Bilberry may be the next potential target by the pharmaceutical companies to extract a single ingredient medicine for improvement of energy metabolism, according to studies.
Energy metabolism is a process to generate energy from protein, fat and carbohydrate or fat already stored in the body.
Although carbohydrates and fat are considered the major sources of energy in the diet, protein is necessary for all kinds of biological processes but less in the direct production of energy purposes.
Energy metabolism alterations are found associated with a large number of diseases including mitochondrial diseases, acute coronary syndrome, chronic kidney disease, asthma or even cancer.
And, energy metabolism alternation can also affect all organs and tissues functioning.
Certain factors can increase and decrease the rate of energy metabolism, such as the immune cells require energy to maintain cellular viability and to perform specific immune functions, including
* Body size such as weight and heigh
* Body composition: fat tissue has a lower metabolic activity than muscle tissue.
* Aging: decrease muscle mass decrease energy metabolism.
* Gender women have a slow rate of energy metabolism compared to men.
Dr. Prabhakar, the lead scientist in the investigation of the energy metabolism on obesity, said, "Energy used by the body is described in terms of the metabolic rate underlying passive and active conditions which are further correlated to body weight".
And, "Energy metabolism and the role of carbohydrates, lipids, and protein in foods are areas of emerging research with a therapeutic approach against obesity and related biological disorders". of e
The results strongly suggested that if you are obese, you are at higher risk of diseases associated with a decreased rate of energy metabolism, such as insulin resistance.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding the natural ingredient for the improvement of energy metabolism investigated the bilberry activity in genes expressed in the intestinal mucosa which is responsible for nutrient absorption and waste secretion.
Injection of bilberry improved the intestinal barrier functioning by enhancing the balance of gut microbiota, thus increasing the absorption of the nutrients.
Furthermore, male C57BL/6J mice (n = 52) selected to the study received a control low-fat diet (LFD; 10 kcal% fat) for 6 weeks followed by 24 weeks of either LFD (n = 13) or high-fat diet (HFD; 45 kcal% fat; n = 13) or HFD supplemented with 0.1% w/w of the flavanol compound epicatechin (HFD+E; n = 13) or an anthocyanin-rich bilberry extract (HFD+B; n = 13), researchers found that
* The switch from an LFD to an HFD increases the plasma cholesterol and hepatic lipid content in non-anthocyanin-rich bilberry extract treatment group.
* The polyphenol compounds in the HFD supplemented with 0.1% w/w of the flavanol compound epicatechin could not prevent HFD-induced systemic rise of inflammatory levels compared to the bilberry treatment group.
* The findings strongly supported the use of supplementation of HFD with an anthocyanin-rich bilberry extract for the beneficial effects on the systemic early inflammatory response associated with HFD-induced obesity.
Dr. the leads scientist wrote, "On the tissue level, long-term treatment with bilberry attenuated TNF-α expression in adipose tissue".
In other words, the intake of anthocyanin-rich bilberry extract lowers the level of systemic inflammation in the adipose tissue against the onset of metabolic syndrome-associated chronic pathologies.
Taken altogether, bilberry may be considered a functional remedy to improve the intestinal barrier functioning in energy metabolism by reducing the intestinal inflammation and promoting healthy adipocytes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M8. (PubMed)
(2) Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity. by van der Heijden RA1, Morrison MC2, Sheedfar F3, Mulder P4, Schreurs M5, Hommelberg PP6, Hofker MH7, Schalkwijk C8, Kleemann R2, Tietge UJ5, Koonen DP7, Heeringa P. (PubMed)
(3) 6 - Protein, Carbohydrates, and Fats: Energy Metabolism by Prabhakar Singh, Rajesh K.Kesharwani, Raj K.Keservani. (Science Direct)
Thursday, April 18, 2019
Herbal Artichoke Inhibits Hepatitis C Virus Against Liver Infection
Scientists may have found a natural remedy for the treatment of hepatitis C infection with no side effects, according to studies.
Hepatitis C infection is an inflammatory liver disease associated with viral hepatitis C. The viral infection has affected over a million Americans today according to the statistic.
Epidemiological studies suggested that persistent infection with hepatitis C virus (HCV) is a major risk for the development of HCC, the fifth most common cancer, and the third most common cause for cancer death in the world.
Contaminated blood and fluids are the most common causes of hepatitis C virus (HCV) infection.
Hepatitis C induces liver cancer through many stages including
* The incubation period which lasts about 45 days after exposing to the virus.
* Acute hepatitis, the short-term illness may last about 6 months. Most people can get rid of the virus in this stage, particularly to those with the strong immune system.
* Chronic hepatitis C if you can not get rid of the virus in the acute stage, the immune system will adapt to the new change, leading to chronic liver inflammation by the hep C virus.
* Cirrhosis, the liver scar, normally is formed due to the progression of the inflammation. Cirrhosis can be developed over a period of 20 years, after initial exposure to the virus.
* Liver cancer, the death of liver cells due to overexpression of liver scars.
Dr. Gremion C, the lead scientist in the attempt to explain the risk hepatitis C and immune system, said, "While a persistent infection is generally associated with a weak CD4+ and CD8+ T cell response during the acute phase, there is no good explanation as to why this response is strong enough in 20% of acutely infected people such that they spontaneously resolve the infection".
