Wednesday, July 24, 2019
Green Tea polyphenol epigallocatechin-3-gallate (EGCG) in Decreased Progression and Treatment of Her-2/ Positive Breast Cancer
Breast cancers with HER2 gene amplification or HER2 protein overexpression are called HER2-positive
HER2 is a protein that causes breast cancer cells to grow aggressively.
HER2-positive breast cancers tend to grow faster and are more likely to spread and come back in compared to HER2-negative breast cancers.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Breast cancer is a medical condition characterized by irregular cells growth in the breast tissues. At the late stage, the cancerous cell may travel a distance away to infect other organs and tissues from the original site.
The study of bioactive green tea polyphenol epigallocatechin-3-gallate (EGCG) was found to decrease the progression of breast cancer cells with Her-2/neu overexpression, through many mechanisms.
Application of green tea EGCG to Her-2/neu-driven mammary tumor cells showed a significant effect in blocking overexpression of key regulators in the epithelial to mesenchymal transition (EMT) pathway in induced invasive cell proliferation in breast outer layer tissues.
Additionally, the bioactive compound also inhibited Her-2/neu-driven mammary tumor cells by enhanced genes expression in related to tumor suppressor(epithelial genes E-cadherin, gamma-catenin) and promoted tumor cell cycle arrest(MTA3) and involved in the regulation of cellular proliferation and differentiation in target tissues(estrogen receptor alpha (ERalpha)).
Further analysis the study also addressed the important role of green tea EGCG in inhibition of Her-2/neu-driven mammary tumor cells through decreased the function of snail gene in the expression of tumor cells proliferative activity.
In cell migration and invasion assays, green tea EGCG also restrained branching colony growth and invasion of Her-2/neu-driven mammary tumor cells
Interestingly, invasive and metastatic I phenotype in mouse mammary tumor cells driven by overexpression of the protein in the transmuted transcription of DNA, involved cell survival and a messenger-independent in protecting against apoptotic tumor cells also inhibited by administration of green tea EGCG.
Furthermore, green tea EGCG treatment activated FOXO3a in triggered apoptosis of tumor cells and reversed the invasive characteristic of in ERalpha-positive breast cancer cells by blocking expression of the protein of transforming growth factor-beta in induced tumor cell growth, cell proliferation, cell differentiation.
Further differentiation of overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer, application of EGCG not only inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growth in culture and soft agar.but also ameliorated the risk of basal Her-2/neu receptor tyrosine phosphorylation in the contribution of exceptional oncogenic potency. via regulation of enzymes involved in cellular growth, proliferation, differentiation (phosphatidylinositol 3- kinase), and proteins in induced oncogenic transformation (Akt kinase to NF-kappaB pathway).
In SMF derived from mammary gland tumors and cultured and also epidermal growth factor receptor 4, green tea EGCG inhibited the expression of a significantly higher phosphorylation state of basal receptor which displays high constitutive Her-2/neu tumor.
Interestingly in the study of epigallocatechin-3 gallate (EGCG) effects in inhibited growth of Trastuzumab-resistant HER2-driven breast cancer cells, researchers found that EGCG treatment in a dose-dependent inhibited trastuzumab-resistant BT474 human breast cancer cells, isolated by chronic trastuzumab exposure and JIMT-1 breast cancer cells, by decreasing tumor growth, tumor cellular ATP production in absorption of chemical energy obtained from the breakdown of food molecules and releases it to fuel other cellular processes, and by inducing tumor cells apoptosis at high concentrations.
Most importantly, EGCG also suppressed multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. of Akt activity, improved FOXO3a function in triggered apoptosis of tumor cells and elevated expression of anti-tumor suppressor proteins. p27Kip1
Dr. Eddy SF, the lead author said, "EGCG in combination with trastuzumab may provide a novel strategy for the treatment of HER2-over expressing breast cancers, given that EGCG can cross the blood-brain barrier".
