Antioxidants are stable molecules that inhibit the onset of oxidation caused by free radicals.
Free radicals, on the other hand, are unstable molecules that cause oxidation, with unpaired electrons in the outermost ring.
Free radical scavengers are types of antioxidants which play a critical to neutralize free radical before they can induce a chain reaction which can not be stopped until all unpaired electrons in the outermost are paired.
Overexpression of free radicals or depletion of antioxidant enzymes in the host body can lead to
oxidative stress, an indicator associated with the unbalanced ratio of the levels of antioxidants/free radicals
Epidemiologically, imbalance ratio of free radicals/antioxidants has been linked to the onset of many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke due to cellular, lipid and protein damage.
However, free radicals have the potential to be extremely harmful contaminants and extremely helpful for the treatment of cancers through their cytotoxic activity because of its high reactivity,
Believe it or not, free radicals present in the body with a moderate amount are important to the body's cardio-functioning, including the promotion of vascular function.
Some researchers in the examination of the effect of antioxidant-rich foods in the risk-free radicals initiation suggested that diet rich in fruits and vegetables and less in meat and process foods have a lower risk of oxidative stress and oxidative stress-related diseases.
The National Centre for Complementary and Integrative Health in the article "Antioxidants: In-Depth" wrote, "Several decades of dietary research findings suggested that consuming greater amounts of antioxidant-rich foods might help to protect against diseases. Because of these results, there has been a lot of research on antioxidant supplements".
And "Observational studies on the typical eating habits, lifestyles, and health histories of large groups of people have shown that those who ate more vegetables and fruits had lower risks of several diseases, including cardiovascular disease, stroke, cancer, and cataracts".
Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
On finding a potent ingredient for the treament of disease associated with oxidative stress, researchers examined the chemical constituents of betacyanin of Djulis (Chenopodium fromosanum), a native cereal plant in Taiwan.
Betacyanin of Djulis exhibited a significant antioxidant capacity at the maximum absorbance at 530 nm, depending on the pH.
Major chemical compounds that exerted a significant antioxidant capacity are betanin (47.8%), isobetanin (30.0%) with m/z 551.0, and armaranthin (13.6%), isoamaranthinee (8.6%).
According to the purified form, the pigment extract by HPLC, betanin, and isobetanin totally accounted for more than 70% of FRAP(ferric-reducing antioxidant power) which plays an important role in this regard of absorptivity for a variety of antioxidants and free radical scavenging capacity.
These results strongly suggested that betanin and isobetanin antioxidants process a strong antioxidant activity that may provide a basis for its sustainable utilization in the food industry.
Taken altogether, isobetanin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity" by Tsai PJ, Sheu CH, Wu PH, Sun YF.(PubMed)
Wednesday, August 28, 2019
Green Tea and Its Bioactive Epigallocatechin gallate EGCG in Reduced Risk and Treatment of Cardiovascular Diseases
Green tea containing bioactive polyphenols may have a strong implication in reduced risk and treatment of cardiovascular disease, some scientists postulated.
Cardiovascular disease is a chronic medical condition characterized by narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.
According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.
In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.
Compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated the risk of CVD without giving rise to adverse effects.
Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.
Additionally, EGCG also exerted significant and profound effects in the ameliorated risk of diabetes through lowering plasma glucose and glycated hemoglobin level, inhibited pro-inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.
Dr. Eng QY, after taking into account of other confounders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".
Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis. by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for a nongreen tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.
Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.
And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to the group who drank <3 cups/day.
Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in the compilation of how green tea initiated protective activity against CVD.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)
Cardiovascular disease is a chronic medical condition characterized by narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.
According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.
In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.
Compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated the risk of CVD without giving rise to adverse effects.
Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.
Additionally, EGCG also exerted significant and profound effects in the ameliorated risk of diabetes through lowering plasma glucose and glycated hemoglobin level, inhibited pro-inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.
Dr. Eng QY, after taking into account of other confounders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".
Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis. by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for a nongreen tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.
Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.
And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to the group who drank <3 cups/day.
Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in the compilation of how green tea initiated protective activity against CVD.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)
Tuesday, August 27, 2019
Phytochemical 3,3'-Diindolylmethane Speeds Up Wound Healing
Wound healing is a natural process to repair the wound or cut through a number of stages.
In the first stage, after receiving the message from the central nervous system, the immune first line of defense white blood cells stimulate the production of blood palettes to the site of damage to cover the wound and activate the protein associated with the production of pro-inflammatory cytokines to fight off the micro pathogens trying to enter the body.
Under normal condition, proteins associated with the production of anti-inflammation cytokines may also switch to proinflammatory cytokines, depending on the size and location of the wound.
