Lung cancer is a medical and chronic condition associated with the alternation of the cells in the lung tissue.
Most cases of lung cancer start in the cell on the surface of the inner lining of lung tissue before striking into deeper layers.
At the early stage, due to the small size of the tumor, most patients are asymptomatic. However, at the advanced stage, besides the common symptoms shared with other types of cancer, the patients may also experience symptoms of difficult breathing, persistent cough and hoarseness, and chest pain.
Some patients may also vomit blood caused by the oversize tumor suppressing on the nearby blood vessels.
Lung cancer is diagnosed mostly in the elderly, particularly in people over 65 years of age.
The mortality rate of lung cancer is higher than the colon, breast, and prostate cancers combined.
According to the statistics, In Canada, the 5-year net survival for lung cancer is 17%.
In other words, on average, only 17% of people diagnosed with lung cancer will survive for at least 5 years after their diagnosis.
However, lung cancer at the early localized stage has 5 years of the survival rate of 60%.
Although there are many risk factors associated with the onset of lung cancer, smoking is considered epidemiologically a major cause of the disease onset.
Dr. Ozlü T, the lead scientist in the examination of smoking and lung cancer risk, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".
And, "After smoking cessation, the cumulative death risk from lung cancer decreases. Patients who continue smoking experience greater difficulties during cancer treatment. Stopping smoking may prolong survival in cancer patients, and also decreases the risk of recurrent pulmonary carcinoma".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern about the risk of inflammatory conditions of the lung such as chronic obstructive pulmonary disease (COPD) that contributes to the onset of lung cancer risk, particularly lung squamous cell carcinoma (LSCC) examined the chemopreventive effects of BioResponse diindolylmethane (DIM).
The study included a mouse model of inflammation-driven LSCC induced by N-nitroso-trischloroethylurea (NTCU) and enhanced by lipopolysaccharide (LPS), a potent pro-inflammatory agent contained in tobacco and tobacco smoke.
Before treatment of DIM, mice treated with the combination of NTCU and LPS had a 9-fold increase in the number of bronchioles with LSC.
Compared to mice treated with LPS alone, mice treated with NTCU plus LPS showed significantly increased expression of the pro-inflammatory cytokines, accompanied by the increased expression of proteins associated with the production of pro-inflammation and cancer cells initiation.
Pretreatment of DIM at a concentration of 0 μmol/g diet or 2,460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold and suppressed activation/expression of proinflammatory and procarcinogenic proteins without affecting the expression of cytokines and p53, a tumor suppressive gene.
In other words, DIM blocked the development of LSCC through cytotoxicity and gene associated with tumor suppression.
In order to reveal more information about DIM anti-lung cancer property, researchers looked into the anticancer efficacy of 1,1-bis (3'-indolyl)-1-(p-biphenyl) methane (DIM-C-pPhC₆H₅) inhalation delivery alone and in combination with i.v. docetaxel in a murine model.
According to assays, the lung weight reduction in mice treated with the drug combination was 64% compared with 40% and 47% in mice treated with DIM-C-pPhC₆H₅ aerosol and docetaxel alone, respectively.
The combination treatment inhibited the lung cancer by decreased expression of proteins associated with the pro-inflammatory cytokines, cancer cells survival, and proliferation through stimulating the production of the new blood vessels.
Furthermore, the combination also increased expression of genes involved autophagy in the tumor formation, compared to the tumor cell counts from single-agent treatment and control groups.
Dr. Ichite N, the lead scientist said, "These results suggest that DIM-C-pPhC₆H₅ aerosol enhanced the anticancer activity of docetaxel in a lung cancer model by activating multiple signaling pathways".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice by Song JM1, Qian X1, Teferi F1, Pan J2, Wang Y2, Kassie F. (PubMed)
(2) Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer by Ichite N1, Chougule M, Patel AR, Jackson T, Safe S, Singh M. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Thursday, May 2, 2019
Herbal Ginger, The Potential Anti Male Infertility Functional Remedy, Researchers Find
Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such group are seeking help from the professionals.
In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factors correlated to the increased infertile rate over the past few decades.
Dr. the lead scientist in the concern of obesity in the risk women infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women".
The results suggested that if you are obese, your risk of infertility is higher compared to normal weight women
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine fro the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of the continued efforts to discover a natural remedy for the treatment of infertility, researchers investigated the ginger activity on male reproductive functions.
The randomized double-blind, placebo-controlled trial included 100 infertility treatment candidates admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in another group).
At the end of the experiment, according to the sperm DNA fragmentation (SDF) analysis, the ginger treatment group showed a significant lower of the average positive percentage of SDF compared to the placebo group.