Taking all together, green tea with abundant bioactive polyphenol epigallocatechin-3-gallate (EGCG) may have therapeutic potential in reduced risk and progression of HER2 positive breast cancer, particularly when combined with other chemo-medicine.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate by Eddy SF1, Kane SE, Sonenshein GE.(PubMed)
(2) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells by Belguise K1, Guo S, Sonenshein GE.(PubMed)
(3) Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells by Pianetti S1, Guo S, Kavanagh KT, Sonenshein GE.(CANCER RESEARCH 62, 652–655, February 1, 2002])
Cucumber Protects the Blood Vessels Against the Risk and Onset of Vascular Disease
Vascular disease is a disease associated with an abnormal condition of the blood vessels, affecting the blood flow to the body.
There are many types of vascular disease, including
* Stroke caused by the blockage of blood flow to the brain, leading to the death of the neurons.
* Peripheral artery disease (PAD), a disease is caused by reduced blood flow to the limbs
* Abdominal aortic aneurysm (AAA), is a condition of a localized enlargement of the abdominal aorta.
*Carotid artery disease (CAD) is a condition caused by plaque builds up inside the carotid arteries. of the neck.
* Arteriovenous malformation (AVM), is a condition associated with an abnormal tangle of blood vessels connecting arteries and veins.
*Pulmonary embolism (blood clots) is a condition caused by the sudden blockage of an artery in the lung,
* Deep vein thrombosis (DVT) is caused by a blood clot formed in a vein deep.
Symptoms of vascular disease are totally depending on the types of conditions.
According to the statistics, vascular diseases are becoming an epidemic in the US. Approximately 8.5 million people in the US are living with Peripheral artery disease (PAD), one of the most common types of vascular disease.
Some researchers suggested that the rise of aging patients with vascular disease may be correlated to the promotion of high-fat diet over the past few decades in inducing a large population with obesity and Type II diabetes in the US.
Dr. Morteza Mowlaie, the lead scientist wrote, " Significant positive association between left ventricular hypertrophy and plaque score and also a significant positive association between left ventricular hypertrophy with the presence of chest pain was found (p<0.05)"
And, "Association of diabetes mellitus with the presence of chest pain was positive. A positive correlation between hypertension with plaque score was demonstrated too (p<0.05). Also, an inverse association of plaque score with left ventricular ejection fraction was detected too (p<0.05)".
In other words, vascular disease is a condition associated with patients with obesity and diabetes.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential ingredient for the treatment of impaired cells of the endothelium in the onset of many chronic and acute vascular diseases, researches examined the effect of cucumbers water/ethanol extract of Cucumis sativus L. (CSE) fruit on the damaging effect of pro-inflammatory lipopolysaccharide (LPS).
In vitro, a model of endothelial cells induced overexpression of pro-inflammatory cytokines with lipopolysaccharide (LPS) are incubated with a water/ethanol extract of Cucumis sativus L. (CSE) fruit.
CSE protected the integrity and viability of endothelial cells against LPS-induced cytotoxicity and decreased the cellular detachment, restoring the expression of tight junction ZO-1 that interacts with proteins associated with adherens junctions.
The increase of TLR4 expression associated with pathogen recognition and activation of innate immunity caused by LPS was also inhibited by the injection of CSE.
Futhermore, CSE also protected the endothelial cells by increasing the function of gene Heme oxygenase (HO)-1 involved in inhibition of oxidative stress.
Moreover, CSE not only inhibited the levels of pro-inflammatory cytokines produced by the administration of LPS but also exhibited the expression of anti-inflammatory cytokines and its detoxed enzymes.
Additonally, also in vitro, the angiogenesis induced by inflammatory LPS was prevented by the presence of Cucumis sativus L. extract (CSE), at any doses tested.
After taking into account other factors, researchers suggested that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells, thus reducing the onset of many chronic and acute vascular diseases.
Taken altogether, cucumber may be used for the treatment of chronic and acute vascular diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Close association of arterial plaques with left ventricular hypertrophy and ejection fraction in hemodialysis patients by Morteza Mowlaie 1 and Hamid Nasri. (PMC)
There are many types of vascular disease, including
* Stroke caused by the blockage of blood flow to the brain, leading to the death of the neurons.
* Peripheral artery disease (PAD), a disease is caused by reduced blood flow to the limbs
* Abdominal aortic aneurysm (AAA), is a condition of a localized enlargement of the abdominal aorta.
*Carotid artery disease (CAD) is a condition caused by plaque builds up inside the carotid arteries. of the neck.
