Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Back pain is a condition of musculoskeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,..
Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.
According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription-polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Furthermore, the application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.
Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain-related pro-inflammatory cytokines such as IL-1β.
Some researchers postulated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.
In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.
More importantly, EGCG expressed a significant effect on the recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.
According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in the induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.
These results demonstrated an important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.
However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy lifestyle behaviors.
Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as a functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in the medical literature.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)
Friday, August 30, 2019
Thursday, August 29, 2019
Phytochemical indicaxanthin, the Best Natural Promotion of Myeloperoxidase Function Against Microbial Infection
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.
In cellular levels, myeloperoxidase (MPO) demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens which may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggerates of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degree of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examiend the effects of phytochemical indicaxanthin on enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to associate with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending to the confirmation of the larger sample size and multicenter human study.
Intake of isobetanin and betalains in the form of supplement should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.
In cellular levels, myeloperoxidase (MPO) demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens which may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggerates of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degree of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examiend the effects of phytochemical indicaxanthin on enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to associate with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending to the confirmation of the larger sample size and multicenter human study.
Intake of isobetanin and betalains in the form of supplement should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Green Tea and its Bioactive Polyphenols in Attenuated Early Onset, Progression and Treatment of Osteoporosis
Green tea may have a therapeutic and positive effect in reduced onset. progression and treatment of osteoporosis, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and considered as a major health problem in both elderly men and women.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that application of green tea and its bioactive compounds exert significant activities in reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.
These results demonstrated a significant decrease of risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound display an impressive osteo-protective impact on bone mass and microarchitecture in various bone loss models associated to aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased the levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.
In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) is considered as an effective measurement in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibited the production of C-reactive protein (CRP) production in the liver in demonstrated of inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
These differentiation were supported by the study in evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated overexpression of bone formation and reduced bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated early-onset, progression and combined with standard medicine for the treatment of osteoporosis. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and considered as a major health problem in both elderly men and women.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that application of green tea and its bioactive compounds exert significant activities in reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.
These results demonstrated a significant decrease of risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound display an impressive osteo-protective impact on bone mass and microarchitecture in various bone loss models associated to aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased the levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.
In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) is considered as an effective measurement in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibited the production of C-reactive protein (CRP) production in the liver in demonstrated of inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
These differentiation were supported by the study in evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated overexpression of bone formation and reduced bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated early-onset, progression and combined with standard medicine for the treatment of osteoporosis. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)
Wednesday, August 28, 2019
Phytochemical isobetanin, the Powerful Antioxidant In Beetroot
Antioxidants are stable molecules that inhibit the onset of oxidation caused by free radicals.
Free radicals, on the other hand, are unstable molecules that cause oxidation, with unpaired electrons in the outermost ring.
Free radical scavengers are types of antioxidants which play a critical to neutralize free radical before they can induce a chain reaction which can not be stopped until all unpaired electrons in the outermost are paired.
Overexpression of free radicals or depletion of antioxidant enzymes in the host body can lead to
oxidative stress, an indicator associated with the unbalanced ratio of the levels of antioxidants/free radicals
Epidemiologically, imbalance ratio of free radicals/antioxidants has been linked to the onset of many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke due to cellular, lipid and protein damage.
However, free radicals have the potential to be extremely harmful contaminants and extremely helpful for the treatment of cancers through their cytotoxic activity because of its high reactivity,
Believe it or not, free radicals present in the body with a moderate amount are important to the body's cardio-functioning, including the promotion of vascular function.
Some researchers in the examination of the effect of antioxidant-rich foods in the risk-free radicals initiation suggested that diet rich in fruits and vegetables and less in meat and process foods have a lower risk of oxidative stress and oxidative stress-related diseases.
The National Centre for Complementary and Integrative Health in the article "Antioxidants: In-Depth" wrote, "Several decades of dietary research findings suggested that consuming greater amounts of antioxidant-rich foods might help to protect against diseases. Because of these results, there has been a lot of research on antioxidant supplements".