However, there were no significant differences in other semen parameters between the two groups.
The finding clearly suggested that ginger improves the SDF profile in the infertile men.
In order to reveal more information about ginger anti-male infertility activity, researchers investigated the preventive effects of ginger and turmeric rhizomes on some biomarkers of male reproductive function in L-NAME-induced hypertensive rats.
Male Wistar rats selected to the study were divided into seven groups (n = 10): normotensive control rats; induced (L-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.
After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of L-NAME (40 mg/kg/day).
Application of L-NAME showed a significant decrease in serum total testosterone and epididymal sperm progressive motility without affecting sperm viability in hypertensive rats.
Hypertensive rats exerted an increase of oxidative stress by decreasing the level of antioxidant enzymes produced by the rats.
Furthermore, hypertensive rats also displayed a decreased testicular and epididymal NO level with concomitant elevation in arginase activity that affects the sperm counts.
Dietary supplementation with turmeric or ginger efficiently normalized the alterations in biomarkers of reproductive function in hypertensive rats.
Dr. Akinyemi AJ, and colleagues wrote, "The inhibition of arginase activity and increase in NO and testosterone levels by both rhizomes could suggest a possible mechanism of action for the prevention of male infertility in hypertension".
Taken altogether, ginger used alone or combined with turmeric may be considered functional remedies for the prevention and treatment of male infertility, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Hosseini J1, Mardi Mamaghani A2, Hosseinifar H2, Sadighi Gilani MA3, Dadkhah F2, Sepidarkish M4. (PubMed)
(2) Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi AJ1,2,3, Adedara IA4,5, Thome GR3, Morsch VM3, Rovani MT6, Mujica LKS6, Duarte T7, Duarte M7, Oboh G1, Schetinger MRC3. (PubMed)
(3) Impact of obesity on infertility in women by Zeynep Özcan Dağ1 and Berna Dilbaz. (PMC)
Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).
Believe it or not, only a very small number of such group are seeking help from the professionals.
In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.
In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.
In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.
Some researchers suggested that the widespread obesity in North America may be the major factors correlated to the increased infertile rate over the past few decades.
Dr. the lead scientist in the concern of obesity in the risk women infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".
And, "Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women".
The results suggested that if you are obese, your risk of infertility is higher compared to normal weight women
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine fro the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of the continued efforts to discover a natural remedy for the treatment of infertility, researchers investigated the ginger activity on male reproductive functions.
The randomized double-blind, placebo-controlled trial included 100 infertility treatment candidates admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in another group).
At the end of the experiment, according to the sperm DNA fragmentation (SDF) analysis, the ginger treatment group showed a significant lower of the average positive percentage of SDF compared to the placebo group.
However, there were no significant differences in other semen parameters between the two groups.
The finding clearly suggested that ginger improves the SDF profile in the infertile men.
In order to reveal more information about ginger anti-male infertility activity, researchers investigated the preventive effects of ginger and turmeric rhizomes on some biomarkers of male reproductive function in L-NAME-induced hypertensive rats.
Male Wistar rats selected to the study were divided into seven groups (n = 10): normotensive control rats; induced (L-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.
After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of L-NAME (40 mg/kg/day).
Application of L-NAME showed a significant decrease in serum total testosterone and epididymal sperm progressive motility without affecting sperm viability in hypertensive rats.
Hypertensive rats exerted an increase of oxidative stress by decreasing the level of antioxidant enzymes produced by the rats.
Furthermore, hypertensive rats also displayed a decreased testicular and epididymal NO level with concomitant elevation in arginase activity that affects the sperm counts.
Dietary supplementation with turmeric or ginger efficiently normalized the alterations in biomarkers of reproductive function in hypertensive rats.
Dr. Akinyemi AJ, and colleagues wrote, "The inhibition of arginase activity and increase in NO and testosterone levels by both rhizomes could suggest a possible mechanism of action for the prevention of male infertility in hypertension".
Taken altogether, ginger used alone or combined with turmeric may be considered functional remedies for the prevention and treatment of male infertility, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1)The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Hosseini J1, Mardi Mamaghani A2, Hosseinifar H2, Sadighi Gilani MA3, Dadkhah F2, Sepidarkish M4. (PubMed)
(2) Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi AJ1,2,3, Adedara IA4,5, Thome GR3, Morsch VM3, Rovani MT6, Mujica LKS6, Duarte T7, Duarte M7, Oboh G1, Schetinger MRC3. (PubMed)
(3) Impact of obesity on infertility in women by Zeynep Özcan Dağ1 and Berna Dilbaz. (PMC)
Wednesday, May 1, 2019
Honey Protects the Bone Mass with No Side Effect, According to Studies
Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.
Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.
Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.
Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.
People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.
Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.
Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.
Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".
And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".
The results indicated a link to an unhealthy diet in the risk of osteoporosis.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.
The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise).
Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.
After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S.
Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.
Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".
In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.
In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.
The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.
HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.
Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.
The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.
Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.
Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)
Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.
Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.
Risk factors of losing bone density include gender, (women are more likely to develop osteoporosis compared to men) the increase in age, race, (African Americans have both lower rates of bone density loss and osteoporosis), family history.
People with low bone mass accompanied by progressive bone density loss over time are associated with an increased risk of developing osteoporosis.
Low bone mass is a risk factor of osteoporosis, The condition may also increase the incidence of bone fracture if it is accompanied by other risk factors.
Some researchers suggested that people who follow a healthy diet pattern are less likely to develop osteoporosis.
Dr. Małgorzata Kostecka in the examination of the role of a healthy diet in the prevention of osteoporosis in perimenopausal period, wrote, "Diet of a large part of society is not properly balanced which can cause abnormalities in achieving proper bone mineralization. Long-term deficiencies in calcium and vitamin D in daily diet are the cause of taking dietary supplements".
And, "Changes in the nutritional regimen are required already during childhood because nutritional mistakes are the main cause of diet-related diseases in adulthood".
The results indicated a link to an unhealthy diet in the risk of osteoporosis.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for the protection of bone structure investigated the honey effects on the cessation of exercise on bone properties in young female rats.
The experiment included a total of eighty four 12-week-old Sprague-Dawley female rats randomly divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8 = 8 weeks, 16 = 16 weeks, S = sedentary without honey supplementation, H = honey supplementation, and J = jumping exercise).
Jumping exercise consisted of 40 jumps/day for 5 days/week and honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week.
After 8 weeks of cessation of exercise, honey supplementation groups (8JH) showed higher tibial energy, proximal total bone density, a midshaft cortical moment of inertia, and cortical area, compared to 16S.
Continuous sixteen weeks of combined jumping and honey group (16JH) exerted a significant greater tibial maximum force, energy, proximal total bone density, proximal trabecular bone density, midshaft cortical bone density, cortical area, and midshaft cortical moment of inertia, compared to 16S.
Dr. Tavafzadeh SS, the lead scientist said, "the beneficial effects of 8 weeks of combined exercise and honey supplementation still can be observed after 8 weeks of the cessation and exercise and supplementation".
In other words, these comparative results suggested that long term combined exercise and honey supplementation may have a long term effect on the bone structure, even after the cessation of exercise and honey supplementation.
In order to reveal more information about honey effects on bone structure, researchers examined the jumping exercise intensities combined with honey on bone and gonadotrophins in an animal model.
The experimental groups selected to the study were required to exercise 20 or 80 jumps per day combined with or without honey supplementation (HJ20, HJ80, J20, and J80), Oher groups selected to the study also included honey supplementation (H), sedentary without supplementation control (C), and baseline control (C0) groups.
HJ80 showed the greatest beneficial effects on tibial and femoral mass, serum total calcium and alkaline phosphatase concentrations, compared to the lower levels of serum follicle stimulating hormone concentrations in H, J20, J80, particularly in the C group.
Furthermore, the serum luteinizing hormone concentrations were significantly (p < 0.05) greater in HJ20, HJ80 and J20 compared to J80.
The surprising result indicated moderate jumping exercise combined with honey supplementation may have a better effect compared to high-intensity exercise + honey supplement on bone mass and density.
Moreover, honey may have protection against the adverse effects induced by jumping exercise on gonadotropins in female rats.
Taken altogether, honey may be considered a functional remedy for the protection of bone mass regardless of the types of exercise, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bone Mechanical Properties and Mineral Density in Response to Cessation of Jumping Exercise and Honey Supplementation in Young Female Rats by Tavafzadeh SS1, Ooi FK1, Chen CK1, Sulaiman SA2, Hung LK. (PubMed)
(2) Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats by Mosavat M, Ooi FK1, Mohamed M. (PubMed)
(3) The role of healthy diet in the prevention of osteoporosis in perimenopausal period by Małgorzata Kostecka. (PMC)
Herbal Artichoke In the Promotion of Digestive Health
The digestive system is an organ consists of the gastrointestinal tract and other organs associated with digestive functioning including the salivary glands, pancreas, liver, and gallbladder.
Digestion is a process of breaking down foods into a smaller and smaller portion that can be absorbed and assimilated into the body.
Digestive disorders can be caused by the digestive problem or some underlying diseases, including GERD, IBS,...