* Arteriovenous malformation (AVM), is a condition associated with an abnormal tangle of blood vessels connecting arteries and veins.
*Pulmonary embolism (blood clots) is a condition caused by the sudden blockage of an artery in the lung,
* Deep vein thrombosis (DVT) is caused by a blood clot formed in a vein deep.
Symptoms of vascular disease are totally depending on the types of conditions.
According to the statistics, vascular diseases are becoming an epidemic in the US. Approximately 8.5 million people in the US are living with Peripheral artery disease (PAD), one of the most common types of vascular disease.
Some researchers suggested that the rise of aging patients with vascular disease may be correlated to the promotion of high-fat diet over the past few decades in inducing a large population with obesity and Type II diabetes in the US.
Dr. Morteza Mowlaie, the lead scientist wrote, " Significant positive association between left ventricular hypertrophy and plaque score and also a significant positive association between left ventricular hypertrophy with the presence of chest pain was found (p<0.05)"
And, "Association of diabetes mellitus with the presence of chest pain was positive. A positive correlation between hypertension with plaque score was demonstrated too (p<0.05). Also, an inverse association of plaque score with left ventricular ejection fraction was detected too (p<0.05)".
In other words, vascular disease is a condition associated with patients with obesity and diabetes.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential ingredient for the treatment of impaired cells of the endothelium in the onset of many chronic and acute vascular diseases, researches examined the effect of cucumbers water/ethanol extract of Cucumis sativus L. (CSE) fruit on the damaging effect of pro-inflammatory lipopolysaccharide (LPS).
In vitro, a model of endothelial cells induced overexpression of pro-inflammatory cytokines with lipopolysaccharide (LPS) are incubated with a water/ethanol extract of Cucumis sativus L. (CSE) fruit.
CSE protected the integrity and viability of endothelial cells against LPS-induced cytotoxicity and decreased the cellular detachment, restoring the expression of tight junction ZO-1 that interacts with proteins associated with adherens junctions.
The increase of TLR4 expression associated with pathogen recognition and activation of innate immunity caused by LPS was also inhibited by the injection of CSE.
Futhermore, CSE also protected the endothelial cells by increasing the function of gene Heme oxygenase (HO)-1 involved in inhibition of oxidative stress.
Moreover, CSE not only inhibited the levels of pro-inflammatory cytokines produced by the administration of LPS but also exhibited the expression of anti-inflammatory cytokines and its detoxed enzymes.
Additonally, also in vitro, the angiogenesis induced by inflammatory LPS was prevented by the presence of Cucumis sativus L. extract (CSE), at any doses tested.
After taking into account other factors, researchers suggested that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells, thus reducing the onset of many chronic and acute vascular diseases.
Taken altogether, cucumber may be used for the treatment of chronic and acute vascular diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Close association of arterial plaques with left ventricular hypertrophy and ejection fraction in hemodialysis patients by Morteza Mowlaie 1 and Hamid Nasri. (PMC)
Tuesday, July 23, 2019
Green Tea, The Liver Protective Functional Food
Liver disease is a reduced function in toxin elimination of liver as a result of damage or injury caused by medication, viral infection,...
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to the joint study lead by the Zhujiang Hospital of Southern Medical University Guangzhou, in the review of the database of PubMed, CNKI, Wanfang and Weipu databases, regular green tea drinking is associated to a significant reduction in the risk of liver disease, including hepatocellular carcinoma, liver steatosis, hepatitis, liver cirrhosis and chronic liver disease.
Also, Green tea demonstrated a reduced risk of liver disease regardless of the race and geography of the patients resided such as Asian, American and European subgroups.
Unfortunately, in a mouse model, different doses of GT fractions and EGCG and a single dose of lipopolysaccharide (LPS) combined with EGCG, administered for 5 days to mice suggested that mice fed with combining a single high dose of EGCG with a single dose of LPS showed to induce liver injury.
Repeat injection of EGCG in the group also found to associate to mild liver injury, probably was attributed to the adverse effect of lipopolysaccharide (LPS), the study insisted.
