Friday, July 12, 2019
Green tea, The Best Drink for Reduced Risk and Treatment of Hypertension
Regular drinking of green tea may have a potential effect in maintaining normal blood pressure and reduced risk of hypertension, a recent study suggested.
Hypertension is an abnormal high of blood pressure, one of the major risk factors in contributing to the early onset of cardiovascular disease.
Green tea, considered as a functional food, linking numbers of health benefit has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding one slice of ginger will do the trick of neutralization.
Hypertension of male Wistar rats induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks], fed with green tea extract exhibited a strong effect in reduced hypertension (119 ± 1 mmHg) and higher renal sympathetic nerve activity (161 ± 12 spikes/s) than the control group (97 ± 2 spikes/s).
Green tea oral administration also showed a significant decreased in hypertensive parameter by ameliorated.arterial baroreceptor function and vascular and systemic oxidative stress.
Furthermore, in a total of 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old with metabolic syndrome randomized into a saline-treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10), group fed with decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 ± 7 vs. 121 ± 3 mmHg, p = 0.01) in compared control fed with saline.
The study also suggested that fed mice with green tea also showed an antihypertensive effect in reduced vascular reactive oxygen species (ROS) formation and NADPH in the generation of ROS, as well as improving endothelium (cell lines the interior surface of blood vessels and lymphatic vessels)and lymphatic vessels dependent relaxation.
Dr. Ihm SH, the lead author said," (green tea extract) improved endothelial dysfunction and IR, and eventually lowered BP".
Taking together, there is no doubt that green tea processes a significant effect in reduced risk and treatment of hypertension through reduced oxidative stress and improved vascular relaxation as well as decreased metabolic syndrome in exaggerated hypertension.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant effects of green tea reduces blood pressure and sympathoexcitation in an experimental model of hypertension by Garcia ML1, Pontes RB, Nishi EE, Ibuki FK, Oliveira V, Sawaya AC, Carvalho PO, Nogueira FN Franco MD, Campos RR, Oyama LM, Bergamaschi CT.(PubMed)
(2) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
Healthy Food Navy Bean Promotes Colon Health through Modulating Microbiome Metabolism
The colon formed part of the digestive system plays a critical role to absorb water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host microbiome metabolism.
The 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).
According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.
* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.
* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.
More precisely, navy-bean protects the colon cells integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.
Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".
Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)
Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host microbiome metabolism.
The 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).
According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.
* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.
* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.
More precisely, navy-bean protects the colon cells integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.
Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".
Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)
Thursday, July 11, 2019
Green Tea, in Reduced Risk of Early Onset and Progression of Dementia
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people. About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Green tea may be used as a functional food for the prevention of early-onset and treatment of dementia due to aging progression, a renowned institute study suggested
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the neutralization trick.
In the 5.7-year prospective cohort study, using a questionnaire, information on daily green tea consumption and other lifestyle factors collected from elderly Japanese individuals aged 65 years or more, green tea consumption is associated to a reduced risk of dementia with an incidence of the occurrent rate of 8.7%.
Furthermore, in the intracerebroventricular (ICV) infusion of streptozotocin (STZ) animal model explicated chronic brain dysfunction involved long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit, mice treated with green tea EGCG at a dose of 10mg/kg/day for 4 weeks, showed a significant improvement in reduced oxidative stress parameter against production of inflammatory and free radical expression.
These inhibitions can be seen in the diminished AChE activity, glutathione peroxidase activity as well as NO metabolites, and reactive oxygen species contents
More importantly, the enhanced antioxidants status induced neuroprotective effect is a result of EGCG injection in ameliorated inflammatory and free radical causes of cell death in the brain of treated mice.
Dr. Tomata Y, the lead author of the study said, "The lower risk of incident dementia was consistent even after selecting participants who did not have subjective memory complaints at the baseline."
More explicitly, in the finding of a natural food for reverse or delay of risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors involved development of dementia and late-life cognitive disorders, green tea with a high amount of caffeine stimulate the psychoactive effects in attenuated cognitive impairment/decline and dementia through heightened alertness and arousal and improvement of cognitive performance.
Promisingly, such results have been proposed by several cross-sectional and longitudinal population-based studies, particularly in patients with mild cognitive impairment and progression to dementia.