Most common symptoms of digestive disorders include bloating, constipation, diarrhea, heartburn. fecal incontinence.and pain in the belly.
Although there are many risk factors associated with the onset of digestive problems, some researchers suggested that the promotion of the Western diet may have a strong implication in the induction of digestive disorders.
Dr. Marit K. Zinöcker, the lead scientist in the investigation of the Western diet and Microbiome wrote, "the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome".
And, " The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".
The findings clearly explained the negative impact of the Western diet in the alternation of the ratio of gut microbes, leading to digestive disorders in the initiation of chronic diseases.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural remedy for the improvement of digestive function examined whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition and other symptoms associated with chronic constipation.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043.
According to tested assays, additional artichoke diet exerted a strong effect in promotion of the colonized by the probiotic strain in all volunteers' gut, after 15 days of feeding.
Injection of artichoke also demonstrated a significant increase of butyric and valeric acids with a decrease of lactic acid, the indications of improvement of gut microbiota.
The diet integrated with artichoke also resolved the constipation symptoms by reducing the fecal beta-glucuronidase activity.
Interestingly, according to the analysis of symptom profile, there was a marked reduction in abdominal distension and feeling of incomplete evacuation in volunteers with constipation problems.
The results suggested that included artichoke in a diet promotes a healthy digestive system by balancing the ratio of gut microbiota.
In order to reveal more information about artichoke enhanced the function of the gastrointestinal tract, researchers investigated the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition fecal microbiota, the concentration of fecal SCFA, bowel habit and gastrointestinal symptoms.
45 volunteers were selected to a double-blind, randomized, placebo-controlled, parallel-group study.
After a 7 days run-in period, subjects were randomly assigned to three groups of fifteen subjects each, consuming either snack bars with CH or JA, or snack bars without fructans (placebo); for 7 d (adaptation period), they ingested one snack bar per day (7.7 g fructan/d) and continued for 14 d with two snack bars per day.
At the end of the intervention, consumption of CH or JA improved the ratio of gut microbiota by increasing the counts of good bacterias such as bifidobacteria (+1.2 log10 in 21 d) and decreasing the counts of bad bacteria such as Bacteroides/Prevotella and Clostridium histolyticum/C. lituseburense group in frequency.
Consumption of CH or JA also resulted in mild and moderate flatulence in a few subjects compared to placebo with a slight effected of tool consistency.
Dr. Kleessen B, the lead scientist said, "...adaptation on increased doses of CH or JA in bakery products stimulates the growth of bifidobacteria and may contribute to the suppression of potentially pathogenic bacteria".
Taken altogether, artichoke alone and combined with other herbal remedies may be considered functional remedies for the treatment of the digestive disorder, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(2) Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers by Kleessen B1, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M.(PubMed)
(3) The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease by Zinöcker MK1, Lindseth IA. (PubMed)
Digestion is a process of breaking down foods into a smaller and smaller portion that can be absorbed and assimilated into the body.
Digestive disorders can be caused by the digestive problem or some underlying diseases, including GERD, IBS,...
Most common symptoms of digestive disorders include bloating, constipation, diarrhea, heartburn. fecal incontinence.and pain in the belly.
Although there are many risk factors associated with the onset of digestive problems, some researchers suggested that the promotion of the Western diet may have a strong implication in the induction of digestive disorders.
Dr. Marit K. Zinöcker, the lead scientist in the investigation of the Western diet and Microbiome wrote, "the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome".
And, " The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".
The findings clearly explained the negative impact of the Western diet in the alternation of the ratio of gut microbes, leading to digestive disorders in the initiation of chronic diseases.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural remedy for the improvement of digestive function examined whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition and other symptoms associated with chronic constipation.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043.
According to tested assays, additional artichoke diet exerted a strong effect in promotion of the colonized by the probiotic strain in all volunteers' gut, after 15 days of feeding.
Injection of artichoke also demonstrated a significant increase of butyric and valeric acids with a decrease of lactic acid, the indications of improvement of gut microbiota.
The diet integrated with artichoke also resolved the constipation symptoms by reducing the fecal beta-glucuronidase activity.
Interestingly, according to the analysis of symptom profile, there was a marked reduction in abdominal distension and feeling of incomplete evacuation in volunteers with constipation problems.
The results suggested that included artichoke in a diet promotes a healthy digestive system by balancing the ratio of gut microbiota.
In order to reveal more information about artichoke enhanced the function of the gastrointestinal tract, researchers investigated the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition fecal microbiota, the concentration of fecal SCFA, bowel habit and gastrointestinal symptoms.
45 volunteers were selected to a double-blind, randomized, placebo-controlled, parallel-group study.