And "Observational studies on the typical eating habits, lifestyles, and health histories of large groups of people have shown that those who ate more vegetables and fruits had lower risks of several diseases, including cardiovascular disease, stroke, cancer, and cataracts".
Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
On finding a potent ingredient for the treament of disease associated with oxidative stress, researchers examined the chemical constituents of betacyanin of Djulis (Chenopodium fromosanum), a native cereal plant in Taiwan.
Betacyanin of Djulis exhibited a significant antioxidant capacity at the maximum absorbance at 530 nm, depending on the pH.
Major chemical compounds that exerted a significant antioxidant capacity are betanin (47.8%), isobetanin (30.0%) with m/z 551.0, and armaranthin (13.6%), isoamaranthinee (8.6%).
According to the purified form, the pigment extract by HPLC, betanin, and isobetanin totally accounted for more than 70% of FRAP(ferric-reducing antioxidant power) which plays an important role in this regard of absorptivity for a variety of antioxidants and free radical scavenging capacity.
These results strongly suggested that betanin and isobetanin antioxidants process a strong antioxidant activity that may provide a basis for its sustainable utilization in the food industry.
Taken altogether, isobetanin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity" by Tsai PJ, Sheu CH, Wu PH, Sun YF.(PubMed)
Free radicals, on the other hand, are unstable molecules that cause oxidation, with unpaired electrons in the outermost ring.
Free radical scavengers are types of antioxidants which play a critical to neutralize free radical before they can induce a chain reaction which can not be stopped until all unpaired electrons in the outermost are paired.
Overexpression of free radicals or depletion of antioxidant enzymes in the host body can lead to
oxidative stress, an indicator associated with the unbalanced ratio of the levels of antioxidants/free radicals
Epidemiologically, imbalance ratio of free radicals/antioxidants has been linked to the onset of many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke due to cellular, lipid and protein damage.
However, free radicals have the potential to be extremely harmful contaminants and extremely helpful for the treatment of cancers through their cytotoxic activity because of its high reactivity,
Believe it or not, free radicals present in the body with a moderate amount are important to the body's cardio-functioning, including the promotion of vascular function.
Some researchers in the examination of the effect of antioxidant-rich foods in the risk-free radicals initiation suggested that diet rich in fruits and vegetables and less in meat and process foods have a lower risk of oxidative stress and oxidative stress-related diseases.
The National Centre for Complementary and Integrative Health in the article "Antioxidants: In-Depth" wrote, "Several decades of dietary research findings suggested that consuming greater amounts of antioxidant-rich foods might help to protect against diseases. Because of these results, there has been a lot of research on antioxidant supplements".
And "Observational studies on the typical eating habits, lifestyles, and health histories of large groups of people have shown that those who ate more vegetables and fruits had lower risks of several diseases, including cardiovascular disease, stroke, cancer, and cataracts".
Isobetanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
On finding a potent ingredient for the treament of disease associated with oxidative stress, researchers examined the chemical constituents of betacyanin of Djulis (Chenopodium fromosanum), a native cereal plant in Taiwan.
Betacyanin of Djulis exhibited a significant antioxidant capacity at the maximum absorbance at 530 nm, depending on the pH.
Major chemical compounds that exerted a significant antioxidant capacity are betanin (47.8%), isobetanin (30.0%) with m/z 551.0, and armaranthin (13.6%), isoamaranthinee (8.6%).
According to the purified form, the pigment extract by HPLC, betanin, and isobetanin totally accounted for more than 70% of FRAP(ferric-reducing antioxidant power) which plays an important role in this regard of absorptivity for a variety of antioxidants and free radical scavenging capacity.
These results strongly suggested that betanin and isobetanin antioxidants process a strong antioxidant activity that may provide a basis for its sustainable utilization in the food industry.
Taken altogether, isobetanin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Thermal and pH stability of betacyanin pigment of Djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity" by Tsai PJ, Sheu CH, Wu PH, Sun YF.(PubMed)
Green Tea and Its Bioactive Epigallocatechin gallate EGCG in Reduced Risk and Treatment of Cardiovascular Diseases
Green tea containing bioactive polyphenols may have a strong implication in reduced risk and treatment of cardiovascular disease, some scientists postulated.
