Antioxidants are stable molecules that inhibit the onset of oxidation caused by free radicals.
Free radicals, on the other hand, are unstable molecules that cause oxidation, with unpaired electrons in the outermost ring.
Free radical scavengers are types of antioxidants which play a critical to neutralize free radical before they can induce a chain reaction which can not be stopped until all unpaired electrons in the outermost are paired.
Overexpression of free radicals or depletion of antioxidant enzymes in the host body can lead to
oxidative stress, an indicator associated with the unbalanced ratio of the levels of antioxidants/free radicals
Epidemiologically, imbalance ratio of free radicals/antioxidants has been linked to the onset of many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke due to cellular, lipid and protein damage.
However, free radicals have the potential to be extremely harmful contaminants and extremely helpful for the treatment of cancers through their cytotoxic activity because of its high reactivity,
Believe it or not, free radicals present in the body with a moderate amount are important to the body's cardio-functioning, including the promotion of vascular function.
Some researchers in the examination of the effect of antioxidant-rich foods in the risk-free radicals initiation suggested that diet rich in fruits and vegetables and less in meat and process foods have a lower risk of oxidative stress and oxidative stress-related diseases.
The National Centre for Complementary and Integrative Health in the article "Antioxidants: In-Depth" wrote, "Several decades of dietary research findings suggested that consuming greater amounts of antioxidant-rich foods might help to protect against diseases. Because of these results, there has been a lot of research on antioxidant supplements".
And "Observational studies on the typical eating habits, lifestyles, and health histories of large groups of people have shown that those who ate more vegetables and fruits had lower risks of several diseases, including cardiovascular disease, stroke, cancer, and cataracts".
Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
On finding a potent ingredient for the treament of disease associated with oxidative stress, researchers examined the chemical constituents of betacyanin of Djulis (Chenopodium fromosanum), a native cereal plant in Taiwan.
Betacyanin of Djulis exhibited a significant antioxidant capacity at the maximum absorbance at 530 nm, depending on the pH.
Major chemical compounds that exerted a significant antioxidant capacity are betanin (47.8%), isobetanin (30.0%) with m/z 551.0, and armaranthin (13.6%), isoamaranthinee (8.6%).
According to the purified form, the pigment extract by HPLC, betanin, and isobetanin totally accounted for more than 70% of FRAP(ferric-reducing antioxidant power) which plays an important role in this regard of absorptivity for a variety of antioxidants and free radical scavenging capacity.
These results strongly suggested that betanin and isobetanin antioxidants process a strong antioxidant activity that may provide a basis for its sustainable utilization in the food industry.
Taken altogether, isobetanin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity" by Tsai PJ, Sheu CH, Wu PH, Sun YF.(PubMed)
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