Osteoarthritis is an inflammation of joints caused by the depletion of the cartilage on the ends of the bones due to the wear and tear over time.
The disease is one most common forms of arthritis that affect millions of people worldwide.
According to the statistics, in the US, approximately 10% of men and 13% of women aged 60 years or older have osteoarthritis (OA).
Most common risk factors found in patients with OA are older adults, female gender, overweight and obesity, knee injury, repetitive use of joints, low bone density.
Besides pain on the joints, the other most common symptoms of OA include tenderness, stiff, low flexibility, grating sensation.
Conventionally, treatment of OA is focused on managing symptoms, by reducing pain, stiffness and swelling through the use of pain killers, improving joint mobility and flexibility and maintaining a healthy weight by exercise.
Some researchers suggested that the high prevalence of OA in the US has become a burden to the health care cost and economic burden.
Dr.Bitton R, the lead scientist at the Health Plan of Nevada wrote, "approximately one-third of direct OA expenditures are allocated for medications, much of which goes toward pain-related agents. Hospitalization costs comprise nearly half of direct costs, although these expenditures are consumed by only 5% of OA patients who undergo knee or hip replacement surgery".
And, "Indirect costs for OA are also high, largely a result of work-related losses and home-care costs".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for diseases associated with inflammation, researchers investigated the effects of bromelain in mild-to-moderate knee OA patients.
The randomized, single-blind, active-controlled pilot study included 40 knee OA patients randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
At week 4, both bromelain and diclofenac treated groups showed an improvement of total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and pain subscales compared to the baseline.
According to the tested assays, bromelain and diclofenac groups exerted similar effects after 4 weeks.
At week 16 of bromelain treatment, patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values.
In other words, bromelain reduced symptoms and improved quality of life in OA patients by inhibiting the levels of oxidative stress and overexpression of pro-inflammatory cytokines at week 16.
Based on the results, researchers after taking other factors into account wrote, "Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of osteoarthritis (OA), pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(2) The economic burden of osteoarthritis by Bitton R. (PubMed)
Friday, November 15, 2019
Thursday, November 14, 2019
Bilberry May Process Anti Breast Cancer Potency with No Side Effects, According to Medical Literature
Bilberry may be the next potential and therapeutic treatment of breast cancer with no side effects, according to studies.
Breast cancer is the chronic condition characterized by irregular cell growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breasts at least once a month for preventive measures.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cells was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
Breast cancer is the chronic condition characterized by irregular cell growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breasts at least once a month for preventive measures.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cells was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
Herbal Anise in Ameliorated Menopausal Hot Flash Frequency and Severity
Anise may have a potential and substantial effect in relief and reduced recurrence of menopausal hot flashes, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....agent
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Hot flashes are the frequent symptoms of menopause induced sudden feelings of warmth in some parts of the body. The symptoms affect approximately 75% of all women in perimenopause in the Western world.
In the investigation of the effect of Pimpinella anisum and symptoms of hot flash in postmenopausal women, researchers at the Shahid Beheshti Universit conducted a review of medical records at health centers of sample of 72 women with hot flashes randomly selected according to the predetermined criteria and divided into experimental group received a capsule containing 330 mg Pimpinella anisum 3 times a day and control group received 3 capsules, each containing 330 mg potato starch, over 4 weeks with pre-treatment of frequency and severity of hot flashes taken in 2 weeks before administration indicated that women in anise treatment group exert a significantly reduced frequency and severity of hot flashes from the pre-treatment of 4.21% and 56.21% to 1.06% and 14.44% at the end of the fourth week respectively in compared to control group.
Further analysis found that women who are in the anise testing group also continue benefits from the ameliorated of the frequency and severity of hot flashes in 4 weeks follow up examination.
These results suggested that long term intake of herbal Anise may have a continued efficacy in relief and recurrence of menopausal hot flashes.
Additional illustration of the prevalence of hot flash in menopause women by reviewing the literature published on MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015), researchers at joint study lead by the Mashhad University of Medical Science showed that overall studies approved the herbal effects of Anise in contribution of reduced hot flash occurrence and frequency as well as alleviating the side effects of hot flashes.
