Medical Advisor Journals

Saturday, May 27, 2017

Thyroid hormone and Oxidative stress

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Thyroid hormone

Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.

Thyroid hormone and Oxidative stress

The liver metabolizes the thyroid hormones and regulates their systemic endocrine effects so liver disease could affect thyroid hormone metabolism. In the study to investigate serum levels of oxidative stress and antioxidant in liver diseases as prognostic markers and know the importance of these antioxidants level in relation to thyroid hormones, researchers at the Ain Shams University, found that measurement of the total T(3), NO, MDA, GSH reduced and GSHPx as biomarkers for liver diseases might be a beneficial tool, helping in monitoring the state of liver disease patients.(17).

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Sources
(17) http://www.ncbi.nlm.nih.gov/pubmed/19818291

Friday, May 26, 2017

Thyroid hormone: Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress

Thyroid hormone: Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress

In the study of Chemiluminescent and respiratory responses in the liver of rats treated with 0.1 mg of triiodothyronine (T3)/kg for 1 to 7 days, showed that the calorigenic response in the hyperthyroid state is accompanied by the development of an hepatic oxidative stress characterized by enhanced spontaneous chemiluminescence, enhanced NADPH-dependent microsomal respiration and a decreased antioxidant cellular activity(16).

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Sources
(16) http://www.ncbi.nlm.nih.gov/pubmed/3215552

Thursday, May 25, 2017

Thyroid hormone: Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity

Thyroid hormone: Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity

In the study to measure the thyroxine 5'-deiodinase I (T(4)5'D-I) activity in thyroid, liver, and kidney and thyroxine 5'-deiodinase II (T(4)5'D-II) activity in brown adipose tissue (BAT) in rats on a low-iodine diet (LID) and to test the possibility that increased deiodinase activity in these tissues might contribute to the maintenance of ther serum 3,5,3'-triiodothyronine (T3) level, found that increased thyroxine(T4)-to-T3 conversion in the greatly enlarged thyroids of LID rats contributed to the maintenance of serum T3. T(4)5'D-II activity in BAT was markedly increased in LID rats and was further greatly increased on cold exposure(15).

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Sources
(15) http://www.ncbi.nlm.nih.gov/pubmed/1996620

Wednesday, May 24, 2017

Thyroid hormone: Thyronamines and body temperature and heart rate

Thyroid hormone: Thyronamines and body temperature and heart rate

The thyronamines which are decarboxylated thyroid hormones initiating physiological actions like lowering body temperature and heart rate, thereby acting in opposite direction to the classical thyroid hormones. So far it is believed that thyronamines function via the activation of a G-protein coupled receptor, TAAR1. The objective of this review is to summarise the recent findings in thyroid hormone synthesis and action and to discuss their implications for diagnosis of thyroid disease and for treatment of patients, according to the study by Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin(14).

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Sources
(14) http://www.ncbi.nlm.nih.gov/pubmed/21835056

Tuesday, May 23, 2017

Thyroid hormone: Triiodothyronine stimulates glucose transport in bone cells

Thyroid hormone: Triiodothyronine stimulates glucose transport in bone cells

In the study to evaluate whether 3,3',5-triiodo-l-thyronine (T₃) stimulates the uptake of glucose in osteoblastic cells, PyMS (a cell line derived from rat bone) cells were kept in serum-free culture medium and treated with T₃, found that T₃ did not influence the cell number but slightly (1.3-fold) increased the protein content of the cell cultures. 2DG ([1-¹⁴C]-2-deoxy-D: -glucose)uptake was low in serum-deprived cell cultures and was increased by T₃ (up to 2.5-fold at 1 nmol l⁻¹ after 4 days) in a dose- and time-dependent manner. Triiodothyronine at 1 nmol l⁻¹ increased GLUT1 and GLUT3 abundance in membranes. Therefore, increased glucose uptake induced by T₃ in osteoblasts may be mediated by the known high-affinity glucose transporters GLUT1 and GLUT3(13).

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Sources
(13) http://www.ncbi.nlm.nih.gov/pubmed/22258767

Monday, May 22, 2017

Thyroid hormone and skeletal growth

Thyroid hormone and skeletal growth

Understanding how bone growth is regulated by hormonal and mechanical factors during early growth periods is important for optimizing the attainment of peak bonemass to prevent or postpone the occurrence of fragility fractures later in life. According to the study by Musculoskeletal Disease Center, Loma Linda VA HealthCare System , there is an important period prior to puberty when the effects of GH are surprisingly small and TH plays a critical role in the regulation of skeletal growth. Daily administration of T3/T4 during days 5 to 14, the time when serum levels of T3 increase rapidly in mice, rescued the skeletal deficit in TH-deficient mice but not in mice lacking both TH and GH. However, treatment of double-mutant mice with both GH and T3/T4 rescued the bone density deficit. Increased body fat in the TH-deficient as well as TH/GH double-mutant mice was rescued by T3/T4 treatment during days 5 to 14(12).

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Sources
(12) http://www.ncbi.nlm.nih.gov/pubmed/22513648

Sunday, May 21, 2017

Thyroid hormone stimulates protein synthesis

Thyroid hormone stimulates protein synthesis

According to the study by North Shore-Long Island Jewish Health System, Thyroid hormones affect cardiac growth and phenotype; however, the mechanisms by which the hormones induce cardiomyocyte hypertrophy remain uncharacterized. Tri-iodo-L-thyronine (T3) treatment of cultured cardiomyocytes for 24 h resulted in a 41 +/- 5% (p < 0.001) increase in [(3)H]leucine incorporation into total cellular protein. This response was abrogated by the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin. Co-immunoprecipitation studies showed a direct interaction of cytosol-localized thyroid hormone receptor TRalpha1 and the p85alpha subunit of PI3K. T3 treatment rapidly increased PI3K activity by 52 +/- 3% (p < 0.005)(11).

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Sources
(11) http://www.ncbi.nlm.nih.gov/pubmed/16717100