Regular Walking Reduces Early Onset and Complications of Atherosclerosis

Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, the joint study led by Universidade Federal de Minas Gerais, showed that regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases(1).

But the regular walking contribution of reduced risk of atherosclerosis in the younger and older elderly have been lacking, probably due to the effectiveness of medication in reduced cholesterol build up on the inner wall of arteries.

Atherosclerosis is a condition of hardening and narrowing of the arteries as a result of plaques of fatty cholesterol on the inner wall, leading to reduce oxygen-rich blood flow to the organs and other parts of the body.

According to the joint study led by the University of Shizuoka, off-site walking program of a prospective, 12-week, randomized and controlled study of Fifty-two women aged 32 to 57 years suggested, the program may decrease fibrinogen levels which were found to be a trigger cardiac events in patients with atherosclerosis(3).

In fact, regular leg exercise not only reduced the complications of patients with atherosclerosis(3) but also induced expansive arterial remodeling in corresponding improvements in risk factors for atherosclerosis in healthy men of different ages(4). Dr. Rauramaa R and colleagues in a randomized clinical trial in overweight men insisted that regular exercise (walking to slow jogging) significantly inhibited secondary platelet aggregation from 27% to 36% of that induced protective effects in the initiation of atherosclerosis(5).


Dr. Kovacić L said, "The criteria for physical active person were walking three times a week for 30 minutes at least .... in the prevention of many health problems, like obesity, arterial hypertension, diabetes, heart diseases, atherosclerosis, osteoporosis and others"(2).


In support of regular exercise in lowering the risk of Atherosclerosis, Dr. Ali Al-Mamari said, "physical activity has been recognized as a preventive measure for atherosclerosis" and " moderately vigorous exercise resulted in a substantial reduction in mortality from all causes by 23% and from CHD by 41% compared with sedentary classmates.59 Maintaining or increasing physical activity level in late middle age was associated with a reduction in mortality rates, and light activities appeared to be sufficient to produce this benefit in older men"(6), probably due to its contribution in the reduced abnormalities in lipid and lipoprotein metabolism(7) and serum TG concentration(8).

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References

(1) Physical Activity and Lipid Profile in the ELSA- Brasil Study.[Article in English, Portuguese] by Silva RC1, Diniz MF1, Alvim S2, Vidigal PG1, Fedeli LM3, Barreto SM1.(PubMed)
(2) [Physical inactivity as public health problem].[Article in Croatian] by Kovacić L1(PubMed)
(3) Effects of an off-site walking program on fibrinogen and exercise energy expenditure in women by Furukawa F1, Kazuma K2, Kojima M3, Kusukawa R4.(PubMed)
(4) Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men by Dinenno FA1, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR.(PubMed)
(5) Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men by Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V.(PubMed)
(6) Atherosclerosis and Physical Activity by Ali Al-Mamari(Oman Med J.)
(7) Regular Walking Reduces Risk and Complications of hyperlipidemia in Older Adults
by Kyle J. Norton
(8) Regular Walking Reduces Risk of high triglyceride level Significantly in 50 plus Adults by Kyle J. Norton

Tomato and Its Bioactive Compound Lycopene Protect the Obese Patients Against Complications

Obesity is a progressive chronic disease, associated with abnormal or excessive fat accumulation in the body.

People who have a BMI of over 30 is considered to be obese.

According to the statistics provided by Obesity Cabada, the rate of obesity has increased at an alarming rate in Canada over the past few decades.

Approximately over 30% of Canadian adults are considered obese that may require medical support to manage their disease.


Epidemiologically, type 2 diabetes, high blood pressure, heart disease, stroke, arthritis, cancer and other major health problems have been found in most obese patients, causing concern to the scientist community in the health care system.

Believe it or not, obesity has been found contributing to one 10 premature deaths among Canadian adults age 20 to 64. As of today, the health care system in Canada has spent between $5 billion and $7 billion for the treatment of obese related complications.

Furthermore, obesity is associated with increased mortality and a number of complications including diabetes, heart disease, dementia, and cancer.

And, the commitment of reduced weight through a healthy diet accompanied by moderate exercise has been proposed to target the complications.

Out of many risk factors associated with the onset of obesity, the social economy may have some implication involved in the onset of the disease.