Moreover, in the double-blind clinical trial conducted to determine the effects of Anise abstract on hot flashes in women referring to rural and urban health centers of Qazvin province during 2006 by randomly assigned 72 postmenopausal women at different verities selected according to pre-determined criteria and divided into group of experimental group took a capsule containing 100 mg Anise 3 times a day and control group received 3 placebo capsules, each containing 330 mg starch over 4 weeks experimental periods, searchers after compared to the frequency of hot flashes and the types of food they took 1 week before administrations found that there is significant difference in hot flash expression in these 2 groups of women
The Anise group showed a substantial decrease in the frequency and severity of hot flashes from 4.21% and 56.21% before treatment and 1.06% and 14.44% at the end of the fourth week, respectively.
And women in control expressed an insignificant change of hot flash frequency and severity in compared to measurement before treatment.
Interestingly, after taking account of other confounders, Dr. Fatemeh Nahidi, the lead author said, " women can be taught to choose different alleviating methods, preferably".
In other words, by providing enough information, women who suffered from menopause hot flash should be able to choose different alleviating methods in relief and recurrence of the symptoms.
Women who do not tolerate the side effect of conventional medicine with symptoms of the hot flash may want to add a portion of Anise into their diet, please consult with your herbalist before taking the herbs for preventive measure.
Due to the short term of 4 weeks of study, some researchers suggested that further studies with longer duration of treatment Anise for assessing hot flashes are necessary.
Taken together, herbal Anise may be considered as adjunct therapy used a combination with the standard treatment of hot flash in women in peri-menopause, menopause and post-menopause. However, intake of herbal Anise supplements should be taken with extreme care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes by Nahidi F1, Kariman N, Simbar M, Mojab F.(PubMed)
(2) The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review by Ghazanfarpour M1, Sadeghi R2, Abdolahian S3, Latifnejad Roudsari R4.(PubMed)
(3) Effect of anise extract on hot flush of menopause by Fatemeh Nahidi, M. Taherpour, F. Mojab, Hamid Alavi Majd(Research Gate)
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....agent
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Hot flashes are the frequent symptoms of menopause induced sudden feelings of warmth in some parts of the body. The symptoms affect approximately 75% of all women in perimenopause in the Western world.
In the investigation of the effect of Pimpinella anisum and symptoms of hot flash in postmenopausal women, researchers at the Shahid Beheshti Universit conducted a review of medical records at health centers of sample of 72 women with hot flashes randomly selected according to the predetermined criteria and divided into experimental group received a capsule containing 330 mg Pimpinella anisum 3 times a day and control group received 3 capsules, each containing 330 mg potato starch, over 4 weeks with pre-treatment of frequency and severity of hot flashes taken in 2 weeks before administration indicated that women in anise treatment group exert a significantly reduced frequency and severity of hot flashes from the pre-treatment of 4.21% and 56.21% to 1.06% and 14.44% at the end of the fourth week respectively in compared to control group.
Further analysis found that women who are in the anise testing group also continue benefits from the ameliorated of the frequency and severity of hot flashes in 4 weeks follow up examination.
These results suggested that long term intake of herbal Anise may have a continued efficacy in relief and recurrence of menopausal hot flashes.
Additional illustration of the prevalence of hot flash in menopause women by reviewing the literature published on MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015), researchers at joint study lead by the Mashhad University of Medical Science showed that overall studies approved the herbal effects of Anise in contribution of reduced hot flash occurrence and frequency as well as alleviating the side effects of hot flashes.
Moreover, in the double-blind clinical trial conducted to determine the effects of Anise abstract on hot flashes in women referring to rural and urban health centers of Qazvin province during 2006 by randomly assigned 72 postmenopausal women at different verities selected according to pre-determined criteria and divided into group of experimental group took a capsule containing 100 mg Anise 3 times a day and control group received 3 placebo capsules, each containing 330 mg starch over 4 weeks experimental periods, searchers after compared to the frequency of hot flashes and the types of food they took 1 week before administrations found that there is significant difference in hot flash expression in these 2 groups of women
The Anise group showed a substantial decrease in the frequency and severity of hot flashes from 4.21% and 56.21% before treatment and 1.06% and 14.44% at the end of the fourth week, respectively.
And women in control expressed an insignificant change of hot flash frequency and severity in compared to measurement before treatment.
