Atherosclerosis is a medical condition characterized by the deposition of plaques of fatty material on the inner walls, causing to hardening of the arterial vessels.
According to statistic, the mortality rate of coronary heart disease was about 60% in 2010 in compared to 30% of stroke and heart failure.
In the study to determine the effect of green tea bioactive epigallocatechin-3-gallate (EGCG) in ameliorated Porphyromonas gingivalis -induced atherosclerosis in a murine model, after injection of the extract EGCG, the tested mice than fed high-fat diets and injected with P. gingivalis three times a week for 3 weeks, observation at weeks 15 displayed a significant reduction of atherosclerotic plaques accumulated in the branches of arteries, observed by Oil Red O staining
Further analysis also found that the polyphenol extract decreased infection of atherosclerotic lesion areas in the anatomic dilations of the ascending aorta through decreased expression of C-reactive protein, in regulated the acute phase of infection and monocyte chemoattractant protein-1 (MCP-1/CCL2) chemokines in regulated migration and infiltration of monocytes/macrophages.of immune system in induced production of cytokines to counter foreign substances.
Additional observation, also indicated that green tea bioactive epigallocatechin-3-gallate (EGCG) not also improved LDL/very LDL cholesterol but also ameliorated ROS activity via antioxidant in induced low-density lipoprotein (LDL) oxidation, a leading indicator of plague accumulation.
In-depth differentiation, the efficacy of green tea epigallocatechin-3-gallate (EGCG) in reduced expression of atherosclerosis due to bacterial P. gingivalis was attributed to decrease secreted proteins with functions in stimulated inflammatory effects, such as chemokines (CCL2) involved in immunoregulatory and inflammatory processes, matrix metallopeptidase 9 (MMP-9) in regulated pathological remodeling processes that involve inflammation, ICAM-1 (Intercellular Adhesion Molecule 1) involved inflammation of capillary vessel walls, the mitochondrial chaperonin hsp60 in induction of inflammation,......
Interestingly, in the process to prevent plague to initiation of development of atherosclerosis through above implications, green tea epigallocatechin-3-gallate (EGCG) also increased levels of antioxidant defense enzyme (heme oxygenase-1 mRNA) HO-1 mRNA levels in reduced expression of oxidative stress in induction of pathogenic inflammatory diseases.
Intrusively, continued investigated the effect of epigallocatechin-3-gallate (EGCG) in inhibit the formation and development of atherosclerosis via its anti-inflammatory capability also found that EGCG restricts the function of IL6 (interleukin 6) in induced overexpression of pro-inflammatory cytokines and Angiotensin (Ang) II functions in stimulated and increased vascular permeability through production of vascular endothelial cell growth factor CRP in initiated the pro-inflammatory process.
Interleukin 6 is an interleukin with duo functions of pro-inflammatory cytokines and anti-inflammatory cytokines.
Amazingly, antioxidant activities of EGCG also acted as free radical scavengers to prevent ROS to establish a chain reaction in the induction of inflammatory effect in encouraging lipid accumulation in the inner wall of arteries, the leading cause of atherosclerosis.
ROS are free radical with function to mediate many pathophysiological processes, such as growth, migration, apoptosis, and secretion of inflammatory cytokines,
Angiotensin is a hormone with function in regulated vasoconstriction in increased blood pressure.
Application of combined (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA). demonstrated a significant effect in reduced risk and treatment of atherosclerosis through ameliorated lipid deposition in tested animals.
In compared to the effects of conventional medicine simvastatin with an approximately successful treatment rate of lipid deposition of 15.6%, injection of (-)-Epigallocatechin gallate (EGCG) +chitosan (CS) and aspartic acid (PAA).exhibited overall treatment rate of 16.9%.
The accounted evidence suggesting that EGCG, as a natural substance, may have a substantial and therapeutic effect in attenuated risk and treatment of atherosclerosis through anti-inflammatory and antioxidative activities.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sourcesase
(1) Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis -induced atherosclerosis by Yu Cai Tomoko Kurita-Ochiai Tomomi Hashizume Masafumi Yamamoto(Pathogen and Disease)
https://academic.oup.com/femspd/article/67/1/76/2367414
(2) Improving the effectiveness of (-)-epigallocatechin gallate (EGCG) against rabbit atherosclerosis by EGCG-loaded nanoparticles prepared from chitosan and polyaspartic acid by Hong Z1, Xu Y, Yin JF, Jin J, Jiang Y, Du Q.(PubMed)
(3) Epigallocatechin-3-gallate inhibits interleukin-6- and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells by NingPeng, Jun-tian Liu Fang. Guo. Rui Li(Science Direct)
Sunday, August 4, 2019
Saturday, August 3, 2019
Green Tea Epigallocatechin Gallete (EGCG) and Theaflavin (TF) in Ameliorated Risk and Treatment of Liver Cancer
Green tea may have a sustainable and positive effect in reduced risk and treatment of liver cancer, Some studies suggested
Liver cancer is a medical condition caused by cell growth disorderly and uncontrollably in the liver tissues. At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.