The results strongly suggested that if you have a strong immune system, your risk of hepatitis C infection can be resolved naturally.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural ingredient for the treatment of hepatitis C which presently affects millions of people globally examined the traditional use of Egyptian artichoke (WEA) for the treatment of HCV-infection and complications.
Injection of water extract of a WEA plant decreased the HCV viral load below the detection level in 12 out of 15 patients. In other words, artichoke exerted strong anti-HCV infection, depending on the state of the severity of the disease.
Furthermore, the water extract normalized the levels of enzymes associated with liver function and damage.
Moreover, The total WEA extract at IC50 ∼ 20 μg ml(-1), inhibited abnormal expression of genes in patients with hepatitis C infection, involving in drug metabolism and synthesis of cholesterol, steroids, and other lipids (CYP2B6 (OH-BUP)) and the formation and breakdown (metabolism) of various molecules and chemicals within cells (CYP2C19 (5-OH-OME)).
WEA was found to be more effective in inhibiting hepatitis C infection compared to the Hepar SL Forte(®) due to the presence of sesquiterpenes versus the abundance of phenolic compounds of the Hepar SL Forte(®).
In chemicals analysis, grosheimol and cynaropicrin, isolated from the WEA showed the most inhibitory effect against HCV with half-maximal effective concentrations (EC50s) in the low micromolar range.
Both tested compounds inhibited HCV entry into target cells in both cell-free infections and cell-cell transmission.
Both compounds belong to the group of sesquiterpene lactones which are found in the WEA but not in the Hepar SL Forte(®).
The results clearly supported the use of WEA in traditional use for the treatment of liver viral infection and complications.
Taken altogether, herbal Artichoke may be considered a functional remedy for the prevention and treatment of HCV infection, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials by Elsebai MF1, Abass K2, Hakkola J3, Atawia AR4, Farag MA. (PubMed)
(2) Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke by Elsebai MF1, Koutsoudakis G2, Saludes V2, Pérez-Vilaró G2, Turpeinen A3, Mattila S3, Pirttilä AM4, Fontaine-Vive F5, Mehiri M5, Meyerhans A6, Diez. (PubMed)
(3) Hepatitis C virus and the immune system: a concise review by Gremion C1, Cerny A. (PubMed)
Hepatitis C infection is an inflammatory liver disease associated with viral hepatitis C. The viral infection has affected over a million Americans today according to the statistic.
Epidemiological studies suggested that persistent infection with hepatitis C virus (HCV) is a major risk for the development of HCC, the fifth most common cancer, and the third most common cause for cancer death in the world.
Contaminated blood and fluids are the most common causes of hepatitis C virus (HCV) infection.
Hepatitis C induces liver cancer through many stages including
* The incubation period which lasts about 45 days after exposing to the virus.
* Acute hepatitis, the short-term illness may last about 6 months. Most people can get rid of the virus in this stage, particularly to those with the strong immune system.
* Chronic hepatitis C if you can not get rid of the virus in the acute stage, the immune system will adapt to the new change, leading to chronic liver inflammation by the hep C virus.
* Cirrhosis, the liver scar, normally is formed due to the progression of the inflammation. Cirrhosis can be developed over a period of 20 years, after initial exposure to the virus.
* Liver cancer, the death of liver cells due to overexpression of liver scars.
Dr. Gremion C, the lead scientist in the attempt to explain the risk hepatitis C and immune system, said, "While a persistent infection is generally associated with a weak CD4+ and CD8+ T cell response during the acute phase, there is no good explanation as to why this response is strong enough in 20% of acutely infected people such that they spontaneously resolve the infection".
The results strongly suggested that if you have a strong immune system, your risk of hepatitis C infection can be resolved naturally.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural ingredient for the treatment of hepatitis C which presently affects millions of people globally examined the traditional use of Egyptian artichoke (WEA) for the treatment of HCV-infection and complications.
Injection of water extract of a WEA plant decreased the HCV viral load below the detection level in 12 out of 15 patients. In other words, artichoke exerted strong anti-HCV infection, depending on the state of the severity of the disease.
Furthermore, the water extract normalized the levels of enzymes associated with liver function and damage.
Moreover, The total WEA extract at IC50 ∼ 20 μg ml(-1), inhibited abnormal expression of genes in patients with hepatitis C infection, involving in drug metabolism and synthesis of cholesterol, steroids, and other lipids (CYP2B6 (OH-BUP)) and the formation and breakdown (metabolism) of various molecules and chemicals within cells (CYP2C19 (5-OH-OME)).
WEA was found to be more effective in inhibiting hepatitis C infection compared to the Hepar SL Forte(®) due to the presence of sesquiterpenes versus the abundance of phenolic compounds of the Hepar SL Forte(®).
In chemicals analysis, grosheimol and cynaropicrin, isolated from the WEA showed the most inhibitory effect against HCV with half-maximal effective concentrations (EC50s) in the low micromolar range.
Both tested compounds inhibited HCV entry into target cells in both cell-free infections and cell-cell transmission.
Both compounds belong to the group of sesquiterpene lactones which are found in the WEA but not in the Hepar SL Forte(®).