After a 7 days run-in period, subjects were randomly assigned to three groups of fifteen subjects each, consuming either snack bars with CH or JA, or snack bars without fructans (placebo); for 7 d (adaptation period), they ingested one snack bar per day (7.7 g fructan/d) and continued for 14 d with two snack bars per day.
At the end of the intervention, consumption of CH or JA improved the ratio of gut microbiota by increasing the counts of good bacterias such as bifidobacteria (+1.2 log10 in 21 d) and decreasing the counts of bad bacteria such as Bacteroides/Prevotella and Clostridium histolyticum/C. lituseburense group in frequency.
Consumption of CH or JA also resulted in mild and moderate flatulence in a few subjects compared to placebo with a slight effected of tool consistency.
Dr. Kleessen B, the lead scientist said, "...adaptation on increased doses of CH or JA in bakery products stimulates the growth of bifidobacteria and may contribute to the suppression of potentially pathogenic bacteria".
Taken altogether, artichoke alone and combined with other herbal remedies may be considered functional remedies for the treatment of the digestive disorder, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(2) Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers by Kleessen B1, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M.(PubMed)
(3) The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease by Zinöcker MK1, Lindseth IA. (PubMed)
Tuesday, April 30, 2019
Phytochemical Sinigrin, the Potential Anti Tongue Cancer Bioactive Compound, Researchers Found
Tongue cancer is a medical condition caused by irregular cell growth in the tissue of the tongue, due to the alternation of cell DNA.
Most cases of tongue cancer begin in the cells on the surface of the inner lining of the tongue. At the early stage, tongue cancer patients may not experience any size due to the very small of the tumors.
However, at the advanced stage, patients may experience symptoms of the persistent tongue and/or jaw pain as the tumor has pressed on the nearby nerve cells, a lump or tumor inside the mouth. a white or red patch on the gums, tongue, tonsil or lining in the mouth and persistent sore throat and difficulty swallowing or chewing.
If you have some of the above symptoms, please make sure to check with your doctor to rule out the possibility.
There are many risk factors associated with the disease, including long-term use of tobacco, excessive alcohol drinking, sun exposure to your lips.
Some researchers suggested that sexually transmitted virus human papillomavirus (HPV) and people with a weakened immune system also have been found in patients with tongue cancer.
The Cleveland Clinic wrote in the article of Oropharyngeal Human Papilloma Virus (HPV) Infection
"Human papillomavirus (HPV), commonly known as the virus that causes genital warts and cervical cancer in women, is increasingly being recognized now as a cause of infections that colonize the back of the mouth (throat or oropharynx), including the tongue base and tonsils, and potentially a cause of cancer of the head and neck".
The results strongly suggested that people who carry the HPV virus in their mouth are at an increased risk of tongue cancer, compared to those without.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on the searching natural compound with the inhibitory activity against the tongue
carcinogenesis examined the effects of indole-3-carbinol (I3C) and sinigrin (SIN) on the initiation and post-initiation phases of tongue cancer.
Selected male ACI/N rats. induced tongue cancer by the injection of by 4-nitroquinoline 1-oxide (4-NQO) divided into
* Group 1 was given 4-NQO (10 ppm) in the drinking water for 12 weeks, starting at 7 weeks of age;
* Groups 2 and 3 were given 4-NQO and fed the diets containing I3C (1,000 ppm) and SIN (1,200 ppm) for 14 weeks, respectively, starting at 6 weeks of age;
* Groups 4 and 5 were given 4-NQO and then they were fed I3C and SIN containing diets for 23 weeks, respectively, starting one week after 4-NQO exposure;
* Groups 6 and 7 were given I3C and SIN alone, respectively, during the experiment; and
* Group 8 served as an untreated control.
At the end of the experiment at week 37, the incidence of tongue neoplasms (squamous cell papilloma and carcinoma) in group 2 (1/15, 7%), group 3 (1/15, 7%), group 4 (3/15, 20%) or group 5 (2/15, 13%) was significantly smaller than that in group 1 (12/17, 71%).
Group groups 2, 3, and 5 showed no tongue carcinomas developed. In other words, the injection of I3C and SIN restored the infected cell to healthy levels induced by the 4-NQO.
Group treated with I3C and SIN also showed reduced levels of the incidence of preneoplastic lesions such as hyperplasia and dysplasia.
In other words, I3C and SIN not only are effective against tongue cancer but also inhibit the progression of preneoplastic lesions of the tongue in group 2 (11/15, 73%), group 3 (10/15, 67%), group 4 (11/15, 73%) or group 5 (10/15, 67%) was significantly lower than that in group 1 (17/17, 100%) (P = 0.04 or P = 0.02).