In the review of medical literature published online, green tea bioactive phytochemicals such as Epigallocatechin gallate (EGCG) and Theaflavin (TF), in prevention and treatment of liver cancer have been postulated by several mechanisms.
In liver cancer, animal model induced by chronic exposure of N-nitrosodiethylamine (NDEA), a carcinogenic and mutagenic organic compound, application of green tea bioactive compounds Epigallocatechin gallate (EGCG) and Theaflavin (TF) demonstrated a strong effect in reduced initiation of cancer formation and potential chemopreventive effect in pre and post-treatment of the injected animal.
Further observation showed that EGCG/TF action in restraining the overexpression of liver cancer also found to modulate similarly to those of CD44-specific cell membrane binding combined with near-infrared irradiation in the induction of cellular apoptosis.
High CD44-positive expression is found to associate with acute cancer cells killing.
The restriction processes of EGCG/TF in modification of onset of liver cancer development, was also found to modify multiple biogenesis involved maintaining a relatively stable equilibrium in organs tissues(self-renewal Wnt/β-catenin, Hh/Gli1 pathways) in gene with implication of cell cycle progression, apoptosis and cellular transformation and cell differentiation and proliferation(Cyclin D1, cMyc and EGFR) and tumor suppressor (E-cadherin) during the carcinogenesis processes.
The additional illustration also indicated that the therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) also regulated the expression of the protein of cell differentiation, polarity and proliferation(the self-renewal Wnt and Hedgehog (Hh) pathways).during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.
Application of green tea bioactive tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) induced chemopreventive potential in maintaining cell integrity at the 30 weeks of CCl4/N-nitosodiethylamine application.
Continuous administration of EGCG/TF exerted a strong impact in reduced proliferation and increased apoptosis, as well as the decreased function of hepatic progenitor cells (HPCs) in the participated restoration of the cancerous liver tissue and population with cancer stem cell-like characteristics in liver carcinoma observed by AFP and CD44 expression.in CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.
More interestingly, also during the restriction processes of EGCG/TF, the bioactive compounds also modulated the expression of tumor progression to a more invasive phenotype(phospho-β-catenin-Y-654), tumor suppressor(β-catenin), the proliferation, migration and invasion of liver cancer gene(sFRP1 ) and gene in control tumor suppressor(β-catenin).
In other words, green tea EGCG/TF inhibited the contaminated cells inflicted by injection of CCl4/N-nitosodiethylamine to prevent the initiation of liver cancer through modulation of certain gene expressions involved in liver cancer progression.
In short, the inhibition of liver carcinogenesis by EGCG/TF was attributed to a reduction in hepatocyte progenitor cell and stem cell population in restored liver cancerous cells damage through various mechanisms indicated above.
Taken together, green tea bioactive ingredients epigallocatechin gallete (EGCG) and theaflavin (TF) may be a useful secondary preventive agent for targeting liver cancer in combination with standard chemotherapies.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice by Sur S1, Pal D2, Roy R2, Barua A2, Roy A3, Saha P2, Panda CK4.(PubMed)
(2) Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways by Sur S1, Pal D2, Mandal S3, Roy A4, Panda CK5.(PubMed)
Liver cancer is a medical condition caused by cell growth disorderly and uncontrollably in the liver tissues. At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.
In the review of medical literature published online, green tea bioactive phytochemicals such as Epigallocatechin gallate (EGCG) and Theaflavin (TF), in prevention and treatment of liver cancer have been postulated by several mechanisms.
In liver cancer, animal model induced by chronic exposure of N-nitrosodiethylamine (NDEA), a carcinogenic and mutagenic organic compound, application of green tea bioactive compounds Epigallocatechin gallate (EGCG) and Theaflavin (TF) demonstrated a strong effect in reduced initiation of cancer formation and potential chemopreventive effect in pre and post-treatment of the injected animal.
Further observation showed that EGCG/TF action in restraining the overexpression of liver cancer also found to modulate similarly to those of CD44-specific cell membrane binding combined with near-infrared irradiation in the induction of cellular apoptosis.
High CD44-positive expression is found to associate with acute cancer cells killing.
The restriction processes of EGCG/TF in modification of onset of liver cancer development, was also found to modify multiple biogenesis involved maintaining a relatively stable equilibrium in organs tissues(self-renewal Wnt/β-catenin, Hh/Gli1 pathways) in gene with implication of cell cycle progression, apoptosis and cellular transformation and cell differentiation and proliferation(Cyclin D1, cMyc and EGFR) and tumor suppressor (E-cadherin) during the carcinogenesis processes.
The additional illustration also indicated that the therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) also regulated the expression of the protein of cell differentiation, polarity and proliferation(the self-renewal Wnt and Hedgehog (Hh) pathways).during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.
Application of green tea bioactive tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) induced chemopreventive potential in maintaining cell integrity at the 30 weeks of CCl4/N-nitosodiethylamine application.