Epigallocatechin Gallate (EGCG) is one of the major and powerful antioxidants of green tea found to be most effective cancer chemopreventive polyphenol in many studies posted on medical literature. However, the single ingredients extract has also been found to induce hepatotoxicity and acute liver dysfunction in many occasions due to overdoses and long term usages.
Additionally, according to the Baylor College of Medicine and Dalhousie University, Halifax reported, "(There is) a case of acute impending liver failure in an adolescent male using a weight-loss product containing green tea extract" and "acute liver toxicity observed in individuals consuming supplements containing green tea extract".
Taking all together, the conflict result of green tea in liver disease may be a result of study design, group selection, sample size, doses intake,........People with liver disease should talk to a specialist of herbal products before consuming.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(2) Effect of green tea and its polyphenols on mouse liver by Saleh IG1, Ali Z, Abe N, Wilson FD, Hamada FM, Abd-Ellah MF, Walker LA, Khan IA, Ashfaq MK.(PubMed)
(3) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(4) Acute liver failure induced by green tea extracts: case report and review of the literature by Molinari M1, Watt KD, Kruszyna T, Nelson R, Walsh M, Huang WY, Nashan B, Peltekian K.(PubMed)
(5) Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury by Mohammad H Jamal,1,* Hamad Ali,2 Ali Dashti,2 Jasim Al-Abbad,1 Husain Dashti,1 Chako Mathew,2 Waleed Al-Ali,3 Sami Asfar1(PubMed)
Phytochemical Quercetin Isolated from Onion Inhibits Parameters Involved in Oral cancer Developing
Oral cancer is a medical condition of malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
Most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting over 90% of all cases and arisen from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. The cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
The cancer is originated from the salivary gland accounted for less than 1% of all cases.
According to the statistics, approximately, 53,000 Americans will be diagnosed with oral or oropharyngeal cancer in 2019.
The disease also causes the death of over 9,750 patients, roughly 1 person per hour, 24 hours per day.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The 5-year survival rate of the localized stage of oral cancer is 84%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the overall 5-year survival rate is 65%.
The survival rate is even lower (39%) If cancer has spread to a distant part of the body,
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In the urgency to find a potential compound for the treatment of oral cancer, researchers investigated the potential effects of quercetin, a principal flavonoid compound in onions anti-oral cancer activities.
On SAS human oral cancer cells, quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments.
Quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 that promotes cancer cell growth and proliferation and (MMP)-9 involved in cancer cells angiogenesis and metastasis.
Additionally, quercetin also inhibited the proteins associated with the promotion of forming new blood vessel in SAS human oral cancer cells.
Furthermore, quercetin also blocked the expression of enzymes associated with the pathogenesis of many solid tumors through its inflammatory activation.
Moreover, proteins involved in cellular interactions with the extracellular matrix that cause tumor initiation, progression, and metastasis were also inhibited by the injection of quercetin.
More importantly, quercetin also exhibited the gene expression of tumor suppression such as P53 and apoptosis.
In other words, quercetin protects the oral cells by blocking the proteins involved in the signaling expression of tumor initiation, progression, and metastasis such as Ras homolog gene family, member A (RhoA) and protein kinase C (PKC).
Taken altogether, onion may be considered a remedy for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)
(2) Mouth ( Oral Cancer) Cancer by Kyle J. Norton
Most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting over 90% of all cases and arisen from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. The cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
The cancer is originated from the salivary gland accounted for less than 1% of all cases.
According to the statistics, approximately, 53,000 Americans will be diagnosed with oral or oropharyngeal cancer in 2019.
The disease also causes the death of over 9,750 patients, roughly 1 person per hour, 24 hours per day.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The 5-year survival rate of the localized stage of oral cancer is 84%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the overall 5-year survival rate is 65%.
The survival rate is even lower (39%) If cancer has spread to a distant part of the body,
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In the urgency to find a potential compound for the treatment of oral cancer, researchers investigated the potential effects of quercetin, a principal flavonoid compound in onions anti-oral cancer activities.
On SAS human oral cancer cells, quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments.
Quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 that promotes cancer cell growth and proliferation and (MMP)-9 involved in cancer cells angiogenesis and metastasis.
Additionally, quercetin also inhibited the proteins associated with the promotion of forming new blood vessel in SAS human oral cancer cells.
