Ovarian cancer is a chronic and medical condition caused by cell growth irregularly in the tissue of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progression, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvis area, changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imagine in the luciferase-expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to placebo, only small individual foci of luminescence at the site of tumor cells inoculation was found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cells apoptosis through its cytotoxic effects without causing harm to the nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
Wednesday, May 8, 2019
Bromelain Found in Pineapple Suppresses the Symptoms and Onset of Osteoarthritis (OA)
Osteoarthritis is an inflammation of joints caused by the depletion of the cartilage on the ends of the bones due to the wear and tear over time.
The disease is one most common form of arthritis that affects millions of people worldwide.
According to the statistics, in the US, approximately 10% of men and 13% in women aged 60 years or older have osteoarthritis (OA).
Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.
Besides pain on the joints, other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.
Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.
Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.
Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".
And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.
The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
At week 4, both bromelain and diclofenac treated groups showed an improvement of total the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.
According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.
At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.
In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.
Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)
The disease is one most common form of arthritis that affects millions of people worldwide.
According to the statistics, in the US, approximately 10% of men and 13% in women aged 60 years or older have osteoarthritis (OA).
Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.
Besides pain on the joints, other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.
Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.
Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.
Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".
And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.
The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
At week 4, both bromelain and diclofenac treated groups showed an improvement of total the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.
According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.
At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.
In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.
Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)
Tuesday, May 7, 2019
Honey, The Functional and Natural Depressant
Depression is a psychological illness which affects a patient mentally, including thinking and feeling and physically such as loss of interest in physical activity.
The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.
There are some types of depression which can be classified as follow
1. Seasonal affective disorder (SAD) is caused by the change of weather. The mood of patients is affected by the weather and time of the year.
2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.
3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.
4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.
Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.
If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measure.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).
The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.
Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.
Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.
Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.
Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.
Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.
Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.
Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.
Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".
Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).
In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.
Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.
Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.
Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.
Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)
The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.
There are some types of depression which can be classified as follow
1. Seasonal affective disorder (SAD) is caused by the change of weather. The mood of patients is affected by the weather and time of the year.
2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.
3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.
4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.
Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.
If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measure.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).
The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.
Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.
Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.
Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.
Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.
Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.
Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.
Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.
Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".
Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).
In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.
Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.
Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.
Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.
Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)
Herbal Artichoke, the Anti Inflammatory Bioactive Compound
Inflammation is a natural response of the immune system against the stimuli and foreign pathogens which try to enter the body through wound or injury.
In the acute phase of infection, after receiving the message transmitted by the central nervous system, the immune macrophages stimulating the blood palette to cover the affected site and production of pro-inflammatory cytokines to protect the body against microorganisms.
Some anti-inflammatory cytokines in this phase may also switch to proinflammatory activity, causing overproduction of proinflammatory cytokines.
In some cases, depending on the severity of the wound, overexpression of pro-inflammatory cytokines may cause damage and death of nearby cells, leading to the formation of scars.
Most common symptoms of the acute phase of infection area pain, swelling and redness in the affected areas.
If the immune macrophages kill off the foreign pathogens in the acute phase of infection, the inflammatory progress proceeds to other stages including the stage one of acute phase of infection followed by the repair and regeneration stage, where collagen fibers are formed then by the remodeling and maturation stage, where the new tissue continue to remodel, strengthen and improve.
Chronic inflammation occurs if the immune system can not kill off all invaders within a set period, it will adapt to the news change, leading to chronic low-grade inflammation, the major cause of various chronic illness, including cardiovascular disease and diabetes.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of Porphyromonas gingivalis, the disease has been found to induce the expression of inflammatory cytokines that promote inflammatory bone destruction, investigated the anti-inflammatory effects of an extract from Cynara scolymus L. and its pharmacologically effective compound cynaropicrin, a sesquiterpene lactone, on human gingival fibroblasts (HGFs).
Human gingival fibroblasts (HGFs)used in the study were induced inflammation by lipopolysaccharide (LPS).
Artichoke bioactive compound injection inhibited the production of pro-inflammatory cytokines in LPS-stimulated HGFs in a dose-dependent manner.
P. gingivalis LPS-induced expression of enzymes and proteins in the cellular response to inflammation were also suppressed by cynaropicrin.
The additional analysis also suggested that cynaropicrin's inhibition of P. gingivalis LPS-induced production pro-inflammatory expression may be due to the inhibition of the activation of the inflammatory pathways.
Dr. Hayata M, the lead scientist said, "These results suggest that cynaropicrin may be useful for preventing periodontal diseases and could prove valuable in the development of more effective preventative approaches for periodontal diseases".