Continuous administration of EGCG/TF exerted a strong impact in reduced proliferation and increased apoptosis, as well as the decreased function of hepatic progenitor cells (HPCs) in the participated restoration of the cancerous liver tissue and population with cancer stem cell-like characteristics in liver carcinoma observed by AFP and CD44 expression.in CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.
More interestingly, also during the restriction processes of EGCG/TF, the bioactive compounds also modulated the expression of tumor progression to a more invasive phenotype(phospho-β-catenin-Y-654), tumor suppressor(β-catenin), the proliferation, migration and invasion of liver cancer gene(sFRP1 ) and gene in control tumor suppressor(β-catenin).
In other words, green tea EGCG/TF inhibited the contaminated cells inflicted by injection of CCl4/N-nitosodiethylamine to prevent the initiation of liver cancer through modulation of certain gene expressions involved in liver cancer progression.
In short, the inhibition of liver carcinogenesis by EGCG/TF was attributed to a reduction in hepatocyte progenitor cell and stem cell population in restored liver cancerous cells damage through various mechanisms indicated above.
Taken together, green tea bioactive ingredients epigallocatechin gallete (EGCG) and theaflavin (TF) may be a useful secondary preventive agent for targeting liver cancer in combination with standard chemotherapies.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice by Sur S1, Pal D2, Roy R2, Barua A2, Roy A3, Saha P2, Panda CK4.(PubMed)
(2) Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways by Sur S1, Pal D2, Mandal S3, Roy A4, Panda CK5.(PubMed)
Friday, August 2, 2019
Green Tea Bioactive Polyphenol EGCG for Ameliorated Risk and Treatment of Colon Cancer
Colon cancer is a medical condition caused by cell growth disorderly and uncontrollably in the colon tissues. At the later stage, the cancerous cell may travel a distance away to infect other healthy organs and tissues.
In the review of medical literature published online, green tea efficacy in reduced risk and treatment of colon cancer may be associated with the bioactive polyphenol EGCG expression in the promoted and
decreased certain interaction in the cell profiles through various mechanisms.
According to the study by the University College of Medicine, Seoul, application of EGCG on HT-29 colon cancer cells showed a significant effect in the inhibition of cell cycle progression of protein in COX-2 expression. through activation of AMPK activity in promoted metabolic tumor suppressor by regulating energy levels, enforcing metabolic checkpoints and inhibiting cell growth.
Cyclooxygenase(COX)-2, is an enzyme with function in speeding up the production of hormone prostaglandins in regulated cell proliferation and cell apoptosis.
AMPK(5' AMP-activated protein kinase) plays a role in cellular energy homeostasis, activation of AMPK may result in tumor growth inhibition, cell cycle arrest, and apoptosis of cancer cells in some tumor types/contexts.
Additionally, in inhibition of COX-2 expression green tea EGCG reduced prostaglandin E(2) secretion, thus reducing risk of Prostaglandin E2 (PGE2) in modulated angiogenesis, including the process of new blood vessel formation, promoted proliferation, migration and formation of endothelial cells, lining the interior surface of blood vessels and lymphatic vessels.
The study also emphasized that inhibiting AMPK by an AMPK inhibitor may interrupt the function of the bioactive compound in initiated such changes.
Continuously, the activation of enzyme AMPK also had a strong implication on VEGF (vascular endothelial growth factor) and glucose transporter in facilitating the transport of glucose over a plasma membrane and Glut-1 in facilitating the transport of glucose across the plasma membranes of mammalian cells in EGCG-treated cancer cells.
Further analysis, application of EGCG activated AMPK enzyme also modulated the production of ROS without causing ROS expression in initiated tumor progression and damage to cellular structures, such as the lipid membrane, protein, and nucleic acid but inducing cancer cells DNA mutations and compromised genome integrity, subsequently in cancer cells senescence and death.
In another aspect of the study of colon cancer in an animal model, diminished levels of retinoid X receptor-alpha (RXRα) in regulated cancer cell growth and modulated suppress tumorigenesis may have a profound effect on cell proliferation.
Application of green tea bioactive EGCG expressed a significant effect in restored RXRα protein and expression levels caused by methylation function in alternated the activity of a DNA segment without changing the sequence, thus reducing risk of cancer expansion.
Additional differentiation also suggested that EGCG induced methylation changes in several other colon cancer-related genes to restore the levels of RXRα without causing a decrease in global methylation in maintaining the epigenetic state of individual genes.
Change of globe methylation expression is found to associate to the occurrence of cancer.
Retinoid X receptor-alpha (RXRα) is a nuclear receptor with function in regulated cancer proliferation and modulated suppression of tumorigenesis.