There is no doubt that green tea may be considered a functional food for reduced risk of early-onset and delay the progression of dementia, but longer follow-up periods are necessary before the use of green tea can open new ways for diet-related prevention and treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study by Tomata Y1, Sugiyama K2, Kaiho Y2, Honkura K2, Watanabe T2, Zhang S2, Sugawara Y2, Tsuji I2(PubMed)
(2) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)
Green tea may be used as a functional food for the prevention of early-onset and treatment of dementia due to aging progression, a renowned institute study suggested
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome", according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the neutralization trick.
In the 5.7-year prospective cohort study, using a questionnaire, information on daily green tea consumption and other lifestyle factors collected from elderly Japanese individuals aged 65 years or more, green tea consumption is associated to a reduced risk of dementia with an incidence of the occurrent rate of 8.7%.
Furthermore, in the intracerebroventricular (ICV) infusion of streptozotocin (STZ) animal model explicated chronic brain dysfunction involved long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit, mice treated with green tea EGCG at a dose of 10mg/kg/day for 4 weeks, showed a significant improvement in reduced oxidative stress parameter against production of inflammatory and free radical expression.
These inhibitions can be seen in the diminished AChE activity, glutathione peroxidase activity as well as NO metabolites, and reactive oxygen species contents
More importantly, the enhanced antioxidants status induced neuroprotective effect is a result of EGCG injection in ameliorated inflammatory and free radical causes of cell death in the brain of treated mice.
Dr. Tomata Y, the lead author of the study said, "The lower risk of incident dementia was consistent even after selecting participants who did not have subjective memory complaints at the baseline."
More explicitly, in the finding of a natural food for reverse or delay of risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors involved development of dementia and late-life cognitive disorders, green tea with a high amount of caffeine stimulate the psychoactive effects in attenuated cognitive impairment/decline and dementia through heightened alertness and arousal and improvement of cognitive performance.
Promisingly, such results have been proposed by several cross-sectional and longitudinal population-based studies, particularly in patients with mild cognitive impairment and progression to dementia.
There is no doubt that green tea may be considered a functional food for reduced risk of early-onset and delay the progression of dementia, but longer follow-up periods are necessary before the use of green tea can open new ways for diet-related prevention and treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study by Tomata Y1, Sugiyama K2, Kaiho Y2, Honkura K2, Watanabe T2, Zhang S2, Sugawara Y2, Tsuji I2(PubMed)
(2) Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia by Biasibetti R1, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, Gonçalves CA.(PubMed)
(3) Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review by Panza F1, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G.(PubMed)
Cucurbitacin B (CuB) Isolated from Cucumbers (Cucumis sativus), a Natural Antiangiogenic and Antimetastatic Potential Bioactve Compound
Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Anti-metastasis is an action in which substance or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.
In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.
Angiogenesis is the process by stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrient in facilitating cancer proliferation.
Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.
Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.
Believe it or not, as of today, there is no anti-metastatic drug on the market, even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".
And, "Moreover we provide with the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatics".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.
During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.
Furthermore, at the sub-IC50 concentrations, injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.
In HUVECs, administration of CubB also inhibited migratory, invasive and tube-forming capacities.
In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.
According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.
Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.
Dr. Sinha S, the lead scientists said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".
In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive and tube-forming capacities.
The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with pass signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
ntake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)
Anti-metastasis is an action in which substance or substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.
Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered process antimetastatic activity.
In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.
Angiogenesis is the process by stimulating the growth of new blood vessels from preexisting blood vessels used by the tumor to obtain nutrient in facilitating cancer proliferation.
Anti-angiogenic activity is an action in which substances such as drugs and herbal medicine are used to stop tumors from growing their own blood vessels.
Conventionally, medicines that block the block vascular endothelial growth factor (VEGF) from attaching to the receptors on the cells that line the blood vessels. such as bevacizumab (Avastin). Bevacizumab is considered anti-angiogenic drugs.
Believe it or not, as of today, there is no anti-metastatic drug on the market, even over 90 percent of cancer deaths today are due to metastasis formation. Dr. Stock AM, the lead scientist in the examined the targets for anti-metastatic drug development, wrote, "Tumor cell migration is the essential prerequisite for invasion and metastasis formation. It is regulated by signal substances in terms of the grade of activity and in terms of direction (chemotaxis)".