Furthermore, quercetin also blocked the expression of enzymes associated with the pathogenesis of many solid tumors through its inflammatory activation.
Moreover, proteins involved in cellular interactions with the extracellular matrix that cause tumor initiation, progression, and metastasis were also inhibited by the injection of quercetin.
More importantly, quercetin also exhibited the gene expression of tumor suppression such as P53 and apoptosis.
In other words, quercetin protects the oral cells by blocking the proteins involved in the signaling expression of tumor initiation, progression, and metastasis such as Ras homolog gene family, member A (RhoA) and protein kinase C (PKC).
Taken altogether, onion may be considered a remedy for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)
(2) Mouth ( Oral Cancer) Cancer by Kyle J. Norton
Monday, July 22, 2019
Green Tea, The Nano-Beverage for Treatment of Ovarian Cancer
Ovarian cancer is a medical condition characterized by cell growth disorderly in the ovaries. At the late stage, cancerous cells may infect tissues and organs far away from the originated site.
In the analysis of the EGCG effects on 8 ovarian cancer cell lines (SKOV3, CAOV3, OVCAR3, OVCAR10, A2780, CP70, C30, and C200) and showed IC50s for EGCG at the micromolar range, researchers found that EGCG inhibited all ovarian cancer cell lines in dose depending manner.
Normal dose application of EGCG displayed a significant increase of antioxidant in reduced ROS overexpression of oxidative stress in inhibited ovarian cancer through cell cycle arrest in G2/M phase.
Further differentiation also revealed that administration of EGCG at a common dose not only demonstrated a 6 fold increase of cisplatin potency for treatment of SKOV3, CAOV3, and C200 cells but also attenuated the chemo drug toxicity.
However, the effect of EGCG on the formation of reactive oxygen species (ROS) was biphasic.
The phytochemical was shown to induce and decrease ROS formation in different doses.
Therefore, a higher dose of EGCG promoted overexpression of antioxidants in reduced oxidative stress may amplify the toxicity in ameliorated human cancer cells proliferation and induced apoptosis.
Dr., the lead author said, "EGCG may accentuate oxidative stress to inhibit the growth of ovarian cancer cells and sensitize them to cisplatin".
Other researchers in the study of the toxicity of EGCG suggested that green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) as a potent adjuvant to enhance the anti-tumor efficacy of cisplatin while mitigating its harmful side effects through various mechanisms.
Application of EGCG showed to promote hyaluronic acid function in the regulation of normal cell division and prevention of the acid in the initiation of cancerous cell proliferation.
Hyaluronic acid, a polysaccharide molecule, plays an important role in cell proliferation and migration and may involve in the progression of some malignant tumors.
Additionally, EGCG also expressed the anti-cancer effect by promoting the injection of chemo medicine cisplatin into the CD44-overexpressing cancer cells to prevent overgrowth of tumor cells.
In regard to toxicity, EGCG, on one hand, reduced overexpression of oxidative stress in initiated toxicity against off-target organs and tissues through induction of significant antioxidant activity on the hand and stimulated the function of toxicity originating from cisplatin into the target tumors on the other.
Further analysis, green tea catechin-based micellar nanocomplexes also inhibited superiorly against tumor growth with no injection of cisplatin and expressed a significant inhibition without induced toxicity in both cancer cells suspended in culture medium and injected into the animal models and peritoneal metastatic model of human ovarian cancer.
In other words, green tea catechin-based micellar nanocomplexes may be considered as a safe and effective cisplatin nanomedicine for ovarian cancer treatment.
More interestingly, in the additionally examined the effect of EGCG in suppressing ovarian cancer cell growth in 3 human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells),
EGCG decreased tumor growth in each cell line in a dose-dependent fashion and induced apoptosis and cell cycle arrest, particular to the G(1) phase in SKOV-3 and OVCAR-3 cells in compared to G(1)/S transition phase arrest in PA-1 cells.