Based the results finding, EGCG with a novel therapeutic effect on common and on chemo-resistant colon cancer cells may be considered as a secondary application used a combination with chemotherapeutic agents, 5-FU for treatment of any types of colon cancer
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway by Hwang JT1, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ.(PubMed)
(2) Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells by Morris J1, Moseley VR2, Cabang AB1, Coleman K2, Wei W3, Garrett-Mayer E4, Wargovich MJ1.(PubMed)
(3) Global Methylation in Exposure Biology and Translational Medical Science by Heather H. Nelson,
1,2 Carmen J. Marsit,3,4 and Karl T. Kelsey4,5(PubMed)
In the review of medical literature published online, green tea efficacy in reduced risk and treatment of colon cancer may be associated with the bioactive polyphenol EGCG expression in the promoted and
decreased certain interaction in the cell profiles through various mechanisms.
According to the study by the University College of Medicine, Seoul, application of EGCG on HT-29 colon cancer cells showed a significant effect in the inhibition of cell cycle progression of protein in COX-2 expression. through activation of AMPK activity in promoted metabolic tumor suppressor by regulating energy levels, enforcing metabolic checkpoints and inhibiting cell growth.
Cyclooxygenase(COX)-2, is an enzyme with function in speeding up the production of hormone prostaglandins in regulated cell proliferation and cell apoptosis.
AMPK(5' AMP-activated protein kinase) plays a role in cellular energy homeostasis, activation of AMPK may result in tumor growth inhibition, cell cycle arrest, and apoptosis of cancer cells in some tumor types/contexts.
Additionally, in inhibition of COX-2 expression green tea EGCG reduced prostaglandin E(2) secretion, thus reducing risk of Prostaglandin E2 (PGE2) in modulated angiogenesis, including the process of new blood vessel formation, promoted proliferation, migration and formation of endothelial cells, lining the interior surface of blood vessels and lymphatic vessels.
The study also emphasized that inhibiting AMPK by an AMPK inhibitor may interrupt the function of the bioactive compound in initiated such changes.
Continuously, the activation of enzyme AMPK also had a strong implication on VEGF (vascular endothelial growth factor) and glucose transporter in facilitating the transport of glucose over a plasma membrane and Glut-1 in facilitating the transport of glucose across the plasma membranes of mammalian cells in EGCG-treated cancer cells.
Further analysis, application of EGCG activated AMPK enzyme also modulated the production of ROS without causing ROS expression in initiated tumor progression and damage to cellular structures, such as the lipid membrane, protein, and nucleic acid but inducing cancer cells DNA mutations and compromised genome integrity, subsequently in cancer cells senescence and death.
In another aspect of the study of colon cancer in an animal model, diminished levels of retinoid X receptor-alpha (RXRα) in regulated cancer cell growth and modulated suppress tumorigenesis may have a profound effect on cell proliferation.
Application of green tea bioactive EGCG expressed a significant effect in restored RXRα protein and expression levels caused by methylation function in alternated the activity of a DNA segment without changing the sequence, thus reducing risk of cancer expansion.
Additional differentiation also suggested that EGCG induced methylation changes in several other colon cancer-related genes to restore the levels of RXRα without causing a decrease in global methylation in maintaining the epigenetic state of individual genes.
Change of globe methylation expression is found to associate to the occurrence of cancer.
Retinoid X receptor-alpha (RXRα) is a nuclear receptor with function in regulated cancer proliferation and modulated suppression of tumorigenesis.
Based the results finding, EGCG with a novel therapeutic effect on common and on chemo-resistant colon cancer cells may be considered as a secondary application used a combination with chemotherapeutic agents, 5-FU for treatment of any types of colon cancer
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway by Hwang JT1, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ.(PubMed)
(2) Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells by Morris J1, Moseley VR2, Cabang AB1, Coleman K2, Wei W3, Garrett-Mayer E4, Wargovich MJ1.(PubMed)
(3) Global Methylation in Exposure Biology and Translational Medical Science by Heather H. Nelson,
1,2 Carmen J. Marsit,3,4 and Karl T. Kelsey4,5(PubMed)
Phytochemical Lycopene Gobbles Up Breast Cancer Cells in Vitro
Breast Cancer is a chronic condition associated with the growth of the irregular cells in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
The 5 years survival rate of the early and localized stage of breast cancer is 100%
Most common signs and symptoms of breast cancer at the early stage include, a painless lump in the breast or armpit and most often discovered by you or your partner may discover the lump or your doctor during a routine physical exam, lump (mass) in the breast, lump in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.
If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, please check with your doctor to rule out the possibility of breast cancer.
In the advanced stage of breast cancer, the cancerous cell not only can travel a distance ways from the breast to infect other healthy tissues and organ, but also induce symptoms of bone pain (Secondary tumors in the bone), shortness of breath (secondary tumors in lung), unintentional weight loss and drop in appetite (Secondary tumors in liver) and headaches, neurological pain or weakness (secondary tumors in the nervous system).
Out of many prevalent factors that cause the onset of breast cancer, some researchers suggested that the promotion of Western diet over the past few decades that cause overweight and obesity in the US may have a strong and negative impact on the breast cancer risk.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
With an aim to find a plant-based secondary metabolite for the treatment of breast cancer with no side effects, scientists examined lycopene found abundantly in cooked tomato alleviated biological cell oxidative injury and inhibited tumor growth activity.