The results clearly supported the use of WEA in traditional use for the treatment of liver viral infection and complications.
Taken altogether, herbal Artichoke may be considered a functional remedy for the prevention and treatment of HCV infection, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials by Elsebai MF1, Abass K2, Hakkola J3, Atawia AR4, Farag MA. (PubMed)
(2) Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke by Elsebai MF1, Koutsoudakis G2, Saludes V2, Pérez-Vilaró G2, Turpeinen A3, Mattila S3, Pirttilä AM4, Fontaine-Vive F5, Mehiri M5, Meyerhans A6, Diez. (PubMed)
(3) Hepatitis C virus and the immune system: a concise review by Gremion C1, Cerny A. (PubMed)
Herbal Ginger, the Potential Anti-Septic Functional Remedy, Scientists Show
On seeking a natural therapy with no side effects, scientists may have found a kitchen pungent spice for the prevention and treatment of sepsis, according to studies.
Sepsis is a medical condition caused by the body over-response to infection by releasing a large number of chemicals into the bloodstream, leading to chemicals imbalance that can damage multiple organ systems.
Most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen) and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allow the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy and diabetes.
Most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, problems breathing. abnormal heart functions, fall blood pressure, fall in body temperature. unconsciousness.
If your child or yourself experience some of the above symptoms, please call the emergency services right the way.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientists said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiates the onset of sepsis and also increases the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkanone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of the inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessels integrity.
Furthermore, injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
Sepsis is a medical condition caused by the body over-response to infection by releasing a large number of chemicals into the bloodstream, leading to chemicals imbalance that can damage multiple organ systems.
Most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen) and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allow the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy and diabetes.
Most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, problems breathing. abnormal heart functions, fall blood pressure, fall in body temperature. unconsciousness.
If your child or yourself experience some of the above symptoms, please call the emergency services right the way.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientists said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiates the onset of sepsis and also increases the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkanone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of the inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessels integrity.
Furthermore, injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
Wednesday, April 17, 2019
Turmeric, the Natural Treatment for Metabolic Dysfunction with No Side Effects, Revealed by Scientists
Scientists may have found a kitchen spice which processes bioactive ingredients for the treatment of metabolic dysfunction with no side effects, according to studies.
Metabolism is a natural chemical process of organisms, including humans with an aim to sustain- life.
According to the purposes of the bioprocess, human metabolism can be classified into the process to convert food to energy by breaking down the carbohydrates, proteins, and fats to run cellular processes, and eliminate nitrogenous wastes.
Metabolic dysfunction is a condition caused by any interruption of the aforementioned processes.
In other words, metabolic dysfunction induces the production of excess or a reduced amount of substances needed to stay healthy.
A metabolic disorder can be caused by genetic proposition induced inborn errors of metabolism, or acquired by an individual in the lifetime
There are many risk factors associated with the onset of metabolic dysfunction depending on the types of disruption such as abnormal blood glucose metabolism induced type 2 diabetes.
Diseases associated with metabolic dysfunction can be moderate or severe depending on the organs involved, including liver or respiratory failure, cancer, chronic obstructive pulmonary disease (COPD, includes emphysema and chronic bronchitis), and HIV/AIDS.
Symptoms of metabolic dysfunction are varied among individuals depending totally to the types of disorder.
Some mild condition of metabolic dysfunction can be managed with only lifestyle change, others may require the long-term intake of certain medication accompanied by a healthy diet and moderate exercise such as diabetes.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of metabolic dysfunction, researchers examined the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™), in the attenuation of risperidone-induced metabolic dysfunction in an animal model.
The study involved 4 groups of mice were treated once a week, for 22 weeks with an intraperitoneal injection of risperidone (Risperdal) at a dose of 12.5 mpk.
One group of mice in the risperidone-treated group were fed a diet with 0.05% Biocurcuma™ (curcumin), one of the vehicle-treated group and two other groups received the standard diet.
Curcumin treatment group inhibited the risperidone effect in reducing spontaneous motricity (motor function) but failed to impede de risperidone-induced increase in food intake.
In other words, curcumin failed to reduced de risperidone-induced weight gain and steatosis.but decreased visceral adiposity stored within the abdominal cavity and decreased the risperidone-induced abnormal enlargement of the liver.
Furthermore, curcumin protected the liver enzymes associated with lipid and glucose metabolism against the overexpression in the induction of metabolic dysfunction by modulating the risperidone-induced glucose intolerance and hypertriglyceridemia.
Moreover, the curcumin treatment group also showed to reduce levels of markers of hepatotoxicity (ALAT, ASAT) and proinflammatory cytokines expression caused by risperidone (Risperdal).
Dr. Auger F, the lead scientist said, "These findings support that nutritional doses of curcumin contained in Curcuma longa extract are able to partially counteract the risperidone-induced metabolic dysfunction in mice".
The findings suggested that Curcuma longa extract inhibited metabolic dysfunction through a number of mechanisms involving adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells.
Taken altogether, turmeric and its bioactive compound curcumin may be considered functional remedies for the treatment of syndrome and diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice by Auger F1,2, Martin F3,4,5,6, Pétrault O2,7, Samaillie J3,8, Hennebelle T3,8, Trabelsi MS4,5,6, Bailleul F3,8, Staels B3,4,5,6, Bordet R2, Duriez P. (PubMed)
(2) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB. (PubMed)
Metabolism is a natural chemical process of organisms, including humans with an aim to sustain- life.
