Hyperlipidemia is a chronic condition of abnormally high blood cholesterol in the bloodstream.
Cholesterol is a waxy substance produced by the liver or dietary intake that processes a significant activity in the improvement of the digestive system by breaking down food, in the production of vitamin D and steroid hormone, particularly in the building of strong cell membranes.
There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and high-density lipoprotein which returns cholesterol back to the liver for reuse.
However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.
According to the free radical theory, overexpression of cholesterol also increases the risk of lipid peroxidation, leading to the onset of various diseases.
Dr, Yagi K, at the Institute of Applied Biochemistry in the analysis of the lipid peroxides and human diseases, said, "The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity"
And. "Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders".
The findings clearly suggested that your risk of diseases is increased substantially if you have abnormally high blood cholesterol.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of abnormal blood cholesterol, researchers examined artichoke leaf extract (ALE) activity in lowering the plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols.
The study included 64 Golden Syrian hamsters (8 weeks old) fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
There were no significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were after 21 days for ALE-fed animals compared with controls.
However, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls after 42 days.
Furthermore, the total neutral sterol and bile acids concentrations also increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls.
Dr. Qiang Z, after taking into account other factors, said, "he ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days".
In order to reveal more information about artichoke anti-high blood cholesterol property, researchers evaluated the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern,
The randomized, double-blind, placebo-controlled clinical trial included 92 overweight subjects with primary mild hypercholesterolemia for 8 weeks.
46 subjects were randomized to supplementation (age: 54.2 ± 6.6 years, body mass index (BMI): 25.8 ± 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 ± 9.0 years, BMI: 24.8 ± 1.6 kg/m(2), male/female: 21/25).
Artichoke leaf extract (ALE) supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004).
Moreover, ALE also significantly decreased the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001) comapred to control.
The findings clearly supported the use of artichoke leaf extract ALE for the treatment of patients with mild high blood cholesterol.
Taken altogether, artichoke may be considered a functional formula for the treatment of patients with high blood cholesterol with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S.(PubMed)
(2) Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial by Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. (PubMed)
(3) Lipid Peroxidation Products in Human Health and Disease by Kota V. Ramana,1 Sanjay Srivastava,2 and Sharad S. Singha. (Hindawi)
Saturday, May 25, 2019
Bioactive Compound Sinigrin, the Dietary Source of Antioxidants
Antioxidants are stable molecules which inhibit oxidation. Antioxidants are either produced by the host or from the dietary sources.
Under normal condition, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.
However, in people with the weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to depletion of the antioxidant enzymes.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order for them to maintain stable, they must either donate or intercept an electron from other molecules, leading a chain reaction that can not be stopped until they are either inhibited by antioxidant or electrons are paired.
Oxidative stress is an imbalance of the ratio of free radicals and antioxidant in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.
Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the major factors that contribute to the severity of the disease due to oxidative stress.
Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".
Researchers on finding a natural ingredient which processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.
Injection of sinigrin suppressed the nitric oxide (NO) production, a free radical although is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney and liver toxicity by reducing the levels of nitric oxide synthase.
In rat study. oral administration of the compound also showed reduced the levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radicals expression through its antioxidant activity.
In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.
Mitochondrial dysfunction is found to interfere with the function of cells in the production of energy for cell or organ needs.
Oxidative balance impairment is another term of oxidative stress.
More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced the host.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant dietary approach in treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)
Under normal condition, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.
However, in people with the weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to depletion of the antioxidant enzymes.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order for them to maintain stable, they must either donate or intercept an electron from other molecules, leading a chain reaction that can not be stopped until they are either inhibited by antioxidant or electrons are paired.
Oxidative stress is an imbalance of the ratio of free radicals and antioxidant in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.
Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the major factors that contribute to the severity of the disease due to oxidative stress.
Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".
Researchers on finding a natural ingredient which processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.
Injection of sinigrin suppressed the nitric oxide (NO) production, a free radical although is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney and liver toxicity by reducing the levels of nitric oxide synthase.
In rat study. oral administration of the compound also showed reduced the levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radicals expression through its antioxidant activity.
In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.
Mitochondrial dysfunction is found to interfere with the function of cells in the production of energy for cell or organ needs.
Oxidative balance impairment is another term of oxidative stress.
More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced the host.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant dietary approach in treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)
Friday, May 24, 2019
Herbal Bilberry the Best for the Prevention and Treatment of Eye Disease
Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).
Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.
Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.
The findings support the regular use of bilberry anthocyanosides as a dietary source against the age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.
Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.
332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.
According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.
After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.
Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).
Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.
Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.
The findings support the regular use of bilberry anthocyanosides as a dietary source against the age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.
Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.
332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.
According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.
After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.
Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
3,3'-Diindolylmethane, the Best Anti-inflammatory Bioactive Compound
Inflammation is a natural response of the immune system which tries to protect our body by destroying the harmful pathogens before they cause damage.
In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
Overproduction of proinflammatory cytokines in some cases have been found to damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a potential compound which processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.
The study carried out by differentiated the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.
According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.
Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.
In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.
Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".
In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.
Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host through inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.
Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.
In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in mouse hippocampus.
Based on the findings, Dr. Kim HW, the lead researchers said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)
In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
Overproduction of proinflammatory cytokines in some cases have been found to damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a potential compound which processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.
The study carried out by differentiated the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.
According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.
Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.
In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.
Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".
In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.
Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host through inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.
Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.
In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in mouse hippocampus.
Based on the findings, Dr. Kim HW, the lead researchers said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)
Whole Food Honey, the Natural Antibiotic with No Side Effects
Antibiotics are conventional medicines used for the treatment of microbial infection except for the virus. The aim of the medicines is to kill off the microbial pathogens that cause the disease.
However, epidemiological suggested that antibiotics also kill the good bacterias and cells in the host, leading to weakened body functioning, including the immune system.
Furthermore, overuse of antibiotics over the past many decades has also caused genetic mutation in the bacteria, inducing the bacterial resistance superbugs that have caused a resurgence in some illnesses.
Out of billions of bacteria existed in the world, only a few hundreds have been known to cause infectious diseases. And bacterial pneumonia was probably the leading cause of death among the elderly.
Bacteria after entering the body and found a specific site to incubate, at the time permitted also secret toxins to attack the cells in the area, leading to infection and signs and symptoms of an illness.
Most common symptoms of the acute phase of infection are associated with an immune system response by stimulating the production of pro-inflammatory cytokines with an aim to kill off the pathogens, including fever, malaise, headache, rash.
People with a weakened immune system such as elderly and taking immune suppressive medicines and immature immune system such as infants are prone to the bacterial infection.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural therapy to replace the antibiotic with no side effects, researchers examined the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds, compared to Manuka honey (MH).
The study included selected honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with untreated control.
According to the tested assays, both honeys at 75% and 50% inhibited the majority of the three bacteria tested. However, the 10% PBH exhibited antimicrobial activity to a lesser extent than 10% MH.
Both honeys were acidic with pH 4, and both produced H2O2 .
The results suggested although both honeys exert the similar antibacterial effects, the MH has significantly higher levels of the polyphenols and antioxidant activity than PBH.
Also, in the comparison of the antibacterial property of other types of honey and Manuka honey, researchers showed that Manuka honey was the most effective against Staphylococcus aureus Oxa R and S. aureus Oxa S with a Minimum Inhibitory Concentration (MIC) of 6% and 7%, respectively, compared to the wild carrot honey with a MIC of 12%.
Furthermore, tested Manuka honey contained the highest content of polyphenols, with 899.09 ± 11.75 mg gallic acid/kg, whereas lavender honey had the lowest, with 111.42 ± 3.54 mg gallic acid/kg.
Dr. the lead scientist wrote in the final report, "The differences between honey samples in terms of antibacterial and antioxidant activity could be attributed to the natural variations in floral sources of nectar and the different locations".
In other words, the antibacterial effect of honeys probably is associated with the levels of polyphenols content.
Taken altogether, honey processed a high amount of polyphenols may be considered antibacterial infection remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-microbial activity and composition of manuka and portobello honey by Schneider M1, Coyle S, Warnock M, Gow I, Fyfe L. (PubMed)
(2) Antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins by Alzahrani HA1, Alsabehi R, Boukraâ L, Abdellah F, Bellik Y, Bakhotmah BA. (PubMed)
However, epidemiological suggested that antibiotics also kill the good bacterias and cells in the host, leading to weakened body functioning, including the immune system.
Furthermore, overuse of antibiotics over the past many decades has also caused genetic mutation in the bacteria, inducing the bacterial resistance superbugs that have caused a resurgence in some illnesses.
Out of billions of bacteria existed in the world, only a few hundreds have been known to cause infectious diseases. And bacterial pneumonia was probably the leading cause of death among the elderly.
Bacteria after entering the body and found a specific site to incubate, at the time permitted also secret toxins to attack the cells in the area, leading to infection and signs and symptoms of an illness.