Furthermore, There were no tongue neoplasms in rats of groups 6, 7, and 8.
Moreover, the Administration of I3C and SIN also caused significant decreases in the number and area of silver-stained nucleolar organizer regions protein (AgNORs) in the expression of in the tongue tumor pathology.
Dr. Tanaka T and colleagues wrote in the final report, " I3C and SIN inhibited rat tongue carcinogenesis in both the initiation and post-initiation phases, when administered in these respective phases together with, or following treatment with, 4-NQO".
Taken altogether, sinigrin (SIN) used alone or combined with I3C may be effective for the prevention and treatment of tongue cancer, pending to the confirmation of large sample size and multicenter human study.
Intake of SIN in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tonguecarcinogenesis by Tanaka T1, Kojima T, Morishita Y, Mori H. (PubMed)
(2) Oropharyngeal Human Papilloma Virus (HPV) Infection by (Cleveland Clinic)
Most cases of tongue cancer begin in the cells on the surface of the inner lining of the tongue. At the early stage, tongue cancer patients may not experience any size due to the very small of the tumors.
However, at the advanced stage, patients may experience symptoms of the persistent tongue and/or jaw pain as the tumor has pressed on the nearby nerve cells, a lump or tumor inside the mouth. a white or red patch on the gums, tongue, tonsil or lining in the mouth and persistent sore throat and difficulty swallowing or chewing.
If you have some of the above symptoms, please make sure to check with your doctor to rule out the possibility.
There are many risk factors associated with the disease, including long-term use of tobacco, excessive alcohol drinking, sun exposure to your lips.
Some researchers suggested that sexually transmitted virus human papillomavirus (HPV) and people with a weakened immune system also have been found in patients with tongue cancer.
The Cleveland Clinic wrote in the article of Oropharyngeal Human Papilloma Virus (HPV) Infection
"Human papillomavirus (HPV), commonly known as the virus that causes genital warts and cervical cancer in women, is increasingly being recognized now as a cause of infections that colonize the back of the mouth (throat or oropharynx), including the tongue base and tonsils, and potentially a cause of cancer of the head and neck".
The results strongly suggested that people who carry the HPV virus in their mouth are at an increased risk of tongue cancer, compared to those without.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on the searching natural compound with the inhibitory activity against the tongue
carcinogenesis examined the effects of indole-3-carbinol (I3C) and sinigrin (SIN) on the initiation and post-initiation phases of tongue cancer.
Selected male ACI/N rats. induced tongue cancer by the injection of by 4-nitroquinoline 1-oxide (4-NQO) divided into
* Group 1 was given 4-NQO (10 ppm) in the drinking water for 12 weeks, starting at 7 weeks of age;
* Groups 2 and 3 were given 4-NQO and fed the diets containing I3C (1,000 ppm) and SIN (1,200 ppm) for 14 weeks, respectively, starting at 6 weeks of age;
* Groups 4 and 5 were given 4-NQO and then they were fed I3C and SIN containing diets for 23 weeks, respectively, starting one week after 4-NQO exposure;
* Groups 6 and 7 were given I3C and SIN alone, respectively, during the experiment; and
* Group 8 served as an untreated control.
At the end of the experiment at week 37, the incidence of tongue neoplasms (squamous cell papilloma and carcinoma) in group 2 (1/15, 7%), group 3 (1/15, 7%), group 4 (3/15, 20%) or group 5 (2/15, 13%) was significantly smaller than that in group 1 (12/17, 71%).
Group groups 2, 3, and 5 showed no tongue carcinomas developed. In other words, the injection of I3C and SIN restored the infected cell to healthy levels induced by the 4-NQO.
Group treated with I3C and SIN also showed reduced levels of the incidence of preneoplastic lesions such as hyperplasia and dysplasia.
In other words, I3C and SIN not only are effective against tongue cancer but also inhibit the progression of preneoplastic lesions of the tongue in group 2 (11/15, 73%), group 3 (10/15, 67%), group 4 (11/15, 73%) or group 5 (10/15, 67%) was significantly lower than that in group 1 (17/17, 100%) (P = 0.04 or P = 0.02).
Furthermore, There were no tongue neoplasms in rats of groups 6, 7, and 8.
Moreover, the Administration of I3C and SIN also caused significant decreases in the number and area of silver-stained nucleolar organizer regions protein (AgNORs) in the expression of in the tongue tumor pathology.
Dr. Tanaka T and colleagues wrote in the final report, " I3C and SIN inhibited rat tongue carcinogenesis in both the initiation and post-initiation phases, when administered in these respective phases together with, or following treatment with, 4-NQO".
