Metabolism is a natural chemical process of organisms, including humans with an aim to sustain- life.
According to the purposes of the bioprocess, human metabolism can be classified into the process to convert food to energy by breaking down the carbohydrates, proteins, and fats to run cellular processes, and eliminate nitrogenous wastes.
Metabolic dysfunction is a condition caused by any interruption of the aforementioned processes.
In other words, metabolic dysfunction induces the production of excess or a reduced amount of substances needed to stay healthy.
A metabolic disorder can be caused by genetic proposition induced inborn errors of metabolism, or acquired by an individual in the lifetime
There are many risk factors associated with the onset of metabolic dysfunction depending on the types of disruption such as abnormal blood glucose metabolism induced type 2 diabetes.
Diseases associated with metabolic dysfunction can be moderate or severe depending on the organs involved, including liver or respiratory failure, cancer, chronic obstructive pulmonary disease (COPD, includes emphysema and chronic bronchitis), and HIV/AIDS.
Symptoms of metabolic dysfunction are varied among individuals depending totally to the types of disorder.
Some mild condition of metabolic dysfunction can be managed with only lifestyle change, others may require the long-term intake of certain medication accompanied by a healthy diet and moderate exercise such as diabetes.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of metabolic dysfunction, researchers examined the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™), in the attenuation of risperidone-induced metabolic dysfunction in an animal model.
The study involved 4 groups of mice were treated once a week, for 22 weeks with an intraperitoneal injection of risperidone (Risperdal) at a dose of 12.5 mpk.
One group of mice in the risperidone-treated group were fed a diet with 0.05% Biocurcuma™ (curcumin), one of the vehicle-treated group and two other groups received the standard diet.
Curcumin treatment group inhibited the risperidone effect in reducing spontaneous motricity (motor function) but failed to impede de risperidone-induced increase in food intake.
In other words, curcumin failed to reduced de risperidone-induced weight gain and steatosis.but decreased visceral adiposity stored within the abdominal cavity and decreased the risperidone-induced abnormal enlargement of the liver.
Furthermore, curcumin protected the liver enzymes associated with lipid and glucose metabolism against the overexpression in the induction of metabolic dysfunction by modulating the risperidone-induced glucose intolerance and hypertriglyceridemia.
Moreover, the curcumin treatment group also showed to reduce levels of markers of hepatotoxicity (ALAT, ASAT) and proinflammatory cytokines expression caused by risperidone (Risperdal).
Dr. Auger F, the lead scientist said, "These findings support that nutritional doses of curcumin contained in Curcuma longa extract are able to partially counteract the risperidone-induced metabolic dysfunction in mice".
The findings suggested that Curcuma longa extract inhibited metabolic dysfunction through a number of mechanisms involving adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells.
Taken altogether, turmeric and its bioactive compound curcumin may be considered functional remedies for the treatment of syndrome and diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice by Auger F1,2, Martin F3,4,5,6, Pétrault O2,7, Samaillie J3,8, Hennebelle T3,8, Trabelsi MS4,5,6, Bailleul F3,8, Staels B3,4,5,6, Bordet R2, Duriez P. (PubMed)
(2) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB. (PubMed)
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