Butterbur, The Functional Herb Which Protects Neurons Integrity, Scientist Find

Scientists have found a herbal plant which processes a potential and therapeutic effect in the protection against damage and death of neurons.

Neuroprotective effects are the protection against anything which causes harm to the brain and spinal cord

In other words, herbal butterbur promotes neuronal integrity against the reduction in the rate of neuronal loss that causes neurodegenerative disease.

Dr. Vajda FJ, the scientist at the St. Vincent's Hospital, Melbourne in the expression of neuro diseases said, "neuroprotection is an effect that may result in salvage, recovery or regeneration of the nervous system, its cells, structure, and function. It is thought that there are many neurochemical modulators of nervous system damage" and " Acute and chronic nervous system damage in response to an insult may lead to acute or delayed neuronal death, apoptotic cell death, neuronal degeneration, injury and loss, and gliosis"(4).

The Mcgovern Institute in the article related to brain disorder wrote, "Many brain disorders are chronic and incurable conditions whose disabling effects may continue for years or even decades. Thus, the overall disease burden from these disorders is much greater than would be suggested by mortality figures alone. The extent of this burden is underlined by data from the World Health Organization".

Most common brain disease neurodegenerative disease including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), affecting millions of people worldwide.

And, dementia is an umbrella term that describes a variety of diseases and conditions caused by nerve cells in the brain die or no longer function normally. Symptoms may affect memory, behavior, and ability to think clearly.


According to statistic, approximately over 5.7 million Americans of all ages have Alzheimer's. as of 2018, 1 in 8 people age 65 and older (10 percent) has Alzheimer's disease in the US. Sadly, The numbers of Alzheimer's disease are growing and growing fast.

Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herbal medicine has been used in herbal medicine as a pain reliever in the digestive system, including stomach, bile ducts,...... and duodenum.

The Ingredients
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.

In the study to investigate neuroprotective effects in a rat transient focal cerebral ischemia-reperfusion model, and in an in vitro cerebral ischemia model, oxygen-glucose deprivation of cultured nerve cells, researchers found that application of total bakkenolides, a major bioactive constituent isolated immediately after reperfusion at doses of 5, 10 and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.

Additional analysis also suggested, the administrated doses also significantly attenuated cell death and apoptosis in primary cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.

The efficacy of herbal butterbur in protected neurons was attributed by total bakkenolides in inhibited an enzyme activators with function in propagated the cellular response to inflammation through NF-κB, a protein complex regulated transcription of DNA, cytokine production and cell survival.

In other words, application of total bakkenolides reduced brain infarct volume and overexpression of pro-inflammation cytokines in response to focal cerebral ischemia-reperfusion that have a strong impact in decreased neuro cell damage and death at the site of reperfusion injury.

Dr. Jiang Q, the lead author after taking into account of other co and confounder said, "(The) results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease.


Some researchers in the study of Bakkenolides in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults suggested, Bakkenolides exerted neuroprotective effects may be results from properties of its antioxidant properties.


Moreover, petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) (Compositae) leaves in study of the oxidative damage in the brain of mice, facilitated a significant effect at dose of 40 mg/kg in alleviated the behavioral signs of kainic acid neurotoxicity and reduced the mortality (50%) by kainic acid to 12.5%.

Administration of PA also restore the levels of antioxidants in the mice that were reduced by injection of kainic acid in compared to control.

Further analysis found that PA (40 mg/kg) effectiveness is comparable to those of butanol fraction (200 mg/kg) of P. japonicus extract in reducing kainic acid neurotoxicity.


These results indicated that butanol fraction (200 mg/kg) of P. japonicus extract exhibited strong neuroprotective, probably is due to the presence of petaslignolide A (PA).