Taken altogether, sinigrin (SIN) used alone or combined with I3C may be effective for the prevention and treatment of tongue cancer, pending to the confirmation of large sample size and multicenter human study.
Intake of SIN in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tonguecarcinogenesis by Tanaka T1, Kojima T, Morishita Y, Mori H. (PubMed)
(2) Oropharyngeal Human Papilloma Virus (HPV) Infection by (Cleveland Clinic)
Herbal Artichoke Normalizes the Level of Total Lipids Profile
Total lipids profile is a lab test that measures the abnormal levels of cholesterol and triglycerides that can lead to cardiovascular disease.
The healthy level of low-density cholesterol is less than 70 mg/dL for those in very high-risk patients, 100 mg/dL for high-risk patients and 130 mg/dL for individuals who are at low risk for coronary artery disease.
The healthy level of high-density cholesterol is any number that is higher than 40 mg/dl.
The healthy level of triglycerides (TG) is any number that is less than 150 mg/dl.
Where dl is milligrams per deciliter
Total cholesterol is the total amount of cholesterol in the blood using the formula HDL level + LDL level + 20 percent of triglyceride level from the results of total lipids profile.
The healthy levels of total cholesterol can be classified as follows
Optimal level: Less than 200 mg/dL
Normal high level: 200-239 mg/dL
High level: 240 mg/dL and above
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural remedy in the reducing risk and treatment of cardiovascular disease, researchers examined the artichoke in the subjects with hypercholesterolemia.
After 2 months of treatment, injection of artichoke showed a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), compared to standard diet.
There were no side effects found in the tested subjects during the course of study.
Dr. Cicero AFG, the lead scientists wrote, " on the short-term, the tested nutraceutical has been shown to be well tolerated and effective, even if not containing any statin-like compound".
Dr. Santos HO in the study to investigate the effect of artichoke on lipid profile by searching the medical literature appraised the Cochrane, MEDLINE, and Web of Science databases, including articles published between 2000 and June 2018 on intervention in humans only.
The review on the selected studies suggested that
* ALE decreased serum LDL, total cholesterol and triglyceride concentrations.
* ALE showed no effect on the levels of HDL.
In details, according to the differentiation, ALE at doses of 2 to 3 g/d decreased 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides.
The improvement of the lipid profile of ALE was attributed to the components luteolin and chlorogenic acids found abundantly in artichoke.
Furthermore, the cardioprotective effect of ALE was associated with soluble fibers and inulin in the herb or food.
The findings clearly suggested that ALE protects the heart by improving the condition of the cluster associated with metabolic syndrome, particularly in blood cholesterol.
Taken together, artichoke may be considered a functional remedy for improving the lipid profile against diseases associated with hypercholesterolemia, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease by Cicero AFG1, Fogacci F2, Bove M2, Giovannini M2, Veronesi M2, Borghi C. (PubMed)
(2) The effect of artichoke on lipid profile: A review of possible mechanisms of action by Santos HO1, Bueno AA2, Mota JF. (PubMed)
Monday, April 29, 2019
3,3'-Diindolylmethane, the Natural Ingredient for the Treatment of Chronic Diseases
Chronic diseases are a group of medical conditions most commonly associated with aging, including
arthritis, cardiovascular diseases such as heart attacks and stroke, cancer, diabetes, epilepsy and seizures, and obesity.
The exacted causes of chronic diseases are not identified. Aging, unhealthy lifestyle such as excessive alcohol drinking smoking, poor diet, lack of physical activity are the most common risk factors associated with the onset of the disease.
According to the joint study led by the Fordham University, chronic diseases are among the most prevalent and costly health conditions in the US, affecting over 133 millions of the US population as many of them suffer from at least one chronic disease and the number is growing in the rapid rate.
Some chronic diseases such as cancer have been found to be the leading causes of hospitalization, long-term disability, reduced quality of life, and death.
According to the Centers for Disease Control, chronic diseases also are the major driver of health care costs accounted for nearly 75 percent of aggregate healthcare spending and increased absenteeism that impact workforce patterns.
Each chronic patient has cost the health care spending $5300 annually.
Believe it or not, chronic diseases in the US, chronic diseases are responsible for 7 out of 10 deaths yearly. In other words, chronic diseases kill more than 1.7 million Americans each year.
Some researchers suggested by changing unhealthy lifestyle pattern, chronic diseases may be preventable.
Dr. Walter C. Willett, the lead scientist in the concern about the risk chronic disease in poor lifestyle individuals wrote, "Several lines of evidence indicate that realistic modifications of diet and lifestyle can prevent most CAD, stroke, diabetes, colon cancer, and smoking-related cancers".