According to the purposes of the bioprocess, human metabolism can be classified into the process to convert food to energy by breaking down the carbohydrates, proteins, and fats to run cellular processes, and eliminate nitrogenous wastes.
Metabolic dysfunction is a condition caused by any interruption of the aforementioned processes.
In other words, metabolic dysfunction induces the production of excess or a reduced amount of substances needed to stay healthy.
A metabolic disorder can be caused by genetic proposition induced inborn errors of metabolism, or acquired by an individual in the lifetime
There are many risk factors associated with the onset of metabolic dysfunction depending on the types of disruption such as abnormal blood glucose metabolism induced type 2 diabetes.
Diseases associated with metabolic dysfunction can be moderate or severe depending on the organs involved, including liver or respiratory failure, cancer, chronic obstructive pulmonary disease (COPD, includes emphysema and chronic bronchitis), and HIV/AIDS.
Symptoms of metabolic dysfunction are varied among individuals depending totally to the types of disorder.
Some mild condition of metabolic dysfunction can be managed with only lifestyle change, others may require the long-term intake of certain medication accompanied by a healthy diet and moderate exercise such as diabetes.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of metabolic dysfunction, researchers examined the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™), in the attenuation of risperidone-induced metabolic dysfunction in an animal model.
The study involved 4 groups of mice were treated once a week, for 22 weeks with an intraperitoneal injection of risperidone (Risperdal) at a dose of 12.5 mpk.
One group of mice in the risperidone-treated group were fed a diet with 0.05% Biocurcuma™ (curcumin), one of the vehicle-treated group and two other groups received the standard diet.
Curcumin treatment group inhibited the risperidone effect in reducing spontaneous motricity (motor function) but failed to impede de risperidone-induced increase in food intake.
In other words, curcumin failed to reduced de risperidone-induced weight gain and steatosis.but decreased visceral adiposity stored within the abdominal cavity and decreased the risperidone-induced abnormal enlargement of the liver.
Furthermore, curcumin protected the liver enzymes associated with lipid and glucose metabolism against the overexpression in the induction of metabolic dysfunction by modulating the risperidone-induced glucose intolerance and hypertriglyceridemia.
Moreover, the curcumin treatment group also showed to reduce levels of markers of hepatotoxicity (ALAT, ASAT) and proinflammatory cytokines expression caused by risperidone (Risperdal).
Dr. Auger F, the lead scientist said, "These findings support that nutritional doses of curcumin contained in Curcuma longa extract are able to partially counteract the risperidone-induced metabolic dysfunction in mice".
The findings suggested that Curcuma longa extract inhibited metabolic dysfunction through a number of mechanisms involving adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells.
Taken altogether, turmeric and its bioactive compound curcumin may be considered functional remedies for the treatment of syndrome and diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice by Auger F1,2, Martin F3,4,5,6, Pétrault O2,7, Samaillie J3,8, Hennebelle T3,8, Trabelsi MS4,5,6, Bailleul F3,8, Staels B3,4,5,6, Bordet R2, Duriez P. (PubMed)
(2) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB. (PubMed)
Tuesday, April 16, 2019
Diallyl trisulfide (DATS), the Bioactive compound isolated from Garlic May Be A Potential Anti Skin Cancer Agent
Polysulfides isolated from the organosulfides may have a profound effect in reducing the risk and treatment of skin cancer, according to studies.
Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue and protects the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.
Skin cancer is a medical conditionn characterized by disordered and irregular cell growth in the skin.
Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.
There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.
Long-term cumulative sun exposure is one of the major cause of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.
Certain risk factors that make some people susceptible to the development of skin cancer than others, include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.
Some researchers also suggested that the general knowledge about the protection of skin against the onset of skin cancer is lacking, therefore, more education in this field may be necessary before the prevalence of skin cancer can be reduced.
Dr. Lee Wheless, the lead scientist in the concern of the association between skin characteristics and skin cancer prevention behaviors said, "Behaviors such as sunscreen use and wearing sun-protective clothing are thought to prevent certain types of skin cancer and precancerous lesions".
However, "The overall prevalence of prevention behaviors was low. Those with phenotypic risk factors for skin cancer were most likely to use sunscreen and sun-protective clothing. Those with high-risk skin cancer phenotypes may also be those who are most receptive to skin cancer prevention educational interventions".
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
In the concern of incidence of skin cancer which increases at an alarming rate, researchers at the National Taiwan University evaluated the anti-skin cancer activity of sulfur metabolites in garlic oil.
Diallyl trisulfide (DATS), a member of polysulfides was found to be more potent than mono- and disulfides against skin cancer.
Injection of DATS inhibited cell growth of human melanoma A375 and basal cell carcinoma (BCC) cells by increasing the cytotoxicity of the reactive oxygen species (ROS).
Furthermore, DATS also induced apoptosis of skin cancer cells through inducing the DNA damage and through cell cycle arrest at the G2/M phase, endoplasmic reticulum (ER) stress associated with the cancer cells proliferation and survival, and mitochondria-mediated apoptosis.