The findings suggested herbal butterbur may be considered as a functional herb for neuroprotection, however, the volume of the herb used should only be prescribed herbal doctor.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of butterbur neuroprotective possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI.(PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE.(PubMed)
(4) Neuroprotection and neurodegenerative disease by Vajda FJ(PubMed)

Strawberry and It's Bioactive Flavonoids That Eradicate Risk Factors of Heart Disease

Scientists may have found a fruit which has a potential effect in reduced risk and treatment of heart disease, some studies suggested.

According to statistic, heart disease, after lung cancer kills more than 2,000 Americans every day.

Approximately, 60 million Americans have heart disease.

There are many causes of heart diseases.

Most of the heart diseases are caused by high blood pressure which contributes to hardening of the arteries.

Some researchers suggested that diet high in saturated and trans fats also plays an important role in the initiated risk of coronary heart disease. As the long-term unhealthy diet can cause obesity, high blood pressure,... and diabetes.

Dr. McNamara DJ, in the study of dietary cholesterol, heart disease risk and cognitive dissonance, wrote, "....dietary cholesterol has a small effect on the plasma cholesterol levels with an increase in the cholesterol content of the LDL particle and an increase in HDL cholesterol, with little effect on the LDL: HDL ratio, a significant indicator of heart disease risk"(4).

Truly, everything that adds to the formation of atherosclerosis lesions, damages the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart, is considered prevalent risk factors of arterial blockage, the main cause of heart disease.

Strawberry is a genius of Fragaria × ananassa belongings to the family Roseaceae.

The edible plants have been grown all over the world with a suitable climate for commercial profits due to their's health benefits.

Chemicals constituents of strawberry
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

According to the followed up study to examine the relationship between anthocyanins, the largest group of water-soluble pigments and the risk of MI, anthocyanin, strawberries intake was found to be potential in preventing myocardial infarction (MI) in young and middle-aged women.

Intake of strawberries was also associated with a decreased risk of MI, in a comparison of those consuming >3 servings a week and those with lower intake.

Dr. Cassidy A, the lead scientist, in the study conducted by the University of East Anglia, including a total of 93 600 women 25 to 42 years of age from the database of the Nurses' Health Study (NHS) II, after taking into account of multivariate adjustment said, "An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles)".

Further differentiation of the effects of anthocyanins in reduced risk of a heart problem, also found that anthocyanins efficacy may be associated to improve a variety of effects on blood vessels, platelets, and lipoproteins, the coronary heart diseases reducers.

Moreover, the study of participants includes 34 489 postmenopausal women in the Iowa Women's Health Study who were free of CVD and had complete food-frequency questionnaire information that include Intakes of total flavonoids and 7 subclasses categorized into quintiles at baseline, using the proportional hazards rate ratios (RR) to compute for CVD, coronary heart disease (CHD), stroke, and total mortality after 16 y of follow-up, showed,

* There was a significant inverse association between anthocyanidins and CHD, CVD, and total mortality in compared to no intake of proportional hazards rate ratios (RR) of 0.88, 0.91, and 0.90, respectively.

* The proportional hazards rate ratios (RR) between flavanones and CHD [RR for highest quintile versus lowest 0.78 and between flavones and total mortality [RR for highest quintile versus lowest: 0.88.

* Intake of strawberry were associated with significantly reduced risk of cardiovascular diseases in compared to other foods in the questionnaire.
These results suggested that dietary intakes of flavanones, anthocyanidins, and foods rich in flavonoids were associated with reduced risk of death due to CHD, CVD, and all causes, according to Dr. Mink PJ, the lead scientist.

Taken altogether, strawberry with rich of flavanones, anthocyanidins, and flavonoids may be considered as a functional food in the prevention of early onset and treatment of heart disease.

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References
(1) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women by Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB..(PubMed)
(2) Anthocyanins and heart health by Mazza GJ. (PubMed)
(3) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. byMink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr.(PubMed)
(4) Dietary cholesterol, heart disease risk and cognitive dissonance by McNamara DJ(PubMed)

The Kitchen Herbal Cayenne Spice Bioactive Compound Which Has The Potential to Cure Non Allergic Rhinitis

Scientists may have a positive and potential effect in reduced risk and treatment of Non-Allergic Rhinitis, according to some studies.