Most common symptoms of the acute phase of infection are associated with an immune system response by stimulating the production of pro-inflammatory cytokines with an aim to kill off the pathogens, including fever, malaise, headache, rash.
People with a weakened immune system such as elderly and taking immune suppressive medicines and immature immune system such as infants are prone to the bacterial infection.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural therapy to replace the antibiotic with no side effects, researchers examined the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds, compared to Manuka honey (MH).
The study included selected honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with untreated control.
According to the tested assays, both honeys at 75% and 50% inhibited the majority of the three bacteria tested. However, the 10% PBH exhibited antimicrobial activity to a lesser extent than 10% MH.
Both honeys were acidic with pH 4, and both produced H2O2 .
The results suggested although both honeys exert the similar antibacterial effects, the MH has significantly higher levels of the polyphenols and antioxidant activity than PBH.
Also, in the comparison of the antibacterial property of other types of honey and Manuka honey, researchers showed that Manuka honey was the most effective against Staphylococcus aureus Oxa R and S. aureus Oxa S with a Minimum Inhibitory Concentration (MIC) of 6% and 7%, respectively, compared to the wild carrot honey with a MIC of 12%.
Furthermore, tested Manuka honey contained the highest content of polyphenols, with 899.09 ± 11.75 mg gallic acid/kg, whereas lavender honey had the lowest, with 111.42 ± 3.54 mg gallic acid/kg.
Dr. the lead scientist wrote in the final report, "The differences between honey samples in terms of antibacterial and antioxidant activity could be attributed to the natural variations in floral sources of nectar and the different locations".
In other words, the antibacterial effect of honeys probably is associated with the levels of polyphenols content.
Taken altogether, honey processed a high amount of polyphenols may be considered antibacterial infection remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-microbial activity and composition of manuka and portobello honey by Schneider M1, Coyle S, Warnock M, Gow I, Fyfe L. (PubMed)
(2) Antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins by Alzahrani HA1, Alsabehi R, Boukraâ L, Abdellah F, Bellik Y, Bakhotmah BA. (PubMed)
Thursday, May 23, 2019
Herbal Artichoke, the Best Anti-Aging Functional Remedy
Skin aging is a natural process which can not be stopped. However, some people may look younger compared to their biological age.
According to the prominent oxidative stress theory, long-term accumulation of cells damage due to overexpression of free radicals in the skin can lead to early skin aging.
The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.
Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".
Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.
In other words, long-term unhealthy lifestyle such as excessive alcohol drinking, substances abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.
Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.
In other words, the polyphenolic artichoke extracts exhibited anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radical and depletion of antioxidant enzymes produced by the host.
The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.
Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.
On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.
Furthermore, in UVB-induced photoaging, researchers examined antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemical in the artichoke.
Cynaropicrin (Cyn) attenuated UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.
In other words, in anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.
Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
According to the prominent oxidative stress theory, long-term accumulation of cells damage due to overexpression of free radicals in the skin can lead to early skin aging.
The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.
Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".
Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.
In other words, long-term unhealthy lifestyle such as excessive alcohol drinking, substances abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.
Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.
In other words, the polyphenolic artichoke extracts exhibited anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radical and depletion of antioxidant enzymes produced by the host.
The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.
Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.
On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.
Furthermore, in UVB-induced photoaging, researchers examined antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemical in the artichoke.
Cynaropicrin (Cyn) attenuated UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.
In other words, in anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.
Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
Wednesday, May 22, 2019
Whole Food Ginger, the Natural Treatment of Premenstrual Syndrome With No Side Effects, according to A Human Study
Scientists may have found a natural kitchen spice for the treatment of premenstrual syndrome symptoms (PMS) with no side effects.
Premenstrual syndrome is a condition caused by the faulty function of the ovaries related to the women's menstrual cycle, due to hormone fluctuation in one to two weeks before menstruation and then declines when the period starts.
PMS affects over 70% to 90% of women in the US compared to a lesser affection to women in Southeast Asia because of the different living style and social structure.
Most common symptoms of PMS include fatigue, fluid retention breast tenderness, acne, sleep disturbances and appetite changes with overeating or food cravings.
PMS can be classified into 4 types, categorizing by the symptoms including1. Anxiety
Anxiety is a common symptom for women with PMS, caused by a hormone imbalance between estrogen and progesterone(1). Most women with PMS is found to have a very high level of estrogen and low levels of progesterone(4) before menstruation.
Withdrawal from chronic exposure to the female sex steroid progesterone (P) may also contribute to the occurrence of PMS anxiety(2).