The study included. MCF-7 cells were treated with different lycopene concentrations for the duration of 24, 48, and 72 h.
According to the tested assays used in the experiment, the application of lycopene showed a significant in cancer cell shrinkage and breakage at a dose and duration-dependent manner compared to untreated breast cancer cells.
Furthermore, lycopene also reduced cell proliferation and increased apoptosis, according to the MTT and Flow cytometry assay.
The cancer cell inhibition was also found by the secondary metabolite in the stimulation of the expression of tumor-suppressive gene p53 and a protein associated with cell apoptosis.
Based on the findings, researchers said, "lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax".
Moreover, breast cancer cell treated by carotenoids (lycopene and beta-carotene) at (0.5-10 μM) for 48 and 96 h, showed a significant decrease in the number of viable breast cancer cells.
In other words, the phytochemical reduced the numbers of active cells compared to the untreated cell line.
Additonally, carotenoids injection also promoted cell-cycle arrest and apoptosis in the majority of cell lines after 96 h, compared to controls.
Dr. Gloria NF, the lead researcher wrote, "These findings indicate that the effect was cell type-dependent and that carotenoids are potential agents for biological interference with cancer".
Taken altogether, lycopene used alone or combined with another phytochemical may be considered supplements for the prevention and treatment of breast cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells by Peng SJ1, Li J1, Zhou Y2, Tuo M2, Qin XX2, Yu Q2, Cheng H2, Li YM. (PubMed)
(2) Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines by Gloria NF1, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ. (PubMed)
(3) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
Most cases of breast cancer start in the cell on the surface of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
The 5 years survival rate of the early and localized stage of breast cancer is 100%
Most common signs and symptoms of breast cancer at the early stage include, a painless lump in the breast or armpit and most often discovered by you or your partner may discover the lump or your doctor during a routine physical exam, lump (mass) in the breast, lump in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.
If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, please check with your doctor to rule out the possibility of breast cancer.
In the advanced stage of breast cancer, the cancerous cell not only can travel a distance ways from the breast to infect other healthy tissues and organ, but also induce symptoms of bone pain (Secondary tumors in the bone), shortness of breath (secondary tumors in lung), unintentional weight loss and drop in appetite (Secondary tumors in liver) and headaches, neurological pain or weakness (secondary tumors in the nervous system).
Out of many prevalent factors that cause the onset of breast cancer, some researchers suggested that the promotion of Western diet over the past few decades that cause overweight and obesity in the US may have a strong and negative impact on the breast cancer risk.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
With an aim to find a plant-based secondary metabolite for the treatment of breast cancer with no side effects, scientists examined lycopene found abundantly in cooked tomato alleviated biological cell oxidative injury and inhibited tumor growth activity.
The study included. MCF-7 cells were treated with different lycopene concentrations for the duration of 24, 48, and 72 h.
According to the tested assays used in the experiment, the application of lycopene showed a significant in cancer cell shrinkage and breakage at a dose and duration-dependent manner compared to untreated breast cancer cells.
Furthermore, lycopene also reduced cell proliferation and increased apoptosis, according to the MTT and Flow cytometry assay.
The cancer cell inhibition was also found by the secondary metabolite in the stimulation of the expression of tumor-suppressive gene p53 and a protein associated with cell apoptosis.
Based on the findings, researchers said, "lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax".
Moreover, breast cancer cell treated by carotenoids (lycopene and beta-carotene) at (0.5-10 μM) for 48 and 96 h, showed a significant decrease in the number of viable breast cancer cells.
In other words, the phytochemical reduced the numbers of active cells compared to the untreated cell line.
Additonally, carotenoids injection also promoted cell-cycle arrest and apoptosis in the majority of cell lines after 96 h, compared to controls.
Dr. Gloria NF, the lead researcher wrote, "These findings indicate that the effect was cell type-dependent and that carotenoids are potential agents for biological interference with cancer".
Taken altogether, lycopene used alone or combined with another phytochemical may be considered supplements for the prevention and treatment of breast cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells by Peng SJ1, Li J1, Zhou Y2, Tuo M2, Qin XX2, Yu Q2, Cheng H2, Li YM. (PubMed)
(2) Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines by Gloria NF1, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ. (PubMed)
(3) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
Thursday, August 1, 2019
Green Tea (-)-Epigallocatechin-3-gallate (EGCG) in Attenuated Risk and Treatment of Gastric Cancer
Gastric cancer is a medical condition characterized by the uncontrollable growth of cells in the gastric tissues. At the late stage, the cancerous cells may infect other organs and tissue a distance away from the original site
According to medical literature published online, in vascular endothelial growth factor (VEGF) overexpression in formation of new blood vessel to provide nutrients and fluids for the survival of gastric cancer, application of green tea (-)-Epigallocatechin-3-gallate (EGCG) restricted the pro-inflammatory cytokine interleukin-6 (IL-6) induced VEGF in stimulated signal protein in transmitted alternated DNA transcript and activated suppression of anti-cell apoptosis transcription 3 (Stat3).