And, "Among U.S. adults, more than 90 percent of type 2 diabetes, 80 percent of CAD, 70 percent of stroke, and 70 percent of colon cancer are potentially preventable by a combination of nonsmoking, avoidance of overweight, moderate physical activity, healthy diet, and moderate alcohol consumption".
Researchers on finding a natural ingredient for the treatment of chronic diseases analyzed 3,3'-diindolylmethane (DIM) several biological activities on cellular and molecular levels against chronic diseases, including cancer.
DIM enhanced the function of the drug-metabolizing enzyme by blocking activity involved the promotion of cancer expression.
DIM affects multiple signaling pathways and target molecules which controls cell division, apoptosis, or angiogenesis deregulated in cancer cells.
DIM also prevented the development of hormone-dependent cancers.
Injection of DIM also was found to inhibit the onset of cardiovascular disease, obesity, and diabetes reduction through its antioxidant property in reducing oxidative stress caused by overexpression of free radical.
Dr. Licznerska B, the lead scientist after taking into account other factors wrote in the final report, "the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in the prevention of chronic diseases".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol and Its Role in Chronic Diseases by Licznerska B1, Baer-Dubowska W. (PubMed)
(2) An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health by Wullianallur Raghupathi1 and Viju Raghupathi. (PubMed)
(3) Prevention of Chronic Disease by Means of Diet and Lifestyle Changes by Walter C. Willett, Jeffrey P. Koplan, Rachel Nugent, Courtenay Dusenbury, Pekka Puska, and Thomas A. Gaziano. (PubMed)
arthritis, cardiovascular diseases such as heart attacks and stroke, cancer, diabetes, epilepsy and seizures, and obesity.
The exacted causes of chronic diseases are not identified. Aging, unhealthy lifestyle such as excessive alcohol drinking smoking, poor diet, lack of physical activity are the most common risk factors associated with the onset of the disease.
According to the joint study led by the Fordham University, chronic diseases are among the most prevalent and costly health conditions in the US, affecting over 133 millions of the US population as many of them suffer from at least one chronic disease and the number is growing in the rapid rate.
Some chronic diseases such as cancer have been found to be the leading causes of hospitalization, long-term disability, reduced quality of life, and death.
According to the Centers for Disease Control, chronic diseases also are the major driver of health care costs accounted for nearly 75 percent of aggregate healthcare spending and increased absenteeism that impact workforce patterns.
Each chronic patient has cost the health care spending $5300 annually.
Believe it or not, chronic diseases in the US, chronic diseases are responsible for 7 out of 10 deaths yearly. In other words, chronic diseases kill more than 1.7 million Americans each year.
Some researchers suggested by changing unhealthy lifestyle pattern, chronic diseases may be preventable.
Dr. Walter C. Willett, the lead scientist in the concern about the risk chronic disease in poor lifestyle individuals wrote, "Several lines of evidence indicate that realistic modifications of diet and lifestyle can prevent most CAD, stroke, diabetes, colon cancer, and smoking-related cancers".
And, "Among U.S. adults, more than 90 percent of type 2 diabetes, 80 percent of CAD, 70 percent of stroke, and 70 percent of colon cancer are potentially preventable by a combination of nonsmoking, avoidance of overweight, moderate physical activity, healthy diet, and moderate alcohol consumption".
Researchers on finding a natural ingredient for the treatment of chronic diseases analyzed 3,3'-diindolylmethane (DIM) several biological activities on cellular and molecular levels against chronic diseases, including cancer.
DIM enhanced the function of the drug-metabolizing enzyme by blocking activity involved the promotion of cancer expression.
DIM affects multiple signaling pathways and target molecules which controls cell division, apoptosis, or angiogenesis deregulated in cancer cells.
DIM also prevented the development of hormone-dependent cancers.
Injection of DIM also was found to inhibit the onset of cardiovascular disease, obesity, and diabetes reduction through its antioxidant property in reducing oxidative stress caused by overexpression of free radical.
Dr. Licznerska B, the lead scientist after taking into account other factors wrote in the final report, "the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in the prevention of chronic diseases".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol and Its Role in Chronic Diseases by Licznerska B1, Baer-Dubowska W. (PubMed)
(2) An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health by Wullianallur Raghupathi1 and Viju Raghupathi. (PubMed)
(3) Prevention of Chronic Disease by Means of Diet and Lifestyle Changes by Walter C. Willett, Jeffrey P. Koplan, Rachel Nugent, Courtenay Dusenbury, Pekka Puska, and Thomas A. Gaziano. (PubMed)
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