Interestingly, after taking account of other confounders, Dr. Fatemeh Nahidi, the lead author said, " women can be taught to choose different alleviating methods, preferably".
In other words, by providing enough information, women who suffered from menopause hot flash should be able to choose different alleviating methods in relief and recurrence of the symptoms.
Women who do not tolerate the side effect of conventional medicine with symptoms of the hot flash may want to add a portion of Anise into their diet, please consult with your herbalist before taking the herbs for preventive measure.
Due to the short term of 4 weeks of study, some researchers suggested that further studies with longer duration of treatment Anise for assessing hot flashes are necessary.
Taken together, herbal Anise may be considered as adjunct therapy used a combination with the standard treatment of hot flash in women in peri-menopause, menopause and post-menopause. However, intake of herbal Anise supplements should be taken with extreme care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes by Nahidi F1, Kariman N, Simbar M, Mojab F.(PubMed)
(2) The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review by Ghazanfarpour M1, Sadeghi R2, Abdolahian S3, Latifnejad Roudsari R4.(PubMed)
(3) Effect of anise extract on hot flush of menopause by Fatemeh Nahidi, M. Taherpour, F. Mojab, Hamid Alavi Majd(Research Gate)
Can Herbal Alfalfa Be Used for the Prevention and Treatment of Cancers?
Scientists do not agree that herbal Alfalfa can be used alone or combined with other primary medicine for the treatment of cancer, according to study.
Cancer is a class of diseases characterized by the cell growth irregularly and disorderly in the body tissue.
Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.
However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.
Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, carcinogens, are associated with the onset of the diseases.
Some researchers also strongly indicated obesity-induced hormones change and, chronic inflammation is a major risk factor involved the development of cancers in the Western world
Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".
And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
It chemical constituents include flavones, isoflavones, sterols, Bichanin A Coumestrol Diadzein Formonetin Genisteincoumarin derivatives, etc.
With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.
The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that 1.54 of the seed.
Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.
Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats by given at 7 weeks of age, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methylnitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.sugegsted
Examine the results from the autopsies at the 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets.
The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran.
The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.
The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet.
These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.
Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Cancer is a class of diseases characterized by the cell growth irregularly and disorderly in the body tissue.
Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.
However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.
Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, carcinogens, are associated with the onset of the diseases.
Some researchers also strongly indicated obesity-induced hormones change and, chronic inflammation is a major risk factor involved the development of cancers in the Western world
Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".
And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
It chemical constituents include flavones, isoflavones, sterols, Bichanin A Coumestrol Diadzein Formonetin Genisteincoumarin derivatives, etc.
With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.
The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that 1.54 of the seed.
Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.
Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats by given at 7 weeks of age, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methylnitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.sugegsted
Examine the results from the autopsies at the 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets.
The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran.
The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.
The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet.
These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.
Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Cucurbitacin B Inhibits Non Small Lung Cancer Cells in Vitro and Vivo
Lung cancer is a medical condition caused abnormal growth of the cells in the lung's tissue. A most common form of primary lung cancer is derived from epithelial cells.
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
According to the statistics provided by the American cancer society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed are younger 45.
Most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaling air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these danger carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or exposing certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increased if one of the members of your direct family has lung cancer.
5. Lung disease
Risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association between consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed with the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
And, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor butithione-sulfoxime (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in vitro and Vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and Vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta, Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
According to the statistics provided by the American cancer society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed are younger 45.
Most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaling air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these danger carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or exposing certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increased if one of the members of your direct family has lung cancer.
5. Lung disease
Risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association between consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed with the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
And, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor butithione-sulfoxime (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in vitro and Vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and Vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta,
Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)Herbal Coltsfoot (Tussilago farfara), the Anti-Inflammation Herbal Remedy
Inflammation is a natural response in which the white blood cells in the first line of defense of the immune system try to destroy the harmful pathogens before they can enter the body to multiply inducing the acute phase of infection.
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Inflammation can be classified into 2 types
*Acute inflammation caused by trauma, microbial invasion, or noxious compounds, is a condition that starts rapidly, and becomes severe in a short time and lasts for a few days.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissue damage.