Oral administration of green tea extract decreased levels of IL-6, VEGF overexpression in doses depending manner.
In compared to a healthy individual, IL-6, VEGF expression was found to increase more than 2.4-fold in patients with gastric cancer.
In fact, the chemical compound exhibited anti-cancer progressive activity by blocking the process of a complex sequence of VEGF expression in transferring faulty DNA transcription to signal the proliferation of cancer cells through mRNA in protein synthesis.
In other words, green tea inhibited the progression of cancer development induced by overexpression of vascular endothelial growth factor (VEGF) was total depended on EGCG's DNA biding activity and inhibition of Stat proteins in differentiated cytoplasm into the nucleus, the important step in the initiation of cancer progression.
Further analysis, according to experiments in vitro and vitro, EGCG also expressed a significant effect in the reduced the IL-6 properties in stimulated vascular endothelial cells in promoted cancer cells proliferation and formation.
After taking into account of other confounders, Dr. Zhu BH, the lead author said, "EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG".
Additionally, researchers in further illustration of the effect of EGCG (0, 5, 10, 25 or 50 μmol/L), in human gastric cancer cells (AGS) caused by IL-6 (50 μg/L) suggested that interleukin 6 (IL-6)overexpression not only significantly increased VEGF expression in AGS gastric cancer cells, but also increased function of mRNA expression by more than 2.4 in the process to initiated tumor development, in dose depending manner.
Truly, treatment of bioactive EGCG with doses of 0, 5, 10, 25 or 50 μmol/L demonstrated therapeutic activities in reduced the released protein of VEGF to stimulated and mRNA expression of the alternated transcript.
In compared to AG490, a Stat3 pathway inhibitor used for the treatment of gastric cancer, green tea EGCG blocked the sequence of transcript transferred step in induced expression of pSTAT3 in the proliferation of cells and tumor tissues without causing a change in STAT3 gene.
In 5-FU resistance of GC SGC7901/FU and MGC803/FU, gastric cancer cell lines, injection of epigallocatechin gallate (EGCG) displayed a significantly suppressed the proliferation and tumor growth through reversed the 5-FU resistance of GC cells thorough inhibited the P-glycoprotein 1 (MDR1) and P-glycoprotein (P-gp) also also known as multidrug resistance proteins in transmitted transcript in obstructing cell internalization of chemotherapeutic agents and developing transporter-mediated resistance by cancer cells during anti-tumor treatments.
Taking all together, green tea bioactive (-)-Epigallocatechin-3-gallate (EGCG) may be considered as a potential agent in reduced risk of angiogenesis and secondary and adjunct treatment is combined with standard chemotherapy in the treatment of gastric cancers.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer by Zhu BH1, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, Zhang CH, He YL.(PubMed)
(2) [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].[Article in Chinese] by Zhu BH1, He YL, Zhan WH, Cai SR, Wang Z, Zhang CH, Chen HY.(PubMed)
(3) Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer by Tang H1,2, Zeng L2, Wang J2, Zhang X2, Ruan Q2, Wang J2, Cui S2, Yang D1.(PubMed)
According to medical literature published online, in vascular endothelial growth factor (VEGF) overexpression in formation of new blood vessel to provide nutrients and fluids for the survival of gastric cancer, application of green tea (-)-Epigallocatechin-3-gallate (EGCG) restricted the pro-inflammatory cytokine interleukin-6 (IL-6) induced VEGF in stimulated signal protein in transmitted alternated DNA transcript and activated suppression of anti-cell apoptosis transcription 3 (Stat3).
Oral administration of green tea extract decreased levels of IL-6, VEGF overexpression in doses depending manner.
In compared to a healthy individual, IL-6, VEGF expression was found to increase more than 2.4-fold in patients with gastric cancer.
In fact, the chemical compound exhibited anti-cancer progressive activity by blocking the process of a complex sequence of VEGF expression in transferring faulty DNA transcription to signal the proliferation of cancer cells through mRNA in protein synthesis.
In other words, green tea inhibited the progression of cancer development induced by overexpression of vascular endothelial growth factor (VEGF) was total depended on EGCG's DNA biding activity and inhibition of Stat proteins in differentiated cytoplasm into the nucleus, the important step in the initiation of cancer progression.
Further analysis, according to experiments in vitro and vitro, EGCG also expressed a significant effect in the reduced the IL-6 properties in stimulated vascular endothelial cells in promoted cancer cells proliferation and formation.
After taking into account of other confounders, Dr. Zhu BH, the lead author said, "EGCG inhibits IL-6-induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG".
Additionally, researchers in further illustration of the effect of EGCG (0, 5, 10, 25 or 50 μmol/L), in human gastric cancer cells (AGS) caused by IL-6 (50 μg/L) suggested that interleukin 6 (IL-6)overexpression not only significantly increased VEGF expression in AGS gastric cancer cells, but also increased function of mRNA expression by more than 2.4 in the process to initiated tumor development, in dose depending manner.