Nonallergic rhinitis is a condition with symptoms resembles allergy induced rhinitis but without a known cause. However, some researchers suggested that environmental pollutants or odors, certain foods or beverages,,,,,,, and changes in the weather can trigger symptoms of the condition.

Some medications and underlying chronic health problems are associated with an increased risk of nonallergic rhinitis,

Most common symptoms are persistent sneezing, congestion, or a runny nose.

Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant allergens. In its broadest sense can be called chronic nonallergic rhinitis(1).

Long-term intake of medicine used for the treatment of nonallergic rhinitis such as nasal sprays containing an antihistamine may reduce symptoms of nonallergic rhinitis but can facilitate side effects of drowsiness or sleepiness, dizziness, dry mouth, nose, or throat,,,, increased appetite, weight gain, and upset stomach

In some cases, patients may experience, thickening of mucus, changes in vision, some psychological symptoms of nervousness, excited,... and irritable.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herb has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

Ingredients
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid,.... and palmitic acid.


ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, in the study of 42 consented subjects meeting inclusion/exclusion criteria randomized to ICX72 (n = 20) or control (n = 22) administered twice daily over 2 weeks, exhibited significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain inpatients with Nonallergic rhinitis(2).

Further analysis in concerns of the application adverse effects, researchers found that there is no difference between groups in adverse events in compared to placebo.

Dr. Bernstein JA, the lead author said, " ......intranasal capsaicin, when used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component".

More importantly, ICX72 group experienced no rebound congestion or impaired olfaction in compared to placebo at the end of the study.

Moreover, in the study of 30 patients randomized into two different treatment regimens

* Group A received capsaicin five times on the first day at 1-h intervals, followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application.

* Group B received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.

At the end of the experiment, researchers showed that

* Treatment group A reduced overall nasal symptoms, rhinorrhea, and nasal blockage, in compared to group B

* Both groups showed a significant reduction in cold dry air does responsiveness and nasal hyperreactivity. up to 9 months after therapy

* There were no No significant changes in safety data (smell, blood pressure, heart rate in group A in compared to group B.

Dr. Van Rijswijk JB, the lead scientist wrote, "....intranasal capsaicin seems safe to use and that five treatments of capsaicin on a single day is at least as effective as five treatments of capsaicin in 2 weeks".

The findings suggested that capsaicin may process the potential to cure nonallergic rhinitis.

However, large example size and multi-center clinical trials are necessary to reconfirm capsaicin anti nonallergic rhinitis validity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasalspray with placebo in subjects with a significant component of nonallergicrhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)

Green Tea: The Drink Which Ameliorates Symptoms and Progression of Rheumatoid Arthritis(RA)

Green tea exhibited an anti-inflammatory effect in reduced symptoms and progression of
Rheumatoid Arthritis, some institutes suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

According to statistic, In US, approximately, 90 million adults and children suffered directly from arthritis, inducing social and economic consequences to over 240 million people who are having a family member affected by the disease.

The disease was also found to infect a third of those aged 18-64.

Although the disease is caused by immune defense attacking its the body healthy tissue, researchers as of today are not sure what triggers the abnormal function. But they do know that certain risk factors are associated with increased risk of rheumatoid arthritis, including genetic alternation, as people with certain genes are more likely to develop RA, geographic factor as RA is rare in less developed and rural parts of the world, hormone factor as RA is more common in women than in men,.... and family history.

Other risk factors including smoking, people with certain medical conditions such as autoimmune disease, an unhealthy diet such as high in red meat and less in fruits and vegetables, physical inactivity also promote early onset of RA.

The Karolinska Institutet in the study of the risk factors of RA wrote, "nongenetic risk factors (smoking, alcohol intake, parity, silica exposure, body mass index, fatty fish consumption, and education), and genetic risk factors (shared epitope [SE] and 76 single-nucleotide polymorphisms [SNPs])" and "....many (familial) risk factors remain to be identified, in particular for seronegative RA"(4).