* Chronic inflammation is a slow, long-term inflammation, lasting for months to years caused by the inability of immunity to repair and overcome the damage or injury.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organ damage, inducing a number of chronic illnesses, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety, and mood disorders and gastrointestinal complications such as constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of the diseases is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of hypercholesterolemia, researchers examined the anti-inflammatory effect of Tussilagone (TSL), isolated from the flower of buds of Tussilago farfara (Compositae).
According to the tested analysis, RAW264.7 cells treated by TSLshowed a significant activity to increase HO-1 protein expression associated with anti-inflammatory activity in a dose- and time-dependent manner without the induction of HO-1 mRNA expression.
In other words, TSL-mediated HO induction may be regulated at the translational level involved in the cellular response to stressors, growth cues, and differentiation through its anti-inflammatory properties.
Pro-inflammatory proteins such as nitric oxide (NO), tumor necrosis factor (TNF)-alpha, and prostaglandin E2 (PGE2) were also inhibited by the administration of TSL in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Based on the findings, researchers said, "TSL may be an effective HO-1 inducer that has anti-inflammatory effects and a valuable compound for modulating inflammatory conditions.".
Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with inflammatory disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages by Hwangbo C1, Lee HS, Park J, Choe J, Lee JH. (PubMed)
(2) Chronic Inflammation by Roma Pahwa, and Ishwarlal Jialal. (NCBI)
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Inflammation can be classified into 2 types
*Acute inflammation caused by trauma, microbial invasion, or noxious compounds, is a condition that starts rapidly, and becomes severe in a short time and lasts for a few days.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissue damage.
* Chronic inflammation is a slow, long-term inflammation, lasting for months to years caused by the inability of immunity to repair and overcome the damage or injury.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organ damage, inducing a number of chronic illnesses, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety, and mood disorders and gastrointestinal complications such as constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of the diseases is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of hypercholesterolemia, researchers examined the anti-inflammatory effect of Tussilagone (TSL), isolated from the flower of buds of Tussilago farfara (Compositae).
According to the tested analysis, RAW264.7 cells treated by TSLshowed a significant activity to increase HO-1 protein expression associated with anti-inflammatory activity in a dose- and time-dependent manner without the induction of HO-1 mRNA expression.
In other words, TSL-mediated HO induction may be regulated at the translational level involved in the cellular response to stressors, growth cues, and differentiation through its anti-inflammatory properties.
Pro-inflammatory proteins such as nitric oxide (NO), tumor necrosis factor (TNF)-alpha, and prostaglandin E2 (PGE2) were also inhibited by the administration of TSL in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Based on the findings, researchers said, "TSL may be an effective HO-1 inducer that has anti-inflammatory effects and a valuable compound for modulating inflammatory conditions.".
Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with inflammatory disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages by Hwangbo C1, Lee HS, Park J, Choe J, Lee JH. (PubMed)
(2) Chronic Inflammation by Roma Pahwa, and Ishwarlal Jialal. (NCBI)
Wednesday, November 13, 2019
Cranberry Inhibits Parameters Associated with the Onset of Colitis
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Most cases of colitis are caused by infection, such as bacteria like C. difficile, viruses, and parasites and inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis (UC).
However, according to the study by the Catholic University of the Sacred Heart, depending to the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.
The most common symptoms of colitis are abdominal pain and diarrhea, bleeding per rectum, distention with bloody diarrhea, abdominal bloating and flatulence, and changes in bowel habits.
In severe cases, patients may also experience symptoms of elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea.
Believe it or not, fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life.
Conventionally, treatments of colitis are total depending on the type and severity of the condition. For example, in patients with inflammatory bowel disease (IBD), Self-care at home through home tele-management, Web-guided therapy and pain management are the most common approach accompanied by biological therapy, if necessary.
Some researchers suggested, the promotion of the Western diet over the past few decades may be the leading cause of colitis in patients with IBD.
Dr. Jimmy K. Limdi wrote, "The parallelism between “westernization” and particularly high dietary intakes of total fat (particularly animal fats, ω-6 polyunsaturated fatty acids (PUFA), milk fats), refined sugars, meat and lower intakes of fruit and vegetables, implicates diet in the great risk of developing IBD".