And, "Moreover we provide with the example of beta-blockers, how established drugs in other indications are possibly effective and can be co-opted as such anti-metastatics".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.
During the experiment, CuB showed significant activity in the inhibition of cellular proliferation and induction of apoptosis in the tested cancer cells in a time- and dose-dependent manner.
Furthermore, at the sub-IC50 concentrations, injection of CuB inhibited the migratory and invasive potential of highly metastatic breast cancer MDA-MB-231 and 4T1 cells.
In HUVECs, administration of CubB also inhibited migratory, invasive and tube-forming capacities.
In chick embryo chorioallantoic membrane, CuB exerted a strong anti-angiogenic effect in the prevention of new blood vessels.
According to the tested assay, the efficacy of Cub antimetastatic and angiogenic properties was attributed to the blocking of the matrix and proteins (VEGF/FAK/MMP-9) in signaling the development of new blood vessels from the existing vessels to induce cancer cells proliferation.
Additionally, the anti-angiogenesis was also evidenced by the decreased protein CD31 associated with more than 90% of angiosarcomas.
Dr. Sinha S, the lead scientists said, "Collectively, our findings suggest that CuB inhibited breast cancer metastasis and angiogenesis, at least in part, through the downregulation of VEGF/FAK/MMP-9 signaling".
In non-small cell lung cancer (NSCLC) both in vitro and in vivo, at nanomolar concentrations injection of CuB demonstrated a strong anti-migratory and anti-invasive ability against metastatic NSCLC by blocking the migratory, invasive and tube-forming capacities.
The efficacy of the tested compound in this experiment inhibited metastasis and angiogenesis was attributable to the suppression of proteins (Wnt/β-catenin) associated with pass signals into a cell through cell surface receptors to induce cell proliferation and formation of new blood vessels.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
ntake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)
Wednesday, July 10, 2019
Green Tea, the Best in Prevention and Treatment of Prostate Cancer
Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth with the possibility of spreading to the distant parts of the body.
Most prostate cancers are slow-growing and prostate cancer may be detected during physical (rectum) exams.
Green tea may be used as a functional food in the prevention and treatment of prostate cancer, a renowned institute study suggested
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will do the trick.
According to the Fu Jen Catholic University, New Taipei City, catechin nanoemulsion preparation showed the highest inhibition of growth of PC-3 tumor cells, with concentration being 15.4 μg/mL and 8.5 μg/mL.
The inhibition of prostate cancer cell line is observed in cell cycle arrest by regulated proteins involved cell cycle division, namely cyclin A, cyclin B, cyclin-dependent kinase 2, and cyclin-dependent kinase 1 expression and activated cell apoptosis and survival.
Dr. Tsai YJ, the lead author said, " catechin extract and nanoemulsion could induce apoptosis of PC-3 cells through decrease in B-cell lymphoma 2 (bcl-2) expression and increase in cytochrome c expression( in the induction of apoptosis) for activation of caspase-3, caspase-8, and caspase-9 (involved cell death)".
Furthermore, in the recruited 404 PCA cases and 395 controls from the same hospital who completed data on habitual tea consumption, including green, oolong, black and pu'er tea regular green drinkers have a significantly reduced risk in prostate cancer development.
The review of the inverse relation of tea drinkers and risk of prostate cancer has shown explicitly:
1. total of 32 cases and 50 controls reported habitual green tea drinking, showing an adjusted OR of 0.60 (95% confidence interval (CI): 0.37, 0.98).
2. A moderate excess risk was observed among the habitual pu'er tea drinkers (OR=1.44, 95% CI: 1.02, 1.91).
3. A significantly lower intake of EGCG was observed among cases (54.4 mg) than the controls (72.5 mg).
Additionally, the differentiation of 7 observational studies and 3 randomized controlled trials retrieved from Cochrane Library, PubMed, ScienceDirect Online, and hand searching the database, also reveal an interest correlated incidence of PCa decrease with each 1 cup/day increase of green tea.
According to of the study, "higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa".