The results of chronic inflammation caused by immune attacking the joints, inducing overexpression of pro-inflammatory cytokines can lead to damage of cells in the inflammatory site and nearby healthy cells, including bone, cartilage, tendons,.... and ligaments,

Untreated chronic joint inflammation can also cause complications of total destruction of joint tissue.

If you experience symptoms of joint pain, tenderness, swelling, redness, stiffness,.... restriction or loss of joint range of motion, you may have RA.

Green tea, a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.

According to the joint study led by Washington State University College of Pharmacy, green tea showed to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

IL-6 and IL-8 are pro-inflammatory cytokines activated by the systematic immune response in prevented damage of tissue in the acute phase of infection. Prolonged overexpression of IL6 and IL8 can cause damage to cells in the infectious region as well as surrounding healthy cells.

Cox-2 are prostaglandins with function in mediated pathogenic infection, including the inflammatory response.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".

In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), researchers found that group treats with a high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared to placebo.

More importantly, researchers also found that the expression of anti-arthritic activity of the high dose of GTE (from day 0) mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues, was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).

Furthermore, the anti-arthritic potency of tea aqueous extracts was dosed dependent in the order of high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Other study suggested that green tea extract in reduced symptoms and risk of complications probably are the result in regulating chemokine(a family of cytokines secreted by cells) production in immune reaction and chemokine receptor expression in interaction with proinflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).

Taking together, green tea may be served as a functional food to reduce symptoms and risk of complications for patients with rheumatoid arthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)
(4) To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors? by Jiang X1, Frisell T, Askling J, Karlson EW, Klareskog L, Alfredsson L, Källberg H(PubMed)

Herbal Anise Detoxes Your Kidney From Medicine and Chemicals Toxicity, Scientists Say

Anise may have a potential and therapeutic effect in reduced risk of nephrotoxicity caused by intake of some medicine and chemicals, some scientists suggested.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by a poisonous effect of prolonged use of certain medication and accumulation of harmful chemicals.


According to the American physician association, long-term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin are associated to increase damage to the kidney.

And people with age over 60 are at increased risk of nephrotoxicity if the above medicine is prescribed for prolonged periods.

Continuously, the association wrote, "Drug-induced nephrotoxicity tends to be more common among certain patients and in specific clinical situations" and " Drugs cause approximately 20 percent of community-and hospital-acquired episodes of acute renal failure".


Dr. Koren G, in the classification of drug and chemicals that cause nephrotoxicity suggested, "Drugs and chemicals may affect renal function by pharmacologically decreasing glomerular filtration rate and/or renal blood flow" and " A variety of xenobiotics or their metabolites may be deposited in the renal tubule causing obstruction of urine flow and a secondary damage to tubular epithelium"(4).

If you experience symptoms of decreased urine output,.fluid retention that causes legs, ankles or feet. swelling,.... and shortness of breath, you may have acute kidney failure, please check with your doctor to rule out the possibility.


Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...


Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the investigation of the effect of Pimpinella anisum (P. anisum) in alleviated gentamicin (GM) in induction of nephrotoxicity, in a group of 40 male Wistar rats divided into four groups: control, sham administrated normal saline orally and intraperitoneally (i.p.), GM received 100 mg/kg bw/day and GM and ethanolic extract of P. anisum with an oral dose of 300 mg/kg bw/day for 8 days, researchers found that GM groups demonstrates a significant increase of plasma levels of creatinine which is an indication of improper function of kidneys, levels of Blood urea nitrogen (BUN) which is an indication of how the kidneys in filtered out the wastes and levels of malondialdehyde (MDA), a maker of oxidative stress.

Mice injected with GM also displayed an absolutely increased excretion of sodium and potassium inducing fluid or electrolyte imbalances and impaired kidney function.

Oral GM administrated mice also showed a decreased level of reducing ability of plasma (FRAP) level, a marker of antioxidant defense in compared to the sham group.

