Green Tea In Reducing Risk and Treatment of Lung Cancer

Lung cancer is a medical condition characterized by cells growth disorderly and uncontrollably of lung tissues. At the late stage, the cancerous cells may travel a distance from the original site to infect other organs and tissues.

In the study to investigate the anti lung cancer effect of Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, after taking into account of other confounders, researchers at the joint study lead by the Kyushu University of Health & Welfare, suggested that
1. The phytochemical induced apoptosis of lung cancer through suppression of cell division, in cell culture
2. In human A549 human non-small-cell lung cancer cell line, EGCg inhibited cancer cell proliferation by interfering mRNA expression in the modulation of apoptotic cell death
3. Additionally, application of 100 μM EGCg for 24 h. exhibited cancerous morphological changes, thus reducing cell proliferation

The study also revealed that the efficacy of EGCg inhibited B-cell lymphoma-extra large (Bcl-xL) through the expression of mRNA and suppression of gene in related to cell death.


Further analysis of Epigallocatechin-3-gallate (EGCg) in inhibited gene expression in risk of lung cancer by binding HIF-1α, in promoted cell proliferation and anchorage-independent growth, researchers launched a study to elucidate the role of microRNA in the EGCG inhibition of tobacco carcinogen-induced lung tumors in A/J mice found that 26 potential targeted genes of the 21 microRNAs. with the mRNA expression profiles may have some implications in increased lung cancer risk.

Interestingly, application of EGCg, indeed, demonstrated a significant effect in improved cell regulation and reduced cell proliferation through many mechanisms, including regulation of

1. AKT pathway in promoted survival and growth in response to extracellular signals.
2. NF-κB expression in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation and
3. MAP kinases, involved a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.


In other words, Epigallocatechin-3-gallate (EGCg) effect reduced risk and treatment of lung cancer is attributed to the inhibition of expression of RNA in transmitting information to proteins with function to initiated cancer cell change, including cell proliferation and apoptosis.


The findings also suggested that green tea Epigallocatechin-3-gallate (EGCg) has a strong effect in reduced risk lung cancer through both expressions of mutating and cancer-related genes.

More importantly, mutated genes expression has been identified in contributing to cancer development and progression, therefore by target the expression of such genes may help scientists in exploring the origins of abnormal gene expression in compared to normal cells.

Other researchers suggested that targeting both DNA and RNA data to identify alternative expression of the mutated gene in patients of lung cancer may open the door by offering specific treatment only for such patients

More precisely, by identified such gene in cancer cell patients, scientists may prescribe gene targeting technology, specific medication, and treatment to stop cancer from growing and spreading.


Further differentiation of the effect of green tea extract in lung cancer risk, researchers at the University in Toruń filed the following report
1. Green tea extract catechins demonstrated a significant effect in inhibition of lung cancer line A549 independent to doses applied and
2. Increased cell and marker of cell degradation
3. Green tea extract catechins also expressed a strong protective effect in reduced self cause of toxicity

Collectively, this illustration indicated that green tea extract catechins exerted anti lung cancer progression through protection against destruction and damage of redundant cellular components occurring in vacuoles within the cell without induced side effects

The evidence indicated that certain phytochemicals found in green tea may have potential in attenuated risk and treatment of lung cancer. But intake of green tea extract supplements have been found to induce liver toxicity, particularly if overdosed.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression by Sonoda JI1, Ikeda R2, Baba Y3, Narumi K1, Kawachi A1, Tomishige E1, Nishihara K1, Takeda Y2, Yamada K4, Sato K5, Motoya T1.(PubMed)
(2) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer by Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H.(PubMed)
(3) Green tea extract induces protective autophagy in A549 non-small lung cancer cell line by Izdebska M1, Klimaszewska-Wiśniewska A1, Hałas M1, Gagat M1, Grzanka A1.(PubMed)