And, "Diet may influence intestinal inflammation through several biologically plausible mechanisms including dietary antigen presentation, alterations in the gut microbiome, the mucosal immune system and epithelial barrier function among others".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry is cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine for the treatment of wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of IBD, researchers examined the effects of cranberry products on preventing dextran sulfate sodium-induced murine colitis.
According to the tested differentiation, both cranberry extract and dried cranberries-fed groups had significant activity against the disease index.
However, dried cranberries were more effective in preventing colitis compared to that of cranberry extract.
Moreover, both cranberry application also showed a significant effect on preventing the shortening of colon length,
Biomarkers associated with inflammatory bowel diseases (IBD) such as colonic myeloperoxidase activity were attenuated in animals fed dried cranberries compared to the controls.
Additionally, dried cranberries also inhibited much better results against the production of pro-inflammatory cytokines caused by the injection of dextran sulfate sodium, compared to the controls.
Based on the findings, researchers wrote, "The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of colitis in IBD patients, pending to the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diets enriched with cranberry beans alter the microbiota and mitigate colitisseverity and associated inflammation by Monk JM1, Lepp D2, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Pauls KP3, Tsao R2, Wood GA4, Robinson LE5, Power KA. (PubMed)
(2) Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice by Xiao X1, Kim J1, Sun Q1, Kim D2, Park CS3, Lu TS4, Park Y. (PubMed)
(3) Colitides by Tortora A1, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G, Giovanni G, Gasbarrini A. (PubMed)
(4) Dietary practices and inflammatory bowel disease by Jimmy K. Limdi. (PMC)
Most cases of colitis are caused by infection, such as bacteria like C. difficile, viruses, and parasites and inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis (UC).
However, according to the study by the Catholic University of the Sacred Heart, depending to the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.
The most common symptoms of colitis are abdominal pain and diarrhea, bleeding per rectum, distention with bloody diarrhea, abdominal bloating and flatulence, and changes in bowel habits.
In severe cases, patients may also experience symptoms of elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea.
Believe it or not, fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life.
Conventionally, treatments of colitis are total depending on the type and severity of the condition. For example, in patients with inflammatory bowel disease (IBD), Self-care at home through home tele-management, Web-guided therapy and pain management are the most common approach accompanied by biological therapy, if necessary.
Some researchers suggested, the promotion of the Western diet over the past few decades may be the leading cause of colitis in patients with IBD.
Dr. Jimmy K. Limdi wrote, "The parallelism between “westernization” and particularly high dietary intakes of total fat (particularly animal fats, ω-6 polyunsaturated fatty acids (PUFA), milk fats), refined sugars, meat and lower intakes of fruit and vegetables, implicates diet in the great risk of developing IBD".
And, "Diet may influence intestinal inflammation through several biologically plausible mechanisms including dietary antigen presentation, alterations in the gut microbiome, the mucosal immune system and epithelial barrier function among others".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry is cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine for the treatment of wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of IBD, researchers examined the effects of cranberry products on preventing dextran sulfate sodium-induced murine colitis.
According to the tested differentiation, both cranberry extract and dried cranberries-fed groups had significant activity against the disease index.
However, dried cranberries were more effective in preventing colitis compared to that of cranberry extract.
Moreover, both cranberry application also showed a significant effect on preventing the shortening of colon length,
Biomarkers associated with inflammatory bowel diseases (IBD) such as colonic myeloperoxidase activity were attenuated in animals fed dried cranberries compared to the controls.
Additionally, dried cranberries also inhibited much better results against the production of pro-inflammatory cytokines caused by the injection of dextran sulfate sodium, compared to the controls.
Based on the findings, researchers wrote, "The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of colitis in IBD patients, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diets enriched with cranberry beans alter the microbiota and mitigate colitisseverity and associated inflammation by Monk JM1, Lepp D2, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Pauls KP3, Tsao R2, Wood GA4, Robinson LE5, Power KA. (PubMed)
(2) Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice by Xiao X1, Kim J1, Sun Q1, Kim D2, Park CS3, Lu TS4, Park Y. (PubMed)
(3) Colitides by Tortora A1, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G, Giovanni G, Gasbarrini A. (PubMed)
(4) Dietary practices and inflammatory bowel disease by Jimmy K. Limdi. (PMC)
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