Interestingly, application of herbal anise in GM group at a dose of 300 mg/kg expressed an improvement of various aspects through significantly reduced the plasma concentrations of renal function markers and gentamicin-induced tubule damage.

Dr. Changizi-Ashtiyani S, the lead author said, " the potential therapeutic impact of P. anisum to attenuate GM-induced nephrotoxicity. Therefore, the simultaneous use of an ethanolic extract of P. anisum during GM administration is recommended to reduce its nephrotoxicity effects".

Amazingly, in the study to evaluate the effect Pimpinella anisum L. against lead intoxication in induction of nephrotoxicity in young rats intoxicated by lead acetate, researchers found that oral administration of aqueous extract of P. anisum L. (500 and 750 mg/kg) for 15 days show a strong improvement in reduced expression of urea, creatinine, aciduric, and gamma-GT by −71%, −1.23%, −1.80% and −5.88% of kidney damage biomarkers caused by lead toxicity.


Importantly, injection of anise extracted also decreased the level of lipid hydroperoxide (LPO) of −13.56%, an indication of antioxidant activity induced by the application
and increased the concentration of total proteins (+8.88%) in the expression of kidney and liver protective effects without changing histological structures of the kidney between the studied groups.
Dr. Bekara Amina, the lead author, after taking into account other confounders, said, "P. anisum L. may have a nephroprotective potential against harmful effect induced by lead toxicity on kidney".


Moreover, in the study of a total of 40 male Wister albino rats divided randomly into four groups (1st group was control; 2nd group treated with star anise, 3 rd group received Etoposide, and 4th group treated with both star anise and Etoposide(chemotherapy medication used for the treatments of a number of types of cancer), application of the herbal products, displayed similar efficacy as those in Ansie through significantly decreased elevation in creatinine, blood urea, sodium, potassium and chloride while calcium ions induced in the injection of Etoposide.


The study also addressed the inter uncorrelated between star anise water extract and the injection of Etoposide observed by assay supported the detrimental effect of Etoposide in the ameliorating effect of star anise water extract on renal toxicity.

Dr. Ali Salman Hassan according to the information findings said, "star anise has a promising role and it worth to be considered as a natural substance for ameliorating the renal toxicity and injury induced by Etoposide chemotherapy".



Taken together, Anise may be considered as an adjunct therapy in combined with standard medicine in reduced risk of nephrotoxicity, particularly in patients undergoing chemotherapy for cancer treatment.

Intake of herbal extract should be taken with extreme care in prevented liver toxicity.

However, further data collection on large example size andmulti-centerss studies performed with human consumption of the whole food during the acute phase of the disease will be necessary to complete the picture of herbal anise kidney protective possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats by Changizi-Ashtiyani S1, Seddigh A2, Najafi H3, Hossaini N4, Avan A5, Akbary A6, Manian M7, Nedaeinia R8.(PubMed))
(2) Prevention of Etoposide induced kidney toxicity, electrolytes, injury and KI67 alternations in male rats tre ated with star anise Ali Salman Hassan Al-Ameri Environmental studies/Biology/Ministry of Education, Iraq(JBAAR)
(3) Nephroprotective effect of Pimpinella anisum L. aqueous extract against lead toxicity: In vivo study by Bekara Amina, Ait Hamadouche, Kahloulakhaled, Aoues Abdelkader(Research Gate)
(4) The nephrotoxic potential of drugs and chemicals. Pharmacological basis and clinical relevance by Koren G(PubMed)

Yoga In Reduced Physical and Psychological Symptoms of Parkinson's Disease

People who participated in a yoga class have a profound and positive impact on reduced symptoms of Parkinson's disease, a renowned study suggested.

Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

Parkinson's disease is a condition affected motor and nonmotor functions and causes severe debility and poor quality of life, a recent study suggested.

According to statistic, approximately one million are living with Parkinson's disease (PD) in the U.S.
Every year, over 60,000 Americans are diagnosed with PD.