These results indicated the importance of DATS in the prevention and treatment of skin cancer by focusing on molecular mechanisms.
Furthermore, in the depth analysis of the effects of Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracts from crushed garlic by steam-distillation against human melanoma A375 cells and basal cell carcinoma cells, researchers showed that DATS reveals better growth inhibition of A375 and BCC cells than DADS and DAS do.
Similar to the previous study, DATS increased intracellular reactive oxygen species (ROS) generation in the induction of cytotoxicity to the tested cancer cell lines.
The cell viability analysis reconfirmed the previous finding that DATS kills tested cancer cells in G(2)/M arrest.
Interestingly, DATS activated the p53 pathway in response to the oxidative DNA damage.
Where p53 is a protein associated with the regulation of the cell cycle and function as a tumor suppression.
Dr. Wang HC, the lead scientist wrote in the final report of the experiment, "DATS also displayed a selective target of growth inhibition between skin cancer cells and normal keratinocyte HaCaT cells".
Taken altogether, Diallyl trisulfide (DATS) a bioactive compound from garlic may be used for the prevention and treatment of skin cancer, pending to reconfirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)
(4) The association between skin characteristics and skin cancer prevention behaviors by Lee Wheless,1 Ingo Ruczinski,3 Rhoda M. Alani,6,7 Sandra Clipp,4,10Judith Hoffman-Bolton,4,10 Timothy J. Jorgensen,4,11 Nanette J. Liégeois,6,8,9Paul T. Strickland,5 and Anthony J. Alberg. (PMC)
Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue and protects the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.
Skin cancer is a medical conditionn characterized by disordered and irregular cell growth in the skin.
Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.
There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.
Long-term cumulative sun exposure is one of the major cause of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.
Certain risk factors that make some people susceptible to the development of skin cancer than others, include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.
Some researchers also suggested that the general knowledge about the protection of skin against the onset of skin cancer is lacking, therefore, more education in this field may be necessary before the prevalence of skin cancer can be reduced.
Dr. Lee Wheless, the lead scientist in the concern of the association between skin characteristics and skin cancer prevention behaviors said, "Behaviors such as sunscreen use and wearing sun-protective clothing are thought to prevent certain types of skin cancer and precancerous lesions".
However, "The overall prevalence of prevention behaviors was low. Those with phenotypic risk factors for skin cancer were most likely to use sunscreen and sun-protective clothing. Those with high-risk skin cancer phenotypes may also be those who are most receptive to skin cancer prevention educational interventions".
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
In the concern of incidence of skin cancer which increases at an alarming rate, researchers at the National Taiwan University evaluated the anti-skin cancer activity of sulfur metabolites in garlic oil.
Diallyl trisulfide (DATS), a member of polysulfides was found to be more potent than mono- and disulfides against skin cancer.
Injection of DATS inhibited cell growth of human melanoma A375 and basal cell carcinoma (BCC) cells by increasing the cytotoxicity of the reactive oxygen species (ROS).
Furthermore, DATS also induced apoptosis of skin cancer cells through inducing the DNA damage and through cell cycle arrest at the G2/M phase, endoplasmic reticulum (ER) stress associated with the cancer cells proliferation and survival, and mitochondria-mediated apoptosis.
These results indicated the importance of DATS in the prevention and treatment of skin cancer by focusing on molecular mechanisms.
Furthermore, in the depth analysis of the effects of Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracts from crushed garlic by steam-distillation against human melanoma A375 cells and basal cell carcinoma cells, researchers showed that DATS reveals better growth inhibition of A375 and BCC cells than DADS and DAS do.
Similar to the previous study, DATS increased intracellular reactive oxygen species (ROS) generation in the induction of cytotoxicity to the tested cancer cell lines.
The cell viability analysis reconfirmed the previous finding that DATS kills tested cancer cells in G(2)/M arrest.
Interestingly, DATS activated the p53 pathway in response to the oxidative DNA damage.
Where p53 is a protein associated with the regulation of the cell cycle and function as a tumor suppression.
Dr. Wang HC, the lead scientist wrote in the final report of the experiment, "DATS also displayed a selective target of growth inhibition between skin cancer cells and normal keratinocyte HaCaT cells".
Taken altogether, Diallyl trisulfide (DATS) a bioactive compound from garlic may be used for the prevention and treatment of skin cancer, pending to reconfirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)
(4) The association between skin characteristics and skin cancer prevention behaviors by Lee Wheless,1 Ingo Ruczinski,3 Rhoda M. Alani,6,7 Sandra Clipp,4,10Judith Hoffman-Bolton,4,10 Timothy J. Jorgensen,4,11 Nanette J. Liégeois,6,8,9Paul T. Strickland,5 and Anthony J. Alberg. (PMC)
Herbal chamomile in the Prevention and Treatment of Anxiety Disorders
Herbal Chamomile may have a potential effect in reducing risk and treatment of anxiety disorder, according to studies.
Anxiety disorders are a group of mental illnesses characterized by symptoms of excessive anxiety, fear, worry, avoidance, and compulsive rituals. The condition is more commonly in women than in men.
Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.
According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.
The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.
The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking and rapid heartbeat.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Dr. Lykouras L, the lead scientist in the investigation of the connection between body weight and anxiety disorders wrote, "Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia" and "Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported".