The chemical also differentiate upregulated the expression of genes and proteins in promoted cancer cell arrest, suppressed tumor growth and induced cell death (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) by more than 2-fold
Taking all together, green tea may have a profound effect on reduced risk and treatment of ovarian cancer through the expression of phytochemical EGCG. However, the intake of green tea extract must be taken with care, as overdoses were found to induce liver toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity by Bae KH1, Tan S1, Yamashita A1, Ang WX1, Gao SJ1, Wang S1, Chung JE1, Kurisawa M2.(PubMed)
(2) Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility by Chan MM1, Soprano KJ, Weinstein K, Fong D.(PubMed)
(3) Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines by Huh SW1, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS.(PubMed)
In the analysis of the EGCG effects on 8 ovarian cancer cell lines (SKOV3, CAOV3, OVCAR3, OVCAR10, A2780, CP70, C30, and C200) and showed IC50s for EGCG at the micromolar range, researchers found that EGCG inhibited all ovarian cancer cell lines in dose depending manner.
Normal dose application of EGCG displayed a significant increase of antioxidant in reduced ROS overexpression of oxidative stress in inhibited ovarian cancer through cell cycle arrest in G2/M phase.
Further differentiation also revealed that administration of EGCG at a common dose not only demonstrated a 6 fold increase of cisplatin potency for treatment of SKOV3, CAOV3, and C200 cells but also attenuated the chemo drug toxicity.
However, the effect of EGCG on the formation of reactive oxygen species (ROS) was biphasic.
The phytochemical was shown to induce and decrease ROS formation in different doses.
Therefore, a higher dose of EGCG promoted overexpression of antioxidants in reduced oxidative stress may amplify the toxicity in ameliorated human cancer cells proliferation and induced apoptosis.
Dr., the lead author said, "EGCG may accentuate oxidative stress to inhibit the growth of ovarian cancer cells and sensitize them to cisplatin".
Other researchers in the study of the toxicity of EGCG suggested that green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) as a potent adjuvant to enhance the anti-tumor efficacy of cisplatin while mitigating its harmful side effects through various mechanisms.
Application of EGCG showed to promote hyaluronic acid function in the regulation of normal cell division and prevention of the acid in the initiation of cancerous cell proliferation.
Hyaluronic acid, a polysaccharide molecule, plays an important role in cell proliferation and migration and may involve in the progression of some malignant tumors.
Additionally, EGCG also expressed the anti-cancer effect by promoting the injection of chemo medicine cisplatin into the CD44-overexpressing cancer cells to prevent overgrowth of tumor cells.
In regard to toxicity, EGCG, on one hand, reduced overexpression of oxidative stress in initiated toxicity against off-target organs and tissues through induction of significant antioxidant activity on the hand and stimulated the function of toxicity originating from cisplatin into the target tumors on the other.
Further analysis, green tea catechin-based micellar nanocomplexes also inhibited superiorly against tumor growth with no injection of cisplatin and expressed a significant inhibition without induced toxicity in both cancer cells suspended in culture medium and injected into the animal models and peritoneal metastatic model of human ovarian cancer.
In other words, green tea catechin-based micellar nanocomplexes may be considered as a safe and effective cisplatin nanomedicine for ovarian cancer treatment.
More interestingly, in the additionally examined the effect of EGCG in suppressing ovarian cancer cell growth in 3 human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells),
EGCG decreased tumor growth in each cell line in a dose-dependent fashion and induced apoptosis and cell cycle arrest, particular to the G(1) phase in SKOV-3 and OVCAR-3 cells in compared to G(1)/S transition phase arrest in PA-1 cells.
The chemical also differentiate upregulated the expression of genes and proteins in promoted cancer cell arrest, suppressed tumor growth and induced cell death (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) by more than 2-fold
Taking all together, green tea may have a profound effect on reduced risk and treatment of ovarian cancer through the expression of phytochemical EGCG. However, the intake of green tea extract must be taken with care, as overdoses were found to induce liver toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity by Bae KH1, Tan S1, Yamashita A1, Ang WX1, Gao SJ1, Wang S1, Chung JE1, Kurisawa M2.(PubMed)
(2) Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility by Chan MM1, Soprano KJ, Weinstein K, Fong D.(PubMed)
(3) Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines by Huh SW1, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS.(PubMed)
Herbal Bilberry Protects the Neurons Against Memory Impairment in Vivo
Memory impairment is a condition of partial or complete loss of memory, depending on the quality of the neuron that has been affected.
Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.
The most common risk factors associated with memory loss in the general population are long-term use of certain medication, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.
In elderly or aging-induced memory loss are associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.
However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.
Dr. Scott E. Kanoski, the lead scientist in the review the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".
And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".
The results clearly stated if you are Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a potential ingredient for the treatment of memory impairment researchers investigated the effects of Vaccinium uliginosum L. (bilberry) on the learning and memory impairments induced by amyloid-β protein (AβP) 1-42.
The evaluation included selected ICR Swiss mice divided randomly into 4 groups: the control (Aβ40-1A), control with 5% bilberry group (Aβ40-1B), amyloid β protein 1-42 treated group (Aβ1-42A), and Aβ1-42 with 5% bilberry group (Aβ1-42B).
According to the tested assays, bilberry added groups showed to decrease the finding time of hidden platform, compared to those of escape latencies of AβP to that of Aβ40-1.
Furthermore, bilberry added Aβ1-42B group also showed a significant (P<0.05) increase of probe crossing frequency compared to Aβ1-42A.
In the passive avoidance test, bilberry significantly (P<0.05) increased the time of staying in the lighted area compared to AD control.
These results suggested that bilberry improved memory and learning capability in chemically induced Alzheimer's disease in experimental animal models.
In the incidence of degenerative disorders including Alzheimer's disease (AD), rats consumed approximately 3.2 mg kg(-1)day (oral), of the anthocyanins significantly enhanced short-term memory, but not long-term memory in the inhibitory avoidance task.
Moreover, injection of approximately 3.2 mg kg(-1)day (oral), of the anthocyanins also induced an increase in the number of crossings in the first exposure to the open field.
However, in the comparison of the radial maze and elevated plus-maze, lyophilized berries (blueberry, bilberry) improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, compared to no effects in the elevated plus-maze task.
The findings strongly indicated the positive effects of administration of lyophilized Vaccinium berries (blueberry, bilberry) and anthocyanin in the prevention of memory deficits related to AD.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of memory impairment, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Vaccinium uliginosum L. Improves Amyloid β Protein-Induced Learning and Memory Impairment in Alzheimer's Disease in Mice by Choi YH1, Kwon HS1, Shin SG1, Chung CK. (PubMed)
(2) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)
(3) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)
Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.
The most common risk factors associated with memory loss in the general population are long-term use of certain medication, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.
In elderly or aging-induced memory loss are associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.
However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.
Dr. Scott E. Kanoski, the lead scientist in the review the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".
And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".
The results clearly stated if you are Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a potential ingredient for the treatment of memory impairment researchers investigated the effects of Vaccinium uliginosum L. (bilberry) on the learning and memory impairments induced by amyloid-β protein (AβP) 1-42.
The evaluation included selected ICR Swiss mice divided randomly into 4 groups: the control (Aβ40-1A), control with 5% bilberry group (Aβ40-1B), amyloid β protein 1-42 treated group (Aβ1-42A), and Aβ1-42 with 5% bilberry group (Aβ1-42B).
According to the tested assays, bilberry added groups showed to decrease the finding time of hidden platform, compared to those of escape latencies of AβP to that of Aβ40-1.
Furthermore, bilberry added Aβ1-42B group also showed a significant (P<0.05) increase of probe crossing frequency compared to Aβ1-42A.
In the passive avoidance test, bilberry significantly (P<0.05) increased the time of staying in the lighted area compared to AD control.
These results suggested that bilberry improved memory and learning capability in chemically induced Alzheimer's disease in experimental animal models.
In the incidence of degenerative disorders including Alzheimer's disease (AD), rats consumed approximately 3.2 mg kg(-1)day (oral), of the anthocyanins significantly enhanced short-term memory, but not long-term memory in the inhibitory avoidance task.
Moreover, injection of approximately 3.2 mg kg(-1)day (oral), of the anthocyanins also induced an increase in the number of crossings in the first exposure to the open field.
However, in the comparison of the radial maze and elevated plus-maze, lyophilized berries (blueberry, bilberry) improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, compared to no effects in the elevated plus-maze task.