And, if you are men, you are 1.5 times more likely to have Parkinson's disease in compared to women.

In the discussion with 28 experienced yoga experts, who fulfilled the inclusion criteria, selected validating the content of the integrated yoga module(IYM) for PD, researchers found that 21 out of 28 exhibited significant content validity by applying Lawshe's formula for the content validity ratio (CVR) of 0.42.

Additionally, in a randomized controlled pilot study investigated the effectiveness of yoga intervention on physiological and health-related QOL measures in people with PD with 13 people with stage 1-2 PD randomized to either a yoga (n = 8) or a control group (n = 5) and the yoga group participated in twice-weekly yoga sessions for 12 weeks, searchers found that yoga participants demonstrate a significant improvement in Unified Parkinson's Disease Rating Scale (UPDRS)scores, improved diastolic blood pressure (P = 0.036) and average forced vital capacity (P = 0.03) over time, in compared to control.

Furthermore, researchers also indicated that the yoga group expressed positive trends of improvement in depression scores (P = 0.056), body weight (P = 0.056) and forced expiratory volume (P = 0.059).

More profoundly, Yoga participants reported more positive symptom changes including immediate tremor reduction in compared to the control group. Collectively, yoga significantly improves aspects of QOL and physiological functions in stages 1-2 PD patients.


Importantly, in support of the above differentiation, the California State University, in the measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease pilot study suggested, after assessing the result of 10 participants with a Hoehn and Yahr stage of 2 or 3 prior to and after an 8-week control phase and again after they underwent an 8-week adaptive yoga program scientists suggested that yoga participants not only reduced expression of depression, anxiety in both gender, but also enhanced sit-and-reach flexibility in male participants in compared to female counterparts.

In younger participants, yoga showed an enormous improvement of Single-Leg Balance test(SLB) time after the intervention.

Indeed, in the compare the effects of power training (PWT) and a high-speed yoga program on physical performances in older patients with Parkinson's disease (PD), researchers indicated that both yoga program and PWT programs can significantly improve physical performance in older persons with PD.

In other words, Dr. Ni M, the led author said, "both training groups showed significant improvements (P<.05) in all physical measurements except functional reach on the more affected side, SLS, and postural sway compared with the pretests, and significantly better scores for UPDRSMS, BBS, Mini-BESTest, Timed Up and Go, functional reach on the less affected side".

Taking all together, yoga no doubt has a fabulous effect in improving both physical and psychological symptoms in the early stage of Parkinson's disease. Some researchers even suggested that yoga may be used as an integrated form of exercise conventionally with conventional therapy.

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Development and validation of a yoga module for Parkinson disease by Kakde N1, Metri KG1, Varambally S1, Nagaratna R1, Nagendra HR1.(PubMed)
(2) Comparative Effect of Power Training and High-Speed Yoga on Motor Function in Older Patients With Parkinson Disease by Ni M1, Signorile JF2, Mooney K3, Balachandran A1, Potiaumpai M1, Luca C4, Moore JG5, Kuenze CM1, Eltoukhy M1, Perry AC1.(PubMed)
(3) A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease by Sharma NK1, Robbins K1, Wagner K1, Colgrove YM1.(PubMed)
(3) Measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease. A pilot study by Boulgarides LK1, Barakatt E, Coleman-Salgado B.(PubMed)
(4) Controlled pilot study of the effects of power yoga in Parkinson's disease by Ni M1, Mooney K2, Signorile JF3.(PubMed)

Carrot, The Functional Food Which Reduces Gastric/Stomach Cancer Risk

Carrots may have a profound and positive effect on reduced risk, progression and treatment of gastric cancer, some scientists suggested.

Gastric cancer is a slowly developed condition characterized by cell growth uncontrollably and disorderly in the stomach tissue. At the later stage, the cancerous cells may travel a distance away to infect other healthy cells of the tissue and organs.