Truly, treatment of bioactive EGCG with doses of 0, 5, 10, 25 or 50 μmol/L demonstrated therapeutic activities in reduced the released protein of VEGF to stimulated and mRNA expression of the alternated transcript.
In compared to AG490, a Stat3 pathway inhibitor used for the treatment of gastric cancer, green tea EGCG blocked the sequence of transcript transferred step in induced expression of pSTAT3 in the proliferation of cells and tumor tissues without causing a change in STAT3 gene.
In 5-FU resistance of GC SGC7901/FU and MGC803/FU, gastric cancer cell lines, injection of epigallocatechin gallate (EGCG) displayed a significantly suppressed the proliferation and tumor growth through reversed the 5-FU resistance of GC cells thorough inhibited the P-glycoprotein 1 (MDR1) and P-glycoprotein (P-gp) also also known as multidrug resistance proteins in transmitted transcript in obstructing cell internalization of chemotherapeutic agents and developing transporter-mediated resistance by cancer cells during anti-tumor treatments.
Taking all together, green tea bioactive (-)-Epigallocatechin-3-gallate (EGCG) may be considered as a potential agent in reduced risk of angiogenesis and secondary and adjunct treatment is combined with standard chemotherapy in the treatment of gastric cancers.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer by Zhu BH1, Chen HY, Zhan WH, Wang CY, Cai SR, Wang Z, Zhang CH, He YL.(PubMed)
(2) [(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].[Article in Chinese] by Zhu BH1, He YL, Zhan WH, Cai SR, Wang Z, Zhang CH, Chen HY.(PubMed)
(3) Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer by Tang H1,2, Zeng L2, Wang J2, Zhang X2, Ruan Q2, Wang J2, Cui S2, Yang D1.(PubMed)
Whole Food Onion Kills Renal Cancer Cells in Vitro
The kidney is an essential organ that not only filters out blood but also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,
Formed part of the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. During the process, some necessary substances are reabsorbed back into the blood, while others wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Kidney cancer is a medical condition caused by malignant cells of the lining of the tubules in the kidney.
At the advanced stage, cancer kidney cells can travel a distance away to infect other healthy tissue and organ through the circulation of blood and fluid, leading to secondary metastasis.
Kidney cancer epidemiologically has been found to spread to the lung.
The exact causes of kidney cancer are not identified. However, the below prevalent factors have been found to induce a higher risk of the disease.
* Gender
Men are twice at risk to develop renal cell carcinoma than women.
* Aging
The onset of renal cell carcinoma has a peak incidence in the 50 but today, the disease has a tendency to affect the younger age population.
* Smoking
Smoking increases the risk of renal cell carcinoma.
* Obesity
Obesity has been associated with an increased risk of renal cell cancer among women, and increased BMI is equally strongly associated with an increased risk of renal cell cancer among men and women.
* Family history
If one of your direct family members has it, your risk of developing renal cell carcinoma increases.
* Chemical toxins
Exposure to certain environment chemical toxins may increase the risk of renal cell carcinoma.
* Cystic kidney disease
This type of genetic disorder of the kidneys accompanied by a renal deficiency can increase the risk of developing kidney cancer.
Because of less nervous in the kidney and location, the early stage of renal cell carcinoma is very hard to detect. In some case, the tumor can grow without causing any pain and discomfort. Most common symptoms are abdominal pain, back pain, blood in the urine, flank pain, anemia, varicocele enlargement, and hypertension.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of kidney cancer
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste, onion is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a natural ingredient for the treatment of renal cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in human renal carcinoma (Caki) cells.
According to the tested assays, Fisetin induced cancer cell apoptosis by causing cell cycle arrest on the sub-G1 phase.
Futhermore, Fisetin also induced cancer cell apoptosis by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.
Moreover, caspases, the major effectors of apoptosis were also activated by the injection of Fisetin.
Additionally, the efficacy of Fisetin in the inhibition of the renal cancer cell line was also attributed by inducing death receptor 5 (DR5) expression and promoting the gene expression of tumor suppressor (p53).
However, in the differentiation of the effect of another gene (CHOP expression) associated with cellular stress and involved in mediating apoptosis and expression of ROS cytotoxicity, researchers found that fisetin-induced apoptosis without the assistance of CHOP and ROS.
Based on the finding, researchers said, " fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level"
Taken altogether, onion used alone or combined with remedies may be considered a remedy for the prevention and treatment of renal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min KJ1, Nam JO2, Kwon TK. (PubMed)
(2) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton
Formed part of the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. During the process, some necessary substances are reabsorbed back into the blood, while others wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.
Kidney cancer is a medical condition caused by malignant cells of the lining of the tubules in the kidney.
At the advanced stage, cancer kidney cells can travel a distance away to infect other healthy tissue and organ through the circulation of blood and fluid, leading to secondary metastasis.