The results clearly indicated if you are obese, your risk of anxiety disorders is increased substantially compared to normal weight people.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract on generalized anxiety disorder (GAD) showed to effective of modest anxiolytic activity with patient mild to moderate GAD(1). The University of Ottawa study on the effects of Matricaria recutita (German chamomile) and Humulus lupulus (hops) showed significant activity in the inhibition of GAD at doses of 0.11-0.65 mg/mL(2).
The study containing 57 participants in the 2009 trial, 19 had anxiety with comorbid depression; 16 had anxiety with a past history of depression, and 22 had anxiety with no current or past depression, chamomile showed a clinically meaningful antidepressant activity to its previously observed anxiolytic activity(3).
Apigenin, a component of Matricaria recutita flowers, in mice study, exerted its anxiolytic and slight sedative effects through the central benzodiazepine receptors(4).
Researchers at the University Science Center on finding a treatment of anxiety disorder examined the effects of chamomile extract therapy in patients with mild to moderate generalized anxiety disorder (GAD) on a randomized, double-blind, placebo-controlled efficacy and tolerability trial.
In a total of 63 outpatients with mild to moderate GAD enrolled, 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks.
Chamomile treated group exerted a significantly greater reduction in mean total HAM-A score compared to the placebo.
Furthermore, besides the better primary outcomes, chamomile group also demonstrated a positive change in all secondary outcomes in the reduction of anxiety symptoms.
Mild and tolerated adverse events or more was not significantly different between groups.
The findings clearly suggested herbal chamomile extract processes a modest anxiolytic activity in patients with mild to moderate GAD.
Moreover, in the evaluation of the chamomile effect on gamma-aminobutyric acid (GABA) which is a neurotransmitter that blocks impulses between nerve cells in the brain researchers compared the herbal plants which were used in the traditional medicine for the treatment of anxiety disorders.
Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter has been found to initiate the risk of anxiety or mood disorders in low levels
In vitro rat brain homogenate assays, compared to other herbal plants such as Melissa officinalis, Centella asiatica (Gotu Kola) and Valeriana officinalis (Valerian), chamomile showed significant inhibition of glutamic acid decarboxylase (GAD) activity (0.11-0.65 mg/mL).
These results strongly suggested that the failure of the interaction of members in the GAGA system caused by dysfunction was attributed to the onset of anxiety disorders.
Additionally, in participants with symptoms of comorbid anxiety and depression, according to the generalized estimating equations analysis to identify clinically meaningful changes over time in scores from the Hamilton Depression Rating (HAM-D) questionnaire among treatment groups, Chamomile group displays a significantly greater reduction over time in total HAM-D scores compared to placebo.
Also, the HAM-D core mood item scores, application of chamomile also showed a significantly greater reduction over time vs placebo in all participants, regardless of the current or past depression.
Taken altogether, herbal chamomile may be considered a functional remedy for the prevention of anxiety disorders in higher risk population and combined with primary medicine for the treatment of anxiety diseases with tolerated adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder by Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(PubMed)
(2) Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system by Awad R1, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. (PubMed)
(3) Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study by Amsterdam JD1, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. (PubMed)
(4) Anxiety disorders and obesity by Lykouras L1, Michopoulos J. (PubMed)
Anxiety disorders are a group of mental illnesses characterized by symptoms of excessive anxiety, fear, worry, avoidance, and compulsive rituals. The condition is more commonly in women than in men.
Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.
According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.
The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.
The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping, irritability, persistent stomachaches or diarrhea, sweaty palms, shaking and rapid heartbeat.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Dr. Lykouras L, the lead scientist in the investigation of the connection between body weight and anxiety disorders wrote, "Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia" and "Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported".
The results clearly indicated if you are obese, your risk of anxiety disorders is increased substantially compared to normal weight people.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract on generalized anxiety disorder (GAD) showed to effective of modest anxiolytic activity with patient mild to moderate GAD(1). The University of Ottawa study on the effects of Matricaria recutita (German chamomile) and Humulus lupulus (hops) showed significant activity in the inhibition of GAD at doses of 0.11-0.65 mg/mL(2).
The study containing 57 participants in the 2009 trial, 19 had anxiety with comorbid depression; 16 had anxiety with a past history of depression, and 22 had anxiety with no current or past depression, chamomile showed a clinically meaningful antidepressant activity to its previously observed anxiolytic activity(3).
Apigenin, a component of Matricaria recutita flowers, in mice study, exerted its anxiolytic and slight sedative effects through the central benzodiazepine receptors(4).
Researchers at the University Science Center on finding a treatment of anxiety disorder examined the effects of chamomile extract therapy in patients with mild to moderate generalized anxiety disorder (GAD) on a randomized, double-blind, placebo-controlled efficacy and tolerability trial.
In a total of 63 outpatients with mild to moderate GAD enrolled, 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks.
Chamomile treated group exerted a significantly greater reduction in mean total HAM-A score compared to the placebo.
Furthermore, besides the better primary outcomes, chamomile group also demonstrated a positive change in all secondary outcomes in the reduction of anxiety symptoms.
Mild and tolerated adverse events or more was not significantly different between groups.
