Insulin resistance (IR), one of metabolic syndrome, is a condition of failure of cellular normal response to the hormone insulin. Patients with insulin resistance are found to have a significant risk to develop type 2 diabetes(1)(2)(3) and Heart diseases(3).
Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of reduced risk of Insulin Resistance in the younger and older elderly have been lacking, probably due to the effectiveness of modern restrict diet(4) and psychological therapies(5) in syndrome controlling.
Recent study conducted by the Klinika za endokrinologiju, showed that 10 sessions--35 min session of walking on treadmill, intensity 60.8 +/- 5.7% (VO2)max, frequency 5 times a week), had had significant influence on the increased aerobic capacity and insulin sensitivity in the tested patients(7), as well as enhanced suppression of hepatic glucose production(8).
In the review of data of 278,989 people (111,524 males and 167,465 females) living in Chiba Prefecture who underwent consecutive medical check-ups in 2008 and 2009, Dr. Ashizawa E and colleagues at the Chiba Prefectural Institute of Public Health said, "In men, the odds of developing MetS were significantly lower for participants who exercised regularly ("walking fast," OR=0.88, 95% CI [0.83-0.93]; and "higher physical activity," 0.85, [0.80-0.90])"(6).
Brisk walking, a popular and readily attainable form of moderate intensity physical activity, is one of the best to suitable for the majority of individuals to improve metabolic syndrome (MetS) risk factors in overweight male subjects, according to the study by University of Tsukuba(10).
Indeed, reductions in walking reduce insulin sensitivity and insulin signaling through multiple cellular processes in glucose metabolism(9) of that induced risk of Insulin Resistance in the progression of type 2 diabetes and cardiovascular diseases.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Increase in homeostasis model assessment of insulin resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes in Japanese individuals with impaired insulinsecretion: the Saku study by Morimoto A1, Tatsumi Y2, Soyano F3, Miyamatsu N1, Sonoda N1, Godai K1, Ohno Y4, Noda M5, Deura K3.(PubMed)
(2) Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study by Song Y1, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S.(PubMed)
(3) Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study by Ghaffarzad A1, Amani R2, Mehrzad Sadaghiani M3, Darabi M4, Cheraghian B5.(PubMed)
(4) Very low-carbohydrate diets in the management of diabetes revisited by Schofield GM, Henderson G1, Thornley S.(PubMed)
(5) A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes by Shomaker LB1,2,3, Kelly NR4,5,6, Pickworth CK4, Cassidy OL4,5, Radin RM4,5, Shank LM4,5, Vannucci A4,5, Thompson KA4, Armaiz-Flores SA4, Brady SM4, Demidowich AP4, Galescu OA4, Courville AB7, Olsen C8, Chen KY9, Stice E10, Tanofsky-Kraff M11,12, Yanovski JA13.(PubMed)
(6) Exploring the link between standard lifestyle questionnaires administered during specific medical check-ups and incidence of metabolic syndrome in Chiba Prefecture by Ashizawa E1, Katano S, Harada A, Yanagibori R, Kobayashi Y, Sato S, Eguchi H.(PubMed)
(7) [Effect of a two-week program of individually monitored physical activity on insulin resistancein obese non-insulin-dependent diabetics].[Article in Serbian] by Cizmić M1, Zivotić-Vanović M, Zivanić S, Dragojević R.(PubMed)
(8) Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus by Kirwan JP1, Solomon TP, Wojta DM, Staten MA, Holloszy JO.(PubMed)
(9) Lack of regular physical exercise or too much inactivity byThyfault JP1, Booth FW.(PubMed)
(10) Lifestyle-based physical activity intervention for one year improves metabolic syndrome in overweight male employees by Kim J1, Tanabe K, Yoshizawa Y, Yokoyama N, Suga Y, Kuno S.(PubMed)
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