Collectively, green tea consumption is associated inversely to the risk of PCA but the injection of a large amount of green tea supplement should be taken with care in prevented toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 by Tsai YJ1, Chen BH1.(PubMed)
(2)Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men by Lee PMY1, Ng CF2, Liu ZM3, Ho WM4, Lee MK5, Wang F1, Kan HD6, He YH7, Ng SSM2, Wong SYS1, Tse LA1.(PubMed)
(3) Green tea and the risk of prostate cancer: A systematic review and meta-analysis by Guo Y1, Zhi F, Chen P, Zhao K, Xiang H, Mao Q, Wang X, Zhang X.(PubMed)
Turmeric Improves Impaired Glucose Tolerance
Turmeric may be used for the prevention and treatment of impaired glucose tolerance (IGT) with no side effects, according to studies.
Impaired glucose tolerance is a condition found in prediabetes and type II diabetes associated with insulin resistance and increased risk of cardiovascular disease.
In other words, people with impaired glucose tolerance are less sensitive to the effects of insulin, leading to high blood glucose that is not high enough in the range of diabetes.
According to epidemiological studies, most people with impaired glucose tolerance are more like to develop diabetes and high blood pressure and cholesterol.
According to the statistics, approximately 11.2% of Americans age between 20-74 have IGT many of them do not know they have it, compared to 6.6% with diabetes.
The exact causes of IGT are unidentified. Some risk factors such as being overweight or obese, family history of diabetes, physical inactivity, high blood pressure or high cholesterol and gestational diabetes are found to induce a substantial risk of IGT.
Some researchers suggested that aging-induced the decrease of production of hormone and reduced function of body organ may have a strong implication to cause the condition developing.
Dr. Ervin Szoke, MD, the lead scientists in the examined the hyperglycemia in a total of 266 individuals with NGT and 130 individuals with IGT, ranging in age from ∼20 to ∼70 years, said, " In people with NGT, the disposition index for first- and second-phase insulin release decreased similarly at a rate of ∼0.7% per year. In people with IGT, the disposition indexes for first- and second-phase insulin release decreased at greater rates (∼2.2 and 1.4% per year, P = 0.002 and 0.009, respectively, vs. NGT), with the decrease in the first phase being greater than that of the second phase (P = 0.025)".
These results suggested that although aging does not correlate to insulin sensitive, it has a significant effect on insulin secretion. Over time, the condition may overwork the β-cell function that increases the risk of IGT.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Researchers on finding a potential compound for the prevention of diabetes evaluated the effect of turmeric on patients with impaired glucose tolerance.
The study included a review of randomized controlled trials (RCTs) conducted with a minimum follow-up period of 6weeks, according to the standard guideline and the Cochrane tool of risk of Bias Tool.
According to the results of the selected trials, curcumin extract intervention showed statistical significance after 3, 6 and 9months on the two-hour fasting plasma glucose.
Curcumin extract injection showed statistical significance in the reduction of glycosylated hemoglobin levels A1c (HbA1c) values after 3, 6 and 9 months.
Furthermore, curcumin extract administration also exerted a statistical significance against insulin resistance (HOMA-IR) after 6months and after 9months.
Compared to the effects of other herbal medicines used in the selected trials, curcumin is effective for the treatment of impaired glucose tolerance.
In order to understand more information about curcumin anti-IGT property, researchers conducted a double-blind, parallel group, placebo-controlled, randomized clinical trial in 40 adults affected by impaired fasting glucose (FPG = 100-125 mg/dL) in primary prevention of cardiovascular disease.
The results of the experiment included 2 weeks of dietary habits correction than patients continued the diet and began a period of 8 weeks of treatment with nutraceutical (combination of Lagerstroemia speciosa, Berberis aristata, Curcuma longa, Alpha-lipoic acid, Chrome picolinate, and Folic acid,) or placebo suggested * Nutraceutical treatment showed a significant improvement in TG (-34.7%), HDL-C (+13.7), FPI (-13.4%), and HOMA-Index (-25%) versus the baseline values compared to placebo.
* Both treatments showed no effect on body mass Index, LDL-C and hsCRP.
* No adverse effects were found in neither group.
In other words, the combination improved the IGT by selectively inducing the decrease of certain parameters without affecting the levels of LDL-C.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other herbal medicines may be considered supplements for the prevention of IGT, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of medicinal food plants on impaired glucose tolerance: A systematic review of randomized controlled trials by Demmers A1, Korthout H2, van Etten-Jamaludin FS3, Kortekaas F4, Maaskant JM. (PubMed)
(2) Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product by Cicero AFG1,2, Fogacci F3, Morbini M3, Colletti A3, Bove M3, Veronesi M3, Giovannini M3, Borghi C. (PubMed)
Impaired glucose tolerance is a condition found in prediabetes and type II diabetes associated with insulin resistance and increased risk of cardiovascular disease.
