncbi.nlm.nih.gov/pubmed/15233470


General Health: Colitis - The Diseases associated to

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                   Colitis


Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.

                             Types of Colitis

According to the study by Catholic University of the Sacred Heart, types of colitis include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a).


                 The Diseases associated to

1. Cholelithiasis (gallstone disease)
Cholelithiasis is considered an extraintestinal manifestation of Crohn's ileitis but has not been associated with ulcerative colitis. In the study to evaluate if an increased risk of cholelithiasis exists in patients with ulcerative colitis, biliary ultrasonography was performed on 159 patients with inflammatory bowel disease, 114 patients with ulcerative colitis, and 45 patients with Crohn's disease, indicated that there is an increased risk of gallstones in both patients with Crohn's disease (odds ratio = 3.6; 95 percent confidence limits = 1.2 - 10.4; P = 0.02) and patients with ulcerative colitis (odds ratio = 2.5; 95 percent confidence limits = 1.2 - 5.2; P = 0.01). The risk was highest in patients with Crohn's disease involving the distal ileum (odds ratio = 4.5; 95 percent confidence limits = 1.5 - 14.1; P = 0.009) and in patients with total ulcerative colitis extending to the cecum (odds ratio = 3.3; 95 percent confidence limits = 1.3 - 8.6; P = 0.01). These results confirm that there is an increased risk of gallstones in Crohn's ileitis but they show that there also exists an increased risk in patients with total ulcerative colitis(31).

2. Liver disorders
Disorders of the hepatobiliary system are relatively common extraintestinal manifestations of inflammatory bowel disease (IBD). According to the study by Department of Pediatric Gastroenterology and Hepatology, these disorders are sometimes due to a shared pathogenesis with IBD as seen in primary sclerosing cholangitis (PSC) and small-duct primary sclerosing cholangitis (small-duct PSC). There are also hepatobiliary manifestations such as cholelithiasis and portal vein thrombosis that occur due to the effects of chronic inflammation and the severity of bowel disease. Lastly, medications used in IBD such as sulfasalazine, thiopurines, and methotrexate can adversely affect the liver(32).

3. Primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that is associated with inflammatory bowel disease (IBD), particularly chronic ulcerativecolitis and, to a lesser degree, Crohn's disease. But according to the study by Hacettepe University, in contrast to findings in Western Europe and the USA, in Turkey: 1) PSC is not regularly associated with idiopathic IBD; 2) most patients with PSC are female; 3) PSC accounts for only 18% of patients with a primary disorder of the biliary tree; 4) the incidence of small-duct primary sclerosing cholangitis is greater than that reported in the literature; and, 5) the incidence of IBD and PSC in Turkey is relatively lower than in other countries(33).

4. Eczema
In the study of nineteen mothers and babies took part in a double blind crossover trial of exclusion of egg and cows' milk, and 18 took part in open exclusion of 11 foods followed by double blind challenge to those mothers whose infants seemed to respond, indicated that the eczema improved in six infants when their mothers avoided egg and cows' milk and worsened again when these were reintroduced. Two infants suffered gastrointestinal reactions after maternal ingestion of egg and cows' milk, one developing colitis. Maternal dietary exclusion seems to benefit some breast fed babies with eczema(34).

5. Chronic polyarthritis and collagenous colitis
There is a report of a 26-year-old woman simultaneously developed chronic seronegative non-destructive polyarthritis and chronic watery diarrhoea. Biopsies from the colorectal mucosa showed a thickened subepithelial collagen layer consistent with collagenous colitis(35).

6. Atopic disease
In the study of three hundred patients with ulcerative colitis, 200 with Crohn's disease and matched control subjects completed questionnaires about atopic disease, indicated that in ulcerative colitis asthma, hay fever, allergic rhinitis or eczema; occurred with twice the frequency, but in Crohn's disease only eczema was more common than in controls(36).

7. Asthma
Recent attention has been devoted to the respiratory manifestations that may be associated with diseases of distant organs. According to the study by Osaka City University, showed that airway microvascular hyper-permeability induced by VEGF may have a profound effect on airway function and can explain the heightened airway hyper-responsiveness characteristic of asthma associated with ulcerativecolitis (UC)(37).

8. Thyroid diseases
In the study to assess the prevalence of abnormalities in the structure of thethyroid gland in IBD patients and to compare it to the control group, found that in patients with inflammatory bowel diseases focal lesions relating to tumors of thethyroid gland are more common than in the control group. In patients with ulcerative colitis enlargement of the thyroid gland is more frequent than in the control group. Initial assessments of IBD patients should include ultrasound examinations of the thyroid gland(38).

9. Psoriasis
Numerous reports have demonstrated the epidemiological, pathogenic, and genetic association between psoriasis and Crohn's disease. According to the study by Clalit Health Services, Tel Aviv, Hod Hasharon, indicated that psoriasis is associated both with Crohn's disease and ulcerative colitis. Future studies on comorbidities in patients with psoriasis should focus on ulcerative colitis(39).