According to the US cancer society, approximately over 26000 new cases of gastric cancer are diagnosed in 2018 inducing death of over 10,000 patients.

The risk that a man and woman will develop gastric cancer in their lifetime is 1 in 95 and 1 in 154 respectively.

The exact causes of gastric cancer are unknown, some researchers suggested that older people, male, heavy smokers, people with a family history of gastric cancer and certain ethnic groups such as
Asian (especially Korean or Japanese), South American, or Belarusian descent are at increased prevalent risk of gastric cancer.

Interestingly, during past several decades, the numbers of common gastric cancer are showing a tendency of receding, however, at the same time, cancer at the area where the top part of the stomach meets the lower end of the swallowing tube (esophagus) has increased rapidly.

Also, some medical conditions such as lymphoma, H. pylori bacterial infections, tumors in the digestive system and stomach polyps are associated with risk of the disease.


If you experiment of persistent feeling floated after eating, and small meal after eating, heartburn, indigestion,... and stomach pain accompanied of general symptoms of cancer such as unexplained weight loss, please check with your doctor to rule out the possibility of gastric cancer..


Carrot, a root vegetable with an orange color is a sub species of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation the hypothesis of "eating carrots may play a major role in the prevention of gastric cancer", researchers at the joint study lead by the J Shahid Sadoughi University of Medical Sciences conducted a medical literature review selected from the databases of including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, those studies satisfied the guidelines and criteria showed that the risk of gastric cancer reduced by 26% with the consumption of carrots.

After taking into account other cofactors, researchers warranted that the result does not show the possibility of a publication bias, according to the funnel graph by comprehensive meta analysis/2.0 software.


Although without mentioning the amount intake daily, these results showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.



Furthermore, in the analysis of the effect of Helicobacter pylori (H. pylori) overgrowth in risk of gastric cancer, scientists found that injection of gene of UreB into a carrot by Agrobacterium-mediated transformation expressed a significant effect in regenerated carrot plants the expressed UreB protein accounted for 25mug/g roots in reduced expression of H. pylori.

The same application also showed a similar effect in the immune response in inhibition of infection of bacterial Helicobacter pylori in mice.

These result suggested that certain chemical compounds in carrot may consist of a strong anti microorganism activity by protecting the plant against bacterial infection.
Therefore, UreB transgenic carrot can be potentially used as an edible vaccine for controlling H. pylori but also ameliorated the risk of the bacteria in the induction of gastric cancer.

The illustration of the above differentiation was supported by the study conducted by the Graduate School of Fudan University.

According to the evaluation of the Wuxing soup containing Daikon Radish Leaves (Green element) Daikon Radish (White element) Carrots (Red color element) Burdock Root (Yellow element) Shittake Mushroom (Black element), application of the soup to the human gastric adenocarcinoma cell line (SGC-7901) expressed a huge inhibitory activity in reduced tumor cells proliferation in a time and dose-dependent manner.
More importantly, Wuxing soup induced tumor cell death through apoptotic morphological changes and DNA ladder of the tested SGC-7901 cells.


Additionally, the used combination with calcium inhibitor Bapta AM, an intracellular calcium chelator not only exerted a strong effect in reduced the cancer apoptotic rate but also protected SGC-7901 cells in a dose-dependent manner.
Dr. Mo F, the lead author said, "Wuxing soup has an effective inhibition on cancer cells, and can induce SGC-7901 cells to apoptosis by calcium".



Taken together, carrot may be considered a functional food in ameliorated risk and used a combination with conventional standard treatment for gastric cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of gastric cancer will be necessary to complete the picture of carrot's anti-cancer possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(2) Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori by Zhang H1, Liu M, Li Y, Zhao Y, He H, Yang G, Zheng C.(PubMed)
(3) [The anti-tumour effect of Wuxing soup and its mechanism in inducing apoptosis of tumour cells mediated by calcium].[Article in Chinese] by Mo F1, Hu JY, Gan Y, Zhao YX, Zhao XT.(PubMed)