The Kitchen Spice Turmeric Inhibits Parameters Associated with the Onset of Stomach/GastricCancer

Cancer is a group of medical conditions caused by the irregular cell growth in the tissue of specific organ due to the alternation of cell DNA.

The stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.

Stomach/gastric cancer is a cancerous condition characterized by abnormal growth of the mucus-producing cells of the inner lining of the stomach. At the advanced stage, after growing in size, over time cancer cells can invade other healthy tissue or organ by traveling a distance away from the stomach, leading to secondary metastasis.

Adenocarcinoma arisen from the glands in the mucosa is the most common type of stomach cancer associated with
* Superficial spreading
It is an early stage of cancer and tends to be less aggressive.

* Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.

*Infiltrating
Cancer grows in infiltrating pattern into the stomach wall and is more aggressive.

* Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.

According to the statistics provided by the American Cancer Society, in the US, approximately
27,510 cases of stomach cancer will be diagnosed in 2019, including 17,230 men and 10,280 women.
Sadly, 11,140 people will also die from stomach cancer in 2019 including 6,800 men and 4,340 women.
Most cases of stomach cancer are diagnosed in older adults with an average age of 68 and over.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of gastric cancer, researchers examined the effect of curcumin in an animal model.

The study included BALB/C mice grafted with a mouse gastric adenocarcinoma cell line (MFC) fed with different doses of curcumin after grafting.
According to the tested assays,
* Tumor growth (size and weight) was significantly inhibited by curcumin treatment, compared to controls.

* The apoptotic rate of gastric cancer cells was significantly increased in the curcumin treatment group.


* Splenocyte cells from mice treated with curcumin exhibited higher cytolytic effects on MFC cancer cells compared to those treated with saline.

* Furthermore, the curcumin treatment group also inhibited the expression of pathways associated with oxidative stress-induced inflammation(STAT3), the promotion of tumor growth and metastasis(HIF-1α,), poor prognosis, and clinical outcome (DEC1), and angiogenesis( VEGF).

Based on the findings, researchers wrote, "curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large number of cytokines, and down-regulating the DEC1, HIF-1α, VEGF and STAT3 signal transduction pathways".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of stomach/gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma by Wang XP1, Wang QX, Lin HP, Chang N. (PubMed)
(2) Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells by Lee TK1, Lee D1, Lee SR1, Ko YJ2, Sung Kang K3, Chung SJ1, Kim KH. (PubMed)