10. Etc. 

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The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

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Sources
(31) http://www.ncbi.nlm.nih.gov/pubmed/2202567
(32) http://www.ncbi.nlm.nih.gov/pubmed/22474447
(33) http://www.ncbi.nlm.nih.gov/pubmed/9951867
(34) http://www.ncbi.nlm.nih.gov/pubmed/3089466
(35) http://www.ncbi.nlm.nih.gov/pubmed/6857179
(36) http://www.ncbi.nlm.nih.gov/pubmed/466750
(37) http://www.ncbi.nlm.nih.gov/pubmed/16297138
(38) http://www.ncbi.nlm.nih.gov/pubmed/23214298
(39) http://www.ncbi.nlm.nih.gov/pubmed/19207663

Most Common Diseases of Ages of 50 Plus: Prostate Cancer - The Grades and Stages

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Among elderly men, cancer of the prostate (451 per 100,000), the lung (449 per 100,000) and the colon (176 per 100,000) make up around half of all diagnosed cancers. Prostate cancer is around 22 times more frequent among elderly men than among younger men. The corresponding most frequent cancers among elderly women, making up 48% of all malignant cancers, are breast (248 per 100,000), colon (133 per 100,000), lung (118 per 100,000) and stomach cancer (75 per 100,000), According to the Danish Cancer Society, Institute of Cancer Epidemiology(PubMed)

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

                             Prostate Cancer

Prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of semen that carries sperm.


Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.



                                  The Grades

The Grades of prostate cancer are depending to the tendency of spreading. Low grade cancers usually grow more slowly and are less likely to spread while high grade cancer indicates otherwise.

                         The Stages
Prostate cancer is classified as 5 stages
1. Stage 0
If the cancerous cell have not penetrated in deeper tissue but in the surface of the prostate lining.


2. Stage I
In stage I, The cancerous cells are no longer in the surface but have invaded into deep the prostate lining, but still completely inside the prostate.


a. Stage IA1
The cancer is not ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
a.1. Stage IA1:The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
a.2. Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.

b. Stage IB:
The cancer in this stage have invaded the connective tissue, & less than 5cm (2 inches).

b.1. Stage IB1: Cancer is 4 cm large (1 3/4 inches).

b.2. Stage IB2:Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (2 inches)

3. Stage II
In stage II, the cancerous cells have spread to distant tissues, but is still within the prostate.

4. Stage III
In this stage, cancerous cells has spread to the tissues immediately surrounding the prostate.

5. Stage IV
In this stage, cancerous cells has spread to the tissues immediately outside of the prostate, into other distant parts of the body
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Dietary Minerals Chromium(chromium 3+): Intravenous chromium treatment of Severe insulin resistance

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Chromium(chromium 3+)

Chromium(chromium 3+) is a essential mineral for the body in fat and carbohydrate metabolism, found abundantly in Beef, Eggs, Chicken, Oysters, Wheat germ, Green peppers, Banana, Apple, Etc.

   

 Intravenous chromium treatment of Severe insulin resistance

Insulin resistance has been well documented in critically ill patients. Adequate blood sugar control has been associated with better wound healing, and better outcomes in selected patient populations. According to the study by the Texas A and M University, Corpus Christi, there is a report of a case of extreme insulin resistance in a 62-year-old woman with history of diabetes who suffered a cardiac arrest and respiratory failure, leading to aspiration pneumonia and septic shock requiring greater than 7000 units of insulin over a period of 12 h which was successfully treated with intravenous chromiumreplacement(2). Other study reported in using intravenous chromium to achieve glycemic control in a patient with extreme insulin resistance and acute critical illness. Prospective clinical trials using intravenous chromium may provide the means to optimize intensive insulin therapy for critically ill patients(2a).

Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Hormones and polycystic ovarian syndrome (PCOS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.

The Studies of  Hormones and polycystic ovarian syndrome (PCOS)


In the study to determine the proportion of polycystic ovarian syndrome (PCOS) patients who have normal body mass index (BMI) and to compare the clinical, hormonal, and metabolic profile between lean and overweight patients of PCOS, conducted by the Lady Hardinge Medical College and Smt, posted in PubMed, indicated that 42% of the PCOS had normal BMI, but clinical and hormonal profile was similar to PCOS patients with elevated BMI (overweight/obese). However, insulin resistance is observed in 83.3% of lean PCOS. Family history of diabetes, impaired GTT, deranged lipid profile, and insulin resistance were more prevalent in overweight PCOS.

Women Health: Menstrual Disorders -Menorrhagia Treatments of Primary menorrhagia in Conventional medicine Perspective - Ethamsylate

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.


 The Treatment  of Primary menorrhagia  in Conventional medicine - Ethamsylate 

In a study of A double-blind trial of ethamsylate in the treatment of primary and intrauterine-device menorrhagia by R F Harrison, S Cambell, researchers found that During ethamsylate treatment the mean menstrual blood-loss was reduced by 50% in patients with primary menorrhagia and by 19% in patients with an I.U.C.D. This difference between the two groups is probably accounted for by the differing values of initial blood-loss which was significantly higher in the group with primary menorrhagia.