The findings clearly suggested herbal chamomile extract processes a modest anxiolytic activity in patients with mild to moderate GAD.
Moreover, in the evaluation of the chamomile effect on gamma-aminobutyric acid (GABA) which is a neurotransmitter that blocks impulses between nerve cells in the brain researchers compared the herbal plants which were used in the traditional medicine for the treatment of anxiety disorders.
Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter has been found to initiate the risk of anxiety or mood disorders in low levels
In vitro rat brain homogenate assays, compared to other herbal plants such as Melissa officinalis, Centella asiatica (Gotu Kola) and Valeriana officinalis (Valerian), chamomile showed significant inhibition of glutamic acid decarboxylase (GAD) activity (0.11-0.65 mg/mL).
These results strongly suggested that the failure of the interaction of members in the GAGA system caused by dysfunction was attributed to the onset of anxiety disorders.
Additionally, in participants with symptoms of comorbid anxiety and depression, according to the generalized estimating equations analysis to identify clinically meaningful changes over time in scores from the Hamilton Depression Rating (HAM-D) questionnaire among treatment groups, Chamomile group displays a significantly greater reduction over time in total HAM-D scores compared to placebo.
Also, the HAM-D core mood item scores, application of chamomile also showed a significantly greater reduction over time vs placebo in all participants, regardless of the current or past depression.
Taken altogether, herbal chamomile may be considered a functional remedy for the prevention of anxiety disorders in higher risk population and combined with primary medicine for the treatment of anxiety diseases with tolerated adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder by Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(PubMed)
(2) Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system by Awad R1, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. (PubMed)
(3) Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study by Amsterdam JD1, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. (PubMed)
(4) Anxiety disorders and obesity by Lykouras L1, Michopoulos J. (PubMed)
Monday, April 15, 2019
Herbal Cascara Sagrada, the Best for the Prevention and Treatment of Mastitis and Lactation Mastitis, According to Studies
Herbal Cascara sagrada processed bioactive compounds emodin and aloin may have a strong inhibited effect against the onset of mastitis according to studies.
Mastitis is an inflammation of breast tissue, affecting mostly the mothers who are breastfeeding.
Most cases of mastitis are caused by a bacterial infection such as Staphylococcus aureus.
Most common risk factors of lactation mastitis are blocked duct(s) and restriction from a tight bra, attachment difficulties, and nipple pain during a feed were the significant predictors for mastitis in the first time breastfeeding mothers, according to the Journal of Human Lactation
Most common symptoms of mastitis are breast pain, swelling, warmth, and redness. Some patients may also experience symptoms of fever and chills.
Most cases of mastitis are treated with antibiotics, the medicine may be effective but it has found epidemiologically to induce some side effects.
If you are currently taking one of them, please make sure you know all the side effect for preventive measure.
According to the study of 946 breastfeeding women from Michigan and Nebraska for the first 3 months postpartum or until they stopped breastfeeding to describe mastitis incidence, mastitis treatment, and any associations between mastitis occurrence and hypothesized host characteristics and behaviors.researchers found that mastitis is a very common condition in lactation women.
Telephone interviewed by at 3, 6, 9, and 12 weeks postpartum or until they ceased breastfeeding, a total of 9.5% reported provider-diagnosed lactation mastitis at least once during the 12-week period, with 64% diagnosed via telephone.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
Researchers on finding herbal medicine for the treatment of mastitis examined the Emodin, the major active compound of herbal Cascara Sagrada and Chinese herb Radix et Rhizoma Rhei effect on mastitis.
The mouse model of mastitis was induced by injection of LPS through the duct of the mammary gland. Pretreatment of emodin intraperitoneally with the dose of 1, 2, and 4 mg/kg respectively 1h before and 12h after induction of LPS showed a significant reduction of levels of proinflammatory cytokines, oxidative stress makers and neutrophils, a type of white blood cell.
Emodin influenced nuclear factor kappa-B signal transduction pathway, a protein associated with the controls of transcription of DNA, cytokine production and cell survival. by inhibiting activation of (nuclear transcription factor-kappaB (NF-κB) p65 involved) a protein complex involved the immune response and (degradation inhibitor of NF-κB α (IκBα), and degradation of the cellular response to inflammation.
Furthermore, the efficacy of emodin also attributed to the activation of the signaling pathways associated with the cellular responses to environmental stress and stimuli and the production of pro and anti-inflammatory cytokines.
Researcher wrote in the conclusion of the study, "Emodin could exert beneficial effects on experimental mastitis induced by LPS and may represent a novel treatment strategy for mastitis".
Moreover, in order to investigate the effects of herbal Cascara Sagrada and (Mastitis), researchers examined the herbal Cascara Sagrada and (Mastitis) therapeutic potential photogenically derived aloin, another major compound of the herb, mediated nanosilver particles (AAgNPs), prepared by reduction of silver nitrate with aloin, in Staphylococcus aureus-induced murine mastitis.
The study included a total of 40 female mice divided into five groups of eight animals each.
* Group I served as lactating control,
* Groups II-V inoculated with 20 μl of 24 h broth culture of S. aureus containing 4.0 × 105 cfu/quarter under ketamine anesthesia. After 6 h post inoculation, and
* Groups III and IV received 20 μl of aloin nanosilver (AAgNPs) through intramammary and intraperitoneal routes, respectively.