Dr. BRIAN HOULE, wrote in the article "How Obesity Relates to Socioeconomic Status" "...obesity rose with a nation’s economic development, but also that socioeconomic status as it related to obesity changed. In lower-income countries, people with higher SES were more likely to be obese. Conversely, in high-income countries, those with higher SES were less likely to be obese".

And, "Why the reversal? It may be that in lower-income countries, higher SES leads to consuming high-calorie food and avoiding physically tough tasks. But in higher-income countries, individuals with higher SES may respond with healthy eating and regular exercise".

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural and potential compound for the treatment of obesity, researchers review the link of high intake of lycopene or tomatoes products in the risk for metabolic diseases by comparing the effect of lycopene and tomato powder on obesity-associated disorders.

The study included selected Male C57BL/J6 mice randomly assigned into four groups to receive: control diet (Chigh-fat fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.

In mice treated with HFD, lycopene and TP supplementation significantly improve the obese complications caused by adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids.


Furthermore, lycopene and TP supplementation also 8-iso-prostaglandin GF2α associated with an increased risk of heart disease and improved glucose homeostasis, against the onset of abnormal blood glucose.

Furthermore, Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes associated with patients of obesity.

Moreover, lycopene and TP also decreased HFD-induced the production of proinflammatory cytokines in the liver and in the epididymal adipose tissue found in obese subjects.

According to the tested assay, lycopene and TP anti-inflammatory effects were attributed to the inhibition of the protein involved promotion of the expression of inflammation in adipose tissue.


Based on the findings, lycopene, and TP protected significantly obese subjects against the onset of obesity complications.

Dr. Fenni S after taking other factors into account wrote, "These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".

Taken altogether, tomatoes processed a high amount of lycopene may be considered whole food for the prevention and treatment of diseases associated with obesity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)

Bromelain Modulates Your Immune System Against Allergic Symptoms

Allergy, also known as an allergic disease is a group of conditions including include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis caused by the overreaction of the immune system response to harmless substances in the environment.

Most common symptoms of allergies are sneezing and runny nose, persistent coughing, skin rash, fatigue, gastrointestinal discomforts, headache, and fever.

In serious cases, people affected by allergies may also experience symptoms of shortness of breath.

Believe it or not, food allergies affect 4-6% of children and 4% of adults epidemiologically. According to the statistics, approximately, 32 million Americans have food allergies, including 5.6 million children under age 18.

Also, every year, in the U.S., 200,000 people require emergency medical care for allergic reactions to food.

There are many risk factors associated with the onset of allergies. However, foods, medications and insect stings are the most common triggers of anaphylaxis, a life threating condition.

People who have asthma, a family history of asthma and allergies and are under 18 years of age are most at risk to develop an allergy and allergic complication.

Treatment of allergies is totally depending on the severity and types of the syndrome. Over-the-counter remedies such as antihistamines which block the effects of histamine, and decongestants and nasal steroid sprays may reduce symptoms in patients with the mild condition.

In a severe case, due to the condition have interfered with the quality of life of the patients, more options may be needed including allergy shots (immunotherapy), please check with your doctors

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient against allergic symptoms, researchers examined the effects of Bromelain (sBr), a mixture of cysteine proteases from pineapple in the incidence of atopic conditions.

The study included C57BL/6J mice sensitized with OVA/alum and challenged with 7 days OVA aerosol following by the sBr 6 mg/kg/0.5 ml or PBS vehicle administered throughout sensitization.

According to the tested assays, throughout the study, sBr treatment throughout OVA-alum sensitization significantly reduced the development of AAD (BAL eosinophils and lymphocytes).

In other words, sBr prevents the expression of allergic symptoms induced by OVA-specific IgE and OVA TET(+) cells by modulating the immune functioning.

In vitro, treatment of sBr significantly reduced CD44, a key receptor involved in lymphocyte infiltration of inflamed tissue in the initiation of the development of airway inflammation in a murine model of allergic asthma.

The results strongly suggested that sBr's processes anti-inflammatory and antiallergic properties.