Overproduction of pro-inflammatory cytokines in this phase can cause the death of nearby healthy cells, leading to the formation of a scar.
Most microbial invaders are stopped at the acute phase of infection.
The wound healing process is divided into four overlapping phases: hemostasis, inflammatory, proliferative, and maturation.
Any interruption of the stage of wound healing also can lead to imbalanced production and dissolving of collagens in the site, inducing the formation of scars.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound for speed-up wound healing without side effects, researchers evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model.
Where human umbilical cord-derived mesenchymal stem cells (hucMSCs) has been used in the laboratory as a promising therapeutic tool in regenerative medicine.
HucMSCs pretreatment of 50 μM of DIM exhibited desirable repairing effects compared to the untreated hucMSCs.
In vivo, DIM enhanced hucMSCs in tissue regeneration by activation of proteins that pass signals into a cell through cell surface receptors.
Furthermore, DIM-primed hucMSCs (DIM-hucMSCs) also promotes tissue regeneration by suppressing the inhibition of β-catenin that impairs the healing effects.
Moreover, DIM promoted the Wnt11 expression associated with all regeneration stages in hucMSC-derived exosomes.
Decreased expression of Wnt11 showed to inhibited β-catenin activation.
Based on the findings, DIM enhanced tissue regeneration after wound by promoting the genes associated with the healing process.
Dr. Shi H the lead scientist said, "DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing".
Taken altogether, 3,3'-Diindolylmethane derived from the indole-3-carbinol may be considered a supplement for speed-up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing by Shi H1, Xu X1, Zhang B1, Xu J1, Pan Z1, Gong A1, Zhang X1, Li R1, Sun Y1, Yan Y1, Mao F1, Qian H1, Xu W. (PubMed)
In the first stage, after receiving the message from the central nervous system, the immune first line of defense white blood cells stimulate the production of blood palettes to the site of damage to cover the wound and activate the protein associated with the production of pro-inflammatory cytokines to fight off the micro pathogens trying to enter the body.
Under normal condition, proteins associated with the production of anti-inflammation cytokines may also switch to proinflammatory cytokines, depending on the size and location of the wound.
Overproduction of pro-inflammatory cytokines in this phase can cause the death of nearby healthy cells, leading to the formation of a scar.
Most microbial invaders are stopped at the acute phase of infection.
The wound healing process is divided into four overlapping phases: hemostasis, inflammatory, proliferative, and maturation.
Any interruption of the stage of wound healing also can lead to imbalanced production and dissolving of collagens in the site, inducing the formation of scars.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound for speed-up wound healing without side effects, researchers evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model.
Where human umbilical cord-derived mesenchymal stem cells (hucMSCs) has been used in the laboratory as a promising therapeutic tool in regenerative medicine.
HucMSCs pretreatment of 50 μM of DIM exhibited desirable repairing effects compared to the untreated hucMSCs.
In vivo, DIM enhanced hucMSCs in tissue regeneration by activation of proteins that pass signals into a cell through cell surface receptors.
Furthermore, DIM-primed hucMSCs (DIM-hucMSCs) also promotes tissue regeneration by suppressing the inhibition of β-catenin that impairs the healing effects.
Moreover, DIM promoted the Wnt11 expression associated with all regeneration stages in hucMSC-derived exosomes.
Decreased expression of Wnt11 showed to inhibited β-catenin activation.
Based on the findings, DIM enhanced tissue regeneration after wound by promoting the genes associated with the healing process.
Dr. Shi H the lead scientist said, "DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing".
Taken altogether, 3,3'-Diindolylmethane derived from the indole-3-carbinol may be considered a supplement for speed-up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing by Shi H1, Xu X1, Zhang B1, Xu J1, Pan Z1, Gong A1, Zhang X1, Li R1, Sun Y1, Yan Y1, Mao F1, Qian H1, Xu W. (PubMed)
The Kitchen Spice Turmeric Inhibits Parameters Associated with the Onset of Stomach/GastricCancer
Cancer is a group of medical conditions caused by the irregular cell growth in the tissue of specific organ due to the alternation of cell DNA.
The stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach/gastric cancer is a cancerous condition characterized by abnormal growth of the mucus-producing cells of the inner lining of the stomach. At the advanced stage, after growing in size, over time cancer cells can invade other healthy tissue or organ by traveling a distance away from the stomach, leading to secondary metastasis.
Adenocarcinoma arisen from the glands in the mucosa is the most common type of stomach cancer associated with
* Superficial spreading
It is an early stage of cancer and tends to be less aggressive.
* Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.
*Infiltrating
Cancer grows in infiltrating pattern into the stomach wall and is more aggressive.
* Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.
According to the statistics provided by the American Cancer Society, in the US, approximately
27,510 cases of stomach cancer will be diagnosed in 2019, including 17,230 men and 10,280 women.
Sadly, 11,140 people will also die from stomach cancer in 2019 including 6,800 men and 4,340 women.
Most cases of stomach cancer are diagnosed in older adults with an average age of 68 and over.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of gastric cancer, researchers examined the effect of curcumin in an animal model.
The study included BALB/C mice grafted with a mouse gastric adenocarcinoma cell line (MFC) fed with different doses of curcumin after grafting.
According to the tested assays,
* Tumor growth (size and weight) was significantly inhibited by curcumin treatment, compared to controls.
* The apoptotic rate of gastric cancer cells was significantly increased in the curcumin treatment group.
* Splenocyte cells from mice treated with curcumin exhibited higher cytolytic effects on MFC cancer cells compared to those treated with saline.
* Furthermore, the curcumin treatment group also inhibited the expression of pathways associated with oxidative stress-induced inflammation(STAT3), the promotion of tumor growth and metastasis(HIF-1α,), poor prognosis, and clinical outcome (DEC1), and angiogenesis( VEGF).
Based on the findings, researchers wrote, "curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large number of cytokines, and down-regulating the DEC1, HIF-1α, VEGF and STAT3 signal transduction pathways".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of stomach/gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma by Wang XP1, Wang QX, Lin HP, Chang N. (PubMed)
(2) Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells by Lee TK1, Lee D1, Lee SR1, Ko YJ2, Sung Kang K3, Chung SJ1, Kim KH. (PubMed)
Monday, August 26, 2019
Green Tea and Its Bioactive Polyphenols Epigallocatechin-3 Gallate (EGCG) in Attenuated Risk and Treatment of Hepatitis B
Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis B, some scientists suggested.
Hepatitis B is a viral infection of acute and chronic liver disease, caused by a double-stranded DNA virus HBV transmitted through infected blood, semen, or other body fluid.
According to the statistic, positive carriers among Canadian is estimated to be 0.5% to 1.0%., depending on ethnicity.
According to the evaluation of the effect of green tea bioactive polyphenols epigallocatechin-3 gallate (EGCG) and risk of hepatitis B, application of the phytochemical inhibited HBV replication in the testing Hep3B2.1-7 hepatocellular carcinoma cell line, through a significant effect in reduced prevalence of liver damage caused by hepatitis B virus.
Interesting, injection of EGCG at the dose of less than 100 μM in the observed liver cancer cell line showed no effect in induced cell apoptosis and decreased proliferation but exhibited a strong effect in ameliorated expression of surface antigen of the hepatitis B virus (HBsAg) and antigen of hepatitis B virus circulated in infected blood (HBeAg) levels found by the ELISA method and the polymerase chain reaction (PCR)assay.
Further differentiation in different HepG2 2.2.15 cells to compare the effects of green tea with standard antiretroviral medication lamivudine (3TC), researchers indicated that administration of EGCG shows significant inhibition of viral proliferation through the attenuated expression of levels of HBsAg and HBeAg in the supernatant and extracellular HBV DNA in a dose- and time-dependent manner. At doses of 50-200 μg/ml EGCG displayed strong effects in compared to lamivudine (3TC) at a dose of 200 μg/ml.
More importantly, the application of EGCG also suppressed the extracellular HBV DNA, a nutrient source for viral cell proliferation and survival through attachment, aggregation, and stabilization of microcolonies.
The results of the experiments pointed out that green tea EGCG consists of a potential anti-HBV activity with low toxicity.
Additional investigation of green tea EGCG effect in the early stages of infection caused by four different Hepatitis B virus genotypes A and D also found that at dose of more than 80%, the phytochemical inhibited both DMSO-differentiated HuS-E/2 cells and HA-NTCP-expressing Huh7 cells involved cancer cell process in early stage of proliferation through induced protein degradation and ameliorated serum of transferrin.(the iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids)which is considered as a liver fibrosis biomarker in patients with chronic hepatitis B.
However, Treatment of cells with EGCG had no effect on HBV genome replication or virion secretion and the characteristic of HBV virion and the expression of known HBV entry factors were unaltered outside of the host before attacking the liver tissue.