In other words, people with impaired glucose tolerance are less sensitive to the effects of insulin, leading to high blood glucose that is not high enough in the range of diabetes.
According to epidemiological studies, most people with impaired glucose tolerance are more like to develop diabetes and high blood pressure and cholesterol.
According to the statistics, approximately 11.2% of Americans age between 20-74 have IGT many of them do not know they have it, compared to 6.6% with diabetes.
The exact causes of IGT are unidentified. Some risk factors such as being overweight or obese, family history of diabetes, physical inactivity, high blood pressure or high cholesterol and gestational diabetes are found to induce a substantial risk of IGT.
Some researchers suggested that aging-induced the decrease of production of hormone and reduced function of body organ may have a strong implication to cause the condition developing.
Dr. Ervin Szoke, MD, the lead scientists in the examined the hyperglycemia in a total of 266 individuals with NGT and 130 individuals with IGT, ranging in age from ∼20 to ∼70 years, said, " In people with NGT, the disposition index for first- and second-phase insulin release decreased similarly at a rate of ∼0.7% per year. In people with IGT, the disposition indexes for first- and second-phase insulin release decreased at greater rates (∼2.2 and 1.4% per year, P = 0.002 and 0.009, respectively, vs. NGT), with the decrease in the first phase being greater than that of the second phase (P = 0.025)".
These results suggested that although aging does not correlate to insulin sensitive, it has a significant effect on insulin secretion. Over time, the condition may overwork the β-cell function that increases the risk of IGT.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Researchers on finding a potential compound for the prevention of diabetes evaluated the effect of turmeric on patients with impaired glucose tolerance.
The study included a review of randomized controlled trials (RCTs) conducted with a minimum follow-up period of 6weeks, according to the standard guideline and the Cochrane tool of risk of Bias Tool.
According to the results of the selected trials, curcumin extract intervention showed statistical significance after 3, 6 and 9months on the two-hour fasting plasma glucose.
Curcumin extract injection showed statistical significance in the reduction of glycosylated hemoglobin levels A1c (HbA1c) values after 3, 6 and 9 months.
Furthermore, curcumin extract administration also exerted a statistical significance against insulin resistance (HOMA-IR) after 6months and after 9months.
Compared to the effects of other herbal medicines used in the selected trials, curcumin is effective for the treatment of impaired glucose tolerance.
In order to understand more information about curcumin anti-IGT property, researchers conducted a double-blind, parallel group, placebo-controlled, randomized clinical trial in 40 adults affected by impaired fasting glucose (FPG = 100-125 mg/dL) in primary prevention of cardiovascular disease.
The results of the experiment included 2 weeks of dietary habits correction than patients continued the diet and began a period of 8 weeks of treatment with nutraceutical (combination of Lagerstroemia speciosa, Berberis aristata, Curcuma longa, Alpha-lipoic acid, Chrome picolinate, and Folic acid,) or placebo suggested * Nutraceutical treatment showed a significant improvement in TG (-34.7%), HDL-C (+13.7), FPI (-13.4%), and HOMA-Index (-25%) versus the baseline values compared to placebo.
* Both treatments showed no effect on body mass Index, LDL-C and hsCRP.
* No adverse effects were found in neither group.
In other words, the combination improved the IGT by selectively inducing the decrease of certain parameters without affecting the levels of LDL-C.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other herbal medicines may be considered supplements for the prevention of IGT, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of medicinal food plants on impaired glucose tolerance: A systematic review of randomized controlled trials by Demmers A1, Korthout H2, van Etten-Jamaludin FS3, Kortekaas F4, Maaskant JM. (PubMed)
(2) Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, Placebo-Controlled, Randomized Clinical Trial on a Combined Product by Cicero AFG1,2, Fogacci F3, Morbini M3, Colletti A3, Bove M3, Veronesi M3, Giovannini M3, Borghi C. (PubMed)
Tuesday, July 9, 2019
Tomatoes Inhibit Parameters Associated with the Risk of Cardiovascular Disease (CVD)
Cardiovascular disease (CVD) is a class of diseases associated with the blood vessels. Depending on the types of blood vessel damage or blocked, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart.