Also Include those in the secondary menorrhagia with the recommendation of your doctor.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Phytochemicals for Treatment of Kaposi's sarcoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Kaposi's sarcoma

Kaposi's sarcoma is a cancerous tumor of the connective tissue caused by human herpesvirus 8 (HHV8), and is often associated with AIDS, leading to red or purple bumps of abnormal tissue to grow under the skin, in the lining of the mouth, face, torso or limb in a short rime. In fact, it is most commonly appear in the skin, the lining of the digestive tract or the lung and in men more often than in women. Kaposi' sarcoma tends to develop slowly, but in HIV/AIDS patients, though, the disease is aggressive and spread quickly. Kaposi' carcoma can be life threatening, if the cancer invades the to other organs, such as in lung, it can cause difficulty of breathing and in
in liver or digestive tract, it can cause internal bleeding.

I. Types of Kaposi' sarcoma1. Classic/Mediterranean Kaposi' sarcoma
Classic Kaposi' sarcome is rare cancer developed more common in older men of Mediterranean, Middle Eastern or Jewish descent as it forms one or more lesions on the legs, ankles, or the soles of the feet. The classic Koposi' sarcoma is a slower growth type of cancer because of the progression without weaken immune system and many early diagnosis do not require treatment.

2. Endemic (African) Kaposi sarcoma
Endemic KS is found in parts of Africa due to human herpes virus 8 or herpesvirus infection is more common. It develops more quickly affect men, women and children of all ages, but tends to occur in younger men under age 40.

3. Iatrogenic/transplant-associated Kaposi sarcoma
In this case, Iatrogenic/transplant-associated Kaposi sarcoma occurs to patient with infection of Kaposi's sarcoma-associated herpesvirus (KSHV) due to medication used to suppress the immune system of the body from rejecting the donated organ in transplant, leading to the increased risk of development of the disease.

4. Kaposi sarcoma in HIV negative men having sex with men
Recently report from the above study from Department of Dermatology, Cochin Hospital, APHP, Faculté de Médecine René Descartes, Paris, France, indicated that Kaposi's sarcoma may develop in homosexual or bisexual men without HIV infection. This type of Kaposi's sarcoma has clinical features in common with classical Kaposi's sarcoma but occurs in younger patients.

5. Epidemic/AIDS-related Kaposi sarcoma
Epidemic/AIDS-related Kaposi sarcoma is a common type of Kaposi's in The US occurred in the people with HIV infection cause of weakening or damaging of the immune system. The risk of developing KS is depended to the CD4 count. If the CD4 count is lower, the higher the risk of developing Kaposi's sarcoma.

II. Types of Food to prevent and treat Kaposi's sarcoma
1. Dark, leafy greens and red, orange and yellow fruits and vegetable
β-Carotene is a phytochemincal in the class of Carotenes, belonging to the group of Carotenoids (tetraterpenoids), found abundantly in dark, leafy greens and red, orange and yellow fruits and vegetable. Short communication: possible activity of beta-carotene in patients with the AIDS related complex. A pilot study , showed that BC appeared to prevent progress to AIDS and, in addition, to lower the effective dosage of AZT used in one case of ARC developed into AIDS, producing a recovery from opportunistic infections and an inhibition of Kaposi sarcomadiffusion, in line with a two-fold rise in CD4 counts(1).

2. Apples, bilberries and cranberries
Oleanolic acid triterpenoid, is a group of phytochemical found abundantly in Apples, bilberries and cranberries has shown potential effect against Kaposi's sarcoma. In vivo, oleanolic acid triterpenoid, called CDDO-Me and CDDO-Imm inhibit angiogenesis in the Matrigel sponge assay and in KS-Imm (an immortalizedKaposi's sarcoma cell line) tumour growth. In vitro they are able to prevent endothelial cell tubulogenesis when cultured on Matrigel. In human umbilical vein endothelial (HUVE) cells these compounds can inhibit the activation of the extracellular signal-regulated kinase ERK1/2 pathway after stimulation with vascular endothelial growth factor (VEGF)(2).

3. Green tea
In the study to investigate the effects of green tea and epigallocatechin-3-gallate (EGCG) tested in a highly vascular Kaposi's sarcoma (KS) tumor model and on endothelial cells in a panel of in vivo and in vitro assays, showed that EGCG inhibited KS-IMM cell growth and endothelial cell growth, chemotaxis, and invasion over a range of doses; high concentrations also induced tumor cell apoptosis. EGCG inhibited the metalloprotease-mediated gelatinolytic activity produced by endothelial cell supernatants and the formation of new capillary-like structures in vitro. Green tea or purified EGCG when administered to mice in the drinking water inhibited angiogenesis in vivo in the Matrigel sponge model and restrained KS tumor growth(3).

4. Etc.