Based on the findings, Dr. Secor ER Jr, the lead scientist said, "sBr was shown to reduce allergic sensitization and the generation of AAD upon antigen challenge".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells by Eric R. Secor, Jr., 1 , 2 ,* Steven M. Szczepanek, 3 Christine A. Castater, 2 Alexander J. Adami, 3Adam P. Matson, 4 Ektor T. Rafti, 4 Linda Guernsey, 3 Prabitha Natarajan, 3Jeffrey T. McNamara, 5 Craig M. Schramm, 4 Roger S. Thrall, 3 and Lawrence K. Silbart. (PMC)

Herbal Ginger Protects the Joints Against Osteoarthritis In Human Trials

Osteoarthritis (OA) is a form of arthritis, found in the general term of musculoskeletal disorders (MSDs) characterized by the wear and tear on joints.

The chronic and medical condition affects over 25 million people in the United States alone.

The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. Therefore one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), compared to other types of arthritis.

Furthermore, the pain usually gets worse ina change of weather, at night and in the advanced diseases, and the pain can occur even at rest.


If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the possibility of osteoarthritis

Conventionally, management of osteoarthritis (OA) focuses on pain relief and improves physical function through pharmacological, nonpharmacological, and surgical treatments if it is necessary.

If you are currently taking some of the medications for the treatment of osteoarthritis, please make sure you know all the side effect for preventive measure.


Out of many risk factors associated with the onset of osteoarthritis, some researchers suggested that the increase in age is one of the disease prevalent factor found in the aging population.


Dr. Richard F. Loeser, said, "Basic aging studies in non-articular cells suggest that cell stress or cell damage response contributes to chronic inflammation that promotes age-related diseases. This cellular response results in the senescence-associated secretory phenotype which has many of the characteristics of an OA chondrocyte in terms of the cytokines, chemokines, and proteases produced".

And, "Because OA occurs in older adults who also have age-related changes in muscle, bone, fat, and the nervous system, it is likely that a more general and systemic approach will be needed to better understand the link between aging and OA".

The result strongly indicated the increased risk of osteoarthritis in the elderly.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of osteoarthritis assessed the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).

The study included 68 participants with osteoarthritis were randomly assigned evenly to receive standard treatment with or without self-knee massage with ginger oil twice a week.


At the end of the first and fifth week, participants in both groups were assessed regarding pain and functional state.

According to the assessed results, the mean Visual Analog Scale (VAS) Pain scores of the intervention group were significantly lower at the end of the first and fifth weeks compared to control.


Furthermore, the mean total scores and mean Function subscale scores of the functionality in activities of daily living with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were significantly lower in the intervention group in the first- and fifth-week assessments, also compared to control.

The results strongly suggested that self-massage of the knee with ginger oil should be used combined with standard medical treatment for osteoarthritis patients.

Based on the findings, Dr.Tosun B, the lead scientist said, "Nurses can easily train patients and their caregivers on knee massage, and the intervention can be implemented by patients at home without any restrictions on location".


In order to reveal more information about the ginger effect on osteoarthritis, researchers launched a systematic literature search followed by meta-analyses on selected studies, including randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years.


According to the Hedges' standardized mean difference (SMD), and safety by risk ratio (RR), out of 122 retrieved references, 117 were discarded, leaving five trials (593 patients) for meta-analyses.

Ginger intake showed a statistically significant pain reduction with a low degree of inconsistency among trials.

Quality of life from the selected trials also statistically and significantly improved in favor of the ginger group.


Interestingly, patients given ginger were more than twice as likely to discontinue treatment compared to placebo.

The results exerted a similar efficacy as seen in the aforementioned study.

Take all together, ginger may be used alone or combined primary therapy for the treatment of osteoarthritis, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effects of Self-Knee Massage With Ginger Oil in Patients With Osteoarthritis: An Experimental Study by Tosun B, Unal N, Yigit D, Can N, Aslan O, Tunay S.(PubMed)
(3) Aging and Osteoarthritis by Richard F. Loeser. (PMC)

Regular Walking Reduces Risk of Insulin Resistance Significantly

Insulin resistance (IR), one of metabolic syndrome, is a condition of failure of cellular normal response to the hormone insulin. Patients with insulin resistance are found to have a significant risk to develop type 2 diabetes(1)(2)(3) and Heart diseases(3).

Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of reduced risk of Insulin Resistance in the younger and older elderly have been lacking, probably due to the effectiveness of modern restrict diet(4) and psychological therapies(5) in syndrome controlling.

