Age-related neurological disorders or neurodegenerative diseases are the conditions of the progressive death of neuron due to aging, leading to the problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually starts slowly with mild memory loss first and worsens over time. In severe cases, the elderly with AD may lose the ability to carry on a conversation and respond to their environment.
Dementia is a general term of neuro-degenerative disease that causes a decline in memory and thinking skills severe enough to reduce a person's ability to perform everyday activities and quality of life, including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease.
For most parts, the causes of these diseases are unknown. researchers cannot explain why elderly with the same health conditions in the same family, some members are susceptible to the onset of dementias while others do not.
Besides aging, geographical, hereditary and viral and toxicological exposure may also correlate to the development of the diseases on the elderly.
Some researchers suggested that unhealthy lifestyle in the Western world in the induction of obesity may be one of the major cause associated with the onset of the condition.
Dr. Mazon JN, the lead scientist, said, "...evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS)".
And, "Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron".
These results clearly suggested that if you are obese, your risk of neurodegenerative diseases is increased substantially compared to non-obese individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the course of continued finding a natural ingredient for the treatment of age-related neurological disorders (ANDs), researchers examined the effects of ginger used in traditional medicine for the treatment of various disease symptoms.
Ginger phytochemicals exhibited anti-ANDs by targeting different ligand sites.
Furthermore, ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone were effective for ameliorating the neurological symptoms.
Moreover, application of ginger also inhibited the pathological conditions of ANDs by modulating cell death or cell survival signaling proteins.
The results suggested that ginger and its bioactive compounds may have therapeutic potential in ANDs.
Additionally, with an aim to reveal more information about the ginger anti ANDs activity, researchers investigated the neurotrophic effects in primary cultured rat cortical neurons and PC12 cells.
In vivo. ginger diet for 1 month in SAMP8 mice induced age-related learning and memory impairments, showed to reverse of spatial learning and memory deficits by significantly increased the numbers of Ki67-positive cells in the dentate gyrus.
Where Ki-67 protein is associated with cell proliferation or reduplication.
In PC12 cells, the ginger application also exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting.
Taken altogether, ginger may be considered a neuroprotective remedy against age-related neurological disorders, pending to the confirmation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Pharmacotherapeutic potential of ginger and its compounds in age-relatedneurological disorders by Choi JG1, Kim SY2, Jeong M2, Oh MS3. (PubMed)
(2) Bangle (Zingiber purpureum) Improves Spatial Learning, Reduces Deficits in Memory, and Promotes Neurogenesis in the Dentate Gyrus of Senescence-Accelerated Mouse P8. by Nakai M1,2, Iizuka M2, Matsui N3, Hosogi K1, Imai A2, Abe N1,2, Shiraishi H1,2, Hirata A1,2, Yagi Y1,2, Jobu K2, Yokota J2, Kato E4, Hosoda S4, Yoshioka S3, Harada K3, Kubo M3, Fukuyama Y3, Miyamura M1,2. (PubMed)
(3) The impact of obesity on neurodegenerative diseases by Mazon JN1, de Mello AH1, Ferreira GK2, Rezin GT. (PubMed)
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