In order to reaffirm the efficacy of artichoke anti-inflammatory activity, researchers at the University of Sfax examined the Artichoke Leaves Extracts (ALE) phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test.
In the carrageenan (Carr) model induced paw edema, EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents exerted the strongest antioxidants activities, according to the DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE.
Moreover, administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo).
Based on the finding, Dr. Ben Salem M, the lead scientist wrote, "ALE displayed high potential as a natural source of minerals and phytochemicals compounds with antioxidant and anti-inflammatory properties".
Taken altogether, artichoke processed abundantly bioactive compound may be considered a functional remedy for the treatment of diseases associated with chronic inflammation, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells by Hayata M1,2, Watanabe N2,3, Kamio N2, Tamura M2, Nodomi K2, Tanaka K4, Iddamalgoda A4, Tsuda H5, Ogata Y6, Sato S3, Ueda K1, Imai K. (PubMed)
(2) Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC by Ben Salem M1, Affes H1, Athmouni K2, Ksouda K1, Dhouibi R1, Sahnoun Z1, Hammami S1, Zeghal KM. (PubMed)
In the acute phase of infection, after receiving the message transmitted by the central nervous system, the immune macrophages stimulating the blood palette to cover the affected site and production of pro-inflammatory cytokines to protect the body against microorganisms.
Some anti-inflammatory cytokines in this phase may also switch to proinflammatory activity, causing overproduction of proinflammatory cytokines.
In some cases, depending on the severity of the wound, overexpression of pro-inflammatory cytokines may cause damage and death of nearby cells, leading to the formation of scars.
Most common symptoms of the acute phase of infection area pain, swelling and redness in the affected areas.
If the immune macrophages kill off the foreign pathogens in the acute phase of infection, the inflammatory progress proceeds to other stages including the stage one of acute phase of infection followed by the repair and regeneration stage, where collagen fibers are formed then by the remodeling and maturation stage, where the new tissue continue to remodel, strengthen and improve.
Chronic inflammation occurs if the immune system can not kill off all invaders within a set period, it will adapt to the news change, leading to chronic low-grade inflammation, the major cause of various chronic illness, including cardiovascular disease and diabetes.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of Porphyromonas gingivalis, the disease has been found to induce the expression of inflammatory cytokines that promote inflammatory bone destruction, investigated the anti-inflammatory effects of an extract from Cynara scolymus L. and its pharmacologically effective compound cynaropicrin, a sesquiterpene lactone, on human gingival fibroblasts (HGFs).
Human gingival fibroblasts (HGFs)used in the study were induced inflammation by lipopolysaccharide (LPS).
Artichoke bioactive compound injection inhibited the production of pro-inflammatory cytokines in LPS-stimulated HGFs in a dose-dependent manner.
P. gingivalis LPS-induced expression of enzymes and proteins in the cellular response to inflammation were also suppressed by cynaropicrin.
The additional analysis also suggested that cynaropicrin's inhibition of P. gingivalis LPS-induced production pro-inflammatory expression may be due to the inhibition of the activation of the inflammatory pathways.
Dr. Hayata M, the lead scientist said, "These results suggest that cynaropicrin may be useful for preventing periodontal diseases and could prove valuable in the development of more effective preventative approaches for periodontal diseases".
In order to reaffirm the efficacy of artichoke anti-inflammatory activity, researchers at the University of Sfax examined the Artichoke Leaves Extracts (ALE) phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test.
In the carrageenan (Carr) model induced paw edema, EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents exerted the strongest antioxidants activities, according to the DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE.
Moreover, administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo).
Based on the finding, Dr. Ben Salem M, the lead scientist wrote, "ALE displayed high potential as a natural source of minerals and phytochemicals compounds with antioxidant and anti-inflammatory properties".
Taken altogether, artichoke processed abundantly bioactive compound may be considered a functional remedy for the treatment of diseases associated with chronic inflammation, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells by Hayata M1,2, Watanabe N2,3, Kamio N2, Tamura M2, Nodomi K2, Tanaka K4, Iddamalgoda A4, Tsuda H5, Ogata Y6, Sato S3, Ueda K1, Imai K. (PubMed)
(2) Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity of Cynara scolymus Leaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC by Ben Salem M1, Affes H1, Athmouni K2, Ksouda K1, Dhouibi R1, Sahnoun Z1, Hammami S1, Zeghal KM. (PubMed)
Monday, May 6, 2019
Plantbased Bioactive Compound Sinigrin, the Anti Fungal Infection Bioactive Compound
A fungus is a primitive organism, including mushrooms, mold, and mildew.found in the air, in the soil, on plants, and in water.
Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.
People with a weakened immune system are more likely to infected by fungi, including the fungus Aspergillus which cause lung infection.
Similar to other bacterias, there are millions of different fungal species on Earth, but only about 300 are known to infect people.
Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.
If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measure.
Most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of affected skin.
In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending to the size of the accumulation.
In the seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against fungus Cladosporium cucumerimun Ellis & Arch.
2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.) showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed a limit activity.
According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.
Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing high amount sinigrin.
The finding strongly supports the use of sinigrin for the treatment of fungal infection.
Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.
At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.
Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.
Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".
Taken altogether, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.
People with a weakened immune system are more likely to infected by fungi, including the fungus Aspergillus which cause lung infection.
Similar to other bacterias, there are millions of different fungal species on Earth, but only about 300 are known to infect people.
Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.
If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measure.
Most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of affected skin.
In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending to the size of the accumulation.
In the seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against fungus Cladosporium cucumerimun Ellis & Arch.
2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.) showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed a limit activity.
According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.
Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing high amount sinigrin.
The finding strongly supports the use of sinigrin for the treatment of fungal infection.
Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.
At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.
Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.
Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".
Taken altogether, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
Ginger Protects the Neurons integrity Against Age-Related Neurological Disorders, According to Scientists
Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neuron due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually starts slowly with mild memory loss first and worsens over time. In severe cases, the elderly with AD may lose the ability to carry on a conversation and respond to their environment.
Dementia is a general term of neuro-degenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life, including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease.
For most parts, the causes of these diseases are unknown. researchers cannot explain why elderly with the same health conditions in the same family, some members are susceptible to the onset of dementias while others do not.
Besides aging, geographical, hereditary and viral and toxicological exposure may also correlate to the development of the diseases on the elderly.
Some researchers suggested that unhealthy lifestyle in the Western world in the induction of obesity may be one of the major cause associated with the onset of the condition.
Dr. Mazon JN, the lead scientist, said, "...evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS)".
And, "Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron".
These results clearly suggested that if you are obese, your risk of neurodegenerative diseases is increased substantially compared to non-obese individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.
Ginger phytochemicals exhibited anti-ANDs by targeting different ligand sites.
Furthermore, ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone were effective for ameliorating the neurological symptoms.
Moreover, application of ginger also inhibited the pathological conditions of ANDs by modulating cell death or cell survival signaling proteins.
The results suggested that ginger and its bioactive compounds may have therapeutic potential in ANDs.
Additionally, with an aim to reveal more information about the ginger anti ANDs activity, researchers investigated the neurotrophic effects in primary cultured rat cortical neurons and PC12 cells.
In vivo. ginger diet for 1 month in SAMP8 mice induced age-related learning and memory impairments, showed to reverse of spatial learning and memory deficits by significantly increased the numbers of Ki67-positive cells in the dentate gyrus.
Where Ki-67 protein is associated with cell proliferation or reduplication.
In PC12 cells, the ginger application also exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting.
Taken altogether, ginger may be considered a neuroprotective remedy against age-related neurological disorders, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pharmacotherapeutic potential of ginger and its compounds in age-relatedneurological disorders by Choi JG1, Kim SY2, Jeong M2, Oh MS3. (PubMed)
(2) Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8. by Nakai M1,2, Iizuka M2, Matsui N3, Hosogi K1, Imai A2, Abe N1,2, Shiraishi H1,2, Hirata A1,2, Yagi Y1,2, Jobu K2, Yokota J2, Kato E4, Hosoda S4, Yoshioka S3, Harada K3, Kubo M3, Fukuyama Y3, Miyamura M1,2. (PubMed)
(3) The impact of obesity on neurodegenerative diseases by Mazon JN1, de Mello AH1, Ferreira GK2, Rezin GT. (PubMed)
Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually starts slowly with mild memory loss first and worsens over time. In severe cases, the elderly with AD may lose the ability to carry on a conversation and respond to their environment.
Dementia is a general term of neuro-degenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life, including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease.
For most parts, the causes of these diseases are unknown. researchers cannot explain why elderly with the same health conditions in the same family, some members are susceptible to the onset of dementias while others do not.
Besides aging, geographical, hereditary and viral and toxicological exposure may also correlate to the development of the diseases on the elderly.
Some researchers suggested that unhealthy lifestyle in the Western world in the induction of obesity may be one of the major cause associated with the onset of the condition.
Dr. Mazon JN, the lead scientist, said, "...evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS)".