All these results suggested that the green tea-derived molecule EGCG potently inhibits HBV entry and could be used in prevention and treatment of Hepatitis B. Intake of green tea supplement should be taken with to prevent overdoses cause of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes by Huang HC1, Tao MH2, Hung TM3, Chen JC4, Lin ZJ5, Huang C6.(PubMed)
(2) Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication by Karamese M1, Aydogdu S, Karamese SA, Altoparlak U, Gundogdu C.(PubMed)
(3) Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro by Pang JY1, Zhao KJ, Wang JB, Ma ZJ, Xiao XH.(PubMed)
Hepatitis B is a viral infection of acute and chronic liver disease, caused by a double-stranded DNA virus HBV transmitted through infected blood, semen, or other body fluid.
According to the statistic, positive carriers among Canadian is estimated to be 0.5% to 1.0%., depending on ethnicity.
According to the evaluation of the effect of green tea bioactive polyphenols epigallocatechin-3 gallate (EGCG) and risk of hepatitis B, application of the phytochemical inhibited HBV replication in the testing Hep3B2.1-7 hepatocellular carcinoma cell line, through a significant effect in reduced prevalence of liver damage caused by hepatitis B virus.
Interesting, injection of EGCG at the dose of less than 100 μM in the observed liver cancer cell line showed no effect in induced cell apoptosis and decreased proliferation but exhibited a strong effect in ameliorated expression of surface antigen of the hepatitis B virus (HBsAg) and antigen of hepatitis B virus circulated in infected blood (HBeAg) levels found by the ELISA method and the polymerase chain reaction (PCR)assay.
Further differentiation in different HepG2 2.2.15 cells to compare the effects of green tea with standard antiretroviral medication lamivudine (3TC), researchers indicated that administration of EGCG shows significant inhibition of viral proliferation through the attenuated expression of levels of HBsAg and HBeAg in the supernatant and extracellular HBV DNA in a dose- and time-dependent manner. At doses of 50-200 μg/ml EGCG displayed strong effects in compared to lamivudine (3TC) at a dose of 200 μg/ml.
More importantly, the application of EGCG also suppressed the extracellular HBV DNA, a nutrient source for viral cell proliferation and survival through attachment, aggregation, and stabilization of microcolonies.
The results of the experiments pointed out that green tea EGCG consists of a potential anti-HBV activity with low toxicity.
Additional investigation of green tea EGCG effect in the early stages of infection caused by four different Hepatitis B virus genotypes A and D also found that at dose of more than 80%, the phytochemical inhibited both DMSO-differentiated HuS-E/2 cells and HA-NTCP-expressing Huh7 cells involved cancer cell process in early stage of proliferation through induced protein degradation and ameliorated serum of transferrin.(the iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids)which is considered as a liver fibrosis biomarker in patients with chronic hepatitis B.
However, Treatment of cells with EGCG had no effect on HBV genome replication or virion secretion and the characteristic of HBV virion and the expression of known HBV entry factors were unaltered outside of the host before attacking the liver tissue.
All these results suggested that the green tea-derived molecule EGCG potently inhibits HBV entry and could be used in prevention and treatment of Hepatitis B. Intake of green tea supplement should be taken with to prevent overdoses cause of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes by Huang HC1, Tao MH2, Hung TM3, Chen JC4, Lin ZJ5, Huang C6.(PubMed)
(2) Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication by Karamese M1, Aydogdu S, Karamese SA, Altoparlak U, Gundogdu C.(PubMed)
(3) Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro by Pang JY1, Zhao KJ, Wang JB, Ma ZJ, Xiao XH.(PubMed)
Phytochemical Betanin Modulates the Production of Reactive Oxidative Species (ROS)
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stable, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading a domino's effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body functioning, including vascular relaxation.
By balancing the ratio of free radicals and antioxidant may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitor may some days be used for the medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect the activity of caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues through stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered supplements for the prevention of the overexpression ROS, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stable, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading a domino's effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body functioning, including vascular relaxation.
By balancing the ratio of free radicals and antioxidant may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitor may some days be used for the medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect the activity of caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues through stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered supplements for the prevention of the overexpression ROS, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
Sunday, August 25, 2019
Green tea In Modulated Fat Metabolism
Green tea may have a therapeutic and positive effect in reduced abnormal fat metabolism, some scientists suggested.
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaluation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat Western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol, and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high-fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated with a substantial impact on lysophospholipid metabolism, in the contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high-fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of overweight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro-inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in the suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing a high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce the onset and progression of overweight and obesity. However, the intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaluation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat Western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol, and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high-fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated with a substantial impact on lysophospholipid metabolism, in the contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high-fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of overweight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro-inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in the suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing a high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce the onset and progression of overweight and obesity. However, the intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
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