Recent study conducted by the Klinika za endokrinologiju, showed that 10 sessions--35 min session of walking on treadmill, intensity 60.8 +/- 5.7% (VO2)max, frequency 5 times a week), had had significant influence on the increased aerobic capacity and insulin sensitivity in the tested patients(7), as well as enhanced suppression of hepatic glucose production(8).
In the review of data of 278,989 people (111,524 males and 167,465 females) living in Chiba Prefecture who underwent consecutive medical check-ups in 2008 and 2009, Dr. Ashizawa E and colleagues at the Chiba Prefectural Institute of Public Health said, "In men, the odds of developing MetS were significantly lower for participants who exercised regularly ("walking fast," OR=0.88, 95% CI [0.83-0.93]; and "higher physical activity," 0.85, [0.80-0.90])"(6).

Brisk walking, a popular and readily attainable form of moderate intensity physical activity, is one of the best to suitable for the majority of individuals to improve metabolic syndrome (MetS) risk factors in overweight male subjects, according to the study by University of Tsukuba(10).

Indeed, reductions in walking reduce insulin sensitivity and insulin signaling through multiple cellular processes in glucose metabolism(9) of that induced risk of Insulin Resistance in the progression of type 2 diabetes and cardiovascular diseases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Increase in homeostasis model assessment of insulin resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes in Japanese individuals with impaired insulinsecretion: the Saku study by Morimoto A1, Tatsumi Y2, Soyano F3, Miyamatsu N1, Sonoda N1, Godai K1, Ohno Y4, Noda M5, Deura K3.(PubMed)
(2) Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study by Song Y1, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S.(PubMed)
(3) Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study by Ghaffarzad A1, Amani R2, Mehrzad Sadaghiani M3, Darabi M4, Cheraghian B5.(PubMed)
(4) Very low-carbohydrate diets in the management of diabetes revisited by Schofield GM, Henderson G1, Thornley S.(PubMed)
(5) A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes by Shomaker LB1,2,3, Kelly NR4,5,6, Pickworth CK4, Cassidy OL4,5, Radin RM4,5, Shank LM4,5, Vannucci A4,5, Thompson KA4, Armaiz-Flores SA4, Brady SM4, Demidowich AP4, Galescu OA4, Courville AB7, Olsen C8, Chen KY9, Stice E10, Tanofsky-Kraff M11,12, Yanovski JA13.(PubMed)
(6) Exploring the link between standard lifestyle questionnaires administered during specific medical check-ups and incidence of metabolic syndrome in Chiba Prefecture by Ashizawa E1, Katano S, Harada A, Yanagibori R, Kobayashi Y, Sato S, Eguchi H.(PubMed)
(7) [Effect of a two-week program of individually monitored physical activity on insulin resistancein obese non-insulin-dependent diabetics].[Article in Serbian] by Cizmić M1, Zivotić-Vanović M, Zivanić S, Dragojević R.(PubMed)
(8) Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus by Kirwan JP1, Solomon TP, Wojta DM, Staten MA, Holloszy JO.(PubMed)
(9) Lack of regular physical exercise or too much inactivity byThyfault JP1, Booth FW.(PubMed)
(10) Lifestyle-based physical activity intervention for one year improves metabolic syndrome in overweight male employees by Kim J1, Tanabe K, Yoshizawa Y, Yokoyama N, Suga Y, Kuno S.(PubMed)

Phytchoemical Alliin Gobbles Up Cancer Cells in Vivo with No Side Effects

Cancer is a class of disease caused by irregular cell growth in the tissue or organ associated with the alternation of cell DNA.

Most cancers at the early stage, due to the small size of the tumor are asymptomatic, However, as the cells continue to proliferation, at some points, the tumor may affect the nearby blood vessels and nerve cell leading to symptoms of severe pain and bleeding accompanied by the general symptoms shared by all cancers.

Most primary cancers at the advanced stage can also travel a distance away from the original site to infect other healthy tissues, leading to a secondary metastasis.

According to the statistics provided by the National Cancer Institute, based on 2011–2015 statistics. approximately, 439.2 per 100,000 men and women per year are diagnosed with cancer. The number of cancer deaths is 163.5 per 100,000 men and women per year, also based on 2011–2015 statistics.
Cancers are classified depending on the types of cells alternation
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.

* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.

* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of the blood cell, including red blood cells, white blood cells, and platelets become cancerous.

* Germ cell tumor
The cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary, However, the cancer is more common in babies and young children.