Heart failure, a major health problem associated with the reduced function of the heart that affects more than 6.5 million Americans is also a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
Epidemiologically, risk factors associated with cardiovascular disease include family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes.
Out of many risk factors, some researchers suggested the widespread obesity caused by the promotion of a high-fat diet over the past few decades may be one major condition that causes the onset of CVD.
Dr. Frank M. Sacks wrote, " Prospective observational studies in many populations showed that lower intake of saturated fat coupled with higher intake of polyunsaturated and monounsaturated fat is associated with lower rates of CVD and of other major causes of death and all-cause mortality. In contrast, replacement of saturated fat with mostly refined carbohydrates and sugars is not associated with lower rates of CVD and did not reduce CVD in clinical trials".
And, "Replacement of saturated with unsaturated fats lowers low-density lipoprotein cholesterol, a cause of atherosclerosis, linking biological evidence with the incidence of CVD in populations and in clinical trials".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural treatment of cardiovascular disease, researchers evaluated the state of the evidence from intervention trials on the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function.
By searching the medical literature database of Medline, Web of science, and Scopus from inception to August 2016, 21 studies fulfilled inclusion criteria out of 1189 publications were identified.
According to the results from the meta-analyses, overall, interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, inflammatory cytokine IL-6.
Furthermore, tomato injection improved the arteries function in blood circulation (flow-mediated dilation (FMD).
Compared to tomatoes, lycopene supplementation only reduced systolic-BP.
In other words, with the exception of blood pressure management by lycopene supplementation, dietary tomato provided more favorable results on cardiovascular risk, compared to lycopene supplementation.
The results strongly support the use of dietary tomatoes for the prevention of CVD.
Dr. Cheng HM. after taking other factors into accounts said, "The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure, and endothelial function".
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of CVD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis by Cheng HM1, Koutsidis G1, Lodge JK1, Ashor A2, Siervo M2, Lara J. (PubMed)
(2) Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors by Burton-Freeman B, Sesso HD. (PubMed)
(3) Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart AssociationFrank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson. (Circulation)
Heart failure, a major health problem associated with the reduced function of the heart that affects more than 6.5 million Americans is also a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
Epidemiologically, risk factors associated with cardiovascular disease include family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes.
Out of many risk factors, some researchers suggested the widespread obesity caused by the promotion of a high-fat diet over the past few decades may be one major condition that causes the onset of CVD.
Dr. Frank M. Sacks wrote, " Prospective observational studies in many populations showed that lower intake of saturated fat coupled with higher intake of polyunsaturated and monounsaturated fat is associated with lower rates of CVD and of other major causes of death and all-cause mortality. In contrast, replacement of saturated fat with mostly refined carbohydrates and sugars is not associated with lower rates of CVD and did not reduce CVD in clinical trials".
And, "Replacement of saturated with unsaturated fats lowers low-density lipoprotein cholesterol, a cause of atherosclerosis, linking biological evidence with the incidence of CVD in populations and in clinical trials".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural treatment of cardiovascular disease, researchers evaluated the state of the evidence from intervention trials on the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function.
By searching the medical literature database of Medline, Web of science, and Scopus from inception to August 2016, 21 studies fulfilled inclusion criteria out of 1189 publications were identified.
According to the results from the meta-analyses, overall, interventions supplementing tomato were associated with significant reductions in LDL-cholesterol, inflammatory cytokine IL-6.
Furthermore, tomato injection improved the arteries function in blood circulation (flow-mediated dilation (FMD).
Compared to tomatoes, lycopene supplementation only reduced systolic-BP.
In other words, with the exception of blood pressure management by lycopene supplementation, dietary tomato provided more favorable results on cardiovascular risk, compared to lycopene supplementation.
The results strongly support the use of dietary tomatoes for the prevention of CVD.
Dr. Cheng HM. after taking other factors into accounts said, "The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure, and endothelial function".
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of CVD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis by Cheng HM1, Koutsidis G1, Lodge JK1, Ashor A2, Siervo M2, Lara J. (PubMed)
(2) Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors by Burton-Freeman B, Sesso HD. (PubMed)
(3) Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart AssociationFrank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson. (Circulation)
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