* Group V received antibiotic cefepime at 1 mg/kg body weight through the intraperitoneal route.
After 18 hours of post-treatment, injection of the compound showed a minimum inhibitory concentration of 21.8 ng/ml against S. aureus.
Nanosilver particles (AAgNPs) showed a significant reduction of 98% of the poly-morpho nuclear cell, a category of white blood cells in the mediation of the phase of inflammation, compared to only 50% in an antibiotic.
Taken altogether, herbal Cascara Sagrada processed abundantly bioactive compounds emodin and aloin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of mastitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
(3) Risk Factors for Lactation Mastitis by Catherine Fetherston, RM, MSc, IBCLC. (Journal of Human Lactation)
(4) Lactation Mastitis: Occurrence and Medical Management among 946 Breastfeeding Women in the United States by Betsy Foxman Hannah D'Arcy Brenda Gillespie Janet Kay BoboKendra Schwartz. (American Journal of Epidemiology)
Mastitis is an inflammation of breast tissue, affecting mostly the mothers who are breastfeeding.
Most cases of mastitis are caused by a bacterial infection such as Staphylococcus aureus.
Most common risk factors of lactation mastitis are blocked duct(s) and restriction from a tight bra, attachment difficulties, and nipple pain during a feed were the significant predictors for mastitis in the first time breastfeeding mothers, according to the Journal of Human Lactation
Most common symptoms of mastitis are breast pain, swelling, warmth, and redness. Some patients may also experience symptoms of fever and chills.
Most cases of mastitis are treated with antibiotics, the medicine may be effective but it has found epidemiologically to induce some side effects.
If you are currently taking one of them, please make sure you know all the side effect for preventive measure.
According to the study of 946 breastfeeding women from Michigan and Nebraska for the first 3 months postpartum or until they stopped breastfeeding to describe mastitis incidence, mastitis treatment, and any associations between mastitis occurrence and hypothesized host characteristics and behaviors.researchers found that mastitis is a very common condition in lactation women.
Telephone interviewed by at 3, 6, 9, and 12 weeks postpartum or until they ceased breastfeeding, a total of 9.5% reported provider-diagnosed lactation mastitis at least once during the 12-week period, with 64% diagnosed via telephone.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
Researchers on finding herbal medicine for the treatment of mastitis examined the Emodin, the major active compound of herbal Cascara Sagrada and Chinese herb Radix et Rhizoma Rhei effect on mastitis.
The mouse model of mastitis was induced by injection of LPS through the duct of the mammary gland. Pretreatment of emodin intraperitoneally with the dose of 1, 2, and 4 mg/kg respectively 1h before and 12h after induction of LPS showed a significant reduction of levels of proinflammatory cytokines, oxidative stress makers and neutrophils, a type of white blood cell.
Emodin influenced nuclear factor kappa-B signal transduction pathway, a protein associated with the controls of transcription of DNA, cytokine production and cell survival. by inhibiting activation of (nuclear transcription factor-kappaB (NF-κB) p65 involved) a protein complex involved the immune response and (degradation inhibitor of NF-κB α (IκBα), and degradation of the cellular response to inflammation.
Furthermore, the efficacy of emodin also attributed to the activation of the signaling pathways associated with the cellular responses to environmental stress and stimuli and the production of pro and anti-inflammatory cytokines.
Researcher wrote in the conclusion of the study, "Emodin could exert beneficial effects on experimental mastitis induced by LPS and may represent a novel treatment strategy for mastitis".
Moreover, in order to investigate the effects of herbal Cascara Sagrada and (Mastitis), researchers examined the herbal Cascara Sagrada and (Mastitis) therapeutic potential photogenically derived aloin, another major compound of the herb, mediated nanosilver particles (AAgNPs), prepared by reduction of silver nitrate with aloin, in Staphylococcus aureus-induced murine mastitis.
The study included a total of 40 female mice divided into five groups of eight animals each.
* Group I served as lactating control,
* Groups II-V inoculated with 20 μl of 24 h broth culture of S. aureus containing 4.0 × 105 cfu/quarter under ketamine anesthesia. After 6 h post inoculation, and
* Groups III and IV received 20 μl of aloin nanosilver (AAgNPs) through intramammary and intraperitoneal routes, respectively.
* Group V received antibiotic cefepime at 1 mg/kg body weight through the intraperitoneal route.
After 18 hours of post-treatment, injection of the compound showed a minimum inhibitory concentration of 21.8 ng/ml against S. aureus.
Nanosilver particles (AAgNPs) showed a significant reduction of 98% of the poly-morpho nuclear cell, a category of white blood cells in the mediation of the phase of inflammation, compared to only 50% in an antibiotic.
Taken altogether, herbal Cascara Sagrada processed abundantly bioactive compounds emodin and aloin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of mastitis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
(3) Risk Factors for Lactation Mastitis by Catherine Fetherston, RM, MSc, IBCLC. (Journal of Human Lactation)
(4) Lactation Mastitis: Occurrence and Medical Management among 946 Breastfeeding Women in the United States by Betsy Foxman Hannah D'Arcy Brenda Gillespie Janet Kay BoboKendra Schwartz. (American Journal of Epidemiology)
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