* Blastoma
The cancer is derived from immature "precursor" or embryonic tissue. These are also most common in children.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential treatment of cancer with no side effect, researchers examined the protective effect of three garlic powder compared to that alliin.

Rat selected to the study were administered for 2 weeks with 5% garlic powder diet.

According to the comet assay, consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

Compared to the other garlic powders increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA induced DNA alteration.

In other words, alliin increased anti-liver cancer activity of garlic powder proportionally compared to normal garlic powders.

Interestingly, DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powder.

In other words, all phytochemical compounds found in the garlic powder must work together to augment the anti-cancer effect regardless of the content of the individual compound.

In the study of liver cancer induced by injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1) in rats, researchers garlic powder decreased the appearance and size of hepatic GST-P foci associated with early markers of the liver cancer.


However, garlic containing the highest level of alliin showed a stronger effect in the protection of liver against the forming hepatic GST-P foci compared to the normal garlic powders.

Levels of alliin showed an inverse associated with the number and area of preneoplastic foci.

Garlic powder ingestion increased the activity of hepatic detoxified enzymes such as glutathione S-transferase and UDP glucuronosyltransferase with no modification of nifedipine oxidase activity.


Dr. Bergès R, the lead researchers said, "It is suggested that garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification. This study highlights the possibility of controlling the cultivation conditions to improve the chemopreventive efficacy of garlic".


Taken altogether, alliin may be considered supplements for the prevention and treatment of cancer with no side effect, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats by Bergès R1, Siess MH, Arnault I, Auger J, Kahane R, Pinnert MF, Vernevaut MF, le Bon AM. (PubMed)

Whole Food Ginger, an Antibiotic Alternative with No Side Effects, Scientists Say

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

Conventionally, most cases of infectious diseases except those caused by viruses are treated by antibiotics.

If you are currently taking one of the antibiotics for the treatment of infectious diseases, please make sure you know all the side effects for preventive measure.


Diagnosis of the type of bacteria that causes the disease in most cases is important for precisive targeting.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound as the antibiotic alternative for the treatment of infectious diseases with no side effects evaluated the antibacterial properties of Allium sativum (garlic) cloves and Zingiber officinale (ginger) rhizomes against multi-drug resistant clinical pathogens causing nosocomial infection.

The study included two crude garlic cloves and ginger rhizomes with 95% (v/v) ethanol tested against five gram-negative and two-gram positive multi-drug resistant bacterial isolates.

Application of the extracts showed significant inhibition against all tested isolates.

The highest inhibition zone of garlic (19.45 mm) was found in the Pseudomonas aeruginosa (P. aeruginosa), with the minimal inhibitory concentration as low as 67.00 µg/mL.

Based on the findings, researchers wrote in the final report, "Natural spices of garlic and ginger possess effective anti-bacterial activity against multi-drug clinical pathogens and can be used for prevention of drug-resistant microbial diseases and further evaluation is necessary".

Additionally, in order to know more information about the ginger antibacterial property, researchers also examined the antimicrobial potency of fresh, natural and commercial dried Allium sativum and Zingiber officinale extracts against seven local clinical bacterial isolates such as Escherichia coli.

Compared to garlic extract, chloroform and diethyl ether extracts of Z. officinale showed a greater zone of inhibition of tested pathogens except for P. aeruginosa and E. coli.

Furthermore, all extracts of A. sativum and Z. officinale have a strong antibacterial effect compared to recommended standard antibiotics through activity index.


The efficacy of ginger against bacterial infectious diseases was attributed to the presence of various phytochemicals such as tannins, phenols, alkaloids, steroids, and saponins.


Dr. the lead scientist said, "These findings provide new insights to use A. sativum and Z. officinale as potential plant sources for controlling pathogenic bacteria and potentially considered as cost-effective in the management of diseases and to the threat of drug resistance phenomenon".

Take all together, ginger processed a high amount of bioactive compounds may be considered an antibiotic alternative for prevention and treatment of bacterial infectious diseases, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Biological activities of Allium sativum and Zingiber officinale extracts on clinically important bacterial pathogens, their phytochemical and FT-IR spectroscopic analysis by Awan UA1, Ali S1, Shahnawaz AM1, Shafique I1, Zafar A1, Khan MAR2, Ghous T3, Saleem A4, Andleeb S. (PubMed)
(2) Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens by Karuppiah P1, Rajaram S. (PubMed)