And, "Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron".
These results clearly suggested that if you are obese, your risk of neurodegenerative diseases is increased substantially compared to non-obese individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.
Ginger phytochemicals exhibited anti-ANDs by targeting different ligand sites.
Furthermore, ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone were effective for ameliorating the neurological symptoms.
Moreover, application of ginger also inhibited the pathological conditions of ANDs by modulating cell death or cell survival signaling proteins.
The results suggested that ginger and its bioactive compounds may have therapeutic potential in ANDs.
Additionally, with an aim to reveal more information about the ginger anti ANDs activity, researchers investigated the neurotrophic effects in primary cultured rat cortical neurons and PC12 cells.
In vivo. ginger diet for 1 month in SAMP8 mice induced age-related learning and memory impairments, showed to reverse of spatial learning and memory deficits by significantly increased the numbers of Ki67-positive cells in the dentate gyrus.
Where Ki-67 protein is associated with cell proliferation or reduplication.
In PC12 cells, the ginger application also exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting.
Taken altogether, ginger may be considered a neuroprotective remedy against age-related neurological disorders, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pharmacotherapeutic potential of ginger and its compounds in age-relatedneurological disorders by Choi JG1, Kim SY2, Jeong M2, Oh MS3. (PubMed)
(2) Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8. by Nakai M1,2, Iizuka M2, Matsui N3, Hosogi K1, Imai A2, Abe N1,2, Shiraishi H1,2, Hirata A1,2, Yagi Y1,2, Jobu K2, Yokota J2, Kato E4, Hosoda S4, Yoshioka S3, Harada K3, Kubo M3, Fukuyama Y3, Miyamura M1,2. (PubMed)
(3) The impact of obesity on neurodegenerative diseases by Mazon JN1, de Mello AH1, Ferreira GK2, Rezin GT. (PubMed)
Sunday, May 5, 2019
Herbal Turmeric, the Best Functional Herb Which Processes Anti Diseases Associated with Chronic Low Grade Inflammation Potential
Inflammation is a natural response induced by the immune system in which the white blood cells in the first line of defense try to destroy the harmful pathogens before they can enter the body to multiply in the acute phase of infection
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.
According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.
In other words, essential oil isolated from turmeric in the form of curcumin-free turmeric (CFT) components is more effective for the treatment of chronic inflammatory disease compared to other extracts.
In the components analysis, turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrene were all contributed to the efficacy of the curcumin-free turmeric (CFT).
In examining the effect of ar-turmerone (ATM) and turmerones (TUR, a mixture of 5 sesquiterpenes including ATM) against disease associated with inflammation, researchers found that both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of inflammation by exhibiting the production of free radicals and protein involved overexpression proinflammatory cytokines.
Furthermore, ATM prevented LPS-induced translocation of certain inflammatory genes.
In a colitis model, oral administration of TUR significantly protected the large bowel against 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58% and colon carcinogenesis.
Moreover, at a low dose, TUR markedly suppressed adenoma multiplicity by 73%, compared to the range of 63-69% of CUR.
Also, the combination of CUR and TUR at both low and high doses showed a complete abolish of tumor formation.
Based on the findings, Murakami A, the lead scientist in the chronic inflammatory disease team wrote, "we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis".
Taken altogether, turmeric in the form of essential oil, CUR, and TUR may be considered herbal remedies for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.
According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.
In other words, essential oil isolated from turmeric in the form of curcumin-free turmeric (CFT) components is more effective for the treatment of chronic inflammatory disease compared to other extracts.
In the components analysis, turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrene were all contributed to the efficacy of the curcumin-free turmeric (CFT).
In examining the effect of ar-turmerone (ATM) and turmerones (TUR, a mixture of 5 sesquiterpenes including ATM) against disease associated with inflammation, researchers found that both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of inflammation by exhibiting the production of free radicals and protein involved overexpression proinflammatory cytokines.
Furthermore, ATM prevented LPS-induced translocation of certain inflammatory genes.
In a colitis model, oral administration of TUR significantly protected the large bowel against 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58% and colon carcinogenesis.
Moreover, at a low dose, TUR markedly suppressed adenoma multiplicity by 73%, compared to the range of 63-69% of CUR.
Also, the combination of CUR and TUR at both low and high doses showed a complete abolish of tumor formation.
Based on the findings, Murakami A, the lead scientist in the chronic inflammatory disease team wrote, "we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis".
Taken altogether, turmeric in the form of essential oil, CUR, and TUR may be considered herbal remedies for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)
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