2. Craving
Some women with PMS may experience the symptom of food craving, caused by an abnormal liver function in carbohydrate synthesis due to dietary habits(6) and abnormal levels of serotonin(10)(8).
Other theories suggest that when a woman under stress before period, she may grasp for everything which makes her feel more comfortable(7).
3. Hyperhydration(11)
Breast tenderness and water retention(12) are always a problem for some women with PMS. Breast tenderness is caused by overproduction of prolactin due to the abnormal function of the pituitary gland(13). Water retention is either caused by overproduction of prolactin-induced renal sodium and potassium excretion(16) or abnormal function of lymphatic function(14)(15).
4. Depression
Researchers found that women with the symptom of depression always have unbalanced levels of estrogen(3) and progesterone as a result of liver abnormal function in fat and protein metabolism(5). This unbalance also induces nervous tension, that causes nervous disorder including depression(3).
Conventionally, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics and hormonal contraceptives. are the most common medicine used for the treatment of PMS, depending on the types of symptom.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of premenstrual syndrome (PMS), evaluated the effects of ginger on the severity of symptoms of PMS.
The clinical trial, double-blinded work, included 70 participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. All persons suffering from PMS were asked to complete the daily record scale questionnaire for two consecutive cycles before treatment.
According to the returned questionnaire, there were no significant differences between the mean scores of PMS symptoms in the two groups before intervention.
Each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded the severity of the symptoms by daily record scale in the questionnaire.
By comparing the date 1, 2, and 3 months after intervention, the ginger treatment group showed a significant improvement of the PMS symptoms compared to control.
Dr. Khayat S, and colleagues wrote in the final report, "Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as a treatment for PMS".
Take all together, ginger may be considered a functional alternative for the treatment of premenstrual syndrome (PMS) pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M. (PubMed)
Premenstrual syndrome is a condition caused by the faulty function of the ovaries related to the women's menstrual cycle, due to hormone fluctuation in one to two weeks before menstruation and then declines when the period starts.
PMS affects over 70% to 90% of women in the US compared to a lesser affection to women in Southeast Asia because of the different living style and social structure.
Most common symptoms of PMS include fatigue, fluid retention breast tenderness, acne, sleep disturbances and appetite changes with overeating or food cravings.
PMS can be classified into 4 types, categorizing by the symptoms including1. Anxiety
Anxiety is a common symptom for women with PMS, caused by a hormone imbalance between estrogen and progesterone(1). Most women with PMS is found to have a very high level of estrogen and low levels of progesterone(4) before menstruation.
Withdrawal from chronic exposure to the female sex steroid progesterone (P) may also contribute to the occurrence of PMS anxiety(2).
2. Craving
Some women with PMS may experience the symptom of food craving, caused by an abnormal liver function in carbohydrate synthesis due to dietary habits(6) and abnormal levels of serotonin(10)(8).
Other theories suggest that when a woman under stress before period, she may grasp for everything which makes her feel more comfortable(7).
3. Hyperhydration(11)
Breast tenderness and water retention(12) are always a problem for some women with PMS. Breast tenderness is caused by overproduction of prolactin due to the abnormal function of the pituitary gland(13). Water retention is either caused by overproduction of prolactin-induced renal sodium and potassium excretion(16) or abnormal function of lymphatic function(14)(15).
4. Depression
Researchers found that women with the symptom of depression always have unbalanced levels of estrogen(3) and progesterone as a result of liver abnormal function in fat and protein metabolism(5). This unbalance also induces nervous tension, that causes nervous disorder including depression(3).
Conventionally, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics and hormonal contraceptives. are the most common medicine used for the treatment of PMS, depending on the types of symptom.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of premenstrual syndrome (PMS), evaluated the effects of ginger on the severity of symptoms of PMS.
The clinical trial, double-blinded work, included 70 participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. All persons suffering from PMS were asked to complete the daily record scale questionnaire for two consecutive cycles before treatment.
According to the returned questionnaire, there were no significant differences between the mean scores of PMS symptoms in the two groups before intervention.
Each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded the severity of the symptoms by daily record scale in the questionnaire.
By comparing the date 1, 2, and 3 months after intervention, the ginger treatment group showed a significant improvement of the PMS symptoms compared to control.
Dr. Khayat S, and colleagues wrote in the final report, "Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as a treatment for PMS".
Take all together, ginger may be considered a functional alternative for the treatment of premenstrual syndrome (PMS) pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M. (PubMed)
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