Kidney cancer epidemiologically has been found to spread to the lung.
The exact causes of kidney cancer are not identified. However, the below prevalent factors have been found to induce a higher risk of the disease.
* Gender
Men are twice at risk to develop renal cell carcinoma than women.
* Aging
The onset of renal cell carcinoma has a peak incidence in the 50 but today, the disease has a tendency to affect the younger age population.
* Smoking
Smoking increases the risk of renal cell carcinoma.
* Obesity
Obesity has been associated with an increased risk of renal cell cancer among women, and increased BMI is equally strongly associated with an increased risk of renal cell cancer among men and women.
* Family history
If one of your direct family members has it, your risk of developing renal cell carcinoma increases.
* Chemical toxins
Exposure to certain environment chemical toxins may increase the risk of renal cell carcinoma.
* Cystic kidney disease
This type of genetic disorder of the kidneys accompanied by a renal deficiency can increase the risk of developing kidney cancer.
Because of less nervous in the kidney and location, the early stage of renal cell carcinoma is very hard to detect. In some case, the tumor can grow without causing any pain and discomfort. Most common symptoms are abdominal pain, back pain, blood in the urine, flank pain, anemia, varicocele enlargement, and hypertension.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of kidney cancer
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste, onion is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a natural ingredient for the treatment of renal cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in human renal carcinoma (Caki) cells.
According to the tested assays, Fisetin induced cancer cell apoptosis by causing cell cycle arrest on the sub-G1 phase.
Futhermore, Fisetin also induced cancer cell apoptosis by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.
Moreover, caspases, the major effectors of apoptosis were also activated by the injection of Fisetin.
Additionally, the efficacy of Fisetin in the inhibition of the renal cancer cell line was also attributed by inducing death receptor 5 (DR5) expression and promoting the gene expression of tumor suppressor (p53).
However, in the differentiation of the effect of another gene (CHOP expression) associated with cellular stress and involved in mediating apoptosis and expression of ROS cytotoxicity, researchers found that fisetin-induced apoptosis without the assistance of CHOP and ROS.
Based on the finding, researchers said, " fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level"
Taken altogether, onion used alone or combined with remedies may be considered a remedy for the prevention and treatment of renal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min KJ1, Nam JO2, Kwon TK. (PubMed)
(2) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton
Wednesday, July 31, 2019
Green Tea and Bioactive Saponin In Prevention and Treatment of Lymphoma
Lymphoma is a medical condition characterized by cell growth disorderly and uncontrollably in the lymph nodes. There were 661,996 people living with non-Hodgkin lymphoma in the United States, 2014.
According to the medical literature online, intake of green tea saponin and phenolic may have a strong influence in lymphoma oncogenesis through some certain aspects.
In EL4 cancer cells line, injection of green bioactive saponin stimulated the immunomodulatory activity in inhibited EL4 cell lines through regulated cytokine expression induced by inflammation and mitogen-activated protein kinases (MAPK) signaling pathway involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.
Furthermore, injected saponin also reduced the expression of EL4 cells line in tumor proliferation by interrupting the process of sequence of mutated DNA transcript in mRNA expression in transmitting transcript by initiating production of inflammatory cytokines to reverse transcription-polymerase chain reaction in making copies of alternated gene, thus attenuating risk of tumor growth, tumor progression and immuno-suppression, activities in host anti-tumor response.
Treatment of green tea saponin also was found to induced cytotoxicity to EL4 cancer cell line without causing harm to healthy cells.
Additionally, the efficacy of tea saponin in inhibition of the proliferation and invasiveness of T-lymphoma (EL4) cells, may be also attributed to the effect of others inflammatory cytokines such as tumor necrosis factor-alpha TNF-α in induced cancer cells death and NF-κB in controlled transcription of DNA, cytokine production and cell survival through mediated the regulation of MAPK pathway in transduction (process by which foreign DNA is introduced into a cell by a virus or viral vector) and extracellular signals to cellular responses in induction of cell proliferation, differentiation, development, transformation, and apoptosis.
Tumor necrosis factor-alpha TNF-α, a pro-inflammatory cytokine plays an important role in the acute phase of inflammation with function in the regulation of biological processes including cell proliferation, differentiation, and apoptosis.
Nuclear factor-κB (NF-κB) is a transcription factor with function in the regulated expression of genes involving many biological processes including innate and adaptive immunity, inflammation and stress responses,
In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines Namalwa, RAP1-EIO and HS-Sultan, injection of green tea displayed significant inhibition of
50% of Namalwa tumors and RAP1-EIO and HS-Sultan tumor through paralyzed tumor invasive activities.
In compared to chemotherapy drug cyclophosphamide, green tea exhibited anti-angiogenic effect in induction of.frequency of apoptotic endothelial and tumor cell and promoted tumor shrinking by blocking the formation of new blood vessels in providing nutrients and fluid for tumor expansion.
Base on the information findings, researchers opinionated, "Further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression".
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(2) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)
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