The findings strongly indicated the positive effects of administration of lyophilized Vaccinium berries (blueberry, bilberry) and anthocyanin in the prevention of memory deficits related to AD.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of memory impairment, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Vaccinium uliginosum L. Improves Amyloid β Protein-Induced Learning and Memory Impairment in Alzheimer's Disease in Mice by Choi YH1, Kwon HS1, Shin SG1, Chung CK. (PubMed)
(2) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)
(3) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)
Sunday, July 21, 2019
Green Tea In Reducing Risk and Treatment of Lung Cancer
Lung cancer is a medical condition characterized by cells growth disorderly and uncontrollably of lung tissues. At the late stage, the cancerous cells may travel a distance from the original site to infect other organs and tissues.
In the study to investigate the anti lung cancer effect of Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, after taking into account of other confounders, researchers at the joint study lead by the Kyushu University of Health & Welfare, suggested that
1. The phytochemical induced apoptosis of lung cancer through suppression of cell division, in cell culture
2. In human A549 human non-small-cell lung cancer cell line, EGCg inhibited cancer cell proliferation by interfering mRNA expression in the modulation of apoptotic cell death
3. Additionally, application of 100 μM EGCg for 24 h. exhibited cancerous morphological changes, thus reducing cell proliferation
The study also revealed that the efficacy of EGCg inhibited B-cell lymphoma-extra large (Bcl-xL) through the expression of mRNA and suppression of gene in related to cell death.
Further analysis of Epigallocatechin-3-gallate (EGCg) in inhibited gene expression in risk of lung cancer by binding HIF-1α, in promoted cell proliferation and anchorage-independent growth, researchers launched a study to elucidate the role of microRNA in the EGCG inhibition of tobacco carcinogen-induced lung tumors in A/J mice found that 26 potential targeted genes of the 21 microRNAs. with the mRNA expression profiles may have some implications in increased lung cancer risk.
Interestingly, application of EGCg, indeed, demonstrated a significant effect in improved cell regulation and reduced cell proliferation through many mechanisms, including regulation of
1. AKT pathway in promoted survival and growth in response to extracellular signals.
2. NF-κB expression in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation and
3. MAP kinases, involved a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.
In other words, Epigallocatechin-3-gallate (EGCg) effect reduced risk and treatment of lung cancer is attributed to the inhibition of expression of RNA in transmitting information to proteins with function to initiated cancer cell change, including cell proliferation and apoptosis.
The findings also suggested that green tea Epigallocatechin-3-gallate (EGCg) has a strong effect in reduced risk lung cancer through both expressions of mutating and cancer-related genes.
More importantly, mutated genes expression has been identified in contributing to cancer development and progression, therefore by target the expression of such genes may help scientists in exploring the origins of abnormal gene expression in compared to normal cells.
Other researchers suggested that targeting both DNA and RNA data to identify alternative expression of the mutated gene in patients of lung cancer may open the door by offering specific treatment only for such patients
More precisely, by identified such gene in cancer cell patients, scientists may prescribe gene targeting technology, specific medication, and treatment to stop cancer from growing and spreading.
Further differentiation of the effect of green tea extract in lung cancer risk, researchers at the University in Toruń filed the following report
1. Green tea extract catechins demonstrated a significant effect in inhibition of lung cancer line A549 independent to doses applied and
2. Increased cell and marker of cell degradation
3. Green tea extract catechins also expressed a strong protective effect in reduced self cause of toxicity
Collectively, this illustration indicated that green tea extract catechins exerted anti lung cancer progression through protection against destruction and damage of redundant cellular components occurring in vacuoles within the cell without induced side effects
The evidence indicated that certain phytochemicals found in green tea may have potential in attenuated risk and treatment of lung cancer. But intake of green tea extract supplements have been found to induce liver toxicity, particularly if overdosed.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression by Sonoda JI1, Ikeda R2, Baba Y3, Narumi K1, Kawachi A1, Tomishige E1, Nishihara K1, Takeda Y2, Yamada K4, Sato K5, Motoya T1.(PubMed)
(2) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer by Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H.(PubMed)
(3) Green tea extract induces protective autophagy in A549 non-small lung cancer cell line by Izdebska M1, Klimaszewska-Wiśniewska A1, Hałas M1, Gagat M1, Grzanka A1.(PubMed)
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