Saturday, September 3, 2016

Phytochemicals for Treatment of Kaposi's sarcoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Kaposi's sarcoma

 Kaposi's sarcoma is a cancerous tumor of the connective tissue caused by human herpesvirus 8 (HHV8), and is often associated with AIDS, leading to red or purple bumps of abnormal tissue to grow under the skin, in the lining of the mouth, face, torso or limb in a short rime. In fact, it is most commonly appear in the skin, the lining of the digestive tract or the lung and in men more often than in women. Kaposi' sarcoma tends to develop slowly, but in HIV/AIDS patients, though, the disease is aggressive and spread quickly. Kaposi' carcoma can be life threatening, if the cancer invades the to other organs, such as in lung, it can cause difficulty of breathing and in
in liver or digestive tract, it can cause internal bleeding.

I. Types of Kaposi' sarcoma1. Classic/Mediterranean Kaposi' sarcoma
Classic Kaposi' sarcome is rare cancer developed more common in older men of Mediterranean, Middle Eastern or Jewish descent as it forms one or more lesions on the legs, ankles, or the soles of the feet. The classic Koposi' sarcoma is a slower growth type of cancer because of the progression without weaken immune system and many early diagnosis do not require treatment.

2. Endemic (African) Kaposi sarcoma
Endemic KS is found in parts of Africa due to human herpes virus 8 or herpesvirus infection is more common. It develops more quickly affect men, women and children of all ages, but tends to occur in younger men under age 40.

3. Iatrogenic/transplant-associated Kaposi sarcoma
In this case, Iatrogenic/transplant-associated Kaposi sarcoma occurs to patient with infection of Kaposi's sarcoma-associated herpesvirus (KSHV) due to medication used to suppress the immune system of the body from rejecting the donated organ in transplant, leading to the increased risk of development of the disease.

4. Kaposi sarcoma in HIV negative men having sex with men
Recently report from the above study from Department of Dermatology, Cochin Hospital, APHP, Faculté de Médecine René Descartes, Paris, France, indicated that Kaposi's sarcoma may develop in homosexual or bisexual men without HIV infection. This type of Kaposi's sarcoma has clinical features in common with classical Kaposi's sarcoma but occurs in younger patients.

5. Epidemic/AIDS-related Kaposi sarcoma
Epidemic/AIDS-related Kaposi sarcoma is a common type of Kaposi's in The US occurred in the people with HIV infection cause of weakening or damaging of the immune system. The risk of developing KS is depended to the CD4 count. If the CD4 count is lower, the higher the risk of developing Kaposi's sarcoma.

II. Types of Food to prevent and treat Kaposi's sarcoma
1. Dark, leafy greens and red, orange and yellow fruits and vegetable
β-Carotene is a phytochemincal in the class of Carotenes, belonging to the group of Carotenoids (tetraterpenoids), found abundantly in dark, leafy greens and red, orange and yellow fruits and vegetable. Short communication: possible activity of beta-carotene in patients with the AIDS related complex. A pilot study , showed that BC appeared to prevent progress to AIDS and, in addition, to lower the effective dosage of AZT used in one case of ARC developed into AIDS, producing a recovery from opportunistic infections and an inhibition of Kaposi sarcomadiffusion, in line with a two-fold rise in CD4 counts(1).

2. Apples, bilberries and cranberries
Oleanolic acid triterpenoid, is a group of phytochemical found abundantly in Apples, bilberries and cranberries has shown potential effect against Kaposi's sarcoma. In vivo, oleanolic acid triterpenoid, called CDDO-Me and CDDO-Imm inhibit angiogenesis in the Matrigel sponge assay and in KS-Imm (an immortalizedKaposi's sarcoma cell line) tumour growth. In vitro they are able to prevent endothelial cell tubulogenesis when cultured on Matrigel. In human umbilical vein endothelial (HUVE) cells these compounds can inhibit the activation of the extracellular signal-regulated kinase ERK1/2 pathway after stimulation with vascular endothelial growth factor (VEGF)(2).

3. Green tea
In the study to investigate the effects of green tea and epigallocatechin-3-gallate (EGCG) tested in a highly vascular Kaposi's sarcoma (KS) tumor model and on endothelial cells in a panel of in vivo and in vitro assays, showed that EGCG inhibited KS-IMM cell growth and endothelial cell growth, chemotaxis, and invasion over a range of doses; high concentrations also induced tumor cell apoptosis. EGCG inhibited the metalloprotease-mediated gelatinolytic activity produced by endothelial cell supernatants and the formation of new capillary-like structures in vitro. Green tea or purified EGCG when administered to mice in the drinking water inhibited angiogenesis in vivo in the Matrigel sponge model and restrained KS tumor growth(3).

4. Etc. 
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