Cardiovascular disease is a chronic medical condition characterized by narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.
According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.
In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.
Compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated the risk of CVD without giving rise to adverse effects.
Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.
Additionally, EGCG also exerted significant and profound effects in the ameliorated risk of diabetes through lowering plasma glucose and glycated hemoglobin level, inhibited pro-inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.
Dr. Eng QY, after taking into account of other confounders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".
Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis. by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for a nongreen tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.
Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.
And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to the group who drank <3 cups/day.
Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in the compilation of how green tea initiated protective activity against CVD.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)
Cardiovascular disease is a chronic medical condition characterized by narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.
According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.
In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.
Compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated the risk of CVD without giving rise to adverse effects.
Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.
Additionally, EGCG also exerted significant and profound effects in the ameliorated risk of diabetes through lowering plasma glucose and glycated hemoglobin level, inhibited pro-inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.
Dr. Eng QY, after taking into account of other confounders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".
Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the meta-analysis. by examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for a nongreen tea drinker, risk of CVD was 1.19, intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.
Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.
And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to the group who drank <3 cups/day.
Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in the compilation of how green tea initiated protective activity against CVD.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)
Tuesday, August 27, 2019
Phytochemical 3,3'-Diindolylmethane Speeds Up Wound Healing
Wound healing is a natural process to repair the wound or cut through a number of stages.
In the first stage, after receiving the message from the central nervous system, the immune first line of defense white blood cells stimulate the production of blood palettes to the site of damage to cover the wound and activate the protein associated with the production of pro-inflammatory cytokines to fight off the micro pathogens trying to enter the body.
Under normal condition, proteins associated with the production of anti-inflammation cytokines may also switch to proinflammatory cytokines, depending on the size and location of the wound.
Overproduction of pro-inflammatory cytokines in this phase can cause the death of nearby healthy cells, leading to the formation of a scar.
Most microbial invaders are stopped at the acute phase of infection.
The wound healing process is divided into four overlapping phases: hemostasis, inflammatory, proliferative, and maturation.
Any interruption of the stage of wound healing also can lead to imbalanced production and dissolving of collagens in the site, inducing the formation of scars.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound for speed-up wound healing without side effects, researchers evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model.
Where human umbilical cord-derived mesenchymal stem cells (hucMSCs) has been used in the laboratory as a promising therapeutic tool in regenerative medicine.
HucMSCs pretreatment of 50 μM of DIM exhibited desirable repairing effects compared to the untreated hucMSCs.
In vivo, DIM enhanced hucMSCs in tissue regeneration by activation of proteins that pass signals into a cell through cell surface receptors.
Furthermore, DIM-primed hucMSCs (DIM-hucMSCs) also promotes tissue regeneration by suppressing the inhibition of β-catenin that impairs the healing effects.
Moreover, DIM promoted the Wnt11 expression associated with all regeneration stages in hucMSC-derived exosomes.
Decreased expression of Wnt11 showed to inhibited β-catenin activation.
Based on the findings, DIM enhanced tissue regeneration after wound by promoting the genes associated with the healing process.
Dr. Shi H the lead scientist said, "DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing".
Taken altogether, 3,3'-Diindolylmethane derived from the indole-3-carbinol may be considered a supplement for speed-up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing by Shi H1, Xu X1, Zhang B1, Xu J1, Pan Z1, Gong A1, Zhang X1, Li R1, Sun Y1, Yan Y1, Mao F1, Qian H1, Xu W. (PubMed)
In the first stage, after receiving the message from the central nervous system, the immune first line of defense white blood cells stimulate the production of blood palettes to the site of damage to cover the wound and activate the protein associated with the production of pro-inflammatory cytokines to fight off the micro pathogens trying to enter the body.
Under normal condition, proteins associated with the production of anti-inflammation cytokines may also switch to proinflammatory cytokines, depending on the size and location of the wound.
Overproduction of pro-inflammatory cytokines in this phase can cause the death of nearby healthy cells, leading to the formation of a scar.
Most microbial invaders are stopped at the acute phase of infection.
The wound healing process is divided into four overlapping phases: hemostasis, inflammatory, proliferative, and maturation.
Any interruption of the stage of wound healing also can lead to imbalanced production and dissolving of collagens in the site, inducing the formation of scars.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a natural compound for speed-up wound healing without side effects, researchers evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model.
Where human umbilical cord-derived mesenchymal stem cells (hucMSCs) has been used in the laboratory as a promising therapeutic tool in regenerative medicine.
HucMSCs pretreatment of 50 μM of DIM exhibited desirable repairing effects compared to the untreated hucMSCs.
In vivo, DIM enhanced hucMSCs in tissue regeneration by activation of proteins that pass signals into a cell through cell surface receptors.
Furthermore, DIM-primed hucMSCs (DIM-hucMSCs) also promotes tissue regeneration by suppressing the inhibition of β-catenin that impairs the healing effects.
Moreover, DIM promoted the Wnt11 expression associated with all regeneration stages in hucMSC-derived exosomes.
Decreased expression of Wnt11 showed to inhibited β-catenin activation.
Based on the findings, DIM enhanced tissue regeneration after wound by promoting the genes associated with the healing process.
Dr. Shi H the lead scientist said, "DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing".
Taken altogether, 3,3'-Diindolylmethane derived from the indole-3-carbinol may be considered a supplement for speed-up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing by Shi H1, Xu X1, Zhang B1, Xu J1, Pan Z1, Gong A1, Zhang X1, Li R1, Sun Y1, Yan Y1, Mao F1, Qian H1, Xu W. (PubMed)
The Kitchen Spice Turmeric Inhibits Parameters Associated with the Onset of Stomach/GastricCancer
Cancer is a group of medical conditions caused by the irregular cell growth in the tissue of specific organ due to the alternation of cell DNA.
The stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach/gastric cancer is a cancerous condition characterized by abnormal growth of the mucus-producing cells of the inner lining of the stomach. At the advanced stage, after growing in size, over time cancer cells can invade other healthy tissue or organ by traveling a distance away from the stomach, leading to secondary metastasis.
Adenocarcinoma arisen from the glands in the mucosa is the most common type of stomach cancer associated with
* Superficial spreading
It is an early stage of cancer and tends to be less aggressive.
* Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.
*Infiltrating
Cancer grows in infiltrating pattern into the stomach wall and is more aggressive.
* Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.
According to the statistics provided by the American Cancer Society, in the US, approximately
27,510 cases of stomach cancer will be diagnosed in 2019, including 17,230 men and 10,280 women.
Sadly, 11,140 people will also die from stomach cancer in 2019 including 6,800 men and 4,340 women.
Most cases of stomach cancer are diagnosed in older adults with an average age of 68 and over.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of gastric cancer, researchers examined the effect of curcumin in an animal model.
The study included BALB/C mice grafted with a mouse gastric adenocarcinoma cell line (MFC) fed with different doses of curcumin after grafting.
According to the tested assays,
* Tumor growth (size and weight) was significantly inhibited by curcumin treatment, compared to controls.
* The apoptotic rate of gastric cancer cells was significantly increased in the curcumin treatment group.
* Splenocyte cells from mice treated with curcumin exhibited higher cytolytic effects on MFC cancer cells compared to those treated with saline.
* Furthermore, the curcumin treatment group also inhibited the expression of pathways associated with oxidative stress-induced inflammation(STAT3), the promotion of tumor growth and metastasis(HIF-1α,), poor prognosis, and clinical outcome (DEC1), and angiogenesis( VEGF).
Based on the findings, researchers wrote, "curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large number of cytokines, and down-regulating the DEC1, HIF-1α, VEGF and STAT3 signal transduction pathways".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of stomach/gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma by Wang XP1, Wang QX, Lin HP, Chang N. (PubMed)
(2) Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells by Lee TK1, Lee D1, Lee SR1, Ko YJ2, Sung Kang K3, Chung SJ1